The protective role and mechanism of ginkgolide B in regulating mTOR signalling pathway involved in Manganese-induced apoptosis and autophagy in N27 cells by Liyu Su, Shunyu Xiang, Huan Mao, Jiayu Fu, Hongwei Ding, Feng Wang, Lan Zhao, Jianwei Bai, Yuyan Cen, Deyu Zhu, Meng Deng, Yan Li

“…Furthermore, the lentiviral vector was adopted to construct Beclin-1 gene overexpression and knockdown models, and CO-IP was employed to detect the interaction between Beclin-1 and BCL-2. …”
Get full text

A novel peptide targeting CCR7 inhibits tumor cell lymph node metastasis by Yixuan Sun, Yuzhen Qian, Lu Qiu, Xueqin Zhu, Haoming Ning, Liwei Pang, Xiaoshuang Niu, Yi Liu, Xiuman Zhou, Guanyu Chen, Wenjie Zhai, Yanfeng Gao

“…It has been reported that cancer cells can upregulate CC Chemokine Receptor 7 (CCR7) expression and hijack its normal functions, enabling them to migrate along the gradient of CCL19 and CCL21 toward the lymph nodes and colonies as the initial stage of distant metastasis. …”
Get full text

Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Linear mixed-effects models examined the interaction of group and time. …”
Get full text

Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression. …”
Get full text

AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway by Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He, Zeyuan Li

“…Methods In this study, we examined adaptor-related protein complex 5 subunit ζ1 (AP5Z1) expression in liver cancer and nearby noncancerous tissues to explore its effects on HCC cell growth, death, and autophagy. The functional and molecular mechanisms of AP5Z1 were studied using clinical sample analysis, Western blot (WB), immunohistochemistry (IHC), quantitative reverse-transcription polymerase chain reaction (qRT‒PCR), coimmunoprecipitation (Co-IP), cell proliferation assays, flow cytometry (FCM), autophagy assays, electron microscopy, mass spectrometry (MS), transcriptome analysis, and animal model experiments. …”
Get full text

The role of gut microbiota in a generalist, golden snub-nosed monkey, adaptation to geographical diet change by Yuhang Li, Yujie Yan, Haojie Wu, Yiyi Men, Yi Yang, Hengguang Fu, Derek Dunn, Xiaowei Wang, Genggeng Gao, Peng Zhang, Guixin Dong, Liyuan Hao, Jia Jia, Baoguo Li, Songtao Guo

“…The impact of temporal dietary shifts on gut microbiota has been elucidated through multidimensional modeling of both food component and macronutrient intake. …”
Get full text

Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Statistical analyses will include regression models to assess the main and interaction effects of the intervention components and cost analyses.Ethics and dissemination The study received ethical approval from the University of Klagenfurt in Austria (approval number: 2023–013), the Medical Faculty at St. …”
Get full text

Dissolved organic matter fosters core mercury-methylating microbiomes for methylmercury production in paddy soils by Q. Pu, B. Meng, J.-H. Huang, K. Zhang, K. Zhang, J. Liu, Y. Liu, M. A. Abdelhafiz, M. A. Abdelhafiz, M. A. Abdelhafiz, X. Feng, X. Feng

“…Overall, DOM simultaneously changes core Hg-methylating microbiome composition and functional activity and thus enhances MeHg production in paddy soils.…”
Get full text

Micro-electrical discharge coating of AlCoCrFeNi high entropy alloy on MgAz31B to enhance the corrosion and wear resistance by Rashi Tyagi, B.D.Y. Sunil, Monty Kumar, Harish Bishwakarma, Kuldeep K. Saxena, Rakesh Chandrashekar, Jabir Ali, Lakshita Sehgal, A. Anitha Lakshmi

“…The hydrophobic nature of coating can be advantageous for various biological functions, particularly in protein interactions. Thus, employing high entropy alloy coatings on magnesium alloys holds significant promise for optimizing their corrosion resistance properties, and make more suitable for implant applications.…”
Get full text

Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration by Youfeng Guo, Xiao Liu, Chao Wang, Shuguang Wang, Yufeng Huang, Shuo Ding, Zeyu Wang, Feng Wang

“…The protective effects of SF/GO-gel@Trox were demonstrated by transcriptomics and functional assays to be underpinned by Tie2/PI3K-Akt signaling, whereas degeneration was exacerbated by Tie2 knockdown. …”
Get full text

Investigating the temperature-dependent selectivity of CO2 reduction on Ru-cluster catalysts supported by MXene by Yueying Liu, Xiang Li, Yi Li, Rong Wei, Hongwei Tan, Xichen Li, Guangju Chen

“…In this study, the detailed reaction mechanism of CO2 reduction on composite Run@Mo2TiC2O2 catalysts was investigated theoretically, employing the four-atom Ru4 cluster as the model system. Electronic structure analysis revealed that the orbital interactions between the Ru4 cluster and CO2 play a pivotal role in determining the adsorption configuration of the CO2 molecule. …”
Get full text

Arsenic trioxide regulates DYNAP through hsa-mir-573 and inhibits the proliferation of laryngeal cancer by Yanru Ren, Xiao Yang, Yang Hui, Weiyao Chen, Yi Cheng, Ning Zhang, Tao Liu, Xinxin Yang, Xiaoyu Li

“…Additionally, a xenograft tumor model was established to examine the in vivo effects of ATO on tumor growth. …”
Get full text

Identification of key modules and hub genes for sepsis-induced myopathy using weighted gene co-expression network analysis by Siming Lin, Siming Lin, Siming Lin, Kexin Cai, Kexin Cai, Kexin Cai, Ai Chen, Weibin Wu, Guili Lian, Shaodan Feng, Shaodan Feng, Zhihong Lin, Zhihong Lin, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie

“…Additionally, we performed functional enrichment analyses using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network approaches.ResultsOur findings revealed that the identified gene clusters predominantly pertained to immune response, inflammation, and apoptosis pathways. …”
Get full text

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus by Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu

“…These tetrahedral frameworks, termed tFNAs‐ASOs‐ceftriaxone sodium (TACs), serve as a dual‐functional system that co‐encapsulates antisense oligonucleotides (ASOs) targeting the mecA gene and the β‐lactam antibiotic ceftriaxone sodium (Cef). …”
Get full text

Formulation-Dependent Extrudability of Highly Filled Alginate System for Vaginal Drug Delivery by Arianna Chiappa, Alice Fusari, Marco Uboldi, Fabiana Cavarzan, Paola Petrini, Lucia Zema, Alice Melocchi, Francesco Briatico Vangosa

“…The incorporation of solid particles as a filler to a hydrogel is a strategy to modulate its properties for specific applications, or even to introduce new functionalities to the hydrogel itself. The efficacy of such a modification depends on the filler content and its interaction with the hydrogel matrix. …”
Get full text

Comparative proteomics of biofilm development in Pseudoalteromonas tunicata discovers a distinct family of Ca2+-dependent adhesins by Sura Ali, Alexander Stavropoulos, Benjamin Jenkins, Sadie Graves, Atiyeh Ahmadi, Vania Marzbanrad, Geoffrey Che, Jiujun Cheng, Huagang Tan, Xin Wei, Suhelen Egan, Brian Ingalls, Josh D. Neufeld, Ulrich Eckhard, Trevor C. Charles, Andrew C. Doxey

“…Ultimately, our work not only provides a useful proteomic data set for studying biofilm development in an ecologically relevant organism but also adds to our knowledge of bacterial adhesin diversity, emphasizing Bap-like proteins as widespread determinants of biofilm formation in bacteria.IMPORTANCEUnderstanding how bacteria form biofilms is essential because biofilms play a crucial role in bacterial survival and interaction with their environments. The marine bacterium Pseudoalteromonas tunicata is a valuable model for studying biofilm formation, as it colonizes diverse marine surfaces and host organisms. …”
Get full text

Regulation of behavioral responses to single prolonged stress in male and female rats: Role of PACAP by Marissa A. Smail, Evelin M. Cotella, Susan E. Martelle, James B. Chambers, Ria K. Parikh, Christine E. Moore, Ben A. Packard, Nawshaba Nawreen, Rachel D. Moloney, James P. Herman

Get full text

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells by Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu

“…We investigated the biological functions of JAG2 in immune evasion using in vitro co‐culture systems, flow cytometry, tumor‐bearing mouse models, and PDTOs. …”
Get full text

RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer by Jing Zhu, Chun Yu, Xin Xu, Chu Zou, Jiaqi Li, Rui Wang, Xinchao Li, Aijun Sun, Shiyan Wang, Chao Jiang

“…Gene_DE module 2.0 (TIMER 2.0) deciphered associations between RAB5B expression and tumor-infiltrating immune cell subsets. To elucidate functional mechanisms, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) identified biological pathways co-regulated with RAB5B, and in silico approaches combining CellMiner with molecular docking predicted interactions between RAB5B and anticancer drugs. …”
Get full text

CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA by Hao Ning, Yan Jiang, Binbin Li, Junwu Ren, Cong Wang, Ling Wei, Linfei Li, Ai Ran, Zuozhang Li, Jiao Li, Wei Li, Yongquan Wang, Bin Xiao

“…In vivo tumorigenesis and metastasis were evaluated using xenograft models and a hepatic metastasis model. Statistical analyses involved Student’s t-tests and ANOVA; significance set at P < 0.05. …”
Get full text