Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…However, the relationship between disulfidptosis and MM is still unclear.MethodsUsing the non-negative matrix factorization and lasso algorithm, we constructed the disulfidptosis-associated subtypes and the prognostic model on the GEO dataset. We further explored genetic mutation mapping, protein-protein interactions, functional enrichment, drug sensitivity, drug prediction, and immune infiltration analysis among subtypes and risk subgroups. …”
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Mesenchymal stem cell-secreted KGF ameliorates acute lung injury via the Gab1/ERK/NF-κB signaling axis by Shuning Xin, Yan Ding, Tong Yu, Yunmei Fu, Yong Cui, Hongguang Nie

“…Further analysis revealed that LPS stimulation weakened the interaction between the NF-κB p65 subunit and inhibitor kappaB (IκB), while KGF enhanced this interaction and inhibited the nuclear translocation of p65. …”
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Effects of a novel HSP90 inhibitor on estrogen receptor α signaling pathways in breast cancer cells by A. M. Scherbakov, D. V. Sorokin, D. I. Salnikova, M. V. Gudkova, O. E. Andreeva, A. L. Mikhaylova, N. A. Varabyeva, Yu. A. Piven

“…Anti-estrogenic activity was assessed in MCF7 cells via a reporter assay, and molecular modeling was used to construct a model of THB5T-1 interaction with the ligand-binding domain of ERα.Results. …”
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Dexamethasone administration restored growth in dairy calves exposed to heat stress by Z. Yu, J.M. Cantet, M.R.R. Nair, A.G. Ríus

“…The immunomodulation and anti-inflammatory effects of dexamethasone could be part of a homeorhetic change that results in a shift from maintenance functions to support growth on calves exposed to heat stress.…”
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Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapy by Li Zhang, Sergio Rutella, Jongbok Lee, Ismat Khatri, Yoosu Na, Enoch Tin, Karen Fang, Michele Nawata, Juan Arteaga, Mark D Minden

“…Collectively, this hinders our ability to bolster DNT functionalities in cancer therapy. Here, we performed single-cell RNA sequencing with in vitro and in vivo functional analysis on DNTs. …”
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Assessing the suitability of the Langevin equation for analyzing measured data through downsampling by Pyei Phyo Lin, Matthias Wächter, Joachim Peinke, M Reza Rahimi Tabar

“…For real-world data that lack Markov properties, we estimate the functions and parameters using the generalized Langevin equation, which incorporates a memory kernel to account for non-Markovian dynamics.…”
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Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study by Xin-Yi Zhu, Xing-Chen Meng, Bei-Jing Cheng, Chun Wang, Jia Wang, Tian-Lin Li, Hui Li, Ke Meng, Ran Liu

“…Univariate exposure-response functions from BKMR models showed similar results. …”
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Synchronic and diachronic analysis of the word families of motion verbs (using the root morphemes -khod-, -id-, and -shed- as an example) by O.I. Dmitrieva, O.I. Jankovsky

“…The functional dynamics was often determined by the expansion of stylistic possibilities for using stem units of the word family. …”
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Establishing a Junior Doctor Digital Network to help implement digital transformation by Marie-Therese Angus, Ragaul Rajagopal, Vivienne MacCallum, Marten Lau

“…Introduction: Electronic prescribing systems provide advanced decision support to reduce medication errors, adverse drug interactions, and transcription mistakes.1 Thus, effective electronic prescribing is vital for enhancing patient safety and care. …”
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Gesture-controlled omnidirectional autonomous vehicle: A web-based approach for gesture recognition by Huma Zia, Bara Fteiha, Maha Abdulnasser, Tafleh Saleh, Fatima Suliemn, Kawther Alagha, Jawad Yousaf, Mohammed Ghazal

“…This paper presents a novel web-based hand/thumb gesture recognition model, validated through the implementation of a gesture-controlled omnidirectional autonomous vehicle. …”
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Representation of a Scientific Supervisor in Internet-Memes by N. V. Stepanova, M. S. Sigaeva

“…The concept of visual metaphor and multimodality is  defined, the role of multimodal metaphor in Internet discourse is described, the features of  the functioning of multimodal metaphor are revealed. The material for the study was  Internet memes representing various aspects of interaction in the academic environment.  …”
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KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity by Yixin Li, Li Peng, Yang Zhou, Yan You, Jin Jiang, Yong Luo

“…In ischemic stroke (IS), microglia exhibit dynamic functional shifts, contributing to tissue damage during the acute phase and promoting repair in the chronic phase. …”
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Ability of SPP1 to Alleviate Post‐Intracerebral Hemorrhage Ferroptosis via Nrf2/HO1 Pathway by Pengpeng Li, Zhenxin Tao, Yangyang Gao, Zhengqian Mu, Jiajia Tian, YaTing Zhang, Wenhui Yang, Yilu Li, Xudong Zhao

“…A protein–protein interaction network was constructed using Cytoscape, and hub genes were identified. …”
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Resilience and Social–Emotional Expertise as Predictors of Problematic Internet Use Among University Students by Gözde Önal, Turan Emre Özdemir

“…Problematic internet use has become an increasing concern among university students, as it may negatively affect academic performance, emotional well-being, and social functioning. Understanding the psychological and emotional factors that influence internet use is crucial to developing effective preventive strategies. …”
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Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families by Xue Rui, Huiping Li, Runqing Ma, Shangying Yang, Yuanyuan lian, Wanyu Cheng, Meijiao Ma, Weining Rong, Xunlun Sheng

“…Abstract Early-onset high myopia (eoHM) occurs before school age and is an ideal model for monogenic studies of high myopia due to minimal environmental influence. …”
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance by Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z

“…Public transcriptomic datasets (GSE26440, GSE26378, GSE25504, GSE28750; 180 sepsis vs 53 controls) were analyzed to identify differentially expressed IRGs (DEIRGs). Functional enrichment (GO/KEGG), protein-protein interaction (PPI) networks, and single-cell RNA sequencing (scRNA-seq) were integrated to prioritize T cell-associated genes. …”
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The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013–2014 by ZhengJun Zhang, Peng Wu, Shaobin Yang, Baozhen Zhu, Dapeng Chen, Xiaocheng Li, Yarong Wang, Ning Yan

“…The FI was calculated using a 49-item model to assess frailty status and participants were stratified into three groups: non-frail (FI ≤ 0.15), pre-frail (0.15 < FI ≤ 0.25), and frail (FI > 0.25). …”
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Engineering of covalent organic framework (COF) via mono-doping and co-doping for the detection of CO2 gas pollutant by John A. Agwupuye, Ekere Nwachukwu Romanus, Janefrances Ngozi Ihedioha, Ismail O. Amodu, Bassey O. Ekpong, Destiny E. Charlie, Fehintola E. Umo, Modestar Chinecherem Agwupuye, Muhammad Zeeshan

“…Upon adsorption, the studied systems showcased a non-covalent form of interaction in most cases as observed in AIM analysis. …”
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Exploration of biomarkers for predicting the prognosis of patients with diffuse large B-cell lymphoma by machine-learning analysis by Shifen Wang, Hong Tao, Xingyun Zhao, Siwen Wu, Chunwei Yang, Yuanfei Shi, Zhenshu Xu, Dawei Cui

“…The key genes in DLBCL patients were screened by differentially expression gene (DEG) and weighted gene co-expression network analysis (WGCNA). Functional enrichment analysis and protein-protein interaction (PPI) network construction were employed to reveal DLBCL-related pathogenic molecules and underlying mechanisms. …”
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THE STRUCTURE OF HAPPINESS REPRESENTATION FOR RUSSIAN AND AMERICAN REPRESENTATIVES by S. Yu. Zhdanova, A. V. Pecherkina, A. A. Strokanov

“…However, the diagnostic tools used in such studies are based primarily on the model of happiness image that has been developed in American psychology. …”
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