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Two-pore channels in MR1-dependent presentation of Mycobacterium tuberculosis infection.
Published 2025-08-01“…We have shown the importance of endosomal trafficking proteins in MR1-dependent presentation of Mycobacterium tuberculosis (Mtb) infection. Two pore channels (TPCs) are endosomal calcium channels that regulate endosomal trafficking. …”
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Features of ionic transport processes in a model of arterial hypertension
Published 2018-12-01“…An increase of the hyperpolarizating response of the erythrocyte membrane from rats with spontaneous hypertension is associated with activation of potassium channels. The selective effect on these intracellular targets can serve as a basis for the development of antihypertensive drugs.…”
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Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
Published 2025-08-01“…We found that Panx1 functions in a noncanonical role as a calcium (Ca2+) leak channel within the endoplasmic reticulum (ER), a key intracellular calcium store. …”
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Ca2+ transmembrane transport enhances oscillatory growth of cancer cell invadopodia
Published 2025-08-01“…Abstract Invadopodia, dynamic cancer cell protrusions, deform and degrade extracellular matrix (ECM) to facilitate invasion. Intracellular calcium ions (Ca2+) are critical second messengers involved in cancer cells migration, proliferation, and apoptosis, but their role in invadopodia dynamics remains unclear. …”
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Tumor cell apoptosis mediated by the orexins
Published 2021-06-01“…The classical signal transmission pathway through orexin receptors in neuronal cells includes an increase of the intracellular calcium as a result of the opening of TRPC membrane channels and IP3 endoplasmic reticulum (ER) channels. …”
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