Perturbation-Theory Machine Learning for Multi-Target Drug Discovery in Modern Anticancer Research by Valeria V. Kleandrova, M. Natália D. S. Cordeiro, Alejandro Speck-Planche

“…Computational methods are of paramount importance to accelerate multi-target drug discovery in cancer research but most of them have several disadvantages such as the use of limited structural information through homogeneous datasets of chemicals, the prediction of activity against a single target, and/or lack of interpretability. …”
Get full text

Coupling characteristics of construction safety risk and complicated factors of metro station: a case study of Ningbo by Ping Wu, Jiamin Huang, Yinqi Chen, Jun Zhang, Yidong Xu

“…To this end, the interpretative structural modeling (ISM) method, a structural interpretation model, is utilized to develop the coupling connection network of construction risk factors. …”
Get full text

Prediction of protein–protein interaction based on interaction-specific learning and hierarchical information by Tao Tang, Taiguang Shen, Jing Jiang, Weizhuo Li, Peng Wang, Sisi Yuan, Xiaofeng Cao, Yuansheng Liu

“…HI-PPI extracts the hierarchical information by embedding structural and relational information into hyperbolic space. …”
Get full text

“Your behavior is not welcome here…”: forced internal displacement of sexual and gender minorities in Kenya by Emmy Kageha Igonya, Ebenezer Kwesi Armah-Ansah, Winstoun Muga, Kristefer Stojanovski

“…Rethinking LGBTQ+ IDPs through the lens of coercion may better capture the lived experiences given the structural stigma and violence in which they live and cannot escape.…”
Get full text

Law as an innovative system: theoretical approach by M. V. Shugurov, A. A. Vasiliev

“…In other words, there is a transition to a new phase of development of the systemic-structural, as well as synergetic approach to law.The paper moves from considering the concept of “legal innovation” as one of the concepts in the family of concepts that reveal the process of updating the law, to considering the law as an innovative system in which the renewal of legal reality in the unity of its normative and technological aspects is placed on the basis of special mechanisms.Achieving a common understanding of the content and structure of the legal innovation process, as well as the corresponding system, including subjects of innovative legal activity and an institutionalized ecosystem, should be supplemented in the future by modeling the segments of the legal innovation system inherent in lawmaking and law enforcement. …”
Get full text

Accelerating materials property prediction via a hybrid Transformer Graph framework that leverages four body interactions by Mohammad Madani, Valentina Lacivita, Yongwoo Shin, Anna Tarakanova

“…It outperforms state-of-the-art models in 8 materials property regression tasks. Also, this model predicts local atomic environments and global structural features better than several models. …”
Get full text

Experimental Study on Blockage Mechanism and Blockage Locations for Polymer-Flooded Reservoirs in the Henan Oilfield by Yu Li, Meilong Fu, Baofeng Hou, Zhiyuan Zhang, Ruiyi Sun

“…In this paper, Nanbaxian oil and gas field, China, was taken as an example to investigate the interpretation method of gas saturation in a complex pore structure. …”
Get full text

Features of the dynamic properties of the working bodies of technological machines with inertial excitation of vibrations by Andrey V. Eliseev, Vladimir B. Kashuba, Nikita Z. Kinash, Sergey V. Eliseev

“…The structural mathematical modeling for the analysis and dynamic synthesis problems involves using the system transfer functions. …”
Get full text

Mapping Hsp104 interactions using cross‐linking mass spectrometry by Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak

“…We applied a panel of cross‐linking reagents to produce cross‐linking maps of Hsp104 and interpret our data on previously determined X‐ray and cryo‐EM structures of Hsp104 from a thermophilic yeast, Calcarisporiella thermophila. …”
Get full text

Design, Dynamics and Development of Upgraded Tiltable Wing associated Quadcopter through Advanced computational simulations incorporated Bottom-Up Approach by Haribalan Saravana Mohan, Karthikeyan Murugaraj, Senthil Kumar Solaiappan, Beena Stanislaus Arputharaj, Parvathy Rajendran, It Ee Lee, Shyam Sundar Jayakumar, Janani Priyadharshini Veeraperumal Senthil Nathan, Arunkumar Karuppasamy, Vijayanandh Raja

“…Different test cases including the Computational fluid dynamics (CFD), Fluid structure interaction (FSI) analysis are executed to estimate the performance of the configuration. …”
Get full text

Explaining the technological cooperation of knowledge and business ecosystems: an approach based on ecotone and ambidextrous organization theories by Bahman Norouzpour, Mahmoud Moradi, Mohamad Rahim Ramezanian, Mostafa Ebrahimpour Azbari

“…The research strategy is "Grounded Theory," which presents a conceptual model. The systematic procedure of Strauss and Corbin was used to create a suitable structure for better understanding and classification of data and findings. …”
Get full text

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…To this end, attention will primarily be focused on the analysis of the X-ray crystallographic structures of HA bound to fusion inhibitors. Furthermore, this study also aims to highlight the efforts made in exploiting the structural information in conjunction with molecular modeling techniques to discern the mechanism of action of the fusion inhibitors and to assist the design and interpretation of structure-activity relationships of novel lead compounds will be highlighted. …”
Get full text

So to Speak: A Computational and Empirical Investigation of Lexical Cohesion of Non-Literal and Literal Expressions in Text by Alexis Palmer, Caroline Sporleder, Linlin Li

“…In this paper, we investigate to what extent a particular class of expressions which can have a non-literal interpretation participates in the cohesive structure of a text. …”
Get full text

Supply Chain Data Governance Optimization Based on Fuzzy DEMATEL-ISM by Yaoxi Liu, Jinyu Wei, Xiaoxuan Wang

“…Further, we employed a combined fuzzy decision-making trial and evaluation laboratory (DEMATEL) and Interpretative Structural Models (ISM) method to explore the index prioritization and hierarchical relationships for data governance optimization. …”
Get full text

RESULTS OF COMPREHENSIVE STUDIES OF THE UNDERGROUND HYDROSPHERE WITHIN THE WESTERN SHOULDER OF THE BAIKAL RIFT (AS EXEMPLIFIED BY THE BAYANDAI – KRESTOVSKY CAPE SITE) by Konstantin Zh. Seminsky, Marina A. Tugarina

“…On the other side, geophysical and hydrogeological data (at least on tectonically active regions) should be interpreted with account to the concept that the fields under study depend on the structural status of the rock massif, rather than on the lithology.…”
Get full text

Anatomical Plausibility in Deformable Image Registration Using Bayesian Optimization for Brain MRI Analysis by Mauricio Castaño-Aguirre, Hernán Felipe García, David Cárdenas-Peña, Gloria Liliana Porras-Hurtado, Álvaro Ángel Orozco-Gutiérrez

“…This paper proposes a novel framework that uses Bayesian optimization to address these challenges, focusing on registering 3D point clouds that represent brain structures. Our method uses probabilistic modeling to optimize non-rigid transformations, providing smooth and interpretable deformations that align with anatomical constraints. …”
Get full text

Prospects for assessing financial ratios in crisis and postcrisis economy by O. V. Berezhnaya, E. V. Berezhnaya, P. N. Kozlov

“…Introduction. Assessment and interpretation of the values and levels of calculated indicators of financial activity of companies is a traditional issue for the micro level of the economy. …”
Get full text

Value-meaningful conceptualisation of educational material in the process of foreign language teaching at the university: A hermeneutic approach by O. A. Zheglova, A. F. Zakirova, L. V. Shilova

“…This is possible in the context of the value and semantic conceptualisation of acquired knowledge, which is carried out in the process of interpreting and structuring the content of training by the principle of linguistic concept.Aim. …”
Get full text

Speech recognition in noise across the life span with cognition and hearing sensitivity as mediators of age effects by Yossi Bugannim, Ilan Roziner, Liat Kishon-Rabin

“…Structural equation modeling (SEM) confirmed that cognitive and auditory factors mediate the relationship between age and SRTn, explaining 61% of the variance. …”
Get full text

COGNITIVE SEMANTICS OF NOUNS IN DENUMERATIVE WORD FORMATION (BASED ON UKRAINIAN LANGUAGE) by Olha V. Kostryba

“…The mental interpretation of word-forma- tive semantics, framed by the word-formative nest as a structured framework of knowledge, underscores the significance of this scientific inquiry. …”
Get full text