Targeting mitochondria: a novel approach for treating platinum-resistant ovarian cancer by Xin Cui, Juan Xu, Xuemei Jia

“…Despite extensive research on the mechanisms of platinum resistance at the nuclear level, the issue of platinum resistance in ovarian cancer remains largely unresolved. …”
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Design, Control, and Evaluation of a Photovoltaic Snow Removal Strategy Based on a Bidirectional DC-DC Converter for Photovoltaic–Electric Vehicle Application by Salma Elakkad, Mohamed Hesham, Hany Ayad Bastawrous, Peter Makeen

“…A novel self-heating technique is proposed to clear snow from photovoltaic panels as a solution to the issue of winter snow accumulation in photovoltaic (PV) power plants. …”
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Chitosan, alginate, and carboxymethyl cellulose-based film for a controlled release of indocyanine green for antibiofilm applications by Veronica Ciaramitaro, Magdalena Szpunar, Filippo Vitale, Enrico Tornatore, Alessandro Presentato, Rosa Alduina, David Aebisher, Delia Francesca Chillura Martino, Andrzej Wal, Elena Piacenza

“…These films retained their structural integrity, showing a homogenous dye distribution. Modulating the ICG concentration enabled obtaining different aggregates, whose stability and release kinetics were evaluated in a phosphate-buffered saline (PBS) solution. …”
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FASQuiC: Flexible Architecture for Scalable Spin Qubit Control by Mathieu Toubeix, Eric Guthmuller, Adrian Evans, Antoine Faurie, Tristan Meunier

“…As scaling becomes a key issue for large-scale quantum computing, hardware control systems will become increasingly costly in resources. …”
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Unimodular Multi-Input Multi-Output Waveform and Mismatch Filter Design for Saturated Forward Jamming Suppression by Xuan Fang, Dehua Zhao, Liang Zhang

“…Therefore, amplitude modulation of MIMO radar angular waveforms offers an advantage in combating forward jamming. …”
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Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

“…With the changes in modern life, hyperuricemia (HUA) has become a serious universal health issue, leading to rising morbidity and mortality. …”
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Temperature Prediction and Fault Warning of High-Speed Shaft of Wind Turbine Gearbox Based on Hybrid Deep Learning Model by Min Zhang, Jijie Wei, Zhenli Sui, Kun Xu, Wenyong Yuan

“…The model was validated to issue early warnings up to seven hours before the fault alert is triggered by the supervisory control and data acquisition system of the wind turbine. …”
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A Lightweight Detection Method for Meretrix Based on an Improved YOLOv8 Algorithm by Zhongxu Tian, Sifan Hou, Xiaoxue Yue, Xuewen Hu

“…Clam farms are typically located in remote areas with limited computational resources, making it challenging to deploy traditional deep learning-based object detection methods due to their large model size and high computational demands. To address this issue, this paper proposes a lightweight detection method, YOLOv8-RFD, based on an improved YOLOv8 algorithm, tailored for clam sorting applications. …”
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AMPK: An energy sensor for non-small cell lung cancer progression and treatment by Zhi-Ting Zhong, Xu-Yan Wang, Ying Pan, Ke Zhou, Jing-Hui Chen, Yu-Qi Gao, Bo Dai, Zhi-Ling Zhou, Rui-Qi Wang

“…Secondly, we summarise the drugs and related substances that modulate the AMPK signalling pathway in NSCLC and evaluate the evidence from preclinical studies on combination AMPK-targeted therapies to address the issue of drug resistance in NSCLC under current clinical treatments. …”
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A Typical Cross-Border Metaverse Model as a Counteraction to Its Fragmentation by Oleksii Kostenko, Dmytro Zhuravlov, Volodymir Nikitin, Volodymyr Manhora, Tamila Manhora, Ivan Gabani

“… The paper addresses the issue of the Metaverse's territoriality and its connection with national and international law. …”
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An Overview of Seafood Allergens: Structure–Allergenicity Relationship and Allergenicity Elimination Processing Techniques by Yang Yang, Yehao Zhang, Xinrong He, Fei Huan, Jinli Chen, Meng Liu, Siyang He, Shinong Gu, Guangming Liu

“…Seafood (fish, crustacean, and mollusk) allergy represents a critical global health issue. Food processing offers a viable strategy for allergenicity mitigation and serves as a critical intervention for seafood allergy prevention. …”
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Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine by Wei Hu, Jiaming Shi, Wenyan Lv, Xiaofang Jia, Katsuhiko Ariga

“…Besides multipotent differentiation, immunomodulation is an important biological function of mesenchymal stem cells (MSCs). MSCs can modulate immune cells to treat multiple immune- and inflammation-mediated diseases. …”
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The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies by Marcos F. DosSantos, Aleli T. Oliveira, Natália R. Ferreira, Antônio C. P. Carvalho, Paulo Henrique Rosado de Castro

“…Chronic pain is an important public health issue. Moreover, its adequate management is still considered a major clinical problem, mainly due to its incredible complexity and still poorly understood pathophysiology. …”
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Convolutional sparse coding network for sparse seismic time-frequency representation by Qiansheng Wei, Zishuai Li, Haonan Feng, Yueying Jiang, Yang Yang, Zhiguo Wang

“…However, the iterative approaches typically employed in sparse TF transforms are computationally intensive, making them impractical for real seismic data analysis. To address this issue, we propose an interpretable convolutional sparse coding (CSC) network to achieve high TF resolution. …”
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NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy? by Claudia Cantoni, Leticia Huergo-Zapico, Monica Parodi, Marco Pedrazzi, Maria Cristina Mingari, Alessandro Moretta, Bianca Sparatore, Segundo Gonzalez, Daniel Olive, Cristina Bottino, Roberta Castriconi, Massimo Vitale

“…Indeed, NK cells may induce tumor cells to change the expression of HLA-I, PD-L1, or NKG2D-L and modulate their susceptibility to the immune response. …”
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Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies by Gangling Xu, Jing Jin, Zhihao Fu, Guangming Wang, Xinhua Lei, Jun Xu, Junzhi Wang

“…Abstract Extracellular vesicles share lipid‒protein membranes with their parent cells, allowing for the targeted transfer of bioactive cargo to recipient cells for functional modulation. The biological features allow extracellular vesicles to serve both as intrinsic therapeutics and as engineered delivery vehicles for targeted molecule transport. …”
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Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

“…ApTOLL, a new modulator of Toll-like receptor 4, has demonstrated safety and efficacy in healthy subjects and in stroke patients; however, the route of administration used so far (30 min infusion) can potentially be an issue in the acute stroke units where “time is brain.” …”
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Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology by Aretha Rambaldi, Francesca Paris, Pasquale Marrazzo, Roberta Costa, Stefano Ratti, Francesco Alviano

“…Its chemical nature structure, rich in conjugated double bonds, carbonyl, and hydroxyl groups, confers potent antioxidant and anti-inflammatory properties. ASX modulates oxidative stress via the PI3K/Akt-Nrf2 pathway and suppresses NF-κB-mediated inflammatory responses, reducing cytokine levels such as TNF-α, IL-6, and iNOS. …”
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Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model by Miri Park, Yu-Rim Chae, Hye-Bin Lee, Jang-Eun Lee, Jang-Eun Lee, Yu Ra Lee, Jinyoung Hur, Ho-Young Park, Ho-Young Park

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. …”
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Development and evaluation of the CoBo application: enhance confidence and social skills through physical education for bullying victims by Iif Firmana, Ribut Wahidi, Davi Sofyan

“… Background: Bullying remains a persistent issue in physical education (PE), often leading to decreased student participation, low self-confidence, and poor social interaction. …”
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