Identification of dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4) as antagonist of NEK-Family... by Mubashir Aziz, Syeda Abida Ejaz, Pervaiz Ali Channar, Ali G. Alkhathami, Tahir Qadri, Zahid Hussain, Mumtaz Hussaain, Rabail Ujan

“…After, having the prognostic importance of These findings provided a rationale for synthesizing novel compound i.e., dimethyl 2,2’-((methylenebis(2-(2H-benzo[d][1,2,3]triazol-2-yl)-4-(2,4,4-trimethylpentan-2-yl)-6,1phenylene))bis(oxy))diacetate (TAJ4)), capable of effectively targeting these proteins using in-vitro cytotoxicity assays and comprehensive computational approaches. …”
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Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. More effective therapeutic strategies are needed not only to improve the survival of cancer patients but also to relieve cancer-related pain. …”
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Properties of the GSN 069 Accretion Disk from a Joint X-Ray and UV Spectral Analysis: Stress-testing Quasi-periodic Eruption Models by M. Guolo, A. Mummery, T. Wevers, M. Nicholl, S. Gezari, A. Ingram, D. R. Pasham

“…Incorporating relativistic effects via numerical ray tracing, we constrain the disk inclination angle ( i ) to be 30 ^∘  ≲  i  ≲ 65 ^∘ and identify a narrow region of spin–inclination parameter space that describes the observations. …”
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A state of the art review on geotechnical reinforcement with end life tires by M. Shariati, M. Afrazi, H. Kamyab, S. Rouhanifar, E. Toghroli, M. Safa, Sh. Chelliapan, H. Afrazi

“…The paper extensively analyzes the mechanical behavior of sand-rubber mixtures through laboratory investigations. …”
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Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve,... by Yahya S. Al-Awthan, Rashid Mir, Fuad A. Alatawi, Abdulaziz S. Alatawi, Fahad M. Almutairi, Tamer Khafaga, Wael M. Shohdi, Amal M. Fakhry, Basmah M. Alharbi

“…Additionally, metagenomic studies offer valuable insights into the composition and functional potential of soil microbial communities. Furthermore, analyzing the obtained data can improve agricultural restoration practices and aid in developing more effective environmental management strategies. …”
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Nasal pathobiont abundance is a moderate feedlot-dependent indicator of bovine respiratory disease in beef cattle by Ruth Eunice Centeno-Delphia, Natalie Glidden, Erica Long, Audrey Ellis, Sarah Hoffman, Kara Mosier, Noelmi Ulloa, Johnnie Junior Cheng, Josiah Levi Davidson, Suraj Mohan, Mohamed Kamel, Josh I. Szasz, Jon Schoonmaker, Jennifer Koziol, Jacquelyn P. Boerman, Aaron Ault, Mohit S. Verma, Timothy A. Johnson

“…Additionally, future research should consider bacterial-viral interactions in the beef nasal metagenome.…”
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Research Progress and Prospect of Multi-robot Collaborative SLAM in Complex Agricultural Scenarios by MA Nan, CAO Shanshan, BAI Tao, KONG Fantao, SUN Wei

“…Secondly, the combination of deep learning and reinforcement learning techniques is expected to empower robots to better interpret environmental patterns, adapt to dynamic changes, and make more effective real-time decisions. Thirdly, large language models will enhance human-robot interaction by enabling natural language commands, improving collaborative operations. …”
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Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis by Hanène Djeghim, Hanène Djeghim, Djamila Benouchenne, Djamila Benouchenne, El Hassen Mokrani, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

“…While 6-methyl octahydro-coumarin exhibited favorable docking scores, its lower effectiveness compared to Galantamine suggests that further optimization is required for enhanced efficacy. …”
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Water footprint management in textile industry through Acid Blue 113 remediation using halloysite nanoclay as a sustainable adsorbent by Mohammed A. H. Dhaif Allah, Syed Noeman Taqui, Usman Taqui Syed, Syida Aameera Yakuth, Razia Sulthana, Rayees Afzal Mir, Akheel Ahmed Syed, Shareefraza J. Ukkund, Majed Alsubih, Saiful Islam, Wahaj Ahmad Khan

“…A two-level fractional factorial experimental design (FFED) was employed to determine the factors influencing HNC’s adsorption capacity and evaluate the feasibility and effectiveness of the approach. The optimal values of the variables were determined using interaction factors derived from multiple regression studies based on FFED to maximize the second-order polynomial equation. …”
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Review of Research on Foundation Scour of River-Crossing Bridges by WANG Lu, LIU Hong-wei, WEI Kai, Bruce Melville, NIE Rui-hua

“…The former’s prediction accuracy is severely affected by scale effects, while the latter has limited applicability. …”
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Research on the micro-pore structure and multiscale fractal characteristics of shale under supercritical CO2 action: A case study of the Chang 73 submember in the Ordos Basin, Chin... by Lili Jiang, Leng Tian, Zhangxing Chen, Zechuan Wang, Wenkui Huang, Xiaolong Chai

“…Following ScCO2 treatment, the total specific surface area of shale samples decreases, whereas total pore volume, average pore diameter, and effective porosity increase. Specifically, total specific surface area and average pore diameter are more sensitive to temperature, while total pore volume and effective porosity are more influenced by pressure. …”
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Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…ObjectiveThis research mainly aims to identify the primary interactions between the factors influencing the carbon sink capacity of urban park green spaces and recognize the most effective landscape design strategies, thereby providing a foundational data set for the further development of a repository of lifecycle design strategies for urban green spaces. …”
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Trust, Trustworthiness, and the Future of Medical AI: Outcomes of an Interdisciplinary Expert Workshop by Melanie Goisauf, Mónica Cano Abadía, Kaya Akyüz, Maciej Bobowicz, Alena Buyx, Ilaria Colussi, Marie-Christine Fritzsche, Karim Lekadir, Pekka Marttinen, Michaela Th Mayrhofer, Janos Meszaros

“…Trust is dynamic, shaped by interactions among individuals, technologies, and institutions, and ultimately centers on people rather than tools alone. …”
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Rock breaking law of TBM hob assisted by low pressure abrasive air jet grooving by Hongtu ZHANG, Yaopu YANG, Yong LIU, Jianping WEI, Zhiping LI

“…Based on the comprehensive experimental platform of low-pressure abrasive air jet assisted hob rock breaking, the effects of different cutting depths on the stress and rock breaking of hob rock breaking tools are studied. …”
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Albiah Khoiruh Ummah Principles in Student Character Education at MAS Al Waslhiyah Stabat by Binasti Asti, Juliani Juliani

“…The study concludes that implementing the Albiah khoiruh ummah principle in educational settings can serve as an effective model for developing students with noble character. …”
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Detrimental impact on work productivity in patients with glaucoma: a systematic review by Hamza Inayat, Mura Abdul-Nabi, Bernice Leung, Jason Jiang, Sara Robertson, Monali S. Malvankar-Mehta

“…In addition to medical expenses, indirect costs encompass lost productivity and adverse effects on mental health and independence. Early glaucoma stages primarily manifest as peripheral vision loss, but as it progresses, it significantly impairs one's quality of life. …”
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Remote sensing techniques to assess badlands dynamics: insights from a systematic review by Rosa Colacicco, Marco La Salandra, Isabella Lapietra, Alberto Refice, Domenico Capolongo

“…Monitoring and analyzing badlands dynamics is crucial for understanding their downstream effects and mitigating natural and environmental hazards such as landslides, debris flows, piping and sediment delivery to rivers. …”
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Pulsed Laser Deposition Method Used to Grow SiC Nanostructure on Porous Silicon Substrate: Synthesis and Optical Investigation for UV-Vis Photodetector Fabrication by Reem Alzubaidi, Makram A. Fakhri, László Pohl

“…This hybrid material’s improved optoelectronic properties, achieved by combining the stability of SiC with the quantum confinement effects of P-Si, make it useful in advanced optoelectronic applications such as UV-Vis photodetectors.…”
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Mobile health in communication disorders: willingness to use, attitude, advantages, and challenges from the perspective of patients by Taleb Khodaveisi, Hamid Bouraghi, Soheila Saeedi, Marjan Ghazisaeedi, Mohammad-Sadegh Seifpanahi, Shokofeh Ahsanifar, Sara Vafaeeyan

“…Also, technological challenges, effectiveness and quality concerns, patient experience and engagement, and trust and confidence issues were mobile health challenges from the patients' point of view. …”
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Increasing prevalence of Diphyllobothrium cestodes in seals from the North and Baltic Sea over 26 years by Lotte Caecilia Striewe, Joy Ometere Boyi, Rémi Pigeault, Peter Wohlsein, Ursula Siebert, Kristina Lehnert

“…A generalized additive model (GAM) assessed host-related factors and longitudinal effects on cestode prevalence in harbor seals from the North Sea (n = 1,284). …”
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