Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy by Ma J, Ding L, Zang X, Yang Y, Zhang W, Li X, Zhao D, Zhang Z, Wang Z, Zhao L, Tong X

“…Supporting evidence from zebrafish models demonstrated that QM not only counteracts EndMT but also improves a range of vascular functional disorders and remodeling issues following EndMT.Conclusion: Our research validates the active compounds, core targets, and signaling pathways through which QM counters PF, providing valuable insights for its therapeutic application in PF management.Keywords: Qimai Feiluoping decoction, pulmonary fibrosis, network pharmacology, molecular docking, endothelial mesenchymal transition, autophagy…”
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Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation by Liu P, Zeng L, Fu H, Li F

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VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation by Wu W, Cai H, Nan Y, Tang J, Wang Y

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Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

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Integrating Network Pharmacology and in vivo Validation to Explore the Mechanisms of Buyang Huanwu Decoction in Myocardial Ischemia-Reperfusion Injury by Luo Y, Hu W, Li Z, Zhang X, Chen S, Yang Q, Hu B, Zou X

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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

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cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats by Liu X, Guo H, Sayed MDSM, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J

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The Efficacy of Fluvoxamine in Preventing the Aging Process of Mouse Neural Stem Cells in a Di-galactose-Induced Model in a Culture Medium by M Jafari Barmak, S Bagheri, A Ghanbari, S Javedansirat

“…Background & aim: Cellular senescence is an irreversible process in cells that is affected by various factors such as oxidative stress and inflammation, and the importance of this issue rises in its effect on neural stem cells. Fluvoxamine at appropriate concentrations provides proliferation and differentiation of neural stem cells into glial and neurons and modulates inflammatory factors. …”
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Study on the Influence and Mechanism of Resveratrol on Cognitive Impairment in Chronic Kidney Disease Rats Through Regulating Gut Microbiota and the TLR4/NFκB Pathway by Shao B, Nong Y, Lin Y, Meng Y, Zhou Y, Huang M, Huang F, Wang J

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Feedback Regulation of sPLA2-COX/5-LOX-Ca2+ in Seminal Plasma and Its Impact on Sperm Quality Parameters by Liu Y, Dai L, Zhang F, Liu Y, Li X, Ma W

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MiR-133a-5p Facilitates Cuproptosis in Hepatocellular Carcinoma Through Targeting of ATP7B by Ren Q, Zhu X, Wang N, Yu K, Lv W, Wang L, Zang Y, Ma D, Zhou X, Yao J, Shen M, Yu L, Li T

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The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP by Zeng R, Wang Y, Song X, Wang J

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Altered Brain Functional Connectivity and Neurometabolite Correlations in Orofacial Chronic Pain with Central Sensitization by Terumitsu M, Takado Y, Fukuda KI, Kato E, Tanaka S, Tha KK

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Acupoint Injection Combined with BCG-PSN and Thymosin Enteric-Coated Tablets Improve China Han Psoriasis Vulgaris by Regulating T Cell Subsets by Li J, Zhao X, Pan H, Duan Y, Li W, Zhao Y, Yao L, Zhang K

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Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway by Yuan X, Long L, Wang M, Chen W, Liang B, Xu L, Wang W, Li C

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The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation by Zhang R, Chai S, Chen Q, Lai J, Cai C

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Prenylated chalcone analog-mediated Inhibition of Toxoplasma gondii growth in human trophoblast cell line and villous explants by Marina Paschoalino, Vilson Serafim Júnior, Otavio Henrique Locateli Soares, Luana Carvalho Luz, Guilherme de Souza, Alessandra Monteiro Rosini, Marcos Paulo Oliveira Almeida, Daniel Pereira Sousa, Joed Pires De Lima Júnior, Natalia Carine Lima Santos, Rafael Martins Oliveira, Izadora Santos Damasceno, Guilherme Vieira Faria, Matheus Carvalho Barbosa, Thales Alves de Melo Fernandes, Rosiane Nascimento Alves, Angelica Oliveira Gomes, Eloisa Amália Vieira Ferro, Samuel Cota Teixeira, Luis Octavio Regasini, Bellisa Freitas Barbosa

“…Abstract Congenital toxoplasmosis is a significant public health issue caused by the transplacental passage of Toxoplasma gondii to the embryo/fetus. …”
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Protective effects of Nippostrongylus brasiliensis-derived uridine via the apical sodium-dependent bile acid transporter in a mouse model of TNBS-induced inflammatory bowel disease by Caiyi Yuan, Qiang Wang, Yuying Chen, Yuying Chen, Xin Ding, Qiang Zhang, Jiakai Yao, Bei Zhang, Yang Dai, Yang Dai, Hongxia Bai

“…The exploration of novel intervention strategies remains a key scientific issue that is urgently needed for IBD treatment. …”
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Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays by Clara Domingo-Vila, Evangelia D. Williams, Megan E. Smithmyer, Basilin Benson, Lauric A. Ferrat, Lauric A. Ferrat, Sefina Arif, Michelle Hudson, Becky Dobbs, Matthew B. Johnson, Iain Yardley, Cate Speake, Richard A. Oram, Timothy I. M. Tree, Benjamin J. Blaise, Benjamin J. Blaise, Benjamin J. Blaise, EXE-T1D consortium

“…One potential approach to address this issue is to recruit healthy children who are referred for elective procedures under general anesthesia. …”
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Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma by Weibin Zhuo, Hongmei Xia, Bin Lan, Bin Lan, Bin Lan, Yu Chen, Yu Chen, Yu Chen, Xuefeng Wang, Xuefeng Wang, Xuefeng Wang, Jingfeng Liu, Jingfeng Liu, Jingfeng Liu

“…IntroductionThe majority of liver cancer cases (90%) are attributed to hepatocellular carcinoma (HCC), which exhibits significant heterogeneity and an unfavorable prognosis. Modulating the immune response and metabolic processes play a crucial role in both the prevention and treatment of HCC. …”
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