Hypomethylation‐Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption by Xueying Geng, Weiwei Chu, Shang Li, Xiying Zhou, Dongshuang Wang, Junyu Zhai, Yun Sun, Zi‐Jiang Chen, Yanzhi Du

“…ABSTRACT Polycystic ovary syndrome (PCOS), a prevalent cause of female infertility, arises from complex interactions between genetic and environmental factors, with hyperandrogenism serving as a core pathological feature. …”
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LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma by Yuxuan Li, Jie Zhu, Fengguang Zhai, Yidong Ge, Ziqing Zhan, Shuyan Wang, Lili Kong, Jianan Zhao, Lecheng Hu, Siyuan Wang, Jiaxin Shi, Jianing Mao, Zongdong Yu, Haoyun Wang, Jiabei Jin, Mengxiang Zhao, Hong Li, Xiaofeng Jin

“…Notably, we discovered that speckle-type POZ protein (SPOP) directly interacts with LMNB2 to mediate its ubiquitination and proteasomal degradation, thereby maintaining physiological PD-L1 expression levels. …”
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HCP5 Derived Novel Microprotein Triggers Progression of Gastric Cancer through Regulating Ferroptosis by Qiuhui Li, Guoqing Guo, Yuli Chen, Lu Lu, Hanyang Li, Zihan Zhou, Jiahao Guo, Xiongkang Gan, Yanming Hu, Qiunuo Li, Ming Sun, Xianghua Liu

“…These ORFs potentially encode novel proteins or peptides with crucial roles in various human cancers, yet the translational potential of these lncRNAs and the functions of the protein products remain largely unexplored, especially in gastric cancer (GC). …”
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METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3 by Ping Zhan, Yizhe Cheng, Yingcan Wu, Jing Lu, Jing Wen, Xiaoqin Chi, Changhong Luo, Yiwei Peng, Xijun Chen, Fuqiang Wang, Zhenyu Yin, Chengrong Xie

“…Transcriptional activation by CCCTC-binding factor (CTCF) was identified as a key driver of METTL21A overexpression. Functional studies demonstrated that METTL21A promotes HCC growth and metastasis in both in vitro and in vivo models. …”
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Green synthesis of nanoparticles using cottonwood and rambutan honeys: Optimization, characterization, and enhanced antioxidant activity with reduced toxicity via oligochitosan coa... by Saidun Fiddaroini, Friske Prisilia, Silvana Br Karo, Luailik Madaniyah, Almas Dwi Khairana, Galuh Rahmaniah, Suci Amalia, Aulanni’am, Moh. Farid Rahman, Layta Dinira, Qonitah Fardiyah, Akhmad Sabarudin

“…The particle size distribution followed a lognormal model with an R² value of 0.925, indicating high statistical reliability. …”
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Assessing the performance of novel and sustainable electrochemical sensor based on cobalt sulfide/upcycled reduced graphene oxide from plastic waste by Arafat Toghan, N. Roushdy, Sami A. Al-Hussain, Mohamed S. Elnouby, Samah M. Yousef, A.A.M. Farag, M. Elsayed Youssef, Noha A. Elessawy

“…Kinetic analysis confirmed that the sensing mechanism follows a pseudo-second-order model, indicative of a chemisorption-driven interaction between paracetamol molecules and the sensor surface. …”
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QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma by Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li

“…Mechanistically, QSOX2 enhances disulfide bond formation in TSC Complex Subunit 2 (TSC2), stabilizing TSC2‐Akt interactions, facilitating phosphorylation of TSC2 at the Ser939 by Akt, and further activating mTOR/4E‐BP1/c‐Myc signaling axis. …”
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Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing by Ziyi Wang, Li Gao, Ziheng Jia, Liguo Liu, Ao Gu, Zhaonan Liu, Qin Zhu, Yichen Zuo, Mingjie Yang, Shijia Wang, Jiyao Ma, Jingyun Zhang, Shimei Qiu, Zhizhen Li, Jinghan Wang, Dongxi Xiang, Fatao Liu, Rong Shao, Yanjing Li, Maolan Li, Wu Wei, Yingbin Liu

“…A novel transcript, designated ERBB2 i14e, was identified for encoding a novel functional protein, and its protein expression was elevated in gallbladder cancer and strongly associated with worse prognosis. …”
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Bioactive Glycyrrhizic Acid Ionic Liquid Self‐Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti‐Photoaging Signal Peptides by Zhuxian Wang, Jun Liu, QiuYu Chen, Yufan Wu, Yamei Li, Mingjie Ou, Shuwei Tang, Ziqing Deng, Li Liu, Cuiping Jiang, Hongxia Zhu, Qiang Liu, Bin Yang

“…The components ratios and inherent forming mechanisms of GA‐OMT (GAO) are optimized by molecular dynamics simulations and density functional theory calculations. Remarkably, GAO can significantly improve the sparingly soluble properties of palmitoyl pentapeptide‐4 (PAL‐4), a model peptide drug. …”
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STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy by Chunxiao Li, Fei Ma, Ying Zhang, Ting Wang, Hongnan Mo, Ning Zhong, Dongkui Xu, Fangzhou Sun, Yantong Zhou, Jianbin Guo, Zhenguo Zhao, Xiaoqi Yang, Haili Qian

“…STS2-deficient CD8+ TILs maintained a more functional state, exhibiting enhanced effector activity, proliferation, and antitumor efficacy while resisting terminal exhaustion. …”
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EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming by Bo Guan, Cong Huang, Cong Huang, Cong Huang, Jun He, Jun He, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…An integrated machine learning approach was employed, utilizing the TCGA dataset as the training set and the MTAB dataset as the test set, to develop prognostic models. Subsequently, EPHX2 was stably overexpressed in the 786-O and ACHN cell lines via lentiviral transfection technology, and its functional effects were validated through in vitro experiments. …”
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Quenching of the quantum p-strength in light exotic nuclei by E. Cravo, R.B. Wiringa, R. Crespo, A. Arriaga, A. Deltuva, M. Piarulli

“…One-nucleon spectroscopic overlaps, their strength or spectroscopic factors (SFs), and nucleon removal cross sections for light nuclei in the mass range A≤12 were evaluated using the fully correlated Quantum Monte Carlo (QMC) wave functions (WFs). Harder (AV18+UX) and softer (NV2+3) bare interactions were used providing consistent results. …”
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Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System by Yanlin Liu, Yuting Jin, Yuxin Liu, Jiaqi Gao, Xiaomei Wang, Hongbin Ren, Yabo Hao, Xibin Yang, Kaitao Luo

“…Seven complement‐related genes (C1QA, C1QB, C1QC, C2, C6, C7, and TREM2) were significantly downregulated by acupuncture. Functional enrichment revealed that these genes were involved in the inflammatory response, coagulation cascades, blood‒brain barrier regulation, and neutrophil extracellular trap (NET) formation. …”
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Transmembrane-4 L-Six Family Member-1 Is Essential for Embryonic Blood Vessel Development by Chi-Iou Lin, Anne Merley, Hiromi Wada, Jianwei Zheng, Shou-Ching S. Jaminet

“…TM4SF1 regulates cellular functions by forming protein complexes called TMED (TM4SF1-enriched microdomains) that either recruit growth-factor activated proteins and internalize them via microtubules to distribute the recruited molecules intracellularly or support the formation of nanopodia for intercellular interactions extracellularly. …”
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Nonylphenol Removal from Water and Wastewater with Alginate-Activated Carbon Beads by Angelica A. Chacon, Elizabeth Noriega Landa, Sheng Yin, Ahsan Habib, Kiana L. Holbrook, Luis R. Duran Bojorquez, Sabur Badmos, Dino Villagrán, Wen-Yee Lee

“…The surface characterization, functional groups, and adsorption behavior were analyzed using multiple analytical techniques. …”
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Multimodal lightweight neural network for Alzheimer's disease diagnosis integrating neuroimaging and cognitive scores by Bhoomi Gupta, Ganesh Kanna Jegannathan, Mohammad Shabbir Alam, Kottala Sri Yogi, Janjhyam Venkata Naga Ramesh, Vemula Jasmine Sowmya, Isa Bayhan

“…To further enhance the model's discriminative capacity, transfer learning techniques are applied. …”
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A Chimeric Peptide Derived from a Bacterial Effector Protein Attenuates TLR-2/4-Mediated Production of Pro-Inflammatory Cytokines and Enhances the Cellular Availability of Gentamic... by Nandi BR, Patra B, Radhakrishnan GK

“…A chimeric peptide, TB4-BBL2, was then generated and evaluated for cellular uptake, interaction with TLR adaptors, and functional activities. …”
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Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression by Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu

“…Mechanistically, multi-omics integration of transcriptomics and 4D-label-free quantitative proteomics identified PVT1-associated pathways driving GC progression. Functional validation through in vitro and in vivo models demonstrated PVT1’s oncogenic role, while transcriptomic profiling further decoded neutrophil activation mechanisms regulated by PVT1. …”
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Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection by Frauke Lange, Jonathan Garn, Matthias Bruhn, Thomas Pietschmann, Arnaud Carpentier

“…Background & Aims: Stem cell-derived hepatocyte-like cells (HLCs) are an in vitro model of hepatocytes reproducing mature hepatic functions. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…Although most investigations have centered on mesenchymal stem cells (MSCs) from long bones, the distinct properties and immunoregulatory functions of craniofacial bone marrow derived MSCs remain largely unexplored. …”
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