Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions by Ioulia Barakou, Bregje L. Seves, Ulric S. Abonie, Tracy Finch, Kate L. Hackett, Florentina J. Hettinga

“…Interaction effects revealed fatigue’s impact on HRQoL varied significantly in physical (β=-13.49), social (β=-6.81), and emotional (β=-4.10) domains. …”
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…Here, we measure direct, high-affinity binding between purified Norrin and Tspan12 in a lipid environment and use AlphaFold models to interrogate this interaction interface. …”
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Combining network pharmacology and molecular docking to explore the pharmacological mechanism of Codonopsis Radix.-Hedysarum Multijugum Maxim.-Atractylodes Macrocephala Koidz. in t... by Bin He, Jun Cui, Zengwang Zhang, Yongjun Zhang

“…The core targets of CHA in LC treatment were determined by topological analysis, and functional annotation of these targets was performed via Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. …”
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Development of novel 3, 5-substituted-1,2,4-oxadiazole derivatives: a multidimensional approach with in vitro antibacterial, antioxidant, DFT insights, and molecular dynamics simul... by Nandeesh Kebbahalli Nagalingaiah, Vivek Hamse Kameshwar, Shwetha Hosahalli Nanjundappa, Shivakumaraswamy Komalapura Ningegowda, Mantelingu Kempegowda

“…Antioxidant assessments identified compound 10f, which features a 2-hydroxy-6-methylpyridine linker, as the most promising antioxidant, with IC50 values of 22 ± 2.8 μg/mL for DPPH radical scavenging and 25 ± 4.4 μg/mL for hydroxyl radical scavenging. Density functional theory (DFT) calculations using implicit solvation models revealed energy gaps of 4.3223 eV for 10f and 4.3378 eV for 10g, indicating favorable electronic properties. …”
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Adaptation and validation of the Multidimensional Measure of Parasocial Relationships (MMPR) in Poland by Aleksandra Witkowska, Dorota Mącik, Danilo Garcia

“…The results underscore the importance of culturally adapted tools to capture the complex interplay between media engagement and psychosocial functioning, particularly in an era of increasing online interaction. …”
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Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort. by Jukka S Alasaari, Markus Lagus, Hanna M Ollila, Auli Toivola, Mika Kivimäki, Jussi Vahtera, Erkki Kronholm, Mikko Härmä, Sampsa Puttonen, Tiina Paunio

“…There was no significant interaction of 5-HTTLPR genotype and work stress with methylation (p = 0.58). …”
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CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation via NSUN5-mediated m5C modification by Zhibin Deng, Wei Zhong

“…An ovariectomy (OVX)-induced osteoporosis mouse model was used for in vivo validation. Results showed that CX3CL1 was significantly upregulated in LPS- and RANKL-stimulated RAW 264.7 cells. …”
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Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics by Haiting Ye, Xiang Zhang, Pengyan Li, Mei Wang, Ruolan Liu, Dingping Yang

“…Hub genes were determined using protein-protein interaction (PPI) network analysis and the Least Absolute Shrinkage and Selection Operator (LASSO). …”
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Personal Resources of Psychological Safety of Students Studying in New Territories of the Russian Federation by Irina A. Baeva, Elena B. Laktionova, Irina V. Kondakova, Yulia S. Savenko

“…The state of a person’s psychological safety determines his/her effective functioning in a crisis situation. The significance of this state and its support increase sharply in a social situation of uncertainty, in which there is no stability of the external environment and there are many threats to the physical and mental status of a person. …”
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The Second Protonation in the Bio-Catalytic Cycles of the Enzymes Cytochrome P450 and Superoxide Reductase by Tudor Spataru, Lisa Maria Dascalu, Andreea Moraru, Mariana Moraru

“…The results of these enzymes’ hydroperoxo adduct models’ geometric optimization showed that, in fact, all their properties, including their spin states, the wave functions in their active zones, and the Fe-N, Fe-S, and Fe-O bond lengths, are different. …”
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Using AI chatbots (e.g., CHATGPT) in seeking health-related information online: The case of a common ailment by Pouyan Esmaeilzadeh, Mahed Maddah, Tala Mirzaei

“…The study emphasizes considering not only the instrumental benefits but also the enjoyment derived from interacting with conversational AI for healthcare purposes. …”
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Impact of sensory organization tasks on prefrontal cortex activity in older women: a comparative fNIRS study of osteoarthritis and healthy aging by Alka Bishnoi, Yang Hu, Manuel E. Hernandez, Manuel E. Hernandez

“…Baseline cognitive and motor assessments preceded three trials of six SOT conditions.ResultsSignificant differences between groups in BMI, WOMAC pain score, repeated chair stand, and TUG scores were found (p < 0.001). Linear mixed-model analysis revealed significant effects of condition (CND; p < 0.001), trial (TR; p < 0.0001), and interactions between CND*TR (p < 0.01) and Cohort*CND (p < 0.01) on PFC activation.DiscussionIn conclusion, both groups demonstrated increased PFC activation with task difficulty. …”
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Transcriptional regulation of hormone signalling genes in black pepper in response to Phytophthora capsici by Chidambareswaren Mahadevan, K. Mohamed Shafi, B Nagarathnam, Manjula Sakuntala, Ramanathan Sowdhamini

“…Abstract Introduction Black pepper (Piper nigrum L.) is a non-model spice crop of significant agricultural and biological importance. …”
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Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer by Yumin Ke, Meili Liang, Zhimei Zhou, Yajing Xie, Li Huang, Liying Sheng, Yueli Wang, Xinyan Zhou, Zhuna Wu

“…To identify differentially immune-related genes (DIRGs) linked to OCCC. We assessed DIRGs functional enrichment and built a protein-protein interaction (PPI) to explore DIRGs interactions. …”
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Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Conversely, greater interactions between TREM2 + TAMs and tumor cells were observed in PSN–LUAD during the MLC stage. …”
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TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC by Chaopin Yang, Chaopin Yang, Jinqi You, Jinqi You, Yizhi Wang, Yizhi Wang, Si Chen, Si Chen, Yan Tang, Yan Tang, Hao Chen, Hao Chen, Haoran Zhong, Ruyue Song, Hao Long, Hao Long, Tong Xiang, Ze-Rui Zhao, Ze-Rui Zhao, Jianchuan Xia, Jianchuan Xia

“…The TLS area-to-tumor ratio distinguishes responders from non-responders, with PD-L1+ dendritic cells near CD8+PD-1+ T cells linked to efficacy, suggesting that PD-1 inhibitors disrupt harmful interactions. Post-immunochemotherapy, CD8+ T cells increase, but CD38+CD8+ T cells show reduced functionality. …”
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The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis by Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye

“…Functionally, we revealed that GI‐Y2 inhibits the formation of atherosclerotic plaques by targeting GSDMD. …”
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Impact of Climate and Soil on Plant Dynamics and Ecosystem Stability in Argan Orchards by Maryem Telmoudi, Chaima Afi, Naima Chabbi, Said Labbassi, Assma Oumasst, Mohamed Ouknin, Rachid Bouharroud, Abdelaziz Mimouni, Mimoun El Kaoua, Driss Hsissou, Abdelghani Tahiri, Naima Ait Aabd

“…Seasonal changes were predominantly influenced by temperature and precipitation, while diverse soil types shaped by relief, climate, and water balance contributed to different ecological functions. The key findings indicated the highest plant diversity in “Tioughza” and the most significant plant density in “Imoulass” and “Ezzaouite”. …”
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Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes by Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng

“…Furthermore, MSR1-positive microglia colocalised with MBP in cortical tissue of PDD patients, suggesting a functional role of MSR1 in myelin debris clearance. …”
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Impact of amber powdered waste on the processability and properties of PCL-based materials by Cláudia A.B. dos Santos, Bartłomiej Kryszak, Michał Grzymajło, Łukasz J. Wilk, Patrycja Szymczyk-Ziółkowska, Adam Junka, Aleksandra Ujćič, Konrad Szustakiewicz

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