Screening and Validation: AI-Aided Discovery of Dipeptidyl Peptidase-4 Inhibitory Peptides from Hydrolyzed Rice Proteins by Cheng Cheng, Huizi Cui, Xiangyu Yu, Wannan Li

“…A random forest classification model achieved 85.37% accuracy in predicting inhibitory activity. …”
Get full text

The Hydrodynamic Performance of a Vertical-Axis Hydro Turbine with an Airfoil Designed Based on the Outline of a Sailfish by Aiping Wu, Shiming Wang, Chenglin Ding

“…Transient numerical simulations employing dynamic mesh techniques and user-defined functions within the Fluent environment were conducted to analyze rotor interactions. …”
Get full text

Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…Recent gene-editing technologies, such as CRISPR/Cas9 and conditional knockout models, have facilitated the functional annotation of genes such as SPAM1 and ADAM family members, further elucidating their roles in capacitation and adhesion. …”
Get full text

The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake by Pedro G. Nachtigall, Brett R. Hamilton, Taline D. Kazandjian, Paolo Stincone, Daniel Petras, Nicholas R. Casewell, Eivind A. B. Undheim

“…Within these venom systems, the molecular, cellular, and morphological components interact and co-evolve to generate distinct, venom phenotypes that are increasingly recognized as models for studying adaptive evolution. …”
Get full text

Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72. by Abhijit Sarkar, Barbara Reinhold-Hurek

“…<h4>Background</h4>The model endophyte Azoarcus sp. strain BH72 is known to contribute fixed nitrogen to its host Kallar grass and also expresses nitrogenase genes endophytically in rice seedlings. …”
Get full text

Social aloofness is associated with non-social explore-exploit decisions by Evan Knep, Xinyuan Yan, Cathy S. Chen, Suma Jacob, David P. Darrow, R. Becket Ebitz, Nicola Grissom, Alexander B. Herman

“…Abstract How humans resolve the explore-exploit dilemma in decision making is central to how we flexibly interact with both social and non-social aspects of dynamic environments. …”
Get full text

Impact of implementing evidence-based acute stroke interventions on survival: the South London Stroke Register. by Juliet Addo, Siobhan Crichton, Ajay Bhalla, Anthony G Rudd, Charles D A Wolfe, Christopher McKevitt

“…In uni-variable analyses, one year cumulative survival rates in socio-demographic groups and by care received was determined. Survival functions were compared using Log-rank tests. Multivariable Cox models were used to test for interactions between components of care and age group, sex, ethnic group, social class, stroke subtype and level of consciousness.…”
Get full text

Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G-actin by Zheng Song, Along Han, Bing Hu

“…Finally, the results showed that the overexpression of Tβ4 effectively restored the functionality of rapid escape behaviors mediated by Mauthner cells. …”
Get full text

m6A-related genes of peripheral white blood cell in spinal cord injury as potential targets for prognosis and treatment by Mingran Luo, Qian Wang, Jian Chen, Guoyong Yin

“…Further understanding of the functions of the identified SCI hub genes may provide deeper insights into the molecular mechanisms of SCI.…”
Get full text

Analysis of MAXIM Application Service Quality on User Satisfaction using the E-Service Quality Method by Putri Wulandari, Nur Rachman Dzakiyullah, Asti Ratnasari, Dadang Heksaputra

“…Because its dimensions are pertinent and completely satisfy the requirements of assessing the quality of electronic services, E-Service Quality is the most thorough and integrative online service quality model. Efficiency, fulfillment, system availability, privacy, responsiveness, compensation, and interaction are the seven factors used, while user satisfaction is the dependent variable. …”
Get full text

Analysis of precancerous lesion-related microRNAs for early diagnosis of cervical cancer in the Thai population by Rooge Suvanasuthi, Suwanit Therasakvichya, Potjanee Kanchanapiboon, Chamras Promptmas, Sarin Chimnaronk

“…Pathway analysis was conducted to provide the cellular functions involved in CC progression. The study identified a shared 18-miRNA panel for both tissue and discharge, with which the prediction model distinguished HSIL and AIS from normal samples with an accuracy of 90.9%. …”
Get full text

Single-Cell RNA Sequencing Identifies Crucial Genes Influencing the Polarization of Tumor-Associated Macrophages in Liver Cancer by Kedong Xu, Mingyi Dong, Zhengqiang Wu, Linfei Luo, Fei Xie, Fan Li, Hongyan Huang, Fenfen Wang, Xiaofeng Xiong, Zhili Wen

“…This investigation delves into the functional transformations of TAMs within the TME by leveraging single-cell transcriptomics to pinpoint critical genes influencing TAM subset polarization. …”
Get full text

Examining the association between maternal prenatal psychiatric disorders and behavioural problems among offspring in early childhood: population-based study by Amy Braddon, Rosa Alati, Kim S. Betts

“…Sensitivity analyses included adjusting the final model for primary psychiatric diagnoses and assessing association of interest for effect modification by child's biological gender. …”
Get full text

Nutritional interventions in muscle hypertrophy research: a scientometric analysis within the context of resistance training (1992–2025) by Wei Chen

“…Results The results indicate that: (1) the combination of protein supplementation and resistance training represents the most prominent intervention strategy; (2) a stable tripartite research model has emerged, centering on the interaction among training, nutrition, and structural adaptation; (3) the thematic focus has gradually shifted from molecular mechanisms toward practical applications, emphasizing issues such as aging and functional improvement; and (4) notable research gaps remain, particularly the underrepresentation of women and Asian populations, insufficient attention to recovery, metabolism, and periodized nutrition, and the lack of a systematic framework for individualized interventions. …”
Get full text

Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. by Toby Andrew, Nikolas Maniatis, Francis Carbonaro, S H Melissa Liew, Winston Lau, Tim D Spector, Christopher J Hammond

“…A total of 575 cases and controls selected from the tails of the trait distribution were genotyped for the discovery sample. Malecot model estimates indicate three loci with putative common functional variants centred on MFN1 (180,566 kb; 95% confidence interval 180,505-180, 655 kb), approximately 156 kb upstream from alternate-splicing SOX2OT (182,595 kb; 95% CI 182,533-182,688 kb) and PSARL (184,386 kb; 95% CI 184,356-184,411 kb), with the loci showing modest to strong evidence of association for the Map 2 discovery samples (p<10(-7), p<10(-10), and p = 0.01, respectively). …”
Get full text

EVALUATING THE EFFICACY OF DISCORD-BASED BLENDED LEARNING ON ENGLISH SPEAKING SKILLS AND STUDENT ENGAGEMENT by Ahmad Zaki Munibi, Endry Boeriswati, Novi Anoegrajekti, Aceng Rahmat

“…Educators utilize Discord's functionalities to host engaging discussions, deliver diverse learning materials, and conduct both formative and summative assessments effectively. …”
Get full text

Phase-lags in large scale brain synchronization: Methodological considerations and in-silico analysis. by Spase Petkoski, J Matias Palva, Viktor K Jirsa

“…Architecture of phase relationships among neural oscillations is central for their functional significance but has remained theoretically poorly understood. …”
Get full text

Targeting Trichloroethylene-Induced Renal Endothelial Cell Injuries: A Role of Poly I:C in Amplification of HMGB1 Acetylation by Feng Wang, Yiting Hong, Jihong Gao, Ruixuan Cheng, Muyue Chen, Dandan Zang, Jiaxiang Zhang, Qixing Zhu

“…Moreover, our data showed that poly I:C, through its interaction with toll-like receptor 3 (TLR3), enhanced HMGB1 acetylation and subsequent release from renal ECs. …”
Get full text

A New Generation of Porous Polymer Materials from Polystyrene Waste: Synthesis and Adsorption of Nitrate Anions in Aqueous Media by Mohamed Anannaz, Fatiha Tafraout, Charaf Laghlimi, Rachida Ouaabou, Jalal Isaad

“…The mechanism of adsorption of nitrate ions onto PS-Succ-DETA occurs via electrostatic interactions and hydrogen bonds between the NO₃⁻ ions and the -NH₂ and NH functions of PS-Succ-DETA.…”
Get full text

Biochar supported photocatalyst (mangrove biochar-TiO2) for organic pollutants removal via synergetic adsorption-photocatalytic process by Dessy Ariyanti, Nadya Ummi Azizah, Dina Lesdantina, Erwan Adi Saputra, Vimal Chandra Srivastava

“…Methylene blue used as a model dye was degraded 100% through the adsorption-photocatalysis process using BSP. …”
Get full text