Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…Abstract Background Sorafenib, an FDA-approved drug for advanced hepatocellular carcinoma (HCC), faces resistance issues, partly due to myeloid-derived suppressor cells (MDSCs) that enhance immunosuppression in the tumor microenvironment (TME). …”
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Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM by Jiaxuan Li, Zhenyu Tian, Tongxue Zhang, Jiajia Jin, Xinjie Zhang, Panpan Xie, Haiyan Lin, Junfei Gu, Yingjie Wu, Xiaowei Wang, Shucui Zhang, Xuefang Yan, Dong Guo, Zhe Wang, Qunye Zhang

“…Methods To address the above issues, we performed single-cell RNA sequencing on the stromal vascular fraction (SVF) of PVAT from normal and T2DM rats. …”
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Increasing Life Expectancy with Plant Polyphenols: Lessons from the Mediterranean and Japanese Diets by Marco Fiore, Anton B. Tonchev, Ruzha Z. Pancheva, Tetsumori Yamashima, Sabrina Venditti, Giampiero Ferraguti, Sergio Terracina

“…Plant polyphenols have emerged as potent bioactive molecules that can modulate key cellular pathways associated with aging and chronic disorders. …”
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LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome by Xiaoli Zhao, Yutian Lei, Han Zhu, Wenyi Shen, Sixuan Qian, Jianyong Li, Yu Zhu

“…Consequently, investigating its pathogenesis and progression mechanisms, and seeking novel targets for diagnosis and treatment, are critical issues that require urgent attention. This study aimed to investigate whether LRRFIP1 might contribute to MDS pathogenesis by modulating the Wnt/β-catenin signaling pathway. …”
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Assembly mechanism of fingolimod in lipid raft nanostructure domain by Wu Huan

“…Loading drugs into the human body through nanoliposomes is a common treatment method, but due to limited observation scale and resolution, there are still many issues regarding the assembly, adsorption, and impact of FTY720 on lipid raft nanostructured domains. …”
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A Low-Complexity Transformer-CNN Hybrid Model Combining Dynamic Attention for Remote Sensing Image Compression by L. L. Zhang，X. J. Wang，J. H. Liu, Q. Z. Fang

“…This framework includes two critical modules: the Dynamic Attention Model (DAM) and the Hyper-Prior Hybrid Attention Model (HPHAM). …”
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The Emerging Role of Botulinum Neurotoxin in Psoriasis Management: A Review of Mechanisms, Evidence, and Challenges by Ramadan S. Hussein

“…Current therapies, including topical and systemic agents, often face limitations such as incomplete efficacy, side effects, and patient compliance issues. Botulinum neurotoxin (BoNT), traditionally used in cosmetic dermatology and neurology, has emerged as a novel potential treatment due to its ability to modulate neuroinflammatory pathways and immune responses. …”
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Enhancing Brain Tumor Detection: A Comparative Study of CNN Architectures Using MRI Data by Zhu Zhimeng

“…VGG19-BMT incorporates targeted optimizations, including adjustments to convolutional layers and improved feature extraction modules. A systematic comparative analysis of VGG19-BMT and traditional CNN models was conducted using the Kaggle dataset “Brain MRI Images for Brain Tumor Detection.” …”
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Internet Supported Psychological Interventions (ISPIs) and Mobile Phone Applications: A Literature Review and Proposed Model by Pieter Rossouw, Francesca Reddington

“…The model provides standardised homework modules as an adjunct to therapy with feedback to the consulting therapist. …”
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Beyond the beats: exploring the link between blood pressure fluctuations with anxiety, depression, and sleep by Yuvthi Lutchman, Suzanne M. Cosh, Suzanne M. Cosh, Fiona Cossey, Deborah A. Turnbull, Rosannah Byrt, Cassandra Sundaraja, Rakesh Agarwal, Rakesh Agarwal, Rajiv Mahajan, Rajiv Mahajan, Christophe Tzourio, John F. Beltrame, John F. Beltrame, Phillip J. Tully, Phillip J. Tully

“…AIx demonstrated significant negative associations with sleep-related issues, with stronger effects seen when adjusting for age and gender (β = -0.04, p < 0.01). …”
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Potential relationship of the gut microbiome with testosterone level in men: a systematic review by Cennikon Pakpahan, Geraldo Laurus, Markus Christian Hartanto, Rajender Singh, Ankur Saharan, Darmadi Darmadi, Andri Rezano, Gito Wasian

“…Imbalance or dysbiosis in the gut microbiome can cause different health issues in men, including reproductive and sexual health issues associated with testosterone levels. …”
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The Imperative of Inclusive Leadership for Excellent Teaching and Learning: A Needs Analysis for Dutch Primary, Secondary, and Higher Education by Michel Hogenes

“…However, policy constraints, limited resources, and inconsistent training opportunities continue to impede progress. To address these issues, the study proposes a structured framework for inclusive leadership, enhanced training modules, policy interventions, and the development of a digital platform for knowledge exchange. …”
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Cardiac Stem Cells in the Postnatal Heart: Lessons from Development by Cristina Aguilar-Sanchez, Melina Michael, Sari Pennings

“…Engraftment may be improved by preconditioning the cultured stem cells and modulating the microenvironment to host these cells. …”
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A Centralized Approach to the Logging Mechanisms of Distributed Complex ERP Applications by Cosmin Strilețchi, Petre G. Pop, Christian Gavrilă

“…The current paper presents a solution that centralizes the logging information issued by the Crosweb components for ensuring a better exposure of the associated information and for simplifying the solutioning of the reflected problems.…”
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Medication safety analysis of elderly inpatients based on improved functional resonance analysis method (FRAM): a mixed methods study by Jing Yang, Xuwen Yin, Yue Xu, Zejuan Gu, Tingru Li, Yanhong Yan, Qiaoling Jiang, Ting Lu, Yangyang Fu, Yan Yu, Zhongyan Hou

“…A total of 18 functional modules were included in the medication process model for elderly inpatients. …”
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Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy by Sumin Sun, Haili Hu, Feiyu Li, Feiyu Li, Sheng Huan, Long Chen, Jiahui Chen, Peihua Sun, Xiaoqing Dong, Xiaoqing Dong

“…This natural product modulated YIPF5-induced mitophagy and influenced both mitosis and senescence in HCC cells. …”
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Improving IR drop effect and power noise using digital OLED power in AMOLED display by Sanguk Lee, Byungmun Kang, DaeEun Kim

“…We implemented an OLED power system that includes a buck converter, a digital pulse width modulation (PWM) control algorithm, and a video sync generator to address these AMOLED issues. …”
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Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects by Zhengrong Chen, Wenxin Yang, Yong Tang, Qianqian Dong, Kui Huang, Jiulin Tan, Jie Zhang, Juan Cai, Qixiu Yu, Qijie Dai, Jianzhong Xu, Shuquan Guo, Ce Dou, Fei Luo

“…These findings demonstrate that SF‐ZIF@NA offers a targeted and multifunctional strategy for osteoporotic bone regeneration by concurrently modulating osteoclast activity and promoting angiogenesis.…”
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Functionalization Strategies of MXene Architectures for Electrochemical Energy Storage Applications by Shude Liu, Huilin Zhang, Jieming Chen, Xue Peng, Yafei Chai, Xian Shao, Yi He, Xiaoqiang Wang, Bin Ding

“…However, their practical application in energy storage devices remains challenged by issues such as the stacking of their layered structure, surface degradation, and limited ion diffusion properties. …”
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Orga-Dete: An Improved Lightweight Deep Learning Model for Lung Organoid Detection and Classification by Xuan Huang, Qin Gao, Hanwen Zhang, Fuhong Min, Dong Li, Gangyin Luo

“…Ablation experiments confirm the synergistic effects of these modules in enhancing morphological feature extraction. …”
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