STRATEGIC COMPETENCE AS A GUARANTEE OF PROFESSIONAL ACTIVITY OF A MODERN IT SPECIALIST by Volkova Nataliia, Oliinyk Iryna, Karpova Maryna

“…The importance of shaping strategic competence in three main sections is substantiated including: elemental (a set of components, the interaction between which ensures the implementation of the relevant activity); functional (methodology for adopting strategies); and procedural (technology for developing and implementing a strategy in the existing environment). …”
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Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…Single-gene Gene Set Enrichment Analysis (GSEA) identified biological functions, while nomograms and ROC curves assessed diagnostic potential. …”
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Characteristics and Mechanisms of Single Event Effects Caused by Atmospheric Neutrons in System in Package Device by YE Jiefeng1, 2, LIANG Chaohui2, ZHANG Zhangang2, ZHENG Shunshun1, 2, LEI Zhifeng2, LIU Zhili3, GENG Gaoying3, HAN Hui1

“…The experimental results were analyzed through simulations performed using GEANT4, a particle transport and interaction modeling software. The simulated results provide essential insights into the underlying mechanisms contributing to the lower SEU cross section observed in the experimental. …”
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Examining the cultuling of Iranians’ concerns for others: From apathy to metapathy by Reza Pishghadam, Shima Ebrahimi

“…Introduction Since birth and throughout all stages of development, humans have been social beings, as effective communication and interaction with others have been crucial for them. …”
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Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome by Mingde Li, Yajun Qi, Guizhen Wang, Su Bu, Ming Chen, Jiahui Yu, Tianyang Luo, Lulu Meng, Anran Dai, Yong Zhou, Shuai Liu, Xingxing Huo

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to functionally annotate the DEPs. The protein–protein interaction (PPI) network was constructed and the core proteins were identified with the STRING website and Cytoscape software. …”
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Atypical cancer risk profile in carriers of Italian founder BRCA1 variant p.His1673del: Implications for classification and clinical management by Giovanni Innella, Cristina Fortuno, Laura Caleca, Bing‐Jian Feng, Courtney Carroll, Michael T. Parsons, Sara Miccoli, Marco Montagna, Daniele Calistri, Laura Cortesi, Barbara Pasini, Siranoush Manoukian, Daniela Giachino, Laura Matricardi, Maria Cristina Foti, Valentina Zampiga, Claudia Piombino, Elena Barbieri, Francesca Vignolo Lutati, Jacopo Azzolini, Rita Danesi, Valentina Arcangeli, Sandrine M. Caputo, Nadia Boutry‐Kryza, Vincent Goussot, Susan Hiraki, Marcy Richardson, Hereditary Breast/Ovarian Cancer IOV network (HBOC IOVnet), Simona Ferrari, Paolo Radice, Amanda B. Spurdle, Daniela Turchetti

“…Likelihood‐ratio in favor of pathogenicity was 98898642.82 under assumption of standard BRCA1 breast and ovarian penetrance, and 104240832.84 after excluding breast cancer diagnoses (based on penetrance results). Functional analysis demonstrated that the variant abrogates the BRCA1‐ABRAXAS1 binding, supporting the PS3 code assignment within the ACMG/AMP rule‐based model. …”
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Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection by Youliang Rao, Chao Qin, Bianca Espinosa, Ting-Yu Wang, Shu Feng, Ali Can Savas, Jill Henley, Lucio Comai, Chao Zhang, Pinghui Feng

“…Screening a SARS-CoV-2 expression library, we identified several viral proteins that interact with CTPS1. Functional analyses demonstrate that ORF8 and Nsp8 activate CTPS1 to deamidate IRF3 and negate IFN induction, whereas ORF7b and ORF8 activate CTPS1 to promote CTP synthesis. …”
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CPLX1 is a novel prognostic biomarker in CRC correlating with immunotherapy resistance and ferroptosis by Canyu Liu, Qiujun Liu, Yuanhao Lv, Tingmin Chang, Shiyi Song, Yuang Ding, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong, Yanxuan Liu

“…Co-expression and functional enrichment analyses, alongside Gene Set Enrichment Analysis (GSEA), were also conducted to delineate pathways impacted by CPLX1.ResultsOur findings indicate that high expression levels of CPLX1 are significantly correlated with poor prognostic outcomes in CRC patients. …”
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Bioinformatics-Based Analysis of Ferroptosis-Related Biomarkers and the Prediction of Drugs Affecting the Adipogenic Differentiation of MSCs by Jiahao Jin, Zihao Yuan, Xinglang Wang, Quanfeng Li, Yunhui Zhang, Yibin Zhang, Pengfei Ji, Yanfeng Wu, Peng Wang, Wenjie Liu

“…Additionally, we explored the functional roles of FRDEGs through GO and KEGG analyses and found that these genes significantly impacted intracellular oxidative stress. …”
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LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer by Jinyan Ma, Yingjie Zhang, Zhuoran Sun, Hui Guo, Xiang Li, Jueting Cai, Meichen Zhang, Mengmeng Chen, Jingjing Jiang, Lingling Zhang

“…Techniques such as molecular docking simulations, chromatin isolation by RNA purification (ChIRP), chromatin immunoprecipitation (ChIP), luciferase reporter assays, and bioinformatics analysis have elucidated the interactions and mechanisms between PVT1 and FDX1. The therapeutic potential of the PVT1-FDX1 axis was evaluated in a mouse xenograft model. …”
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Synthesis of New Pyrazolo[3,4-<i>d</i>]pyrimidine Derivatives: NMR Spectroscopic Characterization, X-Ray, Hirshfeld Surface Analysis, DFT, Molecular Docking, and Antiproliferative... by Mohamed El Hafi, El Hassane Anouar, Sanae Lahmidi, Mohammed Boulhaoua, Mohammed Loubidi, Ashwag S. Alanazi, Insaf Filali, Mohamed Hefnawy, Lhoussaine El Ghayati, Joel T. Mague, El Mokhtar Essassi

“…Geometrical parameters were accurately modeled by DFT calculations using the B3LYP hybrid functional combined with a 6–311++G(d,p) basis set. …”
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Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…The potential QRs determined by boundary functions were reached up to 6.2, 5.26 and 6.12 kg m−3 in NW, at dry years and under NPK, respectively. …”
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TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury by Yunsheng Zhang, Yunsheng Zhang, Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Hanhan Dang, Chuanpeng Zhang, Chuanpeng Zhang, Kun He, Kun He, Xu Yang, Xu Yang, Zixi Wang, Zixi Wang, Li Zhang, Li Zhang, Li Zhang, Yanbing Yu, Yanbing Yu, Yanbing Yu

“…Intranasal administration of the TREM-1 antagonist LP17 treatment attenuated neuroinflammation, reduced blood-brain barrier disruption, ameliorated cerebral blood flow decrease, promoted synaptic remodeling, and improved functional outcomes. Mechanistically, through its interaction with SYK, TREM-1 triggered the CARD9/NF-κB signaling and induced pyroptosis. …”
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Activity and mechanism of naringin in the treatment of post-infectious cough by Yinghan Chen, Dong Wang, Meng Song, Weiqi Pan, Wenda Guan, Zifeng Yang, Shan Zhong

“…GO (Gene Ontology) functional annotation and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses were performed with Metascape. …”
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Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor mi... by Sang Hoon Lee, Jonghwa Won, Sora Kim, Wonjun Son, Yangsoon Lee, Yelim Park, Kyeong-Su Park, Hyunseong Youn, Arim Seo, Byungje Sung

“…The effects of a combined pembrolizumab or atezolizumab treatment with ABL112 were assessed in two mouse models with different genetic backgrounds. Statistical analysis was performed using one-way or two-way analysis of variance (ANOVA) with Dunnett’s multiple-comparison test or one-way ANOVA with Fisher’s multiple-comparison test.Results ABL112 restored T cell activity by blocking TIGIT–CD155 interactions, based on a TIGIT blockade reporter assay. …”
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Active learning for advanced biodegradable film design by Yi Gao, Chengcheng Liu, Yang Zhao, Peng Zhao, Feihui Chen, Qinghai Li, Yanguo Zhang, Bin Yang, Hui Zhou

“…Ultimately, it provides an economically viable and environmentally friendly pathway toward reducing plastic waste while enhancing the functionality and commercial viability of biodegradable films.…”
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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

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Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

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miR‐32533 Reduces Cognitive Impairment and Amyloid‐β Overload by Targeting CREB5‐Mediated Signaling Pathways in Alzheimer's Disease by Li Zeng, Zhongdi Cai, Jianghong Liu, Kaiyue Zhao, Furu Liang, Ting Sun, Zhuorong Li, Rui Liu

“…Bioinformatics and confirmatory experiments revealed that miR‐32533 had a novel 23‐base sequence with minimal coding potential, functioning within the Drosha ribonuclease III (Drosha)/Dicer 1, ribonuclease III (Dicer)‐dependent canonical pathway and identifiable via northern blot. miR‐32533 was abundantly brain‐distributed and downregulated in diverse AD‐related models, including APP/PS1 and five familial AD (5×FAD) mouse brains and AD patient plasma. …”
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FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer by Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li

“…The ribonuclear protein IMP3 was identified as a crucial functional reader that interacted with m6A‐modified sites in the IGFBP3 3′UTR, thereby promoting IGFBP3 mRNA localisation to P‐bodies and suppressing its translation. …”
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