Aqueous extract of Solanum americanum Mill. relieves functional constipation by modulating the enteric nervous system and gut micro-ecosystems by Xiaoyu Gao, Xiaoyu Gao, Xiaoyu Gao, Yanan Li, Yifan Hu, Yifan Hu, Weixing Yang, Lei Peng, Jun Sheng, Yang Tian, Lu Yao, Yan Zhao

“…The present study evaluated the laxative activity of Solanum americanum Mill. aqueous extract (SAAE) using loperamide-induced functional constipation (FC) mouse model. The results demonstrated that SAAE is abundant in nucleotides and polysaccharides. …”
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Modeling traumatic brain and neural injuries: insights from zebrafish by Lada Murashova, Vyacheslav Dyachuk

“…This review discusses some approaches to modeling neural injury in zebrafish and considers the effect of cellular interactions in post-traumatic neurogenesis, with focus on the animal’s age and the specific damaging factor that may be used to select an optimum model for certain nervous system lesions.…”
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Intraspecific variation in the functional responses of an invasive tropical freshwater fish under increasing temperature regimes by Matteo Ventura, Simone Cittadino, Edoardo Calizza, Giulio Careddu, Simona Sporta Caputi, Loreto Rossi, Maria Letizia Costantini

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Structural and Functional Analysis of the Human IQSEC2 S1474Qfs*133 Mutation by Yonat Israel, Aaron Lowenkamp, Michael Shokhen, Shai Netser, Shlomo Wagner, Joseph Zarowin, Shaun Orth, Veronika Borisov, Orit Lache, Nina S. Levy, Andrew P. Levy

“…The objective of this study was to understand the pathophysiology of this specific IQSEC2 mutation using molecular modeling protein–protein interaction assays and a conditional transgenic mouse model of the mutation. …”
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Computer Modelling «Smart Building» by O. Yu. Maryasin, A. S. Kolodkina, A. A. Ogarkov

“…In order to perform study of different functioning modes of engineering subsystems and the whole system, mathematical and computer modeling needs to be used. …”
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SIMULATION OF SPATIAL KINEMATICS diplacement SYSTEM with INTERACTIVE vizualzition of results by S. E. Karpovich, V. V. Kuzniatsou, M. M. Forutan

“…The model allows carrying out the imitational modelling of kinematic characteristics of spatial motion system with interactive visualization in MATLAB environment.…”
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The illocutionary profile of text units with purpose semantics in the aspect of their modeling and interpretation by L.V. Voronina

“…The organization of the communicative continuum within the framework of interaction was investigated. The functionality of the pragmatic context (the background of spoken interaction) was revealed. …”
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Understanding the selectivity in silico of colistin and daptomycin toward gram-negative and gram-positive bacteria, respectively, from the interaction with membrane phospholipids by Yesid Aristizabal, Yamil Liscano, José Oñate-Garzón

“…However, daptomycin displayed strong interactions with several POPG functional groups of the S. aureus membrane model, which favored the insertion of the fatty acid tail into the bilayer. …”
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Application of generalized additive models to explore minerals in sheep milk by Stefano Biffani, Michela Ablondi, Claudio Cipolat-Gotet, Andrea Summer, Elena Mariani, Johanna Ramírez-Díaz, Alessio Negro, Alessandro Lotto, Giorgia Stocco

“…ABSTRACT: This study explores the complex relationships among ovine milk minerals (Ca, P, Na, K, Mg, K, Cl, respectively) and different factors employing generalized additive mixed models (GAMM). The GAMM included milk yield (MY), parity, and breed as parametric terms, and casein, fat, lactose, pH, SCS, DIM, and sampling day as smooth functions. …”
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Psychiatric Implications of Genetic Variations in Oligodendrocytes: Insights from hiPSC Models by Martina D’Angelo, Valeria Di Stefano, Ilaria Pullano, Francesco Monaco, Luca Steardo

“…Future studies integrating independent human cohorts with robust preclinical models are needed to clarify the extent of OPC involvement in psychiatric pathophysiology. …”
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Detection of structural-functional coupling abnormalities using multimodal brain networks in Alzheimer’s disease: A comparison of three computational models by Yinping Lu, Luyao Wang, Toshiya Murai, Jinglong Wu, Dong Liang, Zhilin Zhang

“…This study aimed to explore the interaction between the structural and functional brain network in AD using advanced structural–functional coupling (S-F coupling) models to assess whether these changes correlate with cognitive function, Aβ deposition levels, and gene expression. …”
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Effective connectivity analysis of response inhibition functional network by Monica Di Giuliano, Andy Schumann, Feliberto de la Cruz, Pedro Henrique Rodrigues Da Silva, Karl-Jürgen Bär

“…However, the causal interactions between large-scale functional networks involved in response inhibition remain poorly understood.MethodsIn this study, we examined the effective connectivity (EC) underlying inhibitory processes in the brain using dynamic causal modeling (DCM) and independent component analysis (ICA). …”
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Filling in missing puzzle pieces in protein structural biology with cross-linking mass spectrometry by Zheng Ser

“…In this perspective, I sketch out several ways that cross-linking mass spectrometry can contribute to filling in some of these missing pieces: Identification of cross-linked interactions in highly flexible protein regions not captured by other structural techniques; capturing conformational changes of protein complexes in different functional states; serving as distance constraints in integrative structural modelling and providing structural information of in cellulo proteins. …”
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Analyzing the function of metaverse technology in the retention and absorption of knowledge using the integrated approach of interpretive structural modeling and structural equatio... by Seyed Mojtaba Hosseinibamakan, Hajar Soleymanizadeh, Mehran Ziaeian

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Study on relationship between shrinkage and transformation of resource-based cities in China by YANG He, XUE Dongqian, SONG Yongyong

“…[Objective] Scientifically evaluating the spatiotemporal differentiation characteristics of shrinkage and transformation of resource-based cities in China, and understanding their functional relationship and interaction mechanisms are crucial for achieving sustainable development in these cities. …”
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Single-atom iron on silicon carbide surfaces as catalyst of Fischer-Tropsch-type reactions in astrophysical environments by Gerard Pareras, Albert Rimola

“…., formaldehyde (H2CO) and methanol (CH3OH). Using density functional theory (DFT), we model the catalytic cycle on the most stable β-SiC (110) surface, revealing that H2CO forms efficiently with relatively low activation barriers (up to 18.3 kcal mol−1), while, in contrast, CH3OH formation faces a significant energy barrier (32.6 kcal mol−1) in space. …”
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THE DETERMINATION OF DISTRIBUTION PARAMETERS OF ONE-DIMENSIONAL CONTINUOUS RANDOM VARIABLE ACCORDING TO ITS INITIAL CHARACTERISTICS BY FINANCIAL RISKS MODELLING by V. Y. Dubnytskyi, І. H. Skorikova

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Small-molecule inhibitors of the CD40–CD40L costimulatory interaction are effective in pancreatic islet transplantation and prevention of type 1 diabetes models by Sung-Ting Chuang, Oscar Alcazar, Brandon Watts, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Peter Buchwald, Peter Buchwald

“…As part of our work to develop small-molecule inhibitors (SMIs) of the CD40-CD40L(CD154) costimulatory protein-protein interaction, here, we describe the ability of two of our most promising SMIs, DRI-C21041 and DRI-C21095, to prolong the survival and function of islet allografts in two murine models of islet transplantation (under the kidney capsule and in the anterior chamber of the eye) and to prevent autoimmune type 1 diabetes (T1D) onset in NOD mice. …”
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The analysis of interactive furniture design system based on artificial intelligence by Xiaohong Jiang

“…The Kano model is used to evaluate the interactive features of the furniture. …”
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Quantifying Administrative and Functional Border Effects on Commuting and Non-Commuting Flows: A Case Study of the Shanghai-Suzhou-Jiaxing Area by Yige Li, Ying Jiang, Jin Duan

“…Both administrative and functional borders have significant effects on spatial interactions, but compared to commuting flows, non-commuting flows are more sensitive with functional borders. …”
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