Targeting Sodium Transport Reveals CHP1 Downregulation as a Novel Molecular Feature of Malignant Progression in Clear Cell Renal Cell Carcinoma: Insights from Integrated Multi-Omic... by Yun Wu, Ri-Ting Zhu, Jia-Ru Chen, Xiao-Min Liu, Guo-Liang Huang, Jin-Cheng Zeng, Hong-Bing Yu, Xin Liu, Cui-Fang Han

“…Survival analysis showed that high CHP1 expression correlated with improved prognosis. Functional analyses, including pseudotime trajectory, Mfuzz clustering, and cell–cell communication modeling, indicated that CHP1⁺ epithelial cells engage in immune interaction via PPIA–BSG signaling. …”
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MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers by Eva P. Cuevas, Enrique Madruga, Ignacio Valenzuela-Martínez, David Ramírez, Carmen Gil, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez

“…MicroRNAs (miRNAs) are a class of small, non-coding RNAs involved in different cellular functions that have emerged as key regulators of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). …”
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Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production by Chuan Wang, Chuan Wang, Yuan Zhang, Yuan Zhang, Tingting Liu, Tingting Liu, Zihao Mi, Zihao Mi, Peidian Shi, Peidian Shi, Zhenzhen Wang, Zhenzhen Wang, Wenchao Li, Wenchao Li, Honglei Wang, Honglei Wang, Hong Liu, Hong Liu, Furen Zhang, Furen Zhang

“…Significantly, further functional analyses revealed that in vitro treatment with CXCL13 could enhance the expression of CXCR5, thereby promoting lymphocyte migration and secretion of antimicrobial proteins. …”
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Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration by QianKun Yang, XianJie Zhu, Li Zhang, Fei Luo

“…Multivariable linear regression models, subgroup analyses and interaction tests were employed to explore the association between AIP and PhenoAgeAccel. …”
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Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications by Can Qi, Can Qi, Ziwei Zhao, Lin Chen, Le Wang, Yun Zhou, Guochen Duan, Guochen Duan

“…Differential analysis was performed to identify DEGs between subtypes. Functional items and related pathways of DEGs were identified using enrichment analysis. …”
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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation by Yazhe Ma, Youcheng Wang, Yuanjia Ke, Yuanjia Ke, Yuanjia Ke, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao, Jie Fan, Yang Chen

“…Correlation analysis and WGCNA were performed to assess interactions between lactylation-related genes and immune-associated DEGs. …”
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Integrating bioinformatics and machine learning to identify glomerular injury genes and predict drug targets in diabetic nephropathy by Li Zhang, ZhenPeng Sun, Yao Yuan, Jie Sheng

“…Notably, as the mouse model lacks the C1orf21 gene, RT-qPCR confirmed the upregulated expression of FN1, CD36, CD48, and SRPX2. …”
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Impact of Gentle Touch Stimulation Combined with Advanced Sensory Stimulation in Patients in a Minimally Conscious State: A Quasi-Randomized Clinical Trial by Mirjam Bonanno, Antonio Gangemi, Rosa Angela Fabio, Marco Tramontano, Maria Grazia Maggio, Federica Impellizzeri, Alfredo Manuli, Daniele Tripoli, Angelo Quartarone, Rosaria De Luca, Rocco Salvatore Calabrò

“…Additionally, heart rate (HR) and neurophysiological outcomes (P300) were also recorded for both groups (EG and CG). The MANOVA model revealed a significant interaction effect between group and phase on P300 latency (F (1, 18) = 10.23, <i>p</i> < 0.001, η² = 0.09), indicating that the intervention involving gentle touch stimulation significantly influenced the P300 latency in the EG. …”
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Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…These findings highlight saffron by-products as highly effective and sustainable natural antimicrobials, providing a cost-efficient (40–60% reduction compared to conventional extracts) and multi-functional alternative to synthetic preservatives. Their dual functionality (antimicrobial + natural coloring) and agricultural waste origin make them particularly valuable for industrial applications in food preservation, pharmaceuticals, and biopharmaceuticals. …”
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Genome-wide enhancer-gene regulatory maps of liver reveal novel regulatory mechanisms underlying NAFLD pathogenesis by Ruofan Li, Kaiyan Su, Tianzhun Wu, Li Xu, Wenyu Song, Dandan Sun, Tao Zeng, Jinzhang Chen, Haibei Xin, Yuanfeng Li, Mengya Zang, Minggen Hu

“…However, numerous GWAS signals associated with NAFLD locate in non-coding regions, posing a challenge for interpreting their functional annotation. Results In this study, we utilized the Activity-by-Contact (ABC) model to construct the enhancer-gene maps of liver by integrating epigenomic data from 15 liver tissues and cell lines. …”
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Trehalose polyphleates participate in Mycobacterium abscessus fitness and pathogenesis by Silke Malmsheimer, Wassim Daher, Yara Tasrini, Claire Hamela, John Jairo Aguilera-Correa, Christian Chalut, Graham F. Hatfull, Laurent Kremer

“…The wide distribution of TPPs across mycobacterial species suggests that they may exhibit important functions in these actinobacteria. Here, we demonstrate that Mycobacterium abscessus, an emerging multidrug-resistant pathogen that causes severe lung diseases in cystic fibrosis patients, requires TPPs for survival in macrophages and virulence in a zebrafish model of infection. …”
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Pathway for Renewable Energy Application in Urban Green Space under the Low Carbon Perspective by Kailun WANG, Tonggang NIU, Lian LIU, Zhongjie WANG

“…The research provides a detailed analysis of energy application types and methods, as well as energy consumption models for each of the aforesaid three types of green spaces.ResultsThe research identifies three core challenges in the application of renewable energy in urban green spaces: 1) How to scientifically select the most appropriate renewable energy types and optimize spatial layouts in accordance with natural resource constraints and the functional requirements of green spaces in order to improve energy efficiency; 2) how to effectively integrate the technical functions of energy facilities with landscape and ecological values, so as to achieve a seamless integration of energy infrastructure with landscape, thereby enhancing both environmental adaptability and public acceptance; and 3) how to develop flexible energy utilization and management strategies tailored to the energy consumption characteristics of different green space types, thus ensuring long-term, stable, and sustainable energy supply. …”
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Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

“…Single-cell RNA sequencing, complemented by flow cytometry analysis, was used to characterize hexokinase 3 (HK3)-expressing cell populations. In vivo tumor models were established to assess the functional impact of HK3-expressing cells on the TME, with interventions including Hk3 knockout and CD8+ T-cell depletion. …”
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Impacts of human footprint on habitat quality and permafrost environment in Northeast China by Jianjun Tang, Xiaoying Jin, Haowei Mu, Sizhong Yang, Ruixia He, Xiaoying Li, Wenhui Wang, Shuai Huang, Jiaxing Zu, Hongwei Wang, Zuwang Li, Lin Yang, Shanzhen Li, Yanlin Shi, Suiqiao Yang, Raul-D. Serban, Mihaela Șerban, Alexander Fedorov, Leonid Gagarin, Ze Zhang, Mikhail N Zhelezniak, Huijun Jin

“…In Northeast China, intensified human footprints have greatly altered ecosystem service functions, leading to biodiversity decline, habitat fragmentation, and permafrost warming and thaw. …”
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Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease by Guo-Lin Miao, Wen-Xi Zhang, Yi-Tong Xu, Yi-Ran Liu, Ping-Ping Lai, Jia-Bao Guo, Gong-Lie Chen, Jing-Xuan Chen, Zi-Hao Zhou, Yan-Wei Li, Chong Zhang, Yang Ding, Lian-Xin Zhang, Yu-Fei Han, Jin-Xuan Chen, Jing-Dong Wu, Yin-Qi Zhao, Si Mei, Yang Zhao, Yuan-Wu Ma, Ling Zhang, Wei Huang, Dong-Yu Zhao, Er-Dan Dong, Yu-Hui Wang, Xun-De Xian

“…Abstract Background Kinesin family member 13B (KIF13B), a crucial motor protein, exerts multiple cellular biological functions. However, the implication of KIF13B in metabolic dysfunction-associated fatty liver disease (MAFLD) has not been explored yet. …”
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Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis by Wenfei Qin, Nuoming Yin, Binqiang Xu, Qixiang Mei, Yang Fu, Junjie Fan, Yingying Lu, Guangqiang Wang, Lianzhong Ai, Zhanjun Lu, Yue Zeng, Chunlan Huang

“…Here, we aimed to explore the potential mechanisms focusing on the interaction of F. prausnitzii with host immune response and its potential modulation on gut microbiome. …”
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Water Diplomacy by Implementing Energy Consumption Reduction Scenarios in the Sistan Region by Fazel Ghobeyshavi, Ali Sardar Shahraki, Mahdi Safdari, Neda Aliahmadi

“…Based on the method of dynamic systems, the following steps are performed. 1- Understanding the system 2- Identification and definition of the problem 3- Conceptualization of the system (cause-effect relationships - informational feedbacks) 4- Formulation of the model (decision variables - physical flows of information) In order to build the flow model, the trends of the variables over time are taken into consideration, and based on these trends and based on mathematical laws and regression functions, the relationship between the variables was formulated.Discussion and Results The results, modeling the water, food, energy nexus (NEXUS) with several water diplomacy in the Trans Boundary River show that the current scenarios with water are After applying each of the policies separately on the model as well as applying the combined policy, the scenario of reducing energy consumption by 50%, reducing water loss (evaporation) by 50%, from the solution to improve the security of water, food and energy resources for ten. …”
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Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers by Thang M. Le, Takeyuki Oba, Chiang-Shan R. Li

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Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

“…Mechanistically, Jab1 functioned as an RBP through its MPN domain, stabilizing HRR-related transcripts by competitively antagonizing the RNA exosome complex. …”
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Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy by Chengshuo Fei, Yanlin Chen, Ruiqian Tan, Xinxing Yang, Guanda Wu, Chenglong Li, Jiawei Shi, Shiyong Le, Wenjie Yang, Jiajia Xu, Liang Wang, Zhongmin Zhang

“…An integrated multi-omics approach, encompassing scRNA-seq, bulk RNA sequencing (bulk RNA-seq), and Mendelian randomization (MR), was applied to conduct comprehensive functional analysis. Clinical tissue specimens and animal models were employed to further confirm the multi-omics findings. …”
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