Innovations in Chronic Pain Treatment: A Narrative Review on the Role of Cryoneurolysis by Andrea Tinnirello, Maurizio Marchesini, Silvia Mazzoleni, Carola Santi, Giuliano Lo Bianco

“…<i>Background and Objectives:</i> Chronic pain is a significant global health issue, with conventional treatment strategies often proving insufficient or causing undesirable side effects. …”
Get full text

GPER Enhances Chronic Burn Pain via PKC-Mediated Mu-Opioid Receptor Phosphorylation in the Rostral Ventromedial Medulla by Zhu X, Zhang Y, Zhang Q, Zhang Z

Get full text

Advancements, Challenges, and Future Prospects of Nanotechnology in Sepsis Therapy by Liu Y, Liu J, Wang D, Xu L, Li Z, Bai X, Zhu H, Wang Y

Get full text

The role of social vulnerability in improving interventions for neglected zoonotic diseases: The example of Kyasanur Forest Disease in India. by Festus A Asaaga, Bethan V Purse, Mujeeb Rahman, Prashanth N Srinivas, Suresh D Kalegowda, Tanya Seshadri, Juliette C Young, Meera A Oommen

“…Although surveyed households generally perceived KFD as an important health issue in the study region, there was variability in concern about contracting the disease. …”
Get full text

Electroacupuncture Exerts Anti-Obesity Effects by Affecting the Gut Microbiota and Upregulating Acetic Acid and 5-HT Levels in Obese Rats by Zhang J, Yang C, Xiong J, Qian H, Xie Y, Xie S, Luo Y, Yu J, Yu H, Xu J

Get full text

From Gut to Lung: The Role of Bile Acids in Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD) by Shi YJ, Lin S, Shi YC, Xie J

Get full text

Inter-seizure variability in thalamic recruitment and its implications for precision thalamic neuromodulation by Pariya Salami, Angelique C. Paulk, Daniel J. Soper, Pierre Bourdillon, Peter N. Hadar, Omar A. Alamoudi, Nathaniel D. Sisterson, R. Mark Richardson, Sandipan Pati, Sydney S. Cash

Get full text

Advances in Functionalized Nanoparticles for Osteoporosis Treatment by Cai R, Jiang Y, Sun H, Du F, Zhu L, Tao J, Xiao L, Wang Z, Shi H

Get full text

Dual-channel Potential Energy Recovery and Load Balancing Methods for Large Hydraulic Excavators by Weiping WANG, Shun LU

“…To verify the above theoretical analysis results, a simulation model including the main pump, energy-recovery module, and mechanical structure was built for a 70-ton large hydraulic excavator, and the simulation results are compared with the experimental results for a single-channel system.Results and Discussions The results show that the proposed system reduces the accumulator volume significantly (by more than 50%), saves installation space, eliminates additional energy loss, and solves handling issues caused by the mismatch between the hydraulic pressure and load force of the accumulator. …”
Get full text

Implications and pathophysiology of neuroinflammation in pediatric patients with traumatic brain injury: an updated review by Shalin S. Shah, Arya J. Shetty, David T. Johnston, Caroline L. Hanan, Brendan T. O’Reilly, Max A. Skibber, Ahmed T. Massoud, Ahmed T. Massoud, Banghe Zhu, Eva M. Sevick-Muraca, Jenifer Juranek, Charles S. Cox, Manish N. Shah, Manish N. Shah

“…Traumatic Brain Injury (TBI) in children is a profound public health issue with the potential to disrupt cognitive, behavioral, and psychosocial development significantly. …”
Get full text

Medicinal Plants for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review of Antiemetic, Chemosensitizing, and Immunomodulatory Mechanisms by Sun X, Nie F, Sun J, Zhang J, Wang Y

Get full text

Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review by Liu Y, Zhang M, Wang T, Zhang J

Get full text

Unraveling the multifaceted roles of extracellular vesicles in bladder cancer: diagnostic insights and therapeutic opportunities by Kaiqi Huang, Kaiqi Huang, Kaiqi Huang, Chen Yang, Yanfang Xu, Yanfang Xu, Yanfang Xu, Yujia Wang, Yujia Wang, Yujia Wang

“…Bladder cancer, predominantly urothelial carcinoma, is a global health issue with increasing incidences and mortality. It poses significant diagnostic and therapeutic challenges due to its molecular heterogeneity and the limitations of current detection methods. …”
Get full text

Building damage assessment in natural disasters: A trans- and interdisciplinary approach combining domain knowledge, 3D machine learning, and crowdsourcing by Julia Kohns, Vivien Zahs, Carolin Klonner, Bernhard Höfle, Lothar Stempniewski, Alexander Stark

“…We consider the implementation transferable to various types of natural hazards due to its open-source realisation and the flexibility of its modules and interfaces.…”
Get full text

An Overview of Seafood Allergens: Structure–Allergenicity Relationship and Allergenicity Elimination Processing Techniques by Yang Yang, Yehao Zhang, Xinrong He, Fei Huan, Jinli Chen, Meng Liu, Siyang He, Shinong Gu, Guangming Liu

“…Seafood (fish, crustacean, and mollusk) allergy represents a critical global health issue. Food processing offers a viable strategy for allergenicity mitigation and serves as a critical intervention for seafood allergy prevention. …”
Get full text

Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model by Miri Park, Yu-Rim Chae, Hye-Bin Lee, Jang-Eun Lee, Jang-Eun Lee, Yu Ra Lee, Jinyoung Hur, Ho-Young Park, Ho-Young Park

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. …”
Get full text

Enhanced selectivity of carbon quantum dots for metal ion detection through surface modification by heteroatom doping: A study on optical properties and theoretical approach by María Belén Cánchig, Floralba López, Zaillmar Morales-Navarro, Alexis Debut, Karla Vizuete, Thibault Terencio, Manuel Caetano, Juan Pablo Saucedo-Vázquez

“…Water contamination by toxic metal ions has become a significant issue, requiring the development of effective ion detection methods. …”
Get full text

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems by Louis C. Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Pei-Pei Hsieh, Salman Mustfa, George Thom, Sandra Wimberger, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

“…Together, our data establish small molecule modulation of DNA repair pathways as a general strategy to maximize the precision of diverse prime editing systems.…”
Get full text

Co-occurrence of microplastics and heavy metals in a freshwater lake system in Indian Himalaya: Distribution and influencing factors by Sunil Kumar, Kumar Ajay, Diptimayee Behera, Aarif Yaseen, Balasubramanian Karthick, Sushma Prasad, Sami Ullah Bhat, Arshid Jehangir, Ambili Anoop

“…Microplastic (MP) contamination in freshwater systems is a prevalent and persistent environmental issue, yet their occurrence and distribution remain poorly constrained. …”
Get full text

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions by Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm

“…Abstract Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear. …”
Get full text