Therapeutic potential of celastrol in bacterial infections: Current research advancements and future perspectives by Ziwei Meng, Qing Liu, Haowei Chen, Chun She, Yongjun Huang

“…Celastrol is one of the main effective components extracted from the traditional Chinese medicine Tripterygium wilfordii Hook.F (TWHF). An increasing number of researchers have been focusing on the pharmacological properties of celastrol in the context of bacterial infection and associated inflammatory complications. …”
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The Accuracy Analysis of the Pedicle Screw Placement Using the Three-dimensional Computer Navigation and Intraoperative Computed Tomography Assistance in Long-level Thoracolumbar S... by I-Ting Lin, Hou-Tsung Chen, Fu-Shine Yang, Cheh-Yung Chang, Chieh-Cheng Hsu, Sung-Hsiung Chen, Meng-Ling Lu, Re-Wen Wu

“…The distance from the dynamic reference frame (DRF) was considered interfere the accuracy. Most studies claimed that there are no significant increases in computer-reported registration error at up to two levels from the DRF in spine surgery. …”
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Enhanced differentiation between 3‐hydroxyglutaric and 2‐hydroxyglutaric acids facilitates diagnostic testing for glutaric aciduria type 1 by Denis Cyr, Michel Boutin, Bruno Maranda, Paula J. Waters

“…Our laboratory recently acquired a gas chromatography system coupled to a triple quadrupole mass spectrometer (GC–MS/MS), and we took advantage of its increased sensitivity and specificity to improve our existing GC–MS method. …”
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Feature-based enhanced boosting algorithm for depression detection by Muhammad Sadiq Rohei, Kasturi Dewi Varathan, Shivakumara Palaiahnakote, Nor Badrul Anuar

“…Depression is a rapidly increasing mental disorder that can interfere with a person’s ability and negatively affect functions in various aspects of life. …”
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The double life of glucose metabolism: brain health, glycemic homeostasis, and your patients with type 2 diabetes by Stanley S. Schwartz, Mary E. Herman, May Thet Hmu Tun, Eugenio Barone, D. Allan Butterfield

“…When this milieu is perturbed, brain hyperglycemia, brain glucotoxicity, and brain insulin resistance can ensue and interfere with insulin signaling, a key pathway to cognitive function and neuronal integrity. …”
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The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4+ T Cells by Rudolf Käfer, Lisa Schmidtke, Katharina Schrick, Evelyn Montermann, Matthias Bros, Hartmut Kleinert, Andrea Pautz

“…As KSRP regulates innate immune responses, for instance by the modulation of type I interferon mRNA stability, we were interested whether knockdown of the protein (KSRP-/-) interferes with T cell activation and polarization. …”
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Peran Trait Mindfulness terhadap Fear of Missing Out Pengguna Media Sosial by Laurentius Sandi Witarso

“…Abstract. Indonesia's increasing internet use has positive and negative impacts on social media users. …”
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Electrochemical sensing of 3,3’-Dichlorobiphenyl using green-synthesized gold nanoparticles and Polyvinylpyrrolidone composite by Nahid Rehman, Shraddha Shukla, Ashutosh Pandey, Anjana Pandey

“…Its detection in water is of increasing environmental concern due to its classification as a non-legacy PCB associated with modern pigment manufacturing. …”
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Growth differentiation factor 10 inhibits fat infiltration in tongue muscles of mice with high-fat diet by Seunghyun A. Kim, Christina Xu, Kyungmin Kim, Xiaoxing Xu, Yufei Du, Hyojung J. Choo

“…We found that a HFD increases miR-144-3p in tongue FAPs, which interferes with Gdf10 mRNA expression and induces adipogenesis. …”
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Tandospirone prevents anesthetic-induced respiratory depression through 5-HT1A receptor activation in rats by Meng-ran Song, Ming-zhi Huang, Wei-jie Tao, Zheng Yong, Rui-bin Su

“…Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. …”
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Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments by Yi Zhou, Shaoshuo Li, Bowen Hong, Zihan Wang, Yang Shao, Mao Wu, Mao Wu, Jianwei Wang, Jianwei Wang

“…Concurrently, Iso stimulation markedly increased IκBα expression, thereby rescuing its degradation. …”
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Functional exhaustion of CD4⁺T cells in HIV/HCV coinfected HAART-treated patients by V. V. Vlasova, L. B. Korolevskaya, O. A. Loginova, N. G. Shmagel, E. V. Saidakova

“…While highly active antiretroviral therapy (HAART) suppresses HIV replication and restores the immune system of HIV-infected subjects, HCV coinfection interferes with CD4+T cell regeneration and increases the risk of patients’ morbidity and mortality. …”
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Sevoflurane Preconditioning Rescues PKMζ Gene Expression from Broad Hypoxia-Induced mRNA Downregulation Correlating with Improved Neuronal Recovery by Joan Y. Hou, Kim D. Allen, A. Iván Hernandez, James E. Cottrell, Ira S. Kass

“…The DNA repair enzyme poly ADP-ribose polymerase 1 (PARP-1) was increased by sevoflurane in tissue not subjected to hypoxia (1.23). …”
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From Antiretroviral to Antibacterial: Deep-Learning-Accelerated Repurposing and In Vitro Validation of Efavirenz Against Gram-Positive Bacteria by Ezzeldin Saleh, Omar A. Soliman, Nancy Attia, Nouran Rafaat, Daniel Baecker, Mohamed Teleb, Abeer Ghazal, Ahmed Noby Amer

“…EFV showed restored sensitivity of β-lactams against Methicillin-resistant <i>S. aureus</i> (MRSA). It increased the effectiveness of antibiotics tested against Methicillin-sensitive <i>S. aureus</i> (MSSA). …”
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Effectiveness of a Cognitive Stimulation Program in Older Adults with Mild Neurocognitive Disorder: Insights from fNIRS Analysis in a Randomized Controlled Trial by Susana I. Justo-Henriques, Rosa C. G. Silva, Janessa O. Carvalho, João L. A. Apóstolo, Débora Nogueira, Telmo A. S. Pereira

“…Background/Objectives: Neurocognitive disorders (NCDs) encompass a spectrum of conditions that significantly impact cognitive domains, including attention, memory, and language. Mild NCD, increasingly prevalent with aging, represents an early stage of these disorders, characterized by cognitive deficits that do not interfere with daily functioning. …”
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How Deep Are the Invisible Wounds? The Impact of Maternal Stress During Pregnancy on Adolescent Anxiety: A Cross-Sectional Study by Dessy Ekawati, Nurul Azmi Arfan, Esti Pratiwi Yosin, Endang Yuswatiningsih

“…Background: Pregnancy-related stress can affect a child’s development for a long time, increasing the likelihood of teenage anxiety. High levels of stress hormone exposure during pregnancy may interfere with the development of the nervous system and stress reactions, making a person more susceptible to anxiety disorders. …”
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Autism Spectrum Disorder, Oral Implications, and Oral Microbiota by Emiliana D’Angelo, Fausto Fiori, Giuseppe A. Ferraro, Assunta Tessitore, Luca Nazzaro, Rosario Serpico, Maria Contaldo

“…<b>Results:</b> Individuals with ASD face unique oral health challenges, including injuries from self-injurious behaviors and increased sensory sensitivity, which complicate oral hygiene and care. …”
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Gal-3 blocks the binding between PD-1 and pembrolizumab by Henrik Schmidt, Torben Steiniche, Bent Deleuran, Malene Hvid, Morten Aagaard Nielsen, Stinne Ravn Greisen, Mia Bendix, Kathrine Pedersen, Nina Haunstrup Jensen, Jakob Hauge Mikkelsen, Taner Drace, Thomas Boesen

“…Soluble PD-1 levels in plasma increased after treatment with pembrolizumab and correlated with disease progression.Conclusion We demonstrate that the interaction between PD-1 and Gal-3 interferes with the binding of pembrolizumab, supporting that an immune suppression induced by Gal-3 in the tumor microenvironment cannot be rescued by pembrolizumab.…”
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Comparative genomics analyses of Actinobacteriota identify Golgi phosphoprotein 3 (GPP34) as a widespread ancient protein family associated with sponge symbiosis by Cláudia Ferreira, Ilia Burgsdorf, Tzipora Perez, Gustavo Ramírez, Maya Lalzar, Dorothée Huchon, Laura Steindler

“…Results Our analysis uncovered several differences between symbiotic and free-living bacteria, including an increased abundance of genes encoding prokaryotic defense systems (PDSs) and eukaryotic-like proteins (ELPs) in symbionts. …”
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The Influence of Nordic Walking Training on the Serum Levels of Sirtuins, FOXO3a, and Vitamin D Metabolites in Patients with Multiple Myeloma by Olga Czerwińska-Ledwig, Małgorzata Żychowska, Artur Jurczyszyn, Joanna Kryst, Adrianna Dzidek, Roxana Zuziak, Anna Jurczyszyn, Anna Piotrowska

“…Vitamin 25(OH)D3 level increased significantly in the study group with time. …”
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