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    Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing by Tomoki Yanagi, Shean Fu Phen, Jonah Ayala, Deniz Ece Aydin, Susanna Jaramillo, David M. Truong

    Published 2025-04-01
    “…It also suggests investigating how termination of transcription modulates gene silencing as a novel design parameter. …”
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    Gut microbiota-derived gamma-aminobutyric acid improves host appetite by inhibiting satiety hormone secretion by Shouren Li, Mengqi Liu, Yao Han, Cong Liu, Shixi Cao, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Boshuai Liu, Yinghua Shi

    Published 2024-10-01
    “…ABSTRACT Globally, appetite disorders have become an increasingly prominent public health issue. While short-term appetite loss may seem relatively harmless, prolonged instances can lead to serious physical and mental damage. …”
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  12. 2652
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    Development of a novel macroscopic regulation and microscopic intervention mode nanosystem for osteoporosis treatment by Shichao Meng, Qin Liu, Rong Dai, Yuhang Wang, Lin Chen, Shutong Wu, Jinxuan Li, Jian Zhang, Mengting Gao, Weiwei Kang, Ziliang Zheng, Hua Wu, Ruiping Zhang

    Published 2025-06-01
    “…Osteoporosis is a widespread global health issue characterized by progressive bone loss and impaired regeneration, largely due to an acidic bone microenvironment that suppresses osteoblast differentiation and fails to initiate effective osteogenesis. …”
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    Article
  14. 2654
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    Flexible Glass Hybridized Colloidal Quantum Dots for Gb/s Visible Light Communications by Caroline Foucher, Mohamed Islim Sufyan, Benoit Jack Eloi Guilhabert, Stefan Videv, Sujan Rajbhandari, Ariel Gomez Diaz, Hyunchae Chun, Dimali A. Vithanage, Graham A. Turnbull, Ifor D. W. Samuel, Grahame Faulkner, Dominic C. O'Brien, Harald Haas, Nicolas Laurand, Martin D. Dawson

    Published 2018-01-01
    “…The flexible glass/CQD format addresses the issue of limited modulation speed of typical phosphor-converted LEDs while enhancing the photostability of the color converters and facilitating their integration with the μLEDs. …”
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  16. 2656

    Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

    Published 2025-03-01
    “…ApTOLL, a new modulator of Toll-like receptor 4, has demonstrated safety and efficacy in healthy subjects and in stroke patients; however, the route of administration used so far (30 min infusion) can potentially be an issue in the acute stroke units where “time is brain.” …”
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  17. 2657

    Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice by Yuming Wu, Yujing Zhang, Yuan Yu, Xin Wang, Zifan Zhen, Yin Yuan, Bing Xie, Mengqi Han, Mengyuan Wang, Xinyu Zhang, Xueqiang Sun, Xiaoyue Wen, Kenji Hashimoto, You Shang, Shiying Yuan, Jiancheng Zhang

    Published 2025-07-01
    “…Abstract Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. …”
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  18. 2658

    Smart injectable hydrogels for periodontal regeneration: Recent advancements in biomaterials and biofabrication strategies by Bohan Yin, Jagan Mohan Dodda, Siu Hong Dexter Wong, G. Roshan Deen, Jeffrey S. Bate, Abhishek Pachauri, Behzad Shiroud Heidari, Tomáš Kovářík, Chi-An Luo, Shiao-Wen Tsai

    Published 2025-06-01
    “…Hence, the drastic increase in dental implants for periodontitis has become a severe clinical issue. Injectable hydrogel based on extracellular matrix (ECM) is highly biocompatible and tissue-regenerative with tailor-made mechanical properties and high payload capacity for in situ delivery of bioactive molecules to treat periodontitis. …”
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  19. 2659

    Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

    Published 2022-02-01
    “…E-filing merupakan bentuk penerapan sistem Modul Penerimaan Negara Generasi Kedua (MPN G2) yang mulai diterapkan pada tahun 2007. …”
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  20. 2660

    Silicon and heavy metal dynamics in soil-rice systems: A taihu lake plain case study on silicon depletion by Yumeng Lu, Sihua Huang, Gaili He, Ye Yuan, Jiahao Zhai, Xiaoqing Wang, Dejing Chen, Lijie Pu

    Published 2025-09-01
    “…This study addresses the critical issue of heavy metal contamination (Ni, Cu, As, Cd, Pb) in rice cultivation, with particular focus on silicon-deficient paddy soils in the Taihu Lake Plain, where SiNaAc is 87.97 mg kg−1. …”
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