Synergetic effects of network interconnections in the conditions of virtual reality by Kraus Kateryna, Kraus Nataliia, Shtepa Olena

“…PURPOSE: The disclosure of the content of the synergetic effect, as a result of network interactions of development institutions in a new economic virtual reality, and the presentation of the general characteristics of their relationships through knowledge of the functioning of clusters, which in the XXI century occurs during the digitalization of the economy, resulting in digital products/services and various platforms. …”
Get full text

Adipocytes reprogram the proteome of breast cancer cells in organotypic three-dimensional cell cultures by Karla Tovar-Hernández, Yarely M. Salinas-Vera, Ángeles Carlos-Reyes, Alejandra P. García-Hernández, Laurence A. Marchat, Gilberto Mandujano-Lázaro, Emmanuel Ríos-Castro, Andrea Velasco-Suárez, Ivonne Mendez-Gómez, Ángeles C. Tecalco-Cruz, Eloisa Ibarra-Sierra, César López-Camarillo

“…Of these, 605 showed no significant changes in abundance, whereas 87 proteins were significantly upregulated and 224 downregulated after interaction with fat cells (p < 0.05, FC > 2.0). Bioinformatic analysis of upregulated proteins indicated that the most enriched GO terms and molecular functions were related to lipids transport, cell differentiation, hypoxia response, and cell junctions. …”
Get full text

A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. by Tannistha Nandi, Catherine Ong, Arvind Pratap Singh, Justin Boddey, Timothy Atkins, Mitali Sarkar-Tyson, Angela E Essex-Lopresti, Hui Hoon Chua, Talima Pearson, Jason F Kreisberg, Christina Nilsson, Pramila Ariyaratne, Catherine Ronning, Liliana Losada, Yijun Ruan, Wing-Kin Sung, Donald Woods, Richard W Titball, Ifor Beacham, Ian Peak, Paul Keim, William C Nierman, Patrick Tan

“…Within the Bp core genome, 211 genes exhibited significant levels of positive selection (4.5%), distributed across many cellular pathways including carbohydrate and secondary metabolism. Functional experiments revealed that certain positively selected genes might enhance mammalian virulence by interacting with host cellular pathways or utilizing host nutrients. …”
Get full text

Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges by Seyyed M. R. Kazemi-Bajestani, Vaibhav B. Patel, Wang Wang, Gavin Y. Oudit

“…Recombinant human ACE2 in an animal model of ACE2 knockout mice lowers Ang II. These interactions neutralize the pressor and subpressor pathologic effects of Ang II by producing Ang 1–7 levels in vivo, that might be cardiovascular protective. …”
Get full text

Google Sites as a Tool for Chemistry: Exploring the 8E Learning Cycle Approach by Nani Arum Pratiwi, Muhammad Zamhari, Pandu Ridzaniyanto

“…The media was developed using the ADDIE model by Dick and Carey, limited to the development stage. …”
Get full text

Artificial intelligence in decoding muscle–organ crosstalk: Unveiling myokine networks and therapeutic frontiers by Ehsan Arabzadeh, Fatemeh Khanzadeh, Arezoo Kalhor

“…Advances in artificial intelligence (AI) are revolutionizing our ability to decode these complex interactions by predicting novel myokines, modeling signaling networks, and identifying therapeutic targets. …”
Get full text

Exploring the Spatial Spillovers of Digital Finance on Urban Innovation and Its Synergy with Traditional Finance by Xiaoling Song, Xuan Qin, Wanmeng Wang, Rita Yi Man Li

“…This study fills in the gaps by focusing on the spatial spillover effects of digital finance on urban innovation and complementary functions of traditional finance. It applies the spatial Durbin model to 26 China BRI node cities from 2013 to 2020. …”
Get full text

Impacts of structural properties of myosin II filaments on force generation by Shihang Ding, Pei-En Chou, Shinji Deguchi, Taeyoon Kim

“…Cells need intracellular forces for their physiological functions, such as migration, cytokinesis, and morphogenesis. …”
Get full text

Neuropsychopharmacology in the era of artificial intelligence and biomolecule prediction software by Rubén A. García-Reyes, Laura N. Massó Quiñones, Hajin Ruy, Daniel C. Castro

“…With the implementation of AI, we are now able to expedite this early testing by modeling how a drug or protein complex may interact with a receptor of interest. …”
Get full text

M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…Mechanistic investigations revealed that circRAPGEF5 directly interacts with the KH3-4 functional domain of Insulin-like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), an m6A reader protein. …”
Get full text

Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Our previous investigation provided preliminary evidence that single nucleotide polymorphisms (SNPs) may functionally interact with the LINC00339, potentially contributing to the pathogenesis and progression of osteoporosis through undefined molecular pathways. …”
Get full text

Promoting the Integration of Public Perspective into Urban Design Decision-Making Based on Crowdsourced Visual Perception Method by Lu HUANG, Takuya (JPN) OKI

“…In the data analysis phase, statistical methods establish quantitative models linking built environment factors with visual perception evaluations, uncovering the interaction mechanisms between public preferences and built environment elements. …”
Get full text

Structure-guided design of partial agonists at an opioid receptor by Balazs R. Varga, Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy H. Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L. Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R. Hammond, Shainnel O. Eans, Violetta Weinreb, Elyssa B. Margolis, Jonathan F. Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P. McLaughlin, Susruta Majumdar, Tao Che

“…Here we show that C6-Quino, a bitopic ligand developed through structure-based design, acts as a selective δOR partial agonist. Functional studies reveal that C6-Quino shows differential activity at G-protein and arrestin pathways and interacts with the sodium binding pocket, confirmed through cryo-EM analysis. …”
Get full text

Per- and Polyfluoroalkyl Substances (PFAS) as Emerging Obesogens: Mechanisms, Epidemiological Evidence, and Regulatory Challenges by Niya Lewis, Abubakar Abdulkadir, Shila Kandel, Raphyel Rosby, Ekhtear Hossain

“…Emerging evidence suggests that PFAS may act as endocrine-disrupting chemicals, interfering with lipid metabolism and hormone functions related to obesity. We examine in vitro, in vivo, human, and in silico studies that explore the interaction of PFAS with PPARs and other molecular targets, influencing adipogenesis and lipid homeostasis. …”
Get full text

EGF-Upregulated lncRNA ESSENCE Promotes Colorectal Cancer Growth through Stabilizing CAD and Ferroptosis Defense by Xiaoshan Xie, Boyu Zhang, Jingxuan Peng, Ning Ma, Qihao Pan, Yue Wei, Huilin Jin, Fenghai Yu, Xiaoling Huang, Peng Zhang, Jiarui Wang, Jiaying Zheng, Xiaofang Ying, Ran-yi Liu, Hongyan Yu, Mong-Hong Lee, Xiangqi Meng

“…In this study, based on the profiling of long noncoding RNAs triggered by EGFR/MAPK signaling, we identified that ESSENCE (EGF [epidermal growth factor] Signal Sensing CAD’s Effect; ENST00000415336), which is mediated by the transcription factor early growth response factor 1, functions as a potent oncogenic molecule that predicts poor prognosis in CRC. …”
Get full text

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis by Xinjun Li, Jie Qi, Ren Xu, Shuo Xu, Shengpu Wang, Chunxiao Wang, Sufen Zhao

“…In in vivo experiments, ZNF432 overexpression significantly suppressed tumor growth in a nude mouse xenograft model. Mechanistically, ZNF432 induced apoptosis by interacting with UPF1 and enhancing its ubiquitination, promoting the degradation of pro-survival factors in EC cells. …”
Get full text

HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma by Na Shen, Yuan Xia, Xuxing Shen, Wei Hua, Min Shi, Lijuan Chen

“…Here, we confirmed that HSPA9 is overexpressed in MM samples and correlates with unfavorable outcomes. Functionally, HSPA9 enhances MM cell viability, ferroptosis resistance, and tumorigenicity, suggesting its oncogenic role. …”
Get full text

Bacteria‐responsive transformable peptide‐based nanomaterials inspired by human α‐defensin 6 for labeling and entrapping pathogenic bacteria by Chenlong Zhou, Qi Tang, Peng Tan, Tao Wang, Yucheng Zhang, Shuaikang Yang, Guanghui Zhao, Yue Feng, Xi Ma

“…Specifically, PBANs self‐assemble to form nanoparticles in physiological environments and in situ transform into nanofibers on bacterial surfaces through receptor‐ligand interactions in infected microenvironments, resulting in enhanced fluorescence signal and activation of functions, while labeling and entrapping bacteria. …”
Get full text

A strategy to reduce thermal expansion and achieve higher mechanical properties in iron alloys by Hao Lu, Chang Zhou, Yuzhu Song, Yuanpeng Zhang, Yiming Wu, Feixiang Long, Yonghao Yao, Jiazheng Hao, Yan Chen, Dunji Yu, J. Jakob Schwiedrzik, Ke An, Lunhua He, Zhaoping Lu, Jun Chen

“…Abstract Iron alloys, including steels and magnetic functional materials, are widely used in capital construction, manufacturing, electromagnetic technology, etc. …”
Get full text

IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration by Cheng Zhou, Shunlai Shang, Jing Zhao, Yunzhao Yang, Meihan Shi, Ping Li, Qinggang Li, Jian Zhang, Wenge Li, Chuyue Zhang, Xue-Yuan Bai

“…While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy varies substantially, likely due to their plasticity and capacity to adopt pro-inflammatory (MSC1) or anti-inflammatory (MSC2) functional states in response to different microenvironments. …”
Get full text