MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein by Sarubala Malayaperumal, Sushmitha Sriramulu, Ganesan Jothimani, Antara Banerjee, Hong Zhang, Shabana Thabassum Mohammed Rafi, Ilangovan Ramachandran, Rajesh Kanna NR, Xiao-Feng Sun, Surajit Pathak

“…Dual-luciferase assay was carried out to confirm the interaction between AEG-1 and miR-122. In vivo-JetPEI–transfection reagent was used for in-vivo transient transfection of miR-122 in the AOM/DSS-induced colon tumor mouse model.Results Our results demonstrate that miR-122 was downregulated in colon cancer cells, and it influences the expressions of apoptotic factors and inflammatory cytokines. …”
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Distinct and content-specific neural representations of self- and other-produced actions in joint piano performance by Natalie Kohler, Natalie Kohler, Anna M. Czepiel, Anna M. Czepiel, Örjan de Manzano, Örjan de Manzano, Giacomo Novembre, Peter E. Keller, Peter E. Keller, Arno Villringer, Daniela Sammler, Daniela Sammler

“…Overall, these findings support the notion of parallel, distinct, and content-specific self and other internal forward models that are integrated within cortico-cerebellar auditory-motor networks to support smooth coordination in musical ensemble performance and possibly other forms of social interaction.…”
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In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication by Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha

“…The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. …”
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The critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network by Yi Wang, Yi Wang, Moran Xu, Xiaoli Zuo, Sheng Wang, Yong Yu, Zhaobing Gao, Zhaobing Gao, Jingbo Qie, Ye Jiang, Fang Huang, Bingqing Xia, Bingqing Xia

“…Furthermore, we established an intracerebral hemorrhage model by collagenase IV injection in WT and Mlkl-/- mice. …”
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Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis by Yueyi Yang, Xuchen Hu, Meiling Jing, Xiaohan Zhu, Xiaoyu Liu, Wenduo Tan, Zhanyi Chen, Chenguang Niu, Zhengwei Huang

“…OMD may optimize the immunomodulatory functions of hDPSCs and can be used for regenerative endodontics.…”
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Epstein-Barr virus hijacks histone demethylase machinery to drive epithelial malignancy progression through KDM5B upregulation by Ya-Qing Zhou, Jia-Xin Jiang, Shuai He, Yi-Qi Li, Xi-Xi Cheng, Shu-Qiang Liu, Pan-Pan Wei, Xin-Yuan Guan, Choon Kiat Ong, Vivien Ya-Fan Wang, Chun-Ling Luo, Jin-Xin Bei

“…Functional assays revealed that KDM5B acts as an oncogene, correlating with poor survival outcomes in EBV-associated epithelial cancers. …”
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FlyPhoneDB2: A computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-multimer predictions by Mujeeb Qadiri, Ying Liu, Ah-Ram Kim, Myeonghoon Han, Eric Zhou, Austin Veal, Tzu-Chiao Lu, Hongjie Li, Yanhui Hu, Norbert Perrimon

“…The core algorithm of FlyPhoneDB infers tissue-specific signaling events between cell types by calculating cell-cell interaction scores based on curated ligand-receptor (L-R) expression across major signaling pathways. …”
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Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis by Yi-Jie Huang, Jun-Sing Wang, Cheng-Hsu Chen, Shou-Wu Lee, Chung-Hsin Chang, Szu-Chia Liao, Yen-Chun Peng, Teng-Yu Lee, Tsai-Chung Li

“…Risk factors associated with 5-year all-cause mortality were age, the presence of ascites and hepatic encephalopathy, and MELD scores. Liver functional reserve and age played a critical role in the prognosis of CHB patients with decompensated cirrhosis. …”
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Inhibitory Effect of Fluralaner on GABA Receptor Subunit RDL of <i>Bactrocera dorsalis</i> by Xiangyi Zhou, Guoxing Chen, Keying Chen, Zhanyi Xu, Jiali Qian, Ru Yan, Bosheng Chen, Huiming Wu, Mengli Chen

“…Furthermore, we found that fluralaner exhibited a comparable insecticidal activity to avermectin against <i>B. dorsalis</i> adults. Lastly, the modeling and molecular docking predicted that fluralaner interacted with RDL via hydrogen bonds. …”
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Benchmarking the high conductive two-dimensional layered structured NbS2, ZrS2, ReS2 and NbSe2 materials with zero energy bandgap (E g) for photocatalytic application: a DFT study by Muhammad Hasnain Jameel, Aqeela Yasin, Alaa Nihad Tuama, Abdullah Hasan Jabbar, Samreen Kousar, Mohd Zul Hilmi Mayzan, Muhammad Sufi Roslan, Arman Nawaz, Khaled Althubeiti, Mohammed Aljohani

“…In the present work, density functional theory (DFT) is utilized to model the optical, structural and electrical properties of TMDCs such as NbS2, ZrS2, ReS2 and NbSe2 using the GGA-PBE simulation approximation. …”
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Enhancing Ion Transport in Polymer Electrolytes by Regulating Solvation Structure via Hydrogen Bond Networks by Yuqing Gao, Yankui Mo, Shengguang Qi, Mianrui Li, Tongmei Ma, Li Du

“…Computational modeling confirms that the introduced H–bonds effectively modulate the Li⁺ coordination environment, promote salt dissociation, and create favorable pathways for faster ion transport decoupled from polymer chain motion. …”
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MUC2 expression modulates immune infiltration in colorectal cancer by Christophe M. Raynaud, Ayesha Jabeen, Eiman I. Ahmed, Eiman I. Ahmed, Satanay Hubrack, Apryl Sanchez, Shimaa Sherif, Ahmad A. Al-Shaibi, Bernice Lo, Bernice Lo, Jessica Roelands, Davide Bedognetti, Davide Bedognetti, Wouter Hendrickx, Wouter Hendrickx

“…A deeper understanding of the interaction of cancer cells with other cells in the tumor microenvironment is crucial to devise effective therapeutic strategies. …”
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A comparative study of plasmonic nanoparticles for targeted photothermal therapy of melanoma tumors using various irradiation modes by Lidia Mikhailova, Elizaveta Vysotina, Maria Timofeeva, Elena Kopoleva, Van Gulinyan, Olesia Pashina, Konstantin Arabuli, Olga Gusliakova, Ekaterina Prikhozhdenko, Xiaoli Qi, Andrey Petrov, Eduard Ageev, Mihail Petrov, Constantino De Angelis, Mikhail Durymanov, Gleb Sukhorukov, Mikhail V. Zyuzin

“…In this work, we present a comparative study on targeted photothermal therapy (PTT) using plasmonic gold nanorods (Au NRs) as a robust and safe nanotool to reveal how key treatment parameters affect therapy outcomes. Using an animal model (B16-F10) of melanoma tumors, we compare the targeting abilities of Au NRs modified with two different MC1R agonists, either closely mimicking the αMSH sequence or providing a superior functionalization extent of Au NRs (4.5% (w/w) versus 1.8% (w/w)), revealing 1.6 times better intratumoral localization. …”
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GLUT3 enhances chemosensitivity in glioblastoma by transporting temozolomide and capecitabine by Honglin Diao, Yuxin Sun, Xiaojia Zhou, Qikai Wang, Mingyue Wang, Keyu Chen, Zhihua Huang, Jianlei Wei, Zeping Li, Yaxin Lou, Zebin Mao, Wenhua Yu

“…GLUT3, which is highly expressed in GBM and primarily functions as a glucose transporter, has emerged as a promising therapeutic target. …”
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Human Metabolism of Sirolimus Revisited by Baharak Davari, Touraj Shokati, Alexandra M. Ward, Vu Nguyen, Jost Klawitter, Jelena Klawitter, Uwe Christians

“…We also applied Density Functional Theory (DFT) calculations to assess the energetic favorability of metabolic transformations and conducted molecular dynamics (MD) simulations to model metabolite interactions within the CYP3A4 active site. …”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Based on a high-resolution 2.91 Å CP model that was constructed for the first time, this degradation process is likely driven by hydrophobic interactions between tCuinter-bCDs and CP residues MET1, VAL5, THR55, and THR58, along with hydrogen bonds formed with THR4, VAL5, GLY15, PRO57, and ALA59, thereby promoting degradation of adjacent peptide segments. …”
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Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration by Jianing Liu, Junxi He, Ziqi Zhang, Lu Liu, Yuan Cao, Xiaohui Zhang, Xinyue Cai, Xinyan Luo, Xiao Lei, Nan Zhang, Hao Wang, Ji Chen, Peisheng Liu, Jiongyi Tian, Jiexi Liu, Yuru Gao, Haokun Xu, Chao Ma, Shengfeng Bai, Yubohan Zhang, Yan Jin, Chenxi Zheng, Bingdong Sui, Fang Jin

“…This crosstalk not only maintains the functionality of PDGFRA+ DFSCs but also drives specialized angiogenesis. …”
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Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children by Kavari Hercules, Zhiyuan Liu, Eleni Christofilea, Jia Wei, Gladys Venegas, Olivia Ciocca, Alice Dyer, Goeun Lee, Sasha Santini-Bishop, Heather Shappell, Dylan G. Gee, Denis G. Sukhodolsky, Karim Ibrahim

“…Methods: In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. …”
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Beyond the closed-forest paradigm: Cross-scale vegetation structure in temperate Europe before the late-Quaternary megafauna extinctions by Elena A. Pearce, Florence Mazier, Charles W. Davison, Oliver Baines, Szymon Czyżewski, Ralph Fyfe, Krzysztof Bińka, Steve Boreham, Jacques-Louis de Beaulieu, Cunhai Gao, Wojciech Granoszewski, Anna Hrynowiecka, Małgorzata Malkiewicz, Tim Mighall, Bożena Noryśkiewicz, Irena Agnieszka Pidek, Jaqueline Strahl, Hanna Winter, Jens-Christian Svenning

“…This scale-explicit evidence of Last Interglacial vegetation complexity offers insights into the biodiversity and ecological functionality of pre-anthropogenic ecosystems, with implications for modern conservation and rewilding, particularly in maintaining diversity through disturbance and megafaunal interactions.…”
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Loss of TACC2 impairs chemokine CCL3 and CCL4 expression and reduces response to anti-PD-1 therapy in soft tissue sarcoma by Jing Yang, Xiuxia Lu, Qiyan Cai, Mengmeng Liu, Tianliang Xia, Dongchun Hong, Liyuan Le, Xinke Zhang, Xing Zhang

“…Mechanistic insights were obtained through chromatin immunoprecipitation (ChIP) and co-immunoprecipitation assays, focusing on TACC2’s interaction with the NuRD/CoREST complex. The efficacy of anti-PD-1 therapy was evaluated in TACC2-overexpressing mouse models, and clinical relevance was analyzed using patient survival and treatment response data. …”
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