The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape by Jani Nöthling, Jacqueline Samantha Womersley, Shibe Mhlongo, Carl Lombard, Naeemah Abrahams, Soraya Seedat, Sian Megan Joanne Hemmings

“…Mixed linear regression models were used to analyse the data.Results: The interaction between rs1360780 genotype and childhood trauma was a significant predictor of FKBP5 methylation over time. …”
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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks by Han Lu, Sandra Diaz-Pier, Maximilian Lenz, Andreas Vlachos

“…However, the role of structural plasticity as a homeostatic mechanism remains less consistently reported, particularly under activity inhibition, leading to an incomplete understanding of its functional impact. In this study, we combined live-cell microscopy of eGFP-labeled neurons in mouse organotypic entorhinal-hippocampal tissue cultures (Thy1-eGFP mice of both sexes) with computational modeling to investigate how synapse-number-based structural plasticity responds to activity perturbations and interacts with homeostatic synaptic scaling. …”
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Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery by Tijana Stanković, Tanja Ilić, Branka Divović Matović, Milos Petkovic, Vladimir Dobričić, Ivan Jančić, Biljana Bufan, Kristina Jezdić, Jelena Đoković, Ivana Pantelić, Danijela Randjelović, Dishary Sharmin, James M. Cook, Miroslav M. Savić, Snežana Savić

“…The analysis of protein binding interactions revealed that the PEGylated nanoemulsions had fewer observable interactions compared to the undecorated nanoemulsions, especially when 0.2% DSPE-PEG2000 and 0.1% DSPE-PEG2000-mannose were combined. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…Studies carried out with humans, which are mainly focused on measuring the impact of particulate matter (PM2.5 and PM10) exposure on mental health, showed an increased risk of depression or psychotic relapses through the inflammation and oxidative stress pathways, or through the alteration of the hypothalamic-pituitary-adrenal (HPA) axis. Animal models showed the potential impact of pollution on brain functioning through increased inflammatory responses, oxidative stress, HPA axis disruption, hippocampal damage, and neurotransmitters dysregulation. …”
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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway by Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen Zhao

“…Methods A CPSP model was established in mice, and RNA sequencing of the ipsilateral ventral posterolateral thalamic nucleus/ventral posteromedial thalamic nucleus (VPL/VPM) was performed to identify differentially expressed genes (DEGs). …”
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Methodology and methods of training children with disabilities in an inclusive distance education system by T. M. Egorova, N. N. Belukhina, T. S. Akhmedzyanova

“…In the future, a set of conditions for the functioning and development of an inclusive regional distance education system for children with disabilities will be identified, causing the learning process in the system under study. …”
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Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response by Miaomiao Yan, Ang Su, Suvarin Pavasutthipaisit, Rebecca Spriewald, Guntram A. Graßl, Andreas Beineke, Doris Hoeltig, Georg Herrler, Paul Becher

“…Intestinal epithelial cell interactions with enteric pathogens have been incompletely elucidated owing to the lack of model systems that recapitulate the cellular diversity, architecture and functionality of the intestine. …”
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Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium by Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson

“…In 2022, the RReSTORe Consortium initiated ongoing international collaborative discussions to advance the RGC repopulation field and has identified five critical areas of focus: (1) RGC development and differentiation, (2) Transplantation methods and models, (3) RGC survival, maturation, and host interactions, (4) Inner retinal wiring, and (5) Eye-to-brain connectivity. …”
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Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks by Dania Awata, Vishnubalaji Radhakrishnan, Hibah Shaath, Ramesh Elango, Sameera Rashid, Mohammed Akhtar, Thasni Karedath Abdul Azis, Ikhlak Ahmed, Khalid Ouararhni, Ammira S. Al-Shabeeb Akil, Nehad M. Alajez

“…Functionally, siRNA-mediated knockdown of these circRNAs significantly suppressed cell proliferation, colony formation, three-dimensional organoid growth, and cell migration in TNBC models. …”
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A lightweight triple-modal fusion network for progressive mild cognitive impairment prediction in Alzheimer's disease by Xiangyu Shen, Xiangyang Hu, Renfeng Zhang, Yunzhan Fu, Jiamin Xu, Degang Lyu, Hongbiao Xie, Hongbiao Xie, Deen Shi, Changsheng Shi, Lisi Li, Yuantong Gao

“…Although multimodal neuroimaging and clinical data provide complementary information, existing fusion models often face challenges such as high computational complexity and limited interpretability.MethodsTo address these limitations, we introduce TriLightNet, an innovative lightweight triple-modal fusion network designed to integrate structural MRI, functional PET, and clinical tabular data for predicting MCI-to-AD conversion. …”
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Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies by Xinyi Zhang, Xinyi Zhang, Zhongge Zhu, Peijie Zhai, Peijie Zhai, Peng Lv, You Yang, Chuanhang Cheng, Busen Wang, Ting Fang, Guanying Zhang, Xiangyang Chi, Jianmin Li, Wei Chen, Yunzhu Dong

“…Subsequently, we predicted key functional residues through structural modeling of antigen-antibody complexes and validated their roles via mutagenesis studies. …”
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Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation by Yuchen Cai, Tianyi Zhou, Xueyao Cai, Wenjun Shi, Hao Sun, Yao Fu

“…Based on transcriptomics datasets of KC, mitochondria-related differentially expressed genes (mDEGs) were identified and analyzed for potential functional pathways, protein-protein interaction (PPI), and gene regulatory networks. …”
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Clinical and demographic factors modify the association between plasma phosphorylated tau‐181 and cognition by Corey J. Bolton, Marilyn Steinbach, Omair A. Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L. Jefferson, Timothy J. Hohman, Henrik Zetterberg, Katherine A. Gifford, for the Alzheimer's Disease Neuroimaging Initiative

“…METHODS Participants were drawn from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and included 1185 adults >55 years of age with plasma p‐tau181 and neuropsychological test data. Linear regression models related plasma p‐tau181 to neuropsychological composite and SCD scores with follow‐up models examining plasma p‐tau181 interactions with cognitive diagnosis, apolipoprotein E (APOE) ε4 carrier status, age, and sex on cognitive outcomes. …”
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RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters by Huifang Wei, Dengyun Zhao, Yafei Zhi, Qiong Wu, Jing Ma, Jialuo Xu, Tingting Liu, Jing Zhang, Penglei Wang, Yamei Hu, Xinyu He, Fangqin Guo, Ming Jiang, Dandan Zhang, Wenna Nie, Ran Yang, Tongjin Zhao, Zigang Dong, Kangdong Liu

“…Mechanistically, RTN4IP1 mRNA harbors functional iron‐responsive elements (IREs) in the 3′ UTR, which can be targeted by IRP2, resulting in increased mRNA stability. …”
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Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone by Ning Sun, Xu Zhao, Xu Zhao, Fangyuan Liu, Fangyuan Liu, Ge Song, Mengmeng Zhang, Fuqiang Song

“…IntroductionSoil microorganisms play a critical role in maintaining ecological functions; however, their responses to grassland reclamation and tillage remain poorly understood. …”
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Antioxidant Substance Basis and Mechanism of Flavonoids from Apios americana Medic. by Memitimin METSAWUR, Tong LI, Yadi NI, Tianjie YUAN, Daijie WANG, Jin'ao DUAN, Ping XIAO

“…These findings provide a theoretical basis for developing and utilizing Apios americana as a functional food ingredient.…”
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Safety and Efficacy of Intravenous Thrombolysis by Infarct Type in Patients with No Visible Occlusion: A Secondary Analysis of the AcT Trial by A. Zohaib Siddiqi, Katrina Ignacio, Chitapa Kaveeta, Fouzi Bala, Ayoola Ademola, Aleksander Tkach, Brian H. Buck, Luciana Catanese, Gary Hunter, Dar Dowlatshahi, Michel Shamy, Atif Zafar, Thalia S. Field, Ramana Appireddy, Ankur Wadhwa, Tolulope Sajobi, Rick Swartz, Mohammed Almekhlafi, Andrew Demchuk, Bijoy Menon, Nishita Singh

“…There was no significant interaction between thrombolytic type and treatment outcomes. …”
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Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures by Johannes Laengle, Julijan Kabiljo, Jakob Homola, Gerda Egger, Michael Bergmann, Wolfgang Weninger, Matthias Farlik, Askin Kulu, Anna Theophil, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver Pusch, Henning Walczak, Dietmar Herndler Brandstetter, Helmut Dolznig, Anna Kusienicka

“…Moreover, CAFs enhanced the phagocytic activity in chemotherapy treated CRC triple cultures.Conclusions Primary CAF-containing triple cultures successfully model TAM-like phenotypes ex vivo and allow the assessment of their functional and phenotypic changes in response to treatments following a precision medicine approach.…”
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Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma by Yan Liao, Hao Yao, Weidong Chen, Yutong Zou, Ji Fang, Jiongfeng Zhang, Zehao Guo, Jian Tu, Junkai Chen, Zijun Huo, Lili Wen, Xianbiao Xie

“…Single-cell RNA sequencing was used to explore cell-to-cell interactions within the tumor microenvironment. In vitro coculture functional assays were performed to validate the role of macrophage migration inhibitory factor (MIF) in macrophage polarization and chemotaxis. …”
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CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation by Juan Juan Chen, Zhang Ze Lu, Yu Xin Jing, Xing Mei Nong, Yi Qin, Jin Yang Huang, Na Lin, Jie Wei

“…Machine learning models, particularly SVM (area under the curve, AUC = 0.950), prioritized CD79A and GADD45A as key predictors of hospitalization. …”
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