TRIM55 suppresses inflammatory response after spinal cord injury by accelerating the ubiquitination and degradation of TLR4 by Yang Li

“…This study aimed to explore the potential mechanism of TRIM55 in SCI. Methods An SCI rat model was established to investigate the effects of TRIM55 on SCI. …”
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Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans. by Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun-Ming Lai, Caitlin McDonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin Meiklejohn, Raphaëlle Dubruille, Eric C Lai

“…Importantly, genetic interactions between nmy and tmy mutant alleles reveal that Tmy also specifically maintains male progeny for normal sex ratio. …”
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Key elements of the public resilience management system for territorial communities by O.V. Orel

“…In response, the concept of resilience is gaining importance as an integrative characteristic of communities’ ability to adapt to change, withstand shocks, recover vital functions, and transform risks into development opportunities. …”
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Novel Von Hippel-Lindau Germline Variants in Iranian Patients with Retinal Capillary Hemangioblastoma by Fatemeh Azimi, Kowsar Bagherzadeh, Golnaz Khakpoor, Saeed Talebi, Ahad Sedaghat, Reza Mirshahi, Hengameh Kasraei, Reza Afshar Kiaee, Masood Naseripour

“…These pioneering results that include detailed structural and functional analysis of a variant’s effect on the VHL protein may serve as a model for future studies. …”
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Linsitinib inhibits IGF-1-induced cell proliferation and hyaluronic acid secretion by suppressing PI3K/Akt and ERK pathway in orbital fibroblasts from patients with thyroid-associa... by Ji-Young Lee, Seong-Beom Lee, Suk-Woo Yang, Ji-Sun Paik

“…IGF-1R and TSHR (thyroid stimulating hormone receptor) interact with each other to form a physical or functional complex, further promoting the development of TAO. …”
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MTHFD1L is a novel prognostic marker and therapeutic target in cutaneous melanoma by Xinlian Xie, Guangfu Shi, Kebin Ning, Zhenjie Wu

“…Experimental validation involved: (1) RT-qPCR, Western blot, and IHC staining to compare MTHFD1L expression between SKCM and normal tissues; (2) establishment of MTHFD1L knockdown models in A375 and 2058 cell lines for functional characterization. …”
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BK ZERO isoform HEK293 stably transfected cell lines differing 3'UTRs to assess miR-9 regulation. by Katherine Cordero Padilla, Gerardo Alvarado Monefeldt, Adriel Guevárez Galán, Hector G Marrero, Mario E Lloret-Torres, Cristina Velázquez-Marrero

“…The exact nature of these interactions remains a current topic of discussion. To further study the effects of miR-9 on the expression and distribution of BK channel isoforms we designed an experimental model by transfecting human BK channel isoforms ZERO heterologous constructs in human embryonic kidney cells 293 (HEK293) cells respectively expressing 2.1 (miR-9 responsive), 2.2 (unresponsive) and control (no sequence) 3'untranslated region (3'UTR) miRNA recognition sites. …”
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Legal regulation of the system of public administration entities providing the administrative and legal regime of special economic zones by O. A. Lakaev

“…The author analyzes constitutional norms and provisions of legislative and subordinate acts that form the legal basis for their organization and functioning, the practice of their application.The purpose of the article is to scientifically substantiate the improvement of the system of subjects for ensuring the administrative and legal regime of special economic zones in order to increase the level of their interaction and the progressive economic development of the respective territories.The methodology. …”
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RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats by Sebastien Riquier, Samuel Carthy, Graham M. Hughes, Frederic Touzalin, Wilfried Haerty, Zixia Huang, Emma C. Teeling

“…These include a newly identified lncRNA, BatLnc1, with potential antiviral functions; the M. myotis ortholog of TUG1, implicated in viral-host interactions; and well-known lncRNAs MALAT1 and NEAT1, recognised for their roles in inflammatory regulation. …”
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Generation and characterization of chicken monocyte-derived dendritic cells by Elie Ngantcha Tatchou, Elie Ngantcha Tatchou, Romane Milcamps, Romane Milcamps, Guillaume Oldenhove, Bénédicte Lambrecht, Fiona Ingrao

“…However, these responses were downregulated after 24 hours.ConclusionThese findings provide a comprehensive characterization of chicken MoDCs and suggest their potential as a model for studying host-pathogen interactions.…”
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Internet use patterns and their relationship with frailty in older Japanese adults by Yaya Li, Kayo Godai, Michiko Kido, Susumu Komori, Ryoichi Shima, Kei Kamide, Mai Kabayama

“…We employed logistic regression models to investigate the associations. Stratified analyses were also conducted by sex and age (65–74 years, ≥ 75 years). …”
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A N, S-Containing Graphene Oxide Composite for the Adsorptive Removal of p-Nitrophenol from Aqueous Solutions by Bi Yang, Tao-Tao Shi, Wei-Guo Hu, Guan-Jin Gao, Yi-Ping Liu, Jin-Gang Yu

“…The adsorption behavior of PNP on GO-ATT composite conformed to the nonlinear pseudo-second-order kinetic model. Adsorption mechanism investigation indicated that the electrostatic, π-π stacking, and hydrogen bonding interactions were involved in the adsorption process. …”
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Unraveling the anti-tumor effects of midazolam in non-small cell lung cancer through the lncRNA XLOC_010706/miR-520d-5p/STAT3/autophagy pathway by Jinghua Jiao, Yifang Tang, Lu Ye, Yaru Yang, Zhenghua Liu

“…Within the signaling pathway, lncRNA XLOC_010706 functioned as a competing endogenous RNA (ceRNA) targeting miR-520d-5p, with STAT3 identified as a functional target gene for miR-520d-5p in NSCLC. …”
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Evaluation of the Power Up program: a health promotion program encouraging healthy lifestyle habits among youth in summer day camps—study protocol by David Larose, David Larose, David Larose, David Larose, Melvin Chih-Shing Chen, Tania Paracini, Shirin Panahi, Jennifer Yessis, Angelo Tremblay, Angelo Tremblay, Angelo Tremblay, Vicky Drapeau, Vicky Drapeau, Vicky Drapeau, Vicky Drapeau

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Expression of the IL-18-related gene PTX3 correlates with clinicopathological features and prognosis in glioma patients by Delin Wang, Cuimei Liu, Bohao Sun, Xiaodong Zhang, Yejun Zhou, Zhonglin Hu, Duanzheng Cao, Jing Zhang, Jinfang Xu

“…Functional enrichment analysis revealed that PTX3-associated differentially expressed genes were significantly enriched in pathways such as cytokine–cytokine receptor interaction and PI3K-Akt signaling, which are critical for immune response and cell proliferation in glioma. …”
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Interdisciplinary Distance Learning Workshop for IT Students by I. A. Malyj, V. V. Bulgakov, I. Yu. Sharabanova, O. I. Orlov

“…The problem of effective formation of professional competencies in the field of fire-fighting is caused by the limited training ground base of universities, which does not allow training at various residential, social, industrial, transport and other functional facilities, that requires their replacement with virtual analogues. …”
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Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma by Taibo Huang, Lijie Kou, Qianqian Zhang, Xueya Liu, Xingang Hu

“…To further define cellular characteristics, we applied copy number variation mapping, pseudotime progression modeling, transcription factor regulatory scoring, and cell–cell interaction analyses. …”
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Design and Application of GISC Beijing Global Cache by Gu Wenjing, Guo Ping, Zhang Laien, Xue Lei, Han Xinqiang, Gao Feng, He Wenchun, Wang Huaile, Wang Peng, Wang Bo

“…The global data cache's overall architecture is introduced, including its core functionalities and the underlying technical implementation. …”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Cross-analysis with bulk transcriptomic data highlighted JUN and HLA-A as hub regulators exhibiting elevated expression in SLE T cells. Network modeling further uncovered coordinated interactions between JUN, HLA-A, and RAS events in immune genes, implicating their synergistic roles in modulating T cell effector functions. …”
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Spatial Distribution and Intraspecific and Interspecific Associations of Dominant Tree Species in a Deciduous Broad-Leaved Forest in Shennongjia, China by Jiaxin Wei, Linsen Yang, Zhiguo Jiang, Hui Yao, Huiliang Yu, Fanglin Luo, Xiujuan Qiao, Yaozhan Xu, Mingxi Jiang

“…We analyzed the spatial distribution patterns of 20 dominant species with univariate and bivariate g(r) functions, as well as intraspecific and interspecific associations across different life-history stages. …”
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