Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma by Noelia Moares, Noelia Moares, Pablo Gonzalez-Garcia, Pablo Gonzalez-Garcia, Wenjie Yi-He, Wenjie Yi-He, Juan P. Muñoz-Miranda, Juan P. Muñoz-Miranda, Antonio Gabucio, Antonio Gabucio, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Ricardo Fernandez-Cisnal, Cecilia M. Fernandez-Ponce, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar, Francisco Garcia-Cozar

“…However, several barriers continue to limit the overall effectiveness of this approach, such as high production costs, prolonged manufacturing timelines, safety issues, and the potential for tumor antigen escape due to selective therapeutic pressure. …”
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HIV and the gut microbiome: future research hotspots and trends by Zhen Wu, Zhan-Peng Xie, Xin-Xin Cui, Xiang-Bin Sun, Fang-Yi Zhao, Nuo Wang, Yu Li, Yu Li, Yu Li, Haixia Wang, Haixia Wang, Haixia Wang, Li Zhang, Li Zhang, Li Zhang, Jing Shen, Fulei Chen, Haogang Sun, Jia He, Jia He, Jia He

“…BackgroundThe use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. …”
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Perilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food by Min Li, Nanjie Jiang, Guangqi Guo, Shuaijun Lu, Ziliang Li, Yujie Mu, Xiaoyang Xia, Zhenxia Xu, Yong Hu, Xia Xiang

“…Future investigations should also explore the synergistic effects of combining perilla seed oil with other functional components and its role in modulating gut microbiota to achieve comprehensive health benefits.…”
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Modeling Spatial and Temporal Changes in Land-Uses and Land Cover of the Urmia Lake Basin Applying Cellular Automata and Markov Chain by Hadi Eskandari Damaneh, Hamid Gholami, Hassan Khosravi, Rasoul Mahdavi Najafabadi, Asadollah Khoorani, Gimmy Li

“…Extended Abstract 1-Introduction Land use and land cover change (LULCC) has turned into a global issue that has aroused a grave concern of governments and natural resources officials. …”
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Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers by Yueling Gong, Yueling Gong, Honghui Zhang, Jiang Feng, Li Ying, Mengmeng Ji, Shiyin Wei, Shiyin Wei, Qiming Ma

“…BackgroundObesity and metabolic syndrome (MetS) have become increasingly significant global health issues. Time-restricted feeding (TRF), as a novel dietary intervention, has garnered attention in recent years. …”
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Evaluation of the Impact of Mobile Health App Vitadio in Patients With Type 2 Diabetes: Randomized Controlled Trial by Maxi Pia Bretschneider, Agnieszka Barbara Kolasińska, Lenka Šomvárska, Jan Klásek, Jan Mareš, Peter EH Schwarz

“…Vitadio provided a mobile-based self-management support tool featuring educational modules, motivational messages, peer support, personalized goal setting, and health monitoring. …”
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Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM by Jiaxuan Li, Zhenyu Tian, Tongxue Zhang, Jiajia Jin, Xinjie Zhang, Panpan Xie, Haiyan Lin, Junfei Gu, Yingjie Wu, Xiaowei Wang, Shucui Zhang, Xuefang Yan, Dong Guo, Zhe Wang, Qunye Zhang

“…Methods To address the above issues, we performed single-cell RNA sequencing on the stromal vascular fraction (SVF) of PVAT from normal and T2DM rats. …”
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Parenting and mental health in protracted refugee situations: a systematic review by Qusai Khraisha, Nadeen Abujaber, Sadhbh Carpenter, Robert J. Crossen, Johanna Kappenberg, Ronan Kelly, Cameron Murphy, Orla Norton, Sophie Marleen Put, Kate Schnoebelen, Azza Warraitch, Stella Roney, Kristin Hadfield

“…We identified a universal pathway linking macro-level stressors in protracted refugee situations, such as movement restrictions and documentation issues, to symptoms of depression and anxiety, which, in turn, led to negative parenting practices. …”
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Case Report: Diagnostic assessment, developmental trajectory and treatment approaches in a case of a complex neurodevelopmental syndrome associated with non- synonymous variants in... by V. Napoli, V. Napoli, S. Guerrera, F. Demaria, G. Piccolo, G. Piccolo, A. Cianfa, S. Passarini, S. Passarini, M. G. Logrieco, G. Zanni, G. Valeri, S. Vicari, S. Vicari

“…Although Rett-like features are mainly due to MECP2 loss-of-function, MECP2 deficiency disrupts GABAergic signaling, making GABA modulators potential therapeutic targets. The presence of the GABBR1 variant may further impair GABA receptor neurotransmission. …”
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Isolation of multiple plant growth-promoting fungi and their effect on rice growth improvement on non-grain converted land by Xuqing Li, Xiaoxu Ren, Han Chen, Yukang Xin, Tiefeng Zhou, Jianli Yan, Jun Xu, Munazza Ijaz, Temoor Ahmed, Temoor Ahmed, Bin Li, Qurban Ali

“…To effectively resolve issues caused by non-grain production on cultivated land, Zhejiang Province has initiated efforts to restore non-grain-converted land back to grain cultivation. …”
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Recent advances in the role of high-salt diet in anti- and pro-cancer progression by Shiwei Tang, Juan Xu, Ping Wan, Ping Wan, Ping Wan, Shumen Jin, Ying Zhang, Ying Zhang, Linting Xun, Linting Xun, Jinli Wang, Jinli Wang, Mei Luo, Mei Luo, Wenjie Chen, Wenjie Chen, Zan Zuo, Zan Zuo, Zan Zuo, Hui Tang, Hui Tang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi

“…Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. …”
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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Due to these receptors, bile acids can modulate the rate of self-synthesis, lipid, and glucose and energy metabolism. …”
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Physiological defensive modes to biologically induce drought tolerance in broccoli via inoculation with mycorrhiza and Trichoderma by Amr A. Metwally, Gamal S. Riad, Abdalla A. Ghoname, Sameh M. El-Sawy, Dina S. Salama, Layla Alkhawaga, Mostafa G. Shahin, Hani Saber Saudy, Nora A. AbdelMotlb

“…We hypothesized that AMF and TRI fungi may have different mechanisms to modulate the physiological state and growth of broccoli to be more tolerant to drought stress. …”
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Optimizing Monkeypox Lesions Detection With a Lightweight Hybrid Model by Mehdhar S. A. M. Al-Gaashani, Reem Ibrahim Alkanhel, Dina S. M. Hassan, Abduljabbar S. Ba Mahel, Ahmed Aziz, Mashael M. Khayyat, Ammar Muthanna

“…Existing methods often rely on large architectures that demand high computational resources and lack interpretability. To address these issues, we propose a lightweight, interpretable architecture that truncates MobileNetV2 for efficient feature extraction, incorporates Ghost Modules to reduce redundancy, and integrates a SA-MobileViT block to capture both local and global dependencies in lesion images. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…In contrast, a small number of extensively instrumented research sites would enable community-based experiments in an unprecedented manner, thereby facilitating a deeper understanding of complex, non-linear processes modulated by scale-dependent feedback and multiscale spatiotemporal heterogeneity. …”
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MULTIMODALITY OF INCONGRUITY AS COGNITIVE MECHANISM OF CREATING HUMOUR: CASE STUDY OF POLITICAL STAND-UP COMEDY by Yuliia O. Savina

“…The research material of the presented research is the stand-up monologues of George Carlin (2010, 2011), Andy Haynes (2023) and Joe Kilgallon (2019) on political issues. In the presented stand-up monologues, a total of 100 cases of incongruity are distinguished, of which 52% are valorative, 36% are logical and notional, and 12% are ontological. …”
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Targeting ferroptosis: a promising avenue for ovarian cancer treatment by Xiaolan Wu, Xiaolan Wu, Xiaolan Wu, Xiaolan Wu, Qizhi Liu, Zhili Jiang, Guiyun Wang, Guiyun Wang, Guiyun Wang, Guiyun Wang, Lingyu Liao, Lingyu Liao, Lingyu Liao, Xiaojuan Ye, Xiaojuan Ye, Xiaojuan Ye, Min Xing, Min Xing, Min Xing, Han Sun, Qiying Liu, Huiping Liu, Huiping Liu, Huiping Liu, Huiping Liu, Huiping Liu

“…We also discuss the challenges facing ferroptosis-based treatments for OC, such as species differences, drug resistance, personalized treatment needs, and clinical translation issues. Ultimately, targeted modulation of ferroptosis offers new hope for OC therapy. …”
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Preoperative Briganti Nomogram Score and Risk of Prostate Cancer Progression After Robotic Surgery Beyond EAU Risk Categories by Antonio Benito Porcaro, Rossella Orlando, Andrea Panunzio, Alessandro Tafuri, Alberto Baielli, Francesco Artoni, Claudio Brancelli, Luca Roggero, Sonia Costantino, Andrea Franceschini, Michele Boldini, Lorenzo Pierangelo Treccani, Francesca Montanaro, Sebastian Gallina, Alberto Bianchi, Emanuele Serafin, Giovanni Mazzucato, Francesco Ditonno, Mariana Finocchiaro, Alessandro Veccia, Riccardo Rizzetto, Matteo Brunelli, Vincenzo De Marco, Salvatore Siracusano, Maria Angela Cerruto, Riccardo Bertolo, Alessandro Antonelli

“…Accordingly, it may allow further stratification of patients within each risk category to modulate appropriate treatment paradigms.…”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…Specifically, this study addresses three key issues: (1) an incremental update strategy for random walk sequences, (2) the extraction of the correlation of causal relationships, and (3) the construction of the mutual perceptron.Methods Therefore, an incremental learning social network link prediction (IL−SNLP) method is proposed. …”
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NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing and immunogenic cell death by Tian Zhang, Dongsheng Tang, Pengfei Wu, Shaoping Jiang, Yuquan Zhang, Abid Naeem, Yong Li, Chunhui Li, Bo Hu, Shuai Guo, Caixia Sun, Haihua Xiao, Ran Yan, Yuhua Weng, Yuanyu Huang

“…This study represents a generalized platform for PDT and gene silencing, designed to modulate immune-related signaling pathways for improved anticancer therapy.…”
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