Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy by Minfeng Yang, Shiqiang Hou, Yao Chen, Hongzhao Chen, Minjie Chu, Song-Bai Liu

“…Comprehension of intricate interactions between the tumor microenvironment (TME) and immune checkpoint inhibitors (ICIs) is crucial for optimizing and improving immunotherapies. …”
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Fine-scale spatial organisation of deep-sea sea pens in a NE atlantic submarine canyon conservation area by Irene Susini, Loïc Van Audenhaege, David M. Price, Tabitha R. R. Pearman, Emily G. Mitchell, Veerle A. I. Huvenne

“…Despite their cosmopolitan distribution, evidence of high functional value, and susceptibility to external stressors, sea pens remain poorly investigated relative to other coral species. …”
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Highly efficient and rapid removal of Congo red dye from textile wastewater using facile synthesized Mg/Ni/Al layered double hydroxide by Eslam A. Mohamed, Hend M. Ahmed, Amal A. Altalhi, Hamdan A. S. Al-Shamiri, Nabel A. Negm

“…Abstract Layered double hydroxides (LDH) are compounds with unique structures of hydroxide functional groups on their surfaces, and they have the proper arrangement of divalent and trivalent cations to adjust their unique catalytic actions. …”
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Adenosine improves postmenopausal obesity by regulating neutrophil extracellular traps by Anzhu Wang, Wei Zhang, Mengjiao Kang, Shan Wang, Jingjing Shi, Pengfei Xie, Linhua Zhao, Xiaolin Tong

“…Differentially expressed genes (DEGs) related to obesity were identified from the GEO database (GSE44000), followed by protein-protein interaction (PPI) network construction and functional enrichment analysis. …”
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System Reliability Analysis of Slope Stability of Earth Rock Dams Based on Finite Element Strength Reduction Method by Huibao Huang, Junchi Zhu, Zhenyu Wu, Jiankang Chen, Jichen Tian

“…An elastoplastic finite element model simulates dam construction and impoundment, identifying potential slip pathways. …”
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A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering by Caterina Cristallini, Daniela Rossin, Roberto Vanni, Niccoletta Barbani, Chiara Bulgheresi, Massimiliano Labardi, Sadia Perveen, Silvia Burchielli, Domiziana Terlizzi, Claudia Kusmic, Silvia Del Ry, Manuela Cabiati, Cheherazade Trouki, Dawid Rossino, Francesca Sergi, Anthea Villano, Giovanni D. Aquaro, Giorgia Scarpellino, Federico A. Ruffinatti, Sara Amorim, Ricardo A. Pires, Rui L. Reis, Raffaella Rastaldo, Claudia Giachino

“…Migration tests showed the chemoattractive capacity of the patches and conductivity assays showed unaltered cell-cell interactions and cell beating synchronicity. MENDEP was then epicardially implanted in a rat model of ischemia/reperfusion (I/R). …”
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Adsorption and Removal of Phosphate by Leather Collagen Fiber-based Material Loaded with UiO–66–NH2 by Xiaohan YANG, Songbo DAI, Yuqing HE, Xiudan TAO, Likun CHEN, He ZHENG, Zhengjun LI

“…The quasi-secondary kinetic model can better describe the adsorption process, and the adsorption mechanism mainly involves the electrostatic adsorption and ligand exchange interactions. …”
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Decoding the selective chemical modulation of CYP3A4 by Jingheng Wang, Stanley Nithianantham, Sergio C. Chai, Young-Hwan Jung, Lei Yang, Han Wee Ong, Yong Li, Yifan Zhang, Darcie J. Miller, Taosheng Chen

“…Abstract Drug-drug interactions associate with concurrent uses of multiple medications. …”
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Emerging biomedical engineering strategies for hair follicle regeneration by Xinyue Cao, Minhui Lu, Ning Li, Lijun Cai, Yu Wang, Yuanjin Zhao

“…In this condition, biomedical engineering has advanced hair follicle regeneration from “replacement therapy” to “functional reconstruction” by integrating interdisciplinary approaches such as stem cell technology, tissue engineering, and modern engineering technology. …”
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The buffering effect of secure base leadership on the relationship between emotional demands and burnout: A multilevel study among military officer cadets by María C. Navas-Jiménez, Ana Laguía, Patricia Recio, Carlos García-Guiu, Alberto Pastor, Sergio Edú-Valsania, Fernando Molero, Mario Mikulincer, Juan A. Moriano

“…At the team level (Level 2), cadets who perceive their leaders as a secure base report lower levels of burnout, indicating that SBL functions as a key job resource that mitigates stress-related outcomes. …”
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Electrochemical‐Genetic Programming of Protein‐Based Magnetic Soft Robots for Active Drug Delivery by Hang Zhao, Bo Yu, Dingyi Yu, Ting Ji, Kexin Nie, Jingyi Tian, Xinchen Shen, Kaiyue Zhang, Junhan Ou, Xinyi Yang, Dongfang Xiao, Qi Zhou, Wenwen Huang

“…Optimization of the interaction between the substrate and magnetic components is also critical as it ensures robust actuation of the robot in complex physiological environments. …”
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Ras and Rab interactor 3 as a prognostic biomarker and its impact on immune cell infiltration in cancer by Xin Xu, Ningfeng Zhou, Shasha Zhang, Tingxin Cheng, Jun Ren, Dian Yang, Ying Liu, Shiyan Wang, Aijun Sun, Fengze Cai

“…Additionally, GSEA and GSVA were employed to explore the involvement of RIN3 in immune responses and metabolic processes, while molecular docking and bioinformatics approaches predicted its interactions with anticancer drugs. Functional assays in breast cancer models confirmed that downregulation of RIN3 significantly inhibited cell proliferation and migration. …”
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Snhg18 regulates Yap subcellular localization to maintain bone homeostasis by Jie Huang, Yuteng Weng, Yanhuizhi Feng, Di Wu, Yongliang Chen, Zeyuan Li, Xue Jiang, Haicheng Wang, Zuolin Wang

“…Here, we identify small nucleolar RNA host gene 18 (lnc-Snhg18), a functionally conserved lncRNA enriched in the osteolineage of leptin receptor–positive (LepR⁺) cells within bone, as a key regulator promoting osteogenesis. …”
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USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition by Ji Hye Shin, Ji Young Kim, Mi-Jeong Kim, Yeeun Kang, Bongkum Choi, Dohee Kwon, Yoolim Sung, Seo Hyun Kim, Ha-Jeong Lee, Chaeeun Lee, Kyeong Kyu Kim, Jae-Hyuck Shim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee

“…Mechanistically, USP21 interacts with EGFR and Lyn, preventing their ubiquitination and degradation, thereby sustaining oncogenic signaling. …”
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Establishment of M2 macrophage-related prognostic signature in pancreatic ductal adenocarcinoma by Hui Chen, Jingyang Yin, Xianxing Wang, Renpei Xia, Fanbo Qin, Zhuo Li, Jiali Yang, Changjiang Liu, Shixiang Guo, Huaizhi Wang

“…M2 macrophages (M2) play a crucial role in the microenvironment of PDAC, yet their exact functional significance remains poorly understood. This study sought to explore the potential communication and clinical implications of M2 in PDAC. …”
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Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis by Kaisheng Jiang, Yang He, Bingjie Hu, Li Quan, Longyun Peng, Juntao Tian, Nan Zhou, Erwen Huang, Qianhao Zhao

“…A multi-omics framework integrating transcriptomics, single-cell RNA sequencing, and machine learning to identify and prioritize pyroptosis-related genes (PRGs) in AS. Functional enrichment, immune infiltration profiling, and protein–protein interaction network analyses were conducted. …”
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Machine learning driven multi-omics analysis of the genetic mechanisms behind the double-coat fleece formation in Hetian sheep by Yanwei Zhang, Wenrong Li, Xinming Xu, Mengwan Xie, Liping Tang, Peiyu Zheng, Nannan Song, Lijuan Yu, Jiang Di

“…PPI network analysis and machine learning identified IRF2BP2 and EGFR as key functional genes associated with coat fleece type.DiscussionThis study enhances understanding of the genetic mechanisms governing double-coated fleece formation in Hetian sheep. …”
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Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy by Nicholas Denomme, Samantha L. Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M. Ziobro, Joe Minton, Chunling Chen, Yan Chen, Jacob M. Hull, James Offord, Alan V. Smrcka, Lori L. Isom

“…Summary: Guanine nucleotide-binding protein Gβγ subunits are ubiquitous signaling molecules that interact with numerous effector proteins in neurons, including voltage-gated sodium, calcium, and potassium channels. …”
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Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combinati... by Yonghui Su, Dongqun Guo, Yinghao Liang, Tuerdimaimaiti Meiheriban, Siyu Chen, Qian Tang, Xiqian Chen, Yan Huang, Jianqiao Zhong, Zongjunlin Liu

“…Moreover, with its magnetic resonance imaging capabilities, this multi-functional diagnostic and therapeutic platform shows significant potential for clinical tumor treatment.…”
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Star−Disk Collisions: Implications for Quasi-periodic Eruptions and Other Transients near Supermassive Black Holes by Philippe Z. Yao, Eliot Quataert, Yan-Fei Jiang, Wenbin Lu, Christopher J. White

“…We provide simple fitting functions for the stellar mass loss per collision; the mass loss is much larger after repeated collisions, due to the dilute stellar atmosphere shock-heated in earlier collisions. …”
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