Impacts of reproductive systems on grapevine genome and breeding by Hua Xiao, Yue Wang, Wenwen Liu, Xiaoya Shi, Siyang Huang, Shuo Cao, Qiming Long, Xu Wang, Zhongjie Liu, Xiaodong Xu, Yanling Peng, Pengfei Wang, Zhonghao Jiang, Summaira Riaz, Andrew M. Walker, Brandon S. Gaut, Sanwen Huang, Yongfeng Zhou

“…The impacts are widely divergent, which show interesting patterns of genomic purging and the Hill-Robertson interference. Selfing reduces genomic heterozygosity, while cloning increases it, resulting in a “double U-shaped” site frequency spectrum (SFS). …”
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Regimen comprising GLP-1 receptor agonist and basal insulin can decrease the effect of food on glycemic variability compared to a pre-mixed insulin regimen by Yi-Hsuan Lin, Chia-Hung Lin, Yu-Yao Huang, Hsin-Yun Chen, An-Shun Tai, Shih-Chen Fu, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen, Sheng-Hsuan Lin

“…Abstract Background Increasing evidence suggests that glucagon-like peptide 1 (GLP-1) receptor agonists (RA) can stabilize glycemic variability (GV) and interfere with eating behavior. …”
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Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…The results indicated that BPA (10 and 100 μg/L) caused the abnormal proliferation (increased number of cone cells), morphological abnormalities (increased height of cone cells), mosaic pattern disorder, and depressed expression of key genes related to the photo-transduction pathway, and impaired the light perception ability of both red and UV cones ultimately. …”
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Studying the Uptake of Toxic Metals by Plants using New Mathematical Modeling by Hussein Hassan Kharnoob, Hasan Ahmed Hasan

“…This research proved that some elements increased the absorption of other elements in growth solution to the shoot through root while other elements interfere the absorption phenomena for example zinc effects on absorption of copper …”
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Osteoclast-independent osteocyte dendrite defects in mice bearing the osteogenesis imperfecta-causing Sp7 R342C mutation by Jialiang S. Wang, Katelyn Strauss, Caroline Houghton, Numa Islam, Sung-Hee Yoon, Tatsuya Kobayashi, Daniel J. Brooks, Mary L. Bouxsein, Yingshe Zhao, Cristal S. Yee, Tamara N. Alliston, Marc N. Wein

“…Consistent with patient phenotypes, Sp7 R342C/R342C mice demonstrate increased cortical porosity and reduced cortical bone mineral density. …”
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Investigation on the motion and fragmentation mechanism of rockfall based on PIV-seismic signal monitoring by Sui Zhende, Zhang Ke, Zhang Kai, Lin Qibin

“…In recent years, the frequency of rockfall disasters has been increasing due to the influence of extreme weather and human activities. …”
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Molecular mechanisms and cancer-promoting roles of sodium arsenite in regulating FNDC3B expression in A549 cells by Jinyun JIANG, He MA, Na LIU, Ruihuan ZHAO, Chenglan JIANG, Yuefeng HE

“…Hoechst 33342/propidium iodide (PI) double staining and JC-1 mitochondrial membrane potential assay were employed to detect both early and late apoptosis, while cleaved caspase3 protein and P53 signalling pathway related protein expressions were evaluated by WB.Results(1) The CCK-8 results demonstrated a decline in the viability of A549 cells with an increase in NaAsO2 concentration, with an inhibitory concentration at 50% of 38.12 µmol·L−1. …”
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Markers of Dysmetabolism Revealed Using a Dietary Challenge and Dry Blood Spots in a Remotely Executed Clinical Trial by Stephany Gonçalves Duarte, Tushar More, Carlos Mario Donado-Pestana, Rosa Maria Cerdeira Barros, Elias Da Silva Araújo, Karsten Hiller, Jarlei Fiamoncini

“…The blood levels of markers of insulin resistance such as branched-chain amino acids and tyrosine were increased in the subjects with the larger glucose AUC. …”
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A Tunnel Lining Line Identification Algorithm Based on Supervised Heatmap by Heng SONG, Yisheng ZHANG, Tianbao GENG, Dongjie WANG

“…Continuing the training beyond 10 rounds results in limited further improvements. By increasing the number of outer points, significant enhancements are initially observed. …”
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Bortezomib prevents acute doxorubicin ovarian insult and follicle demise, improving the fertility window and pup birth weight in mice. by Elon C Roti Roti, Ashley K Ringelstetter, Jenna Kropp, David H Abbott, Sana M Salih

“…Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency after chemotherapy. …”
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Infraestrutura de mobilidade urbana e sua articulação com a drenagem sustentável by Talita Montagna, Rafaela Vieira

“…By blocking rainwater infiltration in the soil, surface runoff is increased and, consequently, the threats of inundation, flooding and flash flood, triggered by hydrological events, are potentiated. …”
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BIBLIOMETRIC INFERENCES ON UNFAIR TRADE PRACTICES IN THE AGRICULTURAL SECTOR by Raluca Andreea ION, Cristina Maria STERIE, Marian Valentin POPESCU, Adriana Elena (MARIN) SIMA

“…The results show that there is an increased and relatively recent interest in studying unfair trade practices in the agro-food sector, with a noticeable growth in research since 2018. …”
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TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. by George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C Smith

“…Through gene expression analysis, RNAi, and in vivo injection of recombinant TNF-α, we provide direct evidence for the requirement of TNF signaling in regulating mosquito immune cell function by promoting granulocyte midgut attachment, increased granulocyte abundance, and oenocytoid rupture. …”
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A Golden2-like transcription factor, BnGLK1a, improves chloroplast development, photosynthesis, and seed weight in rapeseed by Qianwei Zhang, Yuanyi Mao, Zikun Zhao, Xin Hu, Ran Hu, Nengwen Yin, Xue Sun, Fujun Sun, Si Chen, Yuxiang Jiang, Liezhao Liu, Kun Lu, Jiana Li, Yu Pan

“…Overexpressing BnGLK1a resulted in significant increases in chlorophyll content, the number of thylakoid membrane layers and photosynthetic efficiency in Brassica napus, while knocking down BnGLK1a transcript levels through RNA interference (RNAi) had the opposite effects. …”
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Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments by Yi Zhou, Shaoshuo Li, Bowen Hong, Zihan Wang, Yang Shao, Mao Wu, Mao Wu, Jianwei Wang, Jianwei Wang

“…Concurrently, Iso stimulation markedly increased IκBα expression, thereby rescuing its degradation. …”
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Sevoflurane Preconditioning Rescues PKMζ Gene Expression from Broad Hypoxia-Induced mRNA Downregulation Correlating with Improved Neuronal Recovery by Joan Y. Hou, Kim D. Allen, A. Iván Hernandez, James E. Cottrell, Ira S. Kass

“…The DNA repair enzyme poly ADP-ribose polymerase 1 (PARP-1) was increased by sevoflurane in tissue not subjected to hypoxia (1.23). …”
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Role of Nutrition in the Management of Hepatic Encephalopathy in End-Stage Liver Failure by Chantal Bémeur, Paul Desjardins, Roger F. Butterworth

“…Among them are inadequate dietary intake, malabsorption, increased protein losses, hypermetabolism, insulin resistance, gastrointestinal bleeding, ascites, inflammation/infection, and hyponatremia. …”
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An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters by Esther Föderl-Höbenreich, Shiva Izadi, Lara Hofacker, Nikolaus F. Kienzl, Alexandra Castilho, Richard Strasser, Ferran Tarrés-Freixas, Guillermo Cantero, Núria Roca, Mònica Pérez, Cristina Lorca-Oró, Carla Usai, Joaquim Segalés, Júlia Vergara-Alert, Lukas Mach, Kurt Zatloukal

“…Abstract Newly emerging SARS-CoV-2 variants of concern (VOCs) continue to drive COVID-19 waves and are typically associated with immune escape and increased resistance to current therapeutics including monoclonal antibodies. …”
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Obstacle Circumvention Strategies During Omnidirectional Treadmill Walking in Virtual Reality by Marco A. Bühler, Anouk Lamontagne

“…Fifteen healthy young individuals walked while avoiding an interferer, performing four consecutive blocks of trials per condition. …”
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Effects of the intestinal microbiota on prostate cancer treatment by androgen deprivation therapy by Safae Terrisse, Laurence Zitvogel, Guido Kroemer

“…Moreover, intestinal bacteria that degrade drugs used for ADT, as well as bacteria that produce androgens, can interfere with the efficacy of ADT. Thus, specific bacteria in the gut serve as a source of testosterone, which accelerates prostate cancer progression, and men with CRPC exhibit an increased abundance of such bacteria with androgenic functions. …”
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