LIPUS Responsive Dopamine-Modified PVDF Piezoelectric Nanofiber Membrane for Full-Thickness Skin Wound Healing by Zhang Z, Liu L, Wang H, Xie W, Zhai W, Wen L, Zhang B, Liu K, Zhang X, Liu S, Huang L, Li D, Zhou Y

“…Finally, the effects of DA/PVDF membranes on full-thickness skin defect healing were tested in a mouse model. The healing process was documented with photographs, and functional skin regeneration was evaluated through histological analysis.Results: The DA/PVDF nanomembranes had an average diameter of 732 ± 232 nm and generated a voltage of 450 mV under LIPUS stimulation, a 1.28-fold increase compared to PVDF membranes alone. …”
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Central nervous system and systemic inflammatory networks associated with acute neurological outcomes in COVID-19 by Nicole Lardini Freitas, João Victor Carvalho Deus, Karen Sampaio, Yago Côrtes Pinheiro Gomes, Rafael Carvalho Torres, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola

“…COVID-19 patients showed elevated serum IL-13, IL-18, TNF-α, VILIP-1, TGF-α, and VEGF levels, indicating systemic inflammation and potential blood–brain barrier (BBB) disruption. β-NGF was increased in the CSF of patients with encephalopathy and IND, suggesting the activation of neuroprotective responses during patient recovery. Functional protein network analysis showed a significant enrichment of interactions between factors altered in the CSF of patients with encephalopathy and IND, many of them related to processes of neuroinflammation and microglial functions, and leukocyte chemotaxis, activation and proliferation. …”
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CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer by Xiao Ma, Baojian Zhang, Xuezhe Yin, ShiPeng Yang, Zhenhua Lin, Yang Yang, Xianchun Zhou

“…Methods First, cell functional assays and animal models were employed to elucidate the pro-carcinogenic effects of CPT1A on BC and its role in metabolic alterations. …”
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Network Pharmacology and In Vitro Experimental Validation Reveal the Anti-Inflammatory and Anti-Apoptotic Effects of Lotus Leaf Extract in Treating Inflammatory Diarrhea in Pigs by Yu Zheng, Jiana Zheng, Jiao Wang, Junxin Li, Jiali Liu, Bohan Zheng, Qinjin Li, Xiaohong Huang, Zhaoyan Lin

“…Subsequently, the STRING database facilitated protein interaction analysis, which was also visualized through Cytoscape. …”
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Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts by Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas

“…This is validated in another cohort of 38 males comprised of different ancestry and HIV-1 subtypes, and with intact proviral DNA assay (IPDA®) measurements. Modeling interactions show monocyte IL1B expression associates inversely with reservoir size at higher frequencies of central memory CD4+ T cells, linking monocyte IL1B expression to cell types known to be reservoirs for persistent HIV-1. …”
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Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer by Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou

“…Antisense oligonucleotide mediated knockdown of CATED reverse platinum‐resistance in sEV‐transmitted mouse models via the DHX36‐RAP1A‐MAPK pathway. This study newly identifies a sEV‐transmitted lncRNA CATED in driving HGSOC platinum‐resistance and elucidates the mechanism it regulates the interacting protein through SUMOylation. …”
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Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…In this study, we used the TCGA-STAD database to identify the expression patterns and prognostic relevance of anoikis-related genes (ARGs) in STAD. Functional enrichment analysis was used to explore the potential pathway. …”
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Genome-Wide Identification and Evolutionary Analysis of <i>Ionotropic Receptors</i> Gene Family: Insights into Olfaction Ability Evolution and Antennal Expression Patterns in <i>Or... by Wen-Qi Yang, Ge Ding, Lin-Lin Wang, Chi-Jie Yin, Hai-Yue Wu, Hua-Bin Zhang, Qiu-Ning Liu, Sen-Hao Jiang, Bo-Ping Tang, Gang Wang, Dai-Zhen Zhang

“…These findings lay a foundation for further investigations and elucidate the functional roles of olfactory receptor genes in crustaceans.…”
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Integrative multi-omics analysis reveals the LncRNA 60967.1–PLCD4–ATRA axis as a key regulator of colorectal cancer progression and immune response by Yiyi Chen, Ningning Zhao, Lingna Xu, Xiya Jia, Fang Liu, Jian Huang, Xuhua Li, Yunfei Wang, Chuanxi Lai, Yanbin Shen, Fei Wang, Yiming Lv, Xuefeng Huang, Fan Zhang, Hongcang Gu, Sheng Dai

“…Functional validation demonstrated that lncRNA 60967.1 is markedly downregulated in CRC cell lines and patient tissues. …”
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Identified candidate genes for pig mental health: Insights from intensive farming systems by Xingyu Wei, Lingyao Xu, Jinyun Jiang, Jian Miao, Fen Wu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang

“…Specifically, we integrated disease gene annotations from three human gene–disease association databases (Disease, DisGeNET, and MalaCards) to pinpoint genes potentially associated with pig mental health, revealing a total of 254 candidate genes related to PMH. In-depth functional analyses revealed that candidate PMH genes were significantly overrepresented in signaling-related pathways (e.g., the dopaminergic synapse, neuroactive ligand‒receptor interaction, and calcium signaling pathways) or Gene Ontology terms (e.g., dendritic tree and synapse). …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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Ultrafast Electron Dynamics at the Water‐Modified InP(100) Surface by Jonathan Diederich, Agnieszka Paszuk, Isaac Azahel Ruiz Alvarado, Marvin Krenz, Mohammad Amin Zare Pour, Diwakar Suresh Babu, Jennifer Velazquez Rojas, Christian Höhn, Yuying Gao, Klaus Schwarzburg, David Ostheimer, Rainer Eichberger, Wolf Gero Schmidt, Thomas Hannappel, Roel van deKrol, Dennis Friedrich

“…Abstract The interaction of water molecules with semiconductor surfaces is relevant to various optoelectronic phenomena and physicochemical processes. …”
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CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation by Kumarkrishna Raychaudhuri, Kumarkrishna Raychaudhuri, Rohita Rangu, Alison Ma, Neriah Alvinez, Andy D. Tran, Sandeep Pallikkuth, Katherine M. McIntire, Joseph A. Garvey, Jason Yi, Lawrence E. Samelson

“…CD28 co-stimulation is also required to generate a functional immune response. Currently we lack a full understanding of the molecular mechanism of CD28 activation.MethodsWe employed TIRF microscopy to establish detailed spatial and kinetic relationships among these molecules in live Jurkat and murine primary T cells. …”
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ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression by Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu

“…Functionally, CD147 deletion in VSMCs significantly mitigated Angiotensin II- and CaPO4-induced AAA formation, accompanied by improved VSMC phenotype, reduced vascular inflammation and extracellular matrix degradation in vivo. …”
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Loss of cadherin 17 downregulates LGR5 expression, stem cell properties and drug resistance in metastatic colorectal cancer cells by Ruben A. Bartolomé, Laura Pintado-Berninches, Javier Robles, Tania Calvo-López, Issam Boukich, Pablo Otero-Núñez, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal

“…Abstract Cadherin 17 (CDH17) plays a crucial role in the metastatic progression of colorectal cancer (CRC) through its interaction with α2β1 integrin and desmocollin 1. To further elucidate the molecular mechanisms involving CDH17 functions in CRC, we examined global expression alterations following CDH17 silencing in various metastatic cell lines. …”
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Eco-friendly corrosion inhibition of copper in NaCl media using Perseana americana extract: Insights from quantum and electrochemical studies by Femiana Gapsari, Saprizal Hadisaputra, Abdul Mujib Sulaiman, Eno Ebenso, Abhinay Thakur, Ashish Kumar

“…The adsorption behavior of PAE on the copper surface adheres to the Langmuir isotherm model, indicating monolayer adsorption with a Gibbs free energy of adsorption (ΔGads) of −18.84 kJ/mol, suggesting a predominantly physisorption mechanism. …”
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Microfluidics-enabled polydopamine-coated selenium nanoparticles in hyaluronic hydrogel microspheres for targeted antioxidant and immunomodulatory therapy of ulcerative colitis by Ying Fang, Hongwei Yu, Xiaochen Feng, Haike Xia, Yunze Xu, Ranjith Kumar Kankala, Aizheng Chen, Chaoping Fu

“…Overall, this microfluidics-enabled, colon-targeted delivery system with integrated antioxidative and immunomodulatory functions offers a promising strategy for the non-invasive treatment of UC and other inflammation-associated gastrointestinal disorders.…”
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Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19 by Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova

“…COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the molecular and cellular processes depending on the sickness severity and virus variants. …”
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Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production by Cheng Chen, Cheng Chen, Cheng Chen, Chenying Shu, Dan Shen, Dan Shen, Dan Shen, Zhaowei Yan, Zeyi Liu, Zeyi Liu, Zeyi Liu, Jian-An Huang, Jian-An Huang, Jian-An Huang

“…Mechanistically, Isoliensinine interacted directly with APEX1, inhibited APEX1 protein levels, and promoted ROS generation. …”
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Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism by Maha Dahawi, Jean-Madeleine de Sainte Agathe, Mohamed S. Elmagzoub, Elhami A. Ahmed, Julien Buratti, Thomas Courtin, Eric Noé, Julie Bogoin, Bruno Copin, Fatima A. Elmugadam, Wasma A. Abdelgadir, Ahmed K. M. A. Ahmed, Mohamed A. Daldoum, Rayan Mamoon Ibrahim Altayeb, Mohamed Bashir, Leena Mohamed Khalid, Sahar Gamil, Sara Baldassari, Liena Elsayed, Boris Keren, Gregory Nuel, Ammar E. Ahmed, Eric Leguern

“…Standard genetic filters and Endeavour algorithm for functional prioritization of genes selected likely susceptibility variants in FAT1, DCHS1 or ASTN2 genes. …”
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