Spatio-Temporal Heterogeneity of Vegetation Coverage and Its Driving Mechanisms in the Agro-Pastoral Ecotone of Gansu Province: Insights from Multi-Source Remote Sensing and Geodet... by Macao Zhuo, Jianyu Yuan, Jie Li, Guang Li, Lijuan Yan

“…The multi-scale analytical framework developed here provides methodological and empirical support for precision ecological governance in climate-sensitive transitional zones, particularly for optimizing ecological barrier functions in arid and semi-arid regions.…”
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Novel insights from comprehensive analysis: The role of cuproptosis and peripheral immune infiltration in Alzheimer's disease. by Jing Wang, Zi-Wen Yu, Qi Liu, Jing-Xun Wu, Yi-Dan Zhang, Hui-Juan Wan, Min Bi, Nai-An Xiao, Kun-Mu Zheng, Bin Jiang

“…Then, four machine-learning models were used to screen hub-genes from the DECAGs. …”
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Serum LINC01278 serves as a negative biomarker for sepsis and its up-regulation inhibits LPS-induced inflammatory response in THP-1 cells by Ying Gu, Honggang Jia, Xinyu Lin, Ling Wang

“…Methods: A sepsis cell model was established by stimulating THP-1 cells with LPS. …”
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Association Between Per- and Polyfluoroalkyl Substances and All-Cause Mortality in Diabetic Patients: Insights from a National Cohort Study and Toxicogenomic Analysis by Zhengxiao Wei, Jinyu Chen, Xue Mei, Yi Yu

“…Kaplan–Meier survival curves and multivariable Cox proportional hazards regression models were used to assess the relationship between PFAS levels and mortality risk. …”
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Participation of the highest official of the constituent entity of the Russian Federation in municipal legal relations by Oleg A. Kozhevnikov, Aleksandr N. Meshcheryakov

“…The research methodology includes general scientific methods, as well as some special ones, such as formal logic, structural analysis, structural-functional and interpretative methods, legal analysis, comparative analysis. …”
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Initial Experiences with Invasive Meningococcal Disease: Insights from Survivors and Their Caregivers by Oscar Herrera-Restrepo, Nuzhat Afroz, Eliazar Sabater Cabrera, Matthew Reaney, France Ginchereau Sowell, Ramiya Kumar, Alicia Stillman, Patti Wukovits, Mariana Rodrigues, Sofia B. Pinto, Zeki Kocaata, Obinna Onwude

“…Survivors able to report on the short-term impacts of IMD (n = 9) described functional limitations (9/9), emotional impacts (6/9) such as fear and trauma, and school (6/9), work (4/9), and financial (5/9) challenges. …”
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Problems of using phenol (hydroxybenzene) and parabens as pharmaceutical stabilizers: analysis using machine learning methods by I. Yu. Torshin, O. A. Gromova

“…Keywords were sorted by empirical Rudakov–Torshin informativeness functionals in the context of combinatorial theory of solvability, followed by combinatorial testing of solvability to find terms with the greatest informativeness.Results. …”
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The role of exosomal lncRNAs in mediating apoptosis and inflammation in UV-induced skin photoaging by Kunjie Li, Songfa Lin, Pengjun Zhou, Yanni Guo, Shu Lin, Shu Lin, Chao Ji

“…The skin, as the body’s largest organ, functions as a vital barrier against environmental insults. …”
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Examination the effects of Zn2+ and Cu2+ on the Pb2+ binding with dissolved organic matter using absorbance spectroscopy by Jilai Zhang, Dan Jian, Chenglei Hu, Wenhua Chen, Ming Jiang, Sheng Wang, Youbo Su, Naiming Zhang, Zhihao Si, Menglan Lu

“…The differential log-transformed absorbance spectral slopes (∆S350-400) exhibited a positive correlation with the predicted NICA-Donnan model value in a wavelength range of 350–400 nm. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…Transcriptomic sequencing and functional verification show that citrullination at the R167 site of IGF2BP1 promotes the proliferation, migration, and invasion of RA fibroblast-like synoviocytes (RA-FLSs) by improving the mRNA stability of Semaphorin 3D (SEMA3D). …”
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NAMPT and NNMT released via extracellular vesicles and as soluble mediators are distinguished traits of BRAF inhibitor resistance of melanoma cells impacting on the tumor microenvi... by Beatrice Ghezzi, Irene Fiorilla, Ágata Carreira, Francesco Recco, Leonardo Sorci, Lidia Avalle, Alessia Ponzano, Francesca Mazzola, Alberto Maria Todesco, Nicoletta Tommasi, Massimiliano Gasparrini, Vito Giuseppe D’Agostino, Flavio Mignone, Alessandro Provenzani, Valentina Audrito

“…Our functional results indicated that exogenous NNMT treatment is able to trigger NF-κB pathway, one of the main TLR4-dependent signaling, sharing this cytokine-like properties with NAMPT, and opening a future deeper exploration of its functional role in the extracellular space. …”
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Generation of non-genetically modified, CAR-like, NK cells by Martine Pugnière, Bruno Robert, Pierre Martineau, Loïs Coënon, Jessy Présumey, Emilie Rigal, Hortense Courot, Caroline Multrier, Sara Zemiti, Jennifer Lambour, Marion de Toledo, Guillaume Bossis, Guillaume Cartron, Bénédicte Fauvel, Martin Villalba

“…We have generated the new technology “Pin”, which enables the arming of modified monoclonal antibodies (mAbs) onto the CD16a of ex vivo expanded NK (eNK) cells.MethodsEx vivo eNK were prepared from umbilical cord blood cells and expanded using interleukin (IL)-2/IL-15 and Epstein-Barr virus (EBV)-transformed B-lymphoblastoid feeder cells. mAbs were engineered with four substitutions called Pin mutations to increase their affinity to CD16a. eNK were incubated with anti-CD20 or anti-CD19 Pin-mAbs to generate “armed” eNK and were used to assess effector functions in vitro on cancer cell lines, lymphoma patient cells and in vivo.Results CD16a/Pin-mAb interaction is stable for several days and Pin-mAb eNK inherit the mAb specificity and exclusively induce ADCC against targets expressing the cognate antigen. …”
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Sulfur-rich deposits associated with the deep submarine volcano Fani Maoré support broad microbial sulfur cycling communities by Stéven Yvenou, Mélanie Le Moigne, Olivier Rouxel, Johanne Aubé, Blandine Trouche, Cécile Cathalot, Emmanuel Rinnert, Xavier Philippon, Sandrine Chéron, Audrey Boissier, Vivien Guyader, Yoan Germain, Anne Godfroy, Erwan G. Roussel, Karine Alain

“…Based on the observations, a conceptual model was proposed to describe the interactions in this sulfur-rich deposit that may occur between the microorganisms, the physico-chemical conditions and the sulfur compounds supplied by the environment. …”
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Effect of communicating genetic risk of type 2 diabetes and wearable technologies on wearable device-measured behavioural outcomes in East Asians: protocol of a randomised controll... by Youngwon Kim, Shan Lou, Brian Chung, Simon Griffin, Ziyuan Chen, Job G Godino, Flora Lai Tung Cheung, Michael Multhaup, Derwin King Chung K C Chan, Harrison Hin Sheung Ho, Tsz Him Timothy Tse, Shiu Lun Ryan Au Yeung, Joni H Zhang, Mengyao Wang

“…A series of linear mixed effects models with fixed effects of time, group and interaction between time and group will be performed, with adjustment for potential confounders.Ethics and dissemination The study protocol has undergone review and received approval from the ethics committee of the University of Hong Kong. …”
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Association of weekend catch-up sleep ratio with depressive risk: insights from NHANES 2021–2023 by Shilin Sun, Min Liu, Han Liu, Runzhou Li, Qun Liang, Weiwei Quan

“…It significantly impacts quality of life and social functioning, posing a major public health challenge. …”
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Kinship Systems and the Internalization of Islamic Values among the Madurese Community in Tanean Lanjheng by Zainal Fanani, Vika Wafa Ilmi, Wahidah Zein Br Siregar

“…The findings indicate that Tanean Lanjheng functions not only as a spatial arrangement but also as a matrilineal social system that facilitates the collective and practical internalization of Islamic values. …”
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The novel diagnostic markers for systemic lupus erythematosus and periodontal disease by Xuedi Cheng, Jinfeng Zhang, Jiali Hou, Xiaocui Han, Bin Han, Jun Zhou, Zhongjun Wang, Junzheng Wang

“…Protein-protein interaction (PPI) network analysis was conducted to explore relationships between hub genes. …”
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Safety of Simultaneous Scalp and Intracranial EEG and fMRI: Evaluation of RF-Induced Heating by Hassan B. Hawsawi, Anastasia Papadaki, Vejay N. Vakharia, John S. Thornton, David W. Carmichael, Suchit Kumar, Louis Lemieux

“…The acquisition of electroencephalography (EEG) concurrently with functional magnetic resonance imaging (fMRI) requires a careful consideration of the health hazards resulting from interactions between the scanner’s electromagnetic fields and EEG recording equipment. …”
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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma by Heng Zhang, Xi Lan, Liquan Cai, Xunfeng Gao, Feng Gao, Dan Yu, Jinlong Zhang, Jinhui Zhang, Qinwen Tai

“…This study investigates the mechanisms by which bacterial infection reshapes tumor metabolism to undermine the efficacy of anti-PD-1 therapy.MethodsWe conducted 16S rRNA gene sequencing on 29 HCC clinical samples and integrated the data with single-cell RNA sequencing of 12,487 cells to map microbial, metabolic, and immune interactions within the tumor microenvironment. Functional validation was performed using orthotopic HCC mouse models (n = 8 per group), coupled with flow cytometry-based immune profiling.ResultsEnrichment of Streptococcaceae was strongly associated with upregulation of key glycolytic enzymes (LDHA, PKM2; p < 0.001) and dysfunction of natural killer cells (reduced CD56dim/CD16bright populations; hazard ratio = 2.15, 95% CI: 1.34–3.42). …”
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Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia by Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao

“…Blockade or genetic knockout of NKG2A effectively reversed NK cell exhaustion both in vitro and in an AML mouse model. Furthermore, activation of the PI3K-AKT pathway significantly enhanced cytotoxicity in exhausted NK cells. …”
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