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Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease
Published 2025-05-01“…Keywords: Alzheimer’s disease, engineering exosomes, intranasal delivery…”
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Empowering Fuel Cell Electric Vehicles Towards Sustainable Transportation: An Analytical Assessment, Emerging Energy Management, Key Issues, and Future Research Opportunities
Published 2024-10-01“…The outcomes and key findings of this review will be helpful for researchers and automotive engineers in developing advanced methods, control schemes, and optimization strategies for FCEVs towards greener transportation.…”
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Research progress,key scientific issues,and prospects of segmented fracturing and pressure relief gas drainage technology for coal seam roof horizontal wells
Published 2025-02-01“…The segmented fracturing and pressure relief gas drainage technology in the horizontal well of the coal seam roof is a key means to guide the efficient gas extraction in deep, high gas, soft and low permeability coal seams.Based on this, a full lifecycle development concept for the segmented fracturing, pressure relief,and gas drainage engineering of the coal seam roof horizontal well is proposed, including three stages: early scientific planning, mid-term engineering construction, and later safety management.This paper summarizes the research progress on the full life cycle development of segmented fracturing and pressure relief gas drainage in coal seam roof horizontal wells, constructs an overall research framework for key scientific issues related to segmented fracturing and pressure relief gas drainage in coal seam roof horizontal wells, and looks forward to its future development direction.The results show that the expansion of segmented fracturing cracks in the horizontal well of the coal seam roof is extremely complex due to geological factors, construction parameters, and physical properties.It is urgent to comprehensively evaluate the primary and secondary relationships under the influence of multiple factors in crack expansion, and reveal the mechanism of coal seam roof fracturing crack expansion under the influence of multiple factors.Exploring the critical relationship between the coupling of stress, water, temperature, and coal factors on the promotion and inhibition of coalbed methane adsorption, desorption, and migration, and establishing an optimal model for coalbed methane adsorption and desorption under multiple critical indicators, is the key to achieving efficient coalbed methane extraction. …”
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Socioeconomic and Health Impacts of Dust Storms in Southwest Iran
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A model for utilising crises-related issues to facilitate transdisciplinary outdoor STEAM education for sustainability in integrated mathematics, language arts and technology class...
Published 2025-01-01“…Abstract STEAM (Science, Technology, Engineering, Arts and Mathematics) Education is one of the approaches that teachers adopt as they shift from content delivery focused teaching to skills development teaching. …”
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ЭКСПОРТНЫЕ СТРАТЕГИИ ГОСУДАРСТВА В УСЛОВИЯХ СТРУКТУРНОЙ ДИВЕРСИФИКАЦИИ КАЗАХСТАНСКОЙ ЭКОНОМИКИ
Published 2018-06-01“…The article examines the issues of increasing the industrial development of the national economy on the basis of the engineering. …”
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Analysis of China's data circulation policy mechanisms based on protection motivation theory: policy trends
Published 2024-11-01“…In recent years, local governments have issued numerous policy documents related to data circulation, yet the specific mechanisms and their content remain vague. …”
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Science, Technology, Engineering and… Masculinity? How psychological theory can help understand and improve the gender gap within STEM subjects
Published 2020-11-01“…The under-representation of females in science, technology, engineering and mathematics (STEM) is a key educational issue which warrants discussion. …”
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