MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Cancer remains a prominent worldwide health concern, presenting existing therapies with frequent difficulties, including major toxicity, limited effectiveness, and treatment resistance emergence. These issues highlight the necessity for novel and enhanced remedies. …”
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Research on Enhanced Dynamic Pig Counting Based on YOLOv8n and Deep SORT by Peng Shen, Keyu Mei, Haori Xue, Tenglong Li, Guoqing Zhang, Yongxiang Zhao, Wei Luo, Liang Mao

“…The ELA attention mechanism, GSConv, and VoVGSCSP lightweight convolution modules are introduced in YOLOv8n, which improve detection accuracy and speed for pig target recognition. …”
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Plant-Derived Exosomes: Carriers and Cargo of Natural Bioactive Compounds: Emerging Functions and Applications in Human Health by Sorur Yazdanpanah, Silvia Romano, Anna Valentino, Umberto Galderisi, Gianfranco Peluso, Anna Calarco

“…Although studies conducted before clinical trials have yielded encouraging results, numerous unresolved issues and gaps in understanding remain, which must be resolved to facilitate the effective advancement of PDEs toward medical use in human patients. …”
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Efficacy and putative mechanisms of action of nutraceuticals in the management of erectile dysfunction: a narrative review by Lorenzo Romano, Michele Musone, Luigi Napolitano, Lorenzo Spirito, Celeste Manfredi, Davide Arcaniolo, Ferdinando Fusco, Biagio Barone, Antonio Tufano, Pier Paolo Prontera, Ugo Amicuzi, Antonio Cioffi, Ciro Imbimbo, Marco De Sio, Carmine Sciorio, Felice Crocetto

“…These natural products have different mechanisms of action, including modulation of endothelial function, reduction of oxidative stress and balance of sex hormones, thus addressing multiple therapeutical targets for the management of ED. …”
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Insight-HXMT Observations of the Extremely Bright GRB 221009A by Wen-Long Zhang, Wang-Chen Xue, Cheng-Kui Li, Shao-Lin Xiong, Gang Li, Yong Chen, Wei-Wei Cui, Xiao-Bo Li, Cong-Zhan Liu, Ming-Yu Ge, Wen-Jun Tan, Jia-Cong Liu, Chen-Wei Wang, Chao Zheng, Yan-Qiu Zhang, Yue Wang, Zhen Zhang, Shu-Xu Yi, Shuo Xiao, Ce Cai, Shuang-Xi Yi, Li-Ming Song, Lian Tao, Shu Zhang, Shuang-Nan Zhang

“…The Insight Hard X-ray Modulation Telescope (Insight-HXMT) detected GRB 221009A, the brightest gamma-ray burst (GRB) observed to date, with all its three telescopes, i.e., the High Energy (HE) telescope (20–250 keV), Medium Energy (ME) telescope (5–30 keV), and Low Energy (LE) telescope (1–10 keV). …”
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Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases by Tian Tian, Monan Liu, Peter J. Little, Hans Strijdom, Jianping Weng, Suowen Xu

“…Lifestyle interventions such as ketogenic, high-fat diets, and exercise modulate GDF15 levels, underscoring its role in pan-metabolic health. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Description of the State of Knowledge: GLP-1 receptor agonists modulate appetite, resulting in lower calory intake. …”
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Tumor-microenvironment responsive nanomodulator for near infrared photothermal immunotherapy of hepatocellular carcinoma by Fei Kong, Tian Xia, Xiaorong Zhu, Xueping Zeng, Fengyu Wang, Jianxin Lyu, Lisen Lu, Zhen Wang

“…Thus, this study not only presents a novel strategy for designing vaccine-like prodrugs to precisely modulate cancer immunotherapy, but also opens new avenues for the development of advanced therapies for HCC. …”
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Barriers and solutions regarding to infection prevention and control practices in the intensive care units: A qualitative study by ZEYNEP ILGIN DEMİR, BÜŞRA YALÇIN, OĞUZ TAHA AYAZ, KAAN İYİKÖŞKER, ALEYNA KESKİN, AZRA GÖREL, YUNUS AKSOY, NİLAYDA SAĞALTICI, KORAY HACIOĞLU, İLKER KAYI, ÖNDER ERGÖNÜL, SİBEL SAKARYA, ŞİRAN KESKE, BAHAR MADRAN

“…CONCLUSIONS: According to HCWs, increased workload, structural issues, and inefficient training modules were identified as the main IPC barriers. …”
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A system approach to the modeling of fungal infections of the wheat leaf by S. V. Nikolaev, U. S. Zubairova, E. S. Skolotneva, E. A. Orlova, D. A. Afonnikov

“…The article presents the structure of the hierarchical system for modeling the development of leafy infection, provides an overview of the units constituting the system, and discusses the issues of parametric adaptation of submodels. We demonstrated that, to date, plant growth and development models have been developed with varying degrees of detail. …”
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Efficacy of a Novel <i>Lactiplantibacillus plantarum</i> Strain (LP815^TM) in Reducing Canine Aggression and Anxiety: A Randomized Placebo-Controlled Trial with Qualitati... by Emmanuel M. M. Bijaoui, Noah P. Zimmerman

“…Behavioral issues in domestic dogs represent a significant welfare concern affecting both canines and their caregivers, with prevalence rates reported to range from 34 to 86% across the population. …”
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Simulation Bridges LGBTQ+ Educational Gaps in Gynecologic Care: Menstrual Suppression for a Gender and Sexually Diverse Patient by Callie K. King, Amanda M. Ryan, Tess Chase

“…Methods Residents were given optional American College of Obstetricians and Gynecologists Modules on Transgender Care, a lecture about LGBTQ+ health issues, and a standardized patient simulation followed by a debrief. …”
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STA-AgriNet: A Spatio-Temporal Attention Framework for Crop Type Mapping from Fused Multi-Sensor Multi-Temporal SITS by Jayakrishnan Anandakrishnan, Venkatesan Meenkaski Sundaram, Prabhavathy Paneer

“…The spectral spatial feature mapper (SSFM), mixed parallel spatial attention (MPSA), and spatio-temporal attention mapper (STAM) modules of the STA-AgriNet extract key classification-defining, discriminative patterns for semantic segmentation. …”
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CDAS: A Secure Cross-Domain Data Sharing Scheme Based on Blockchain by Jiahui Jiang, Tingrui Pei, Jiahao Chen, Zhiwen Hou

“…In response to the security and privacy issues in cross-domain data sharing, we proposed a cross-domain secure data sharing scheme (CDAS) based on multiple blockchains. …”
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Preprocessing-Free Convolutional Neural Network Model for Arrhythmia Classification Using ECG Images by Chotirose Prathom, Ryuhi Fukuda, Yuto Yokoyanagi, Yoshifumi Okada

“…However, these models face challenges in terms of input coverage and robustness against data imbalance issues. Typically, existing methods employ a single cardiac cycle as the input, possibly overlooking the intervals between cycles, potentially resulting in the loss of critical temporal information. …”
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Robust QoT Assured Resource Allocation in Shared Backup Path Protection Based EONs by Venkatesh Chebolu, Sadananda Behera, Goutam Das

“…In this process, we use the efficient robust bitloading technique for spectrum allocation where each frequency slot of a request is assigned with different modulation format. In addition, we propose novel SBPP-impairment aware (SBPP-IA) algorithm considering the limitations of MILP for larger networks. …”
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Thermal and mechanical degradation mechanisms in heterostructural field-effect transistors based on gallium nitride by Vadim M. Minnebaev

“…The main research method consists in an analytical review of the results of publications by a wide range of specialists in the field of semiconductor physics, production technology of heteroepitaxial structures and active devices based on them, as well as the modeling and design of modules and equipment in terms of their reliable operation.Results. …”
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Methanolic crude extract of Litsea Monopetala leaves combats oxidative stress, clot formation, inflammation and stool frequency in animal model. by Sarder Arifuzzaman, Zubair Khalid Labu, Banani Das Ani, Samira Karim, Md Tarekur Rahman

“…<h4>Introduction</h4>Litsea monopetala (LM) leaves are used in traditional medicine system in the South Asian region for treating ailments such as digestive issues, respiratory problems and skin disorders. In this study, we investigated the possible antioxidant, thrombolytic, analgesic and antidiarrheal properties of the methanolic extract of LM leaves.…”
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Challenge and path of high-quality development of coal mine intelligent construction by Guofa WANG, Huaiwei REN, Jiaxing FU

“…For technological system construction, the key technical modules of intelligent coal mines are summarized. …”
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Technology-enabled hybrid cardiac rehabilitation: Qualitative study of healthcare professional and patient perspectives at three cardiac rehabilitation centres in England. by Sarah Damery, Janet Jones, Alexander Harrison, Sebastian Hinde, Kate Jolly

“…Despite some technical issues and governance delays, Active+me REMOTE was perceived as acceptable, convenient and allowed tailoring of support to meet patients' needs and circumstances. …”
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