Quercetin and Nano-Derivatives: Potential and Challenges in Cancer Therapy by Li XR, Qi L, Zhang XW, Wei C, Yu B, Pei TL

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Safety and efficacy of abatacept among patients with refractory rheumatoid arthritis: Experience from a North Indian Tertiary Care Hospital by M N Arjun, Arun Hegde, Krishnan Shanmuganandan, Darshan S Bhakuni, Kavita Singh, Abhishek Kumar

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An Integral of Fox’s H-Functions With Application to the Performance of Hybrid FSO/RF Systems Over Generalized Fading Channels by Wagdy Ameen Alathwary, Essam Saleh Altubaishi

“…Motivated by the need to solve this issue, we evaluate an integral of a product of Fox’s H-functions (FHFs). …”
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Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome by Cao Z, Zhou Q, An J, Guo X, Jia X, Qiu Y

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Mechanisms and Targeted Therapeutic Strategies in Sepsis-Induced Myocardial Dysfunction: The Role of NLRP3 Inflammasome-Mediated Inflammation by Yu YY, Wang R, Chen GQ, Gui YF, Ma J, Ma JH, Li SJ

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FGFR inhibition as a new therapeutic strategy to sensitize glioblastoma stem cells to tumor treating fields by Pauline Deshors, Ziad Kheil, Laetitia Ligat, Valerie Gouazé-Andersson, Elizabeth Cohen-Jonathan Moyal

“…Studying mechanisms of resistance of GSC to TTFields is thus a major issue to address. Fibroblast Growth Factor Receptors (FGFR) play a major role in numerous processes essential for cancer development, and dysregulation of FGFR signaling has been observed in many cancer types, including GBM. …”
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MicroRNA: a clinician’s view of the state of the problem. Part 3: MicroRNA and approaches to the treatment of cardiovascular diseases by O. Iu. Mironova, M. V. Berdysheva, E. S. Deeva, E. M. Elfimova

“…This  article  touches   upon  the  issue  of such  an important problem  as  myocardial  infarction. …”
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Orchard-Wide Visual Perception and Autonomous Operation of Fruit Picking Robots: A Review by CHEN Mingyou, LUO Lufeng, LIU Wei, WEI Huiling, WANG Jinhai, LU Qinghua, LUO Shaoming

“…Multi-view information fusion tackles the issue of occlusions by combining data from multiple cameras and sensors around the robot, providing a more comprehensive view of the environment and enabling more reliable sensing. …”
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Design, Synthesis, and Evaluation of Nitroxide Radical Derivatives Based on Rhein as Potential Anti-Aging Agents Targeting the Keap1-Nrf2 Pathway by Wang J, Peng X, Zhang X, Lin J, Zhang Q, Li J, Cui L, Zhao L

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Multi-Target Mechanism of Compound Qingdai Capsule for Treatment of Psoriasis: Multi-Omics Analysis and Experimental Verification by Qiao Y, Li C, Chen C, Wu P, Yang Y, Xie M, Liu N, Gu J

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Cannabinoids in Chronic Pain Management: A Review of the History, Efficacy, Applications, and Risks by Brooks W. Johnson, Natalie H. Strand, John C. Raynak, Christian Jara, Kisanet Habtegiorgis, Brennan A. Hand, Sang Hong, Jillian A. Maloney

“…<b>Background/Objectives</b>: Chronic pain remains a pervasive and challenging public health issue, often resistant to conventional treatments such as opioids, which carry substantial risks of dependency and adverse effects. …”
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Dose to cardiac substructures and cardiovascular events in esophageal cancer patients treated with definitive radiotherapy by Victor Nguyen, Jean-Philippe Metges, Moncef Morjani, Pierre-Guillaume Pourreau, Estelle Dhamelincourt, Lucille Quenehervé, Olivier Pradier, Vincent Bourbonne

“…The use of volumetric modulated arctherapy significantly reduced V15LA compared with 3D conformal RT. …”
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Improved YOLOv8 Model for Phenotype Detection of Horticultural Seedling Growth Based on Digital Cousin by Yuhao Song, Lin Yang, Shuo Li, Xin Yang, Chi Ma, Yuan Huang, Aamir Hussain

“…In the second phase, an improved YOLOv8 model is created to segment and measure the seedlings, and it is modified by adding the LADH, SPPELAN, and Focaler-ECIoU modules. Compared with the original YOLOv8, the precision of our model is 91%, and the loss metric is lower by approximately 0.24. …”
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Simulation design of 542kWp DC/480kWp AC Solar Photovoltaic System at Institute of Southern Punjab by Muhammad Muneeb Khan, Sadiq Ahmad, Muhammad Usman Tariq, Zeshan Haider Anjum, Muhammad Amir Shafi

“…Current study developed an effective, long-lasting, and environmentally friendly Grid Tie PV System (GTPVS) to address this issue. One location where solar energy has enormous promise is Multan. …”
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Activation of cellular immune responses using a dengue tetravalent subunit DNA vaccine candidate with different cytokines as adjuvants by Luciana de Souza Fernandes, Carine Ribeiro Pessoa, Roberto Sousa Dias, Cynthia Canedo da Silva, Sérgio Oliveira de Paula

“…Dengue remains a critical public health issue in endemic areas, with four co-circulating serotypes (DENV-1–4) and no widely accessible vaccine in Brazil. …”
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Kolmogorov–Arnold Network in the Fault Diagnosis of Oil-Immersed Power Transformers by Thales W. Cabral, Felippe V. Gomes, Eduardo R. de Lima, José C. S. S. Filho, Luís G. P. Meloni

“…To address this issue, we propose a novel approach based on Kolmogorov–Arnold Network (KAN) for the fault diagnosis of power transformers. …”
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Teachers’ awareness and emotional response to cyberbullying: Exploring emotional regulation strategies in the classroom by Paula da Costa Ferreira, Nádia Pereira, Carlos Martinho, Hugo Marques, Hélio Martins, Alexandra Marques Pinto, Alexandra Barros, Aristides Ferreira, Mafalda Gomes, Ana Margarida Veiga Simão

“…Cyberbullying is a major and pressing issue in schools, reducing students' well-being and placing emotional burden on teachers. …”
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In vitro antibacterial efficacy of a novel chicken-derived Bacillus subtilis GX15 strain and its protective mechanisms in mice challenged by Salmonella enterica serovar typhymurium by Huili Bai, Yuying Liao, Jingshan Lu, Zhe Pei, Yangyan Yin, Chunxia Ma, Zhongwei Chen, Changting Li, Jun Li, Yu Gong, Ling Teng, Leping Wang, Zijuan Su, Hailan Chen, Hao Peng

“…Abstract Background The escalating issue of bacterial resistance, coupled with stringent restrictions on antibiotic use in many countries, has prompted the search for alternative strategies to combat bacterial infections. …”
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Subchronic and Chronic Toxicity Assessment of Sublancin in Sprague–Dawley Rats by Yong Guo, Zhihao Li, Penglong Xu, Gantong Guo, Tao He, Yujiao Lai

“…Sublancin, an S-linked antimicrobial (glycol) peptide produced by <i>Bacillus subtilis</i>, has emerged as a novel and promising veterinary drug due to its unique antibacterial mechanism, low risk of resistance, and properties that modulate the immune system, reduce inflammation, and promote gut health. …”
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Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics an... by Rongfang Guo, Shuying Zhang, Anyao Li, Ping Zhang, Xin Peng, Xiaoyan Lu, Xiaohui Fan

“…Type 2 diabetes mellitus (T2DM) is a significant public health issue with high morbidity and mortality. Ginsenoside Rb1 (Rb1) and berberine (BBR), the main bioactive compounds of Panax ginseng and Coptis chinensis, respectively, are known for their hypoglycemic effects. …”
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