Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…The expression of Hub PCD-DEGs was validated in human OA samples by qRT-PCR. A diagnostic model for OA was constructed based on the expression levels of Hub PCD-DEGs. …”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…Abstract Background Ageing results in diminished adaptability, as well as declines in physiological and psychological functions and resilience. The epigenetic clock ‘Phenotypic Age’ (PhenoAge) represents ‘preclinical ageing’. …”
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Multi-dimensional Exposure Characteristics and Health Benefits Differentiation of Green Spaces within Community Life Circle by Hailin HONG, Qing CHANG

“…This is closely related to the functional attributes and usage of these spaces. The impact of different green space exposure dimensions on residents’ physical and mental health also shows marked differences. …”
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Carbohydrate utilization by the gut microbiome determines host health responsiveness to whole grain type and processing methods by Caroline Smith, Mallory J. Van Haute, Yibo Xian, Rafael R. Segura Munoz, Sujun Liu, Robert J. Schmaltz, Amanda E. Ramer-Tait, Devin J. Rose

“…Little is known about how interactions among grain processing, grain type, and carbohydrate utilization (CU) by the microbiome influence the health benefits of whole grains. …”
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Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis by Lijuan Feng, Kaiyong Bai, Limeng He, Hao Wang, Wei Zhang

“…Additionally, a nomogram model was employed to predict the diagnostic ability of biomarkers for RA. …”
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Peculiarities of the pedagogical situation at the training of bachelors on the direction 08.03.01 «Construction» on the example of discipline of specialization by Nelli I. Taraseeva

“…Basic materials were the order of the Ministry of Education and Science of Russia from 12.03.2015 N 201 “On approval of the federal state educational standard of higher education in preparing 08.03.01 construction (Bachelor level)” (Registered with the Ministry of Justice of Russia 07.04.2015 N 36767); core curriculum educational programs for Bachelors in 08.03.01 “Construction”, as well as educational and methodical complex of discipline that was developed by the leading lecturer in accordance with the legal requirements.Results: The presented model of the logical structure of the training course of the discipline “Fundamentals of the design of transport structures” makes it possible to visualize in the graph system the totality of interaction between the didactic units of the discipline under study with other disciplines of the basic educational program, their interrelation and hierarchy. …”
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LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1 by Shuaihui Wu, Qian Cheng, Yang Shi, Kunlei Wang, Zhinan Chen, Xinyin Li, Ping Jiang, Zhixiang Cheng, Zhiyong Yang, Bo Liao

“…Results The data revealed that TGF-β1 upregulates PVT1, while Smad3 functions as a transcription factor to modulate PVT1. …”
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Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism by Yujie Huang, Weiqi Xu, Wei Dong, Guijie Chen, Yi Sun, Xiaoxiong Zeng

“…Introduction: The human gut microbiome plays a pivotal role in health and disease, notably through its interaction with bile acids (BAs). BAs, synthesized in the liver, undergo transformation by the gut microbiota upon excretion into the intestine, thus influencing host metabolism. …”
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Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis. by Xiaoqian Gong, Shanhuan Feng, Jiehuang Wang, Bo Gao, Wenxiang Xue, Hongyan Chu, Shouguo Fang, Yanmei Yuan, Yuqiang Cheng, Min Liao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Edwin Tijhaar, Maria Forlenza, Ying Liao

“…However, our understanding of its interactions with host cellular targets remains limited. …”
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Health Perceptions and Mental Well-Being: A LASI-Based Study of Depression in Indian Older Adults by Shanku Paul, Jayashree Das, Dipankaj Das, Ujjal Paul

“… Background: Depression among older adults is an emerging public health challenge in India, often influenced by complex interactions between physical health and socio-demographic factors. …”
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Bioinformatics-based identification of CTSS, DOK2, and ENTPD1 as potential blood biomarkers of schizophrenia by Lei Zhang, Jiale Zhang, Na Wang, Chenwei Liu, Shuting Wang, Xiaotao Dong, Lu Yang, Xiaohong Bao, Xiaobo Nie, Jicheng Li

“…Subsequently, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses on these DEGs to elucidate their biological functions and related pathways. Furthermore, we constructed a protein-protein interaction (PPI) network of the differentially expressed genes to identify key genes and matched them with their target microRNAs (miRNAs). …”
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Comprehensive transcriptome analysis reveals MSTRG.19853.1/ssc-miR-361-3p/NPPA axis is related to hypoxic adaptation in Tibetan pigs by Pan Li, Wei Cheng, Zhandui Pubu, Peng Shang, Hao Zhang, Bo Zhang

“…Graphical Abstract The model of MSTRG.19853.1/ssc-miR-361-3p/NPPA axis for regulating hypoxia adaptation in Tibetan and Yorkshire pigs.…”
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Direct numerical simulation study of multi-dispersed particle-bubble turbulent collision frequency based on the lattice boltzmann method by Xuesong YANG, Dongqin CHEN, Yunlin WANG, Zhe LI, Yaowen XING, Xiahui GUI

“…By examining radial relative velocity and distribution functions, this study explores the characteristics of turbulent collisions under the effects of large-scale eddy transport and microscale eddy local enrichment, and the impact of size effects on the collision process. …”
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Weight bias among students and employees in university settings: an exploratory study by Léonie Sohier, Claudia Mc Brearty, Stéphanie LeBlanc, Dominic J. Chartrand, Audrey St-Laurent, Schohraya Spahis, Léonel Philibert, Inès Auclair Mangliar, Marie-Pierre Gagnon-Girouard, Clara Lakritz, Sylvain Iceta

“…Experience of weight-related stigma was found to be associated with gender (X 2 = 7.88, p = 0.019), and a higher prevalence of psychological health problems (X 2 = 9.41, p = 0.002), while having prejudice was associated with gender, with men scoring higher at the FPS (F = 7.64, p = 0.006), but not with the status (student or employee). The regression model identified significant effects of status [F(4, 347) = 2.856, p = 0.005] and the interaction between gender and status [F(4, 347) = -2.326, p = 0.021] on the FPS scores. …”
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Molecular evolution of TRPC4 regulatory sequences supports a role in mammalian thermoregulatory adaptation by Robert S. Cornman

“…The drivers of increased diversification of Trpc4 and interacting genes in bats remain to be determined.…”
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WDR3 undergoes phase separation to mediate the therapeutic mechanism of Nilotinib against osteosarcoma by Minglei Li, Nan Li, Yuying Fan, Zhan Zhang, Long Zhou, Yifan Yu, Man Ni, Mingzi Tan, WanJie Huang, Tong Zhu

“…Functions of key genes were investigated in U2-OS cells and xenograft mice. …”
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Impact of dual sensory impairment on cognition in older Chinese adults: a moderated chain-mediated effect by Qingyun Mao, Qingyun Mao, Heting Liang, Xiaoli Yuan, Zhixia Jiang, Rujun Hu, Yumeng Zhang, Shuang Li, Xiaoling Yang

“…This finding also implies that therapies for psychological issues, frailty, and sensory functioning in older adults can preserve their cognitive ability.…”
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High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently by Valeria De Matteis, Mariafrancesca Cascione, Agnese De Luca, Daniela Erminia Manno, Rosaria Rinaldi

“…The NPs achieved by microemulsion were further functionalized with amino groups making the NPs surface positively charged. …”
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The Concept of Post-Non-Classic al Methodological Strategy by Professor Olexander Oguy by Olha Chervinska

“…It was introduced into scientific circulation as the so-called “trichotomic model” of functional types of the interacting spatial structures. …”
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Exploring perceptions of dignity among older adults living in nursing homes: a qualitative study by Kejimu Sunzi, Hui Luo, Lina Yin, Yadi Li, Xin Zhou, Cheng Lei

“…Future studies should develop and test targeted dignity-enhancement interventions and include family perspectives to create holistic, dignity-oriented care models.…”
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