Impact of Urban Waterfront Green Space Landscape Elements on Public Health Behaviors Based on Restorative Perception by Yi WU, Hongfei QIU, Xinyue LUO, Yaping HU

“…Firstly, prioritize the development of natural landscapes while minimizing artificial elements, and leverage natural features to create inviting environments while ensuring their regular maintenance; secondly, strategically plan spatial colors to foster vibrant and diverse landscapes, with a focus on color harmony; and thirdly, implement tailored designs for landscape nodes to cater to diverse needs and establish functional spaces based on health behavior types, for which specific measures include promoting restorative activities through the integration of vibrant floral displays in open waterfront areas, providing physical activity infrastructure along watersides and on rubberized surfaces to satisfy public exercise requirements, and augmenting architectural spaces in aesthetically pleasing colorful venues to facilitate social interactions. …”
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Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination by Yanqin Bian, Fang Li, Xinyu A, Zheng Xiang, Nanshan Ma, Jianye Wang, Boran Cao, Pengfei Xin, Xuan Cheng, Chang Liu, Bei Xiang, Jun Shen, Qigui Lu, Lianbo Xiao

“…This study aims to investigate the functional interplay between JBQG and the lncRNA ITSN1-2/NOD2/RIP2 axis in regulating FLS behavior during RA development. …”
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Traditional Mongolian Medicine Qiqirigan-8 alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism by Dandan Yang, Dandan Yang, Wuyunsiqin, Wuyunsiqin, YanNiu, Hashentuya, Tana, Anna, Mingxing Ma, Wenhui Zhao, Menggenduxi, Minjie Wang, Minjie Wang

“…C57BL/6J mice were fed a choline-deficient diet for 12 weeks to induce a NAFLD model. Hematoxylin and Eosin (H&E)-staining, combined with serum biochemical indexes, was used to observe liver appearance and characterize the pathological changes and functions of the liver. …”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…Key findings include:Hydrophilic characteristics: Mineralogical analysis, high-temperature/high-pressure (HTHP) wettability experiments, and macromolecular modeling revealed that deep coal exhibits macroscale hydrophilicity and microscale strong hydrophilicity due to hydrophilic clay mineral filling and oxygen-containing functional groups. …”
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The Effect of New Water-soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates on the Hemostasis System <i>In vitro</i> by A. V. Starkova, F. V. Sobin, I. P. Rudakova, N. A. Pulina, N. V. Dozmorova, V. G. Luzhanin

“…To study the effect of new water-soluble 2-amino heteryl-3-ium 4-(get)aryl-2-hydroxy-4-oxobut-2-enoates on the hemostasis system using an in vitro model.Materials and methods. Direct interaction 4-(het)aryl-2-hydroxy-4-oxobut-2-enoic acids with heterocyclic amines have been obtained new water soluble 2-aminoheteryl-3-ium 4-(het)aryl-2-hydroxy-4-oxobut-2-enoates. …”
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Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications by Yu He, Shiyan Zhuo, Meng Li, Jie Pan, Yongguang Jiang, Yidan Hu, Robert A. Sanford, Qin Lin, Weimin Sun, Na Wei, Shuming Peng, Zhou Jiang, Shuyi Li, Yongzhe Li, Yiran Dong, Liang Shi

“…To address these knowledge gaps, a serpentinite-like environment was selected as a simplified model system to investigate the CPR communities in hyperalkaline environments and their association with hosts in extreme conditions. …”
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Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
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Results from AD-HEARING (ADherence to and adjustment of HEARING aids in clinical routine care as preventive dementia strategy): a prospective 6-month follow-up study on cognition a... by Michael Belz, Sebastian Gmeinwieser, Mona Abdel-Hamid, Mona Abdel-Hamid, Robert Kühler, Jenny Blum, Philipp Hessmann, Nicola Strenzke, Claudia Bartels

“…Hearing aid use might reduce this risk by preserving cognitive and psychological functions.ObjectiveThis study aims to investigate the influence of ARHL and hearing aid use on cognition and different aspects of psychological well-being.MethodsDuring 05/2021 and 05/2023, 31 subjects with audiometrically confirmed ARHL were included and 28 underwent follow-up 6 months later (final analysis sample). …”
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Spatial Patterns and Perception Differences in Slow-Tourism Behavior: Insights from Popular Citywalk Routes in Chengdu, Wuhan, and Shanghai, China by Han Chenglong, Li Lingling, Li Gang, Lan Li, He Ying, Guo Jianying

“…Geographical location affects the natural environment, tourism facilities, and cultural atmosphere of a city, whereas planning concepts influence urban spatial layouts, functional zoning, and the mode of tourism resource development, which affect the form and experiences in slow tourism. …”
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Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smoo... by Smriti Bohara, Atefeh Bagheri, Elif G. Ertugral, Igor Radzikh, Yana Sandlers, Peng Jiang, Chandrasekhar R. Kothapalli

“…Finally, the altered levels in genes involved in ECM organization, elastic fiber synthesis and formation, laminin interactions, and ECM proteoglycans were identified. …”
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Integrating Patient Choice and Collaborative Care Managers to Implement eHealth Tools in Depression: Self-Report Pilot Study by Jennifer Severe, Adrienne Lapidos, Danielle S Taubman, Amy Sochowicz, Sophia Wolk, Daniela Lopez, Abigail Biehl, Sagar V Parikh

“… Abstract BackgroundImproving mental health treatment within the collaborative care model (CoCM) may be achieved by using e-mental health (e-MH) tools and addressing the challenges to their integration. …”
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Cross-lagged analysis of physical fitness and cognitive control in Chinese early adolescents by Lei Xu, Fengling Zhang, Jianbo Zhu

“…Eight-month follow-up (T2: November–December 2023) retained 143 participants (mean age: 12.7 ± 0.52). Cross-lagged path modeling in Mplus 8.0 examined bidirectional causation relationships between fitness domains and cognitive functions, supplemented by SPSS 26.0-based correlational analyses. …”
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Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…Circular RNAs were confirmed to possess circular structures. The interactions among circular RNAs, microRNAs, and messenger RNAs were examined using dual-luciferase reporter assays. …”
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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimen... by Wang Y, Fan Y, Li M, Song Z, Wang P, Xie F, Miao Y, Wang Y, Zhang P, Zhan Q

“…The protein–protein interaction (PPI) network, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were performed to predict the core targets and pathways of SZY in the treatment of SONFH. …”
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Green Synthesis, Characterization and Pharmaceutical Applications of Biocompatible Zinc Oxide Nanoparticles Using <i>Heliotropium rariflorum</i> Stocks by Noor Ul Uza, Ghulam Dastagir, Syed Tanveer Shah, Elitsa Pavlova, Aftab Jamal, Mahmoud F. Seleiman, Jakub Černý

“…For analgesic and antipyretic activities, a two-way ANOVA revealed that dose, time, and the interaction between dose and time were significant. …”
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EXPRESSION OF CONCERN: CircZNF124 regulates cell proliferation, leucine uptake, migration and invasion by miR‐199b‐5p/SLC7A5 pathway in endometrial cancer by Liuping Shu, Yan Peng, Liyan Zhong, Xi Feng, Lifu Qiao, Yi Yi

“…The interaction between miR‐199b‐5p and circZNF124 or SLC7A5 was predicted by starbase online database, and identified by mechanism assays. …”
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Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against Ruminococcus gnavus strain RJX1120 by Hou Dingding, Hou Dingding, Sher Muhammad, Irfan Manzoor, Sana Abdul Ghaffar, Hissah Abdulrahman Alodaini, Nadine MS. Moubayed, Ashraf Atef Hatamleh, Xu Songxiao

“…Structural refinement of the construct revealed that 95.7% of the amino acid residues were located in favored regions, indicating a high-quality structural model. Molecular docking analysis demonstrated a robust interaction between the vaccine construct and the human Toll-like receptor 4 (TLR4), with a binding energy of −1277.0 kcal/mol. …”
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Integrated multi-omics for potential biomarkers and molecular mechanism of persistent inflammatory refractory rheumatoid arthritis by Ping-Heng Zhang, Ya-Nan Bi, Xiao-Feng Zhao, Kang Chen, En-Sheng Chen, Chang-Hong Xiao

“…Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein-protein interaction networks, and KEGG Markup Language (KGML) network analysis were employed to characterize the functional roles of differentially expressed genes (DEGs), proteins, metabolites, and associated biological pathways. …”
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CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1 by Valerio Taverniti, Laura Meiss-Heydmann, Cloé Gadenne, Hannah Vanrusselt, Dieudonné Buh Kum, Fabio Giannone, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Yannick Debing, Eloi R. Verrier

“…Conclusions: Our results unravel a previously undiscovered mechanism of action involving CAM-As and open the door to new therapeutic strategies involving CAM to achieve a functional cure in patients with chronic infections. …”
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Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy by Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji

“…Western blot and coimmunoprecipitation were performed to demonstrate the interaction between GSK3β and PD-L1. We carried out in vivo experiments in a C57BL/6 mouse model of HCC established through subcutaneous injection.Results GEO single-cell RNA sequencing data suggested that GSK3β was highly enriched in TAMs of HCC. …”
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