Hepatoprotective drug screening identifies daclatasvir, a promising therapeutic candidate for MASLD by targeting PLIN2 by Rui Shu, Song Tian, Weiyi Qu, Jinjie Yang, Wei Shi, Xinyan Li, Toujun Zou, Changjin Jiang, Yuxuan Zhang, Zifeng Yang, Han Tian, Hailong Yang, Jiajun Fu, Zhi-Gang She, Hongliang Li, Xiao-Jing Zhang

“…Using the molecular docking assay followed by isothermal titration calorimetry confirmation, we identified that daclatasvir functions as a new perilipin-2 (PLIN2) inhibitor by interrupting its stability. …”
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Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway by Yushan Ye, Fan Wu, Bowen Li, Hanyu Ma, Lianxi Mai, Yu Peng, Xiaodi Feng, Xiao Tan, Min Fu, Yongmei Tan, Tianjun Lan, Ruixin Wang, Siqi Ren, Jinsong Li, Shaohai Chang, Shule Xie

“…Here, we explored the functional mechanism of exosomal piRNAs in OSCC development. …”
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PRMT1 alleviates isoprenaline-induced myocardial hypertrophy by methylating SRSF1 by Yan Zi, Zhao Wenhui, Zhao Naixin, Liu Yufeng, Yang Bowen, Wang Li, Liu Jingyi, Wang Deping, Wang Jin, Jiao Xiangying, Cao Jimin, Li Jianguo

“…In addition, there is an interaction between PRMT1 and SRSF1, whereby PRMT1 reduces the phosphorylation level of SRSF1 via methylation, thus further altering its functional activity and eventually improving MH. …”
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Activated carbon from olive pomace for hexavalent chromium removal: synthesis, characterization, and adsorption mechanism analysis by Imad Alouiz, Mouhssine Benhadj, Kaoutar Harboul, Mostafa Boukhris, Dahmane Elmontassir, Mohamed Sennoune, Mohamed Yassine Amarouch, Driss Mazouzi

“…Additionally, density functional theory (DFT) calculations were employed to optimize the activated carbon structure and gain molecular-level insights into its interactions with Cr(VI) species. …”
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ggClusterNet 2: An R package for microbial co‐occurrence networks and associated indicator correlation patterns by Tao Wen, Yong‐Xin Liu, Lanlan Liu, Guoqing Niu, Zhexu Ding, Xinyang Teng, Jie Ma, Ying Liu, Shengdie Yang, Penghao Xie, Tianjiao Zhang, Lei Wang, Zhanyuan Lu, Qirong Shen, Jun Yuan

“…To address emerging challenges, including multi‐factor experimental designs, multi‐treatment conditions, and multi‐omics data, we present a comprehensive upgrade with four key components: (1) A microbial co‐occurrence network pipeline integrating network computation (Pearson/Spearman/SparCC correlations), visualization, topological characterization of network and node properties, multi‐network comparison with statistical testing, network stability (robustness) analysis, and module identification and analysis; (2) Network mining functions for multi‐factor, multi‐treatment, and spatiotemporal‐scale analysis, including Facet.Network() and module.compare.m.ts(); (3) Transkingdom network construction using microbiota, multi‐omics, and other relevant data, with diverse visualization layouts such as MatCorPlot2() and cor_link3(); and (4) Transkingdom and multi‐omics network analysis, including corBionetwork.st() and visualization algorithms tailored for complex network exploration, including model_maptree2(), model_Gephi.3(), and cir.squ(). …”
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Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair by Xingxiao Huang, Xingxiao Huang, Yan Ping, Yan Ping, Qiuli Sun, Qiuli Sun, Mingjun Yu, Mingjun Yu, Chao Yang, Xiao Liu, Long Wang, Jinyu Huang, Jinyu Huang

“…And distinct subpopulations within these cell types were identified, each exhibiting unique functional characteristics and temporal dynamics during repair. (2) Notably, we identified an inflammatory SMC subpopulation (SMC2) that actively secretes chemokine CXCL2, which promotes SMC proliferation and mediates arterial remodeling after injury, suggesting its potential as a therapeutic target.ConclusionsThis study provides a comprehensive cell atlas of the injured artery, offering valuable insights into the complex cellular interactions, signaling pathways and immune responses involved in orchestrating vascular repair. …”
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A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination by Canghai Guan, Jianjun Gao, Xinlei Zou, Wujiang Shi, Yunhe Hao, Yifei Ge, Zhaoqiang Xu, Chengru Yang, Shaowu Bi, Xingming Jiang, Pengcheng Kang, Xiaoxue Xu, Xiangyu Zhong

“…Functionally, this study elucidates the regulatory effect of circPCSK6‐167aa on IκBα ubiquitination within the NF‐κB pathway, which is mediated by its competitive binding to the E3 ligase RBBP6. …”
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Differential coping capacities underlie the overall resistance of temperate seagrasses to herbivory by J. Boada, T. M. Smith, A. M. Ricart, T. Alcoverro, M. Pérez, J. Romero, N. Sanmartí, Y. Ontoria, M. Pierrejen, R. Arthur, D. Alonso, M. P. Adams, F. Rossi

“…The overall ecosystem functioning and associated biodiversity depend on these responses but there is still little understanding on how the intensity and duration of herbivory interact and impact vegetated ecosystems. …”
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Multiple dimensions of the quality of life among Asian American breast cancer survivors: The impact of a technology-based program by Eun-Ok Im, Wonshik Chee, Sudeshna Paul, Seo Yun Kim, Mi-Young Choi, Jun J. Mao, Giang T. Nguyen, Marilyn M. Schapira, Connie M. Ulrich, SeonAe Yeo, Janet A. Deatrick, Jillian Inouye, Grace Ma, Salimah Meghani, David Shin, Ting Bao

“…Significant interaction between time and group were found only in physical well-being (β = 0.84, p = .025) from T0 to T1 (post 1-month) and social well-being (β = 1.05, p = .006) from T0 to T2 within the mixed-effect model with AR1. …”
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A Recovery-Oriented Suicide Prevention Program Led by Peer Specialists for Veterans With Serious Mental Illness: Protocol for a Pilot Randomized Controlled Trial by Samantha Chalker, Jillian Carter, Yuki Imai, Colin Depp, Matthew Chinman

“…Aim 2 will determine the preliminary impact of SUPPORT versus enhanced standard care on personal recovery and suicide ideation severity (primary outcomes), as well as domains of veteran functioning (secondary outcomes). Standard care is enhanced such that all veterans receive additional suicide risk assessment, which may result in additional clinical interaction. …”
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Depression, cognitive dysfunction and other factors associated with 5-year overall mortality in type 2 diabetes mellitus: a pilot prospective observational study by E. G. Starostina, M. N. Volodina, I. V. Starostin

“…The 5-year predicted probability of death in the patients without CHF was 6,7%, with CHF I NYHA functional class, 9,8%, II functional class 13,6%, III functional class 18,2%, and IV functional class 23,5%. …”
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Investigation of the «Structure – analgesic activity» Relationship Using Molecular Docking for Cyclooxygenases 1 and 2 in the Series 5-<i>N</i>-arylaminocarbonyl-6-(get)aryl-4-meth... by N. A. Buzmakova, K. V. Аndryukov, T. M. Zamaraeva, I. P. Rudakova, K. V. Podchezertseva, A. S. Goman, E. V. Avdeeva, N. V. Slepova, N. V. Dozmorova

“…To identify the dependence "structure – analgesic activity" using the method of molecular docking for cyclooxygenase type 1 and type 2 in the series of 5-N-arylaminocarbonyl-6-(get)aryl-4-methyl-1,2,3,6-tetrahydropyrimidine-2-thions.Materials and methods. 19 compounds 5-N-arylaminocarbonyl-6-(get)aryl-4-methyl-1,2,3,6-tetrahydropyrimidine-2-thions are objects of research The study of the interaction of tetrahydropyridine derivatives with COX 1 and 2 was carried out by the method of molecular docking by the AutoDock 4 program using scoring functions.Results and discussion. …”
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The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation by Madalina Ene, Alexandra Savuca, Alin-Stelian Ciobica, Roxana Jijie, Irina Luciana Gurzu, Luminita Diana Hritcu, Ionut-Alexandru Chelaru, Gabriel-Ionut Plavan, Mircea Nicusor Nicoara, Bogdan Gurzu

“…Recent studies have suggested that probiotics may offer protective effects against environmental neurotoxins by modulating the gut microbiota and associated neurological functions. The zebrafish (<i>Danio rerio</i>) has emerged as a valuable model organism for studying the biological mechanisms underlying neurotoxicity and potential therapeutic interventions. …”
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Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…A KRAS-Macrophage Prognostic Associated Gene (KMPAG) signature was developed by integrating these findings, followed by validation using a least absolute shrinkage and selection operator (LASSO) regression model. The prognostic value of the KMPAG signature was assessed through its correlation with clinical outcomes, immune cell infiltration patterns, response to therapy, drug sensitivity, and miRNA-gene regulatory interactions. …”
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AI-driven pharmacovigilance: Enhancing adverse drug reaction detection with deep learning and NLP by Dr. Bharti Khemani, Dr. Sachin Malave, Samyukta Shinde, Mandvi Shukla, Razzaq Shikalgar, Harshita Talwar

“…BERT and GPT, were also employed to provide the functionality of textual interactions over medical data. • Performance metrics such as accuracy, precision, recall, and F1-score were systematically applied to evaluate each model’s performance. …”
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STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis by Fuda Xie, Yang Lyu, Bonan Chen, Hoi Wing Leung, Peiyao Yu, Tiejun Feng, Canbin Fang, Alvin H.K. Cheung, Bin Zhou, Jianhui Jiang, Ge Zhang, Dazhi Xu, Liang Li, Chen Jiang, Jianwu Chen, Zhaocai Zhou, Liwei An, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Kam Tong Leung, Ching Hei To, Brigette BY Ma, Chi Chun Wong, William KK Wu, Jun Yu, Ka Fai To, Wei Kang

“…The regulation of YAP1 on STK3 was assessed through a combination of bulk and single-cell RNA-sequencing, Western blot, ChIP-qPCR, gene knockout mouse models, and functional rescue assays. The oncogenic roles of STK3 were confirmed through subcutaneous xenograft formation models and functional assays including spheroid formation and organoid growth. …”
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Fusion of a bacterial cysteine desulfurase to redox-sensitive green fluorescent protein produces a highly sensitive cysteine biosensor for monitoring changes in intracellular cyste... by Damien Caubrière, Arthur de Butler, Anna Moseler, Pauline Leverrier, Jean-François Collet, Andreas J. Meyer, Nicolas Rouhier, Jérémy Couturier

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Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing by Yizhen Chen, Meng Cheng, Rong Dai, Weili Wang, Yonghao Sang, Liuting Wei, Yilin Gao, Wei Zhang, Yiping Wang, Lei Zhang

“…Enrichment analysis was performed to explore potential functions.Results Sequencing analysis revealed significant dysregulation of ncRNAs in all models compared to the normal group. …”
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Optimization of the Encapsulation of Lemuru Fish Protein Hydrolysate by Spray-Drying Using Response Surface Methodology by Ayu Hanifah, Wawan Kosasih, Diah Ratnaningrum, Dian Andriani, Herlian Eriska Putra, Yellianty Yelliantty, Sri Priatni

“…Further research should explore the functional properties of fish protein hydrolysate.…”
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ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer by Liyong Huang, Yixin Tong, Xu Li, Wei Wang, Zhen Wang, Bingchen Chen, Jifu E., Ruzhen Zhou, Hantao Wang, Jinghu He

“…Moreover, in vivo studies using xenograft models confirmed that ALDOC knockdown attenuated tumor growth. …”
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