Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Males receiving anti-PD-(L)1 monotherapy had the worst outcomes, with a 3-year PFS and 3-year OS of 23.9% and 41.8%, respectively, while the addition of anti-CTLA-4 agents rescued such a worse outcome. …”
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A longitudinal cohort study on dispensed analgesic and psychotropic medications in older adults before, during, and after the COVID-19 pandemic: the HUNT study by Tanja Louise Ibsen, Ekaterina Zotcheva, Sverre Bergh, Debby Gerritsen, Gill Livingston, Hilde Lurås, Svenn-Erik Mamelund, Anne Marie Mork Rokstad, Bjørn Heine Strand, Richard C. Oude Voshaar, Geir Selbæk

“…People without dementia had increased prescriptions of opioids, other analgesics, and antidepressants after lockdown, whereas no changes were observed among those with dementia. …”
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Impact of Oxycodone HCl Extended-release Formulary Restrictions on Extended-release Opioid Market Share, Healthcare Resource Utilization and Costs in Commercial and Medicare Plans by Rolin L. Wade, Chi-Chang Chen, Ajita P. De, Jaren C. Howard

“…**Conclusions:** This study observed that despite reducing the market share of OER, OER formulary restrictions had negligible impact on overall ER opioid utilization, and did not result in substantial pharmacy/medical cost savings.…”
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PENGEMBANGAN DESAIN BAHAN AJAR FISIKA BERBASIS E-MODUL PADA MATERI MOMENTUM by Nadah Qolbi Shobrina, Indra Sakti, Andik Purwanto

“…The results showed that the e-module based physics teaching materials developed included in the category good validity and as a tested design for getting a positive response with the percentage of total validity test is 80.6% and also had reliability on the content aspect and served with coefficient value equal 0.9 and 0.88, the coefficient value language aspect 0.79 with category very high reliability and reliability media aspect 0,88 with category very high. …”
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Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities by Hanzun Zhang, Shipeng Dong, Hongwei Shan, Chao Yang, Fang Wang

“…The maturation process was accelerated for crabs in saline conditions, with puberty achieved at 45, 36, and 31 days, compared to the freshwater group that had not matured. Furthermore, the LC50 for salinity decreased from 9.07 ‰ (95 % CI: 7.33–10.15 ‰) at 35 days to 4.59 ‰ (95 % CI: 3.12–5.83 ‰) at 60 days. …”
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Comparison of the effects of production and processing parameters on the eating quality of lamb by L.J. Farmer, A.W. Gordon, D.W. Sanderson, J.S. Speers, T.D.J. Hagan, E.L. Swancott, J.L. Evans, D.J. Richards, E.M. Thomas

“…The three factors that had the most significant effect on consumer sensory quality were muscle, season and individual farm. …”
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Phase II clinical trial assessing the addition of hyperthermia to salvage concurrent chemoradiotherapy for unresectable recurrent head and neck cancer in previously irradiated pati... by Kai-Lin Yang, Mau-Shin Chi, Chung-Yu Hao, Hui-Ling Ko, Yi-Ying Huang, Ren-Hong Wu, Hung-Chih Lai, Ying-Chu Lin, Sheng-Po Hao, Kwan-Hwa Chi

“…Methods We enrolled patients with non-metastatic recurrent head and neck cancer who had previously undergone radiotherapy (RT) and were unfit for salvage surgery. …”
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To remove or to replace traditional electronic games? A crossover randomised controlled trial on the impact of removing or replacing home access to electronic games on physical act... by Anne J Smith, Leon M Straker, Rebecca A Abbott

“…From 210 children who were eligible, 74 met inclusion criteria, 8 withdrew and 10 had insufficient primary outcome measures, leaving 56 children (29 female) for analysis.Intervention A counterbalanced randomised order of three conditions sustained for 8 weeks each: no home access to electronic games, home access to traditional electronic games and home access to active input electronic games.Main outcome measures Primary outcome was accelerometer assessed moderate/vigorous physical activity (MVPA). …”
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Cost-Effectiveness of Apomorphine Sublingual Film as an “On-Demand” Treatment for “OFF” Episodes in Patients with Parkinson's Disease by Andrew Thach, Noam Kirson, Miriam L. Zichlin, Ibrahima Dieye, Eric Pappert, G. Rhys Williams

“…**Results:** In the base case, APL had the lowest total “on-demand” treatment costs (\$42,095) compared with SC-APO (\$276,320; difference: –\$234,225) and CVT-301 (\$69,577; difference: –\$27,482) over the 10-year horizon. …”
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The Impact of Coronavirus Disease 2019 Pandemic on Female Patients Seeking or Undergoing Fertility Treatment in a Single In Vitro Fertilisation Clinic in Greece: An International,... by Konstantina Pappa, Emmanouil M. Xydias, Apostolos C. Ziogas, Kanelina Bimba, Elias Tsakos, Efstratios Kolibianakis

“…Conclusion: The COVID-19 pandemic lockdowns had a significant emotional impact on patient receiving or undergoing ART treatment in Greece. …”
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Bacteriological and Physicochemical Qualities of Ebutte River in Ebutte Community, Uhunmwonde Local Government Area, Edo State, Nigeria by Fred Osaro Ekhaise

“…The results of most of the physicochemical parameters analysed were shown to be higher at sampling point 3, which is the point that had direct effect of human activities. Similarly the values obtained for dissolved oxygen was shown to be lowest in the inhabited sampling point 3. …”
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Trends and distribution patterns of infant mortality and maternal HIV positivity in South Africa: A decade review (2007 - 2016) by M Makhele, N Ledibane, H Ramatsoma, A Musekiwa

“…The infant mortality proportions by province showed KwaZulu-Natal Province having the highest IMR (17.5 deaths per 1 000 live births in 2007 and 6.3 in 2016). Males had a higher IMR (28 deaths per 1 000 live births in 2007 and 17.7 in 2016) compared with females at 26.7 deaths per 1 000 live births in 2007 and 13.8 in 2016. …”
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Nymphaea pubescens Willd. extract and its flavonoid constituents vasodilate rat isolated pulmonary artery via NO-sGC-cGMP pathway by Teerapap Panklai, Prapapan Temkitthawon, Nungruthai Suphrom, Corine Girard, Perle Totoson, Kowit Hengphasatporn, Yasuteru Shigeta, Krongkarn Chootip, Kornkanok Ingkaninan

“…Sodium nitroprusside (SNP)-induced relaxation was enhanced by the WLE. WLE had no effect neither on extracellular Ca2+ influx through ROCCs/VOCCs nor intracellular Ca2+ release from the sarcoplasmic reticulum. …”
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Initial versus Subsequent Injury and Illness and Temporal Trends Among Professional Hockey Players by Chelsea Martin, Allison Lieb, John Tokish, Ellen Shanely, Stefan Kluzek, Gary Collins, Garrett Bullock

“… # Results Nine thousand, seven-hundred and thirty four injuries and illnesses were recorded. Centers had the highest overall IR at 15.14 per 1000 athlete game exposures (AGEs) (95%CI:15.12-15.15) and were 1.4 times more likely to sustain a subsequent injury compared to other positions. …”
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Individual-Level Determinants of Self-Care Behaviors and Adaptation to Chronic Illness in Turkish Patients With Chronic Disease: A Single-Center Cross-Sectional Study by Kılıç YF, Yardımcı Gürel T

“…Regression analyses revealed that age (β = − 0.115, t = − 0.511, P < 0.05) and economic status (β = 2.698, t = − 2.487, P < 0.05) had a significant effect on adaptation to chronic illness. …”
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Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

“…Methods We conducted 158 in-depth interviews (IDIs) with randomly selected rural-living women who had delivered a baby in the prior 12 months. Half lived in catchment areas where new quality MWHs were constructed, half in catchment areas with standard of care (ranging from low quality community structures to no MWH). …”
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Eating Habits, Anxiety and Depression in Patients with Irritable Bowel Syndrome: Clinical and Laboratory Comparisons by O. V. Gaus, M. A. Livzan

“…All individuals included in the study were assessed for diet and eating habits using the WHO CINDI program questionnaire, “Information on Nutrition and Eating Behavior”, the severity of anxiety and depression according to the HADS questionnaire, the level of specific anxiety in relation to gastrointestinal symptoms according to the VSI questionnaire, quality of life according to the IBS-QoL questionnaire. …”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…Results Before PSM, the RAMIE group had a longer operation time (min) than the MIE group (P = 0.019). …”
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The position of Lithuanian parties towards Poland in 1920-1926: from modus vivendi to permanent confrontation by Andrius Grodis

“…However, the attitude of the Christian Democrats that it was possible to launch economic relationships with Poland, and the Social Democrats' belief that it was even crucial to do so, which were regarded as a first step in resuming Vilnius, in fact reflected that the leaders of the parties had enough rational reasoning as well as a mature attitude to international relations. …”
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Age modulates, religious coping mediates: the role of attitude to self in cancer patients’ quality of life by Maria-Chidi C. Onyedibe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Runcie C.W. Chidebe, Barbara L. Andersen, Uzoamaka F. Ugwoke, Lawrence Ejike Ugwu, Lawrence Ejike Ugwu

“…Positive religious coping had limited effects.ConclusionThe study highlights the significant impact of cognitive vulnerabilities and maladaptive religious coping on the HRQoL of older cancer patients in LMICs. …”
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