Mechanism of DNASE1L3 delaying renal fibrosis by inhibiting PI3K-AKT signaling pathway by WEI Xiao, YU Hong, YUAN Yuan, KUANG Qihui, WANG Xiong, YANG Jun, LUO Pengcheng

“…GEO database combined with GO and KEGG pathway enrichment were used to analyze the possible interaction genes and functional analysis of DNASE1L3. …”
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Trends of Climate Extremes and Their Relationships with Tropical Ocean Temperatures in South America by Luiz Octávio Fabrício dos Santos, Nadja Gomes Machado, Carlos Alexandre Santos Querino, Marcelo Sacardi Biudes

“…Understanding these relationships is essential for developing effective adaptation and mitigation strategies in response to the increasing frequency and intensity of climate extremes.…”
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Intercellular Communication Network of CellChat Uncovers Mechanisms of Kidney Fibrosis Based on Single-Cell RNA Sequencing by Lei Lei, Yun-Xiu Xiang, Mao-Lin Luo, Ze-Yu Zhang, Hong-Wei Wu, Chun Tang, Tian-Jiao Cui, Xue-Mei Zhang, Xiao-Hua Wang, Denis Delic, Thomas Klein, Yvonne Liu, Bernhard K. Krämer, Zhi-Hua Zheng, Yong-Ping Lu, Berthold Hocher, Ting Zhu

“…This study aimed to investigate the effects of Empa on renal fibrosis in a nondiabetic CKD model and to elucidate the underlying mechanisms. …”
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Examining the relationship between consumer innovativeness and trust in chatbot applications: A study on Turkish banking sector by Sevda Deneçli, Öykü Ezgi Yıldız Balaban, Ceyda Deneçli Arıbakan

“…Businesses are using these technologies more and more every day to reach consumers who are constantly open to interaction thanks to technological tools. This is especially true in the service sector and e-commerce sites, where the effects of the digital transformation in banking are seen more clearly. …”
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Ecological population dynamics, host preferences, and associated parasitoids of Bactrocera carambolae and Bactrocera papayae on fruits by D. Koswanudin, H. Widyanto, D. Hutapea, Wawan , R. Yuniawati, V.N.O. Subagyo, S. Utami, I.M. Samudra, W. Darwiati

“…Understanding the species of fruit flies in fruit-growing regions is crucial for evaluating pest risk, establishing effective plant quarantine measures, and managing control programs. …”
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Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation by Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X

“…A PPI network and H-C-T-P network were constructed to analyze interactions among these targets. GO and KEGG enrichment analyses were performed using WebGestalt. …”
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Research review of digital modeling technologies with 3D spatial visualization for pipelines by Xin LIU, Shengwen TU, Yanfang HOU, Dong LIN, Jie SHU, Yu TANG

“…These visualization systems accurately reflect the spatial relationships of pipelines, providing effective guidance for selecting and planning pipeline routes, as well as for excavation during maintenance and rush repair. …”
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Mechanisms of improved nitrogen utilization and root architecture in cotton under reduced fertilization: a comparative study of individual and group planting systems by Sijia Wang, Sijia Wang, Jinghua Zhao, Jinghua Zhao, Chunxia Wang, Tingrui Yang, Tingrui Yang

“…Under China’s national policy of zero-growth in fertilizer application, it is critical to elucidate the spatial distribution patterns of cotton root systems under nitrogen reduction conditions, quantify the contributions of water and nitrogen inputs to total nitrogen accumulation in different cotton organs, and analyze water-nitrogen management interactions to enhance water and nitrogen use efficiency in cotton cropping systems.MethodsIn this study, three irrigation quotas (488 mm, 444 mm, and 400 mm are denoted as W1, W2, and W3) and four nitrogen fertilization levels (440 kg ha–1, 387 kg ha–1, 336 kg ha–1, and 294 kg ha–1, respectively) were implemented in 2023 through root box and field experiments to investigate root growth dynamics and nitrogen accumulation in cotton fields. …”
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Liquid–liquid–solid three-phase flow in horizontal wells: flow pattern modeling and dimensionless analysis by Hamed Nejati, Saeed Shad, Sasan Yousefirad, Aras Sheikhi

“…An accurate and reliable model to predict the flow regimes in these systems are yet to be developed due to the complexity and uncertainties associated with fluid interactions and their effects on transport of solid particles. …”
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Exposure to a mixture of arsenic species and growth indicators in 6–12-year-old children from the cycles 2007–2020 NHANES by Miguel García-Villarino, Rocío Fernández-Iglesias, Ana Victoria García, Elsa Villa-Fernández, Lucía Fernández-Arce, Isolina Riaño-Galán, Carmen Lambert, Vicente Martín, Margaret R. Karagas, Elías Delgado-Álvarez, Ana Fernández-Somoano, Antonio J. Signes-Pastor

“…Linear regression and BKMR models were applied to identify adverse effects, nonlinear associations, interactions, and combined effects. …”
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Beyond Cannabidiol: The Contribution of <i>Cannabis sativa</i> Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes by Marco Fumagalli, Giulia Martinelli, Giuseppe Paladino, Nora Rossini, Umberto Ciriello, Vincenzo Nicolaci, Nicole Maranta, Carola Pozzoli, Safwa Moheb El Haddad, Elisa Sonzogni, Mario Dell’Agli, Stefano Piazza, Enrico Sangiovanni

“…The aim of this study is to analyze the specific contributions of the main constituents of CSE to inflammatory responses in human keratinocytes by fractionating the extract and examining the effects of its individual components. …”
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Comparative evaluation of methods for isolating extracellular vesicles from ICC cell culture supernatants: Insights into proteomic and glycomic analysis by Linlin Wu, Jiao Wei, Yueping Zhan, Xiao Xiao, Xuewen Xu, Chenjun Huang, Tian Long, Yueyue Li, Bin Fu, Mengmeng Wang, Chunfang Gao

“…Intrahepatic cholangiocarcinoma (ICC) is a highly invasive malignancy marked by abnormal sialylated glycosylation. Analyzing proteins and glycans in EVs provides insights into ICC molecular subtyping and mechanisms. …”
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Evaluation of EMG patterns in children during assisted walking in the exoskeleton by Margherita Villani, Priscilla Avaltroni, Priscilla Avaltroni, Giulia Scordo, Giulia Scordo, Damiana Rubeca, Damiana Rubeca, Peter Kreynin, Ekaterina Bereziy, Denise Berger, Denise Berger, Germana Cappellini, Germana Cappellini, Francesca Sylos-Labini, Francesca Sylos-Labini, Francesco Lacquaniti, Francesco Lacquaniti, Yury Ivanenko

“…To this end, we assessed the effects of a robotic exoskeleton (ExoAtlet Bambini) on gait performance, by recording electromyographic activity of leg muscles and analyzing the corresponding spinal motor pool output. …”
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Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer by Zongming Dong, Xiaosa Chang, Xing Luo, Hui Li, Ming Deng, Zeyu Huang, Tingting Chen, Yu Chen, Bishao Sun, Yingbing Wu, Ronghua Wu, Qingjian Wu, Jingzhen Zhu, Ji Zheng

“…Targets of CH and PCa-related genes were identified using different databases, and the biological processes through which CH might exert its therapeutic effects were predicted via protein–protein interaction (PPI) network and enrichment analyses. …”
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<i>Achnatherum inebrians</i> Bacterial Communities Associated with <i>Epichloë gansuensis</i> Endophyte Infection Under Low-Concentration Urea Treatment: Links to Plant Growth and... by Yuanyuan Jin, Zhenjiang Chen, Kamran Malik, Chunjie Li

“…These findings provide valuable insights into the knowledge of the effects of the symbiotic relationship between host plants and <i>Epichloë</i> endophyte on interspecific interactions of plant microbiome, beneficial for harnessing endophytic symbiosis, promoting plant growth.…”
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A one health study on phylogenetics and risk of pathogenic intestinal parasites at a ranch in Inner Mongolia by Ziran Mo, Jingwei Quan, Bin Xu, Huixia Yu, Junyan Li, Xiaoping Luo, Qimuge Wuyun, Jian Li, Wenbin Yang, Wei Hu

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Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Traditional control methods often fail to address these underlying processes, necessitating a deeper understanding of clogging mechanisms and effective mitigation strategies. Significance: This study provides an in-depth analysis combining a review of existing literature and experimental insights into the role of microbial communities in clogging formation and the effectiveness of aged refuse layers as a mitigation measure.To provide a comprehensive assessment, a life cycle assessment (LCA) framework is employed to analyze the environmental impacts of various clogging control methods.This study contributes to theoretical advancements by integrating a comprehensive review of LCA frameworks in the context of landfill management, addressing a gap in current literature. …”
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Therapeutic role of aripiprazole in cartilage defects explored through a drug repurposing approach by Jun-Ku Lee, Hyunjeong Yeo, Sujin Choi, Kyeong Mi Kim, Hannah Kim, Sung-Sahn Lee, Hyun Il Lee, Younghoon Jeong, Hyun-Ju An, Soonchul Lee

“…Furthermore, aripiprazole effectively enhanced cartilage regeneration in the rat model. …”
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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…Cox regression was used to analyze clinical outcomes, and multivariable fractional polynomial interaction analysis to examine the effects of sacubitril‐valsartan, according to PNI. …”
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Random forest algorithm integrated with an initial basic feasible solution in buckling analysis of a two-dimensional functionally graded porous taper beam by Ravikiran Chinthalapudi, Jagadesh Kumar Jatavallabhula, Geetha Narayanan Kannaiyan, Bridjesh Pappula, Seshibe Makgato

“…Porosity is included by a porosity index, and the tapering effects are captured using linear thickness and width ratios. …”
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