Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction by Junrui Xu, Ussama Sadiq, Wangruizhi Zhao, Hengbo Xia, Yiwei Liu, Renquan Zhang, Aman Xu

“…Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.MethodsWe employed single-cell RNA sequencing to analyze the tumor heterogeneity and microenvironmental landscape in patients with AEGJ liver metastases. …”
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Clinical metagenomics analysis of bacterial and fungal microbiota from sputum of patients suspected with tuberculosis infection based on nanopore sequencing by Pawarisa Terbtothakun, Suthida Visedthorn, Pavit Klomkliew, Prangwalai Chanchaem, Vorthon Sawaswong, Pavaret Sivapornnukul, Samitanan Sunantawanit, Ariya Khamwut, Suwatchareeporn Rotcheewaphan, Pornchai Kaewsapsak, Sunchai Payungporn

“…Abstract Tuberculosis (TB) remains a significant global health challenge, demanding rapid and comprehensive diagnostics for effective treatment. Secondary infections further complicate TB infection, worsening outcomes. …”
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Transformation of Industry Management in the Rocket and Space Industry Based on Digital Technologies by Vasily Kupriyanovsky, Roman Stupin, Vladimir Sukhomlin, Konstantin Utolin

“…As predictive condition of effective digitalization of the main, the administrative and supporting processes at the enterprises carrying out actions for transformation of system of sectoral management is considered: implementations of flexible forms of project management, forming of array structures, and development of technology cooperation and improvement of formats of interaction of the state, business and citizens. …”
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Associations between childhood maltreatment and personality traits in individuals with and without depression: a CTQ-based assessment by Yilin Peng, Shazia Rehman, Jin Liu, Yumeng Ju, Mi Wang, Jinrong Sun, Xiaowen Lu, Qiangli Dong, Liang Zhang, Mei Liao, Ping Wan, Hua Guo, Futao Zhao, Bangshan Liu, Yan Zhang, Lingjiang Li

“…Results The 2*2 ANCOVA results indicated significant interaction effects between CM and diagnosis on personality traits, with CM’s impact notably different between groups. …”
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MALDI-TOF Mass Spectrometry as the Tool for the Identification of Features of Polymers Obtained by Inverse Vulcanization by Natalia Tarasova, Efrem Krivoborodov, Diana Kirakosian, Alexey Zanin, Ilya Toropygin, Yaroslav Mezhuev

“…The MALDI-TOF mass-spectrometry was employed to analyze the structure of the reaction products of limonene, a natural terpene, and elemental sulfur, with the objective of identifying the occurrence of side processes, such as oxidative dehydrogenation, aromatization, and the Diels–Alder reaction cascade. …”
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The Role of the Electronic Service Desk in Enhancing Structural Capital at Tehran University of Medical Sciences During the COVID-19 Pandemic by Maryam Goodarzi, Mashallah Torabi, Maryam Ahmadi, Hamideh Hamidi, Samira Elmi, Reyhaneh Sadat Karimi, Fatemeh Golmahi, Samira Mortezaie, Parisa Nezari

“…Other significant effects included easier user access, the ability to refer documents to other departments or organizations, improved resolution of requests during initial user contact, and enhanced interactions with clients. …”
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Insights into intestinal barrier disruption during long-term gut Chlamydia colonization in mice: a single-cell transcriptomic approach by Ziqing Wan, Yicun Jiang, Sheng Xie, Jiao Wan, Youyou Huang, Luying Wang, Qi Zhang, Zengzi Zhou, Xin Sun, Chuqiang Shu, Chuqiang Shu, Tianyuan Zhang, Tianyuan Zhang, Qi Tian, Qi Tian

“…However, the mechanisms enabling its persistence in the gut remain poorly understood, hindering the development of effective treatments for chronic infections.MethodsWe employed single-cell RNA sequencing (scRNA-seq) to analyze gene expression profiles and cellular heterogeneity in mouse colonic tissues during Chlamydia long-term colonization to characterize transcriptional changes and intercellular interactions critical for bacterial persistence.ResultsOur analysis revealed significant alterations in gene expression across intestinal cell populations, with distinct molecular pathways implicated in Chlamydia persistence. …”
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Comprehensive Search for Genes Involved in Thalidomide Teratogenicity Using Early Differentiation Models of Human Induced Pluripotent Stem Cells: Potential Applications in Reproduc... by Yu Kato, Takeshi Inaba, Koudai Shinke, Noriko Hiramatsu, Tetsuhiro Horie, Takuya Sakamoto, Yuko Hata, Eiji Sugihara, Tetsuya Takimoto, Noriaki Nagai, Yasuhito Ishigaki, Hajime Kojima, Osamu Nagano, Naoki Yamamoto, Hideyuki Saya

“…These genes were implicated in pathways related to tissue development, cell growth, and molecular interactions. While the assay effectively detected VPA and Thalido, its limitations include testing only soluble substances and focusing on early differentiation stages. …”
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Productivity drivers of winter crop production in Australia: Examining both long-run and short-run impacts by Jaba Sarker, John Rolfe, Monira Parvin Moon, Farhana Arefeen Mila, Siddhartha Shankar Roy, Delwar Akbar

“…Importantly, the varying short-run (immediate responses to changes in variables) effects underline the complexity of interactions between the crop yield and productivity drivers. …”
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Vegetation Greening Promoted the Precipitation Recycling Process in Xinjiang by Xuewei Li, Xingming Hao, Sen Zhang, Guanyu Hou, Jingjing Zhang, Xue Fan, Zhuoyi Zhao

“…Under the combined influences of climate and vegetation change, land–atmosphere interactions have enhanced, and precipitation recycling is an important part of this. …”
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Studying the impact of probiotic agents on the pathogenetic and clinical features of generalized periodontitis by M. A. Luchynskyi, O. O. Pompii, A. P. Oshurko, E. S. Pompii

“…The aim of this study is to examine the influence of various probiotic agents on the pathogenetic and clinical characteristics, treatment effectiveness of generalized periodontitis in adult patients by analyzing professional scientific literature. …”
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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient. …”
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Hierarchical Modeling for Medical Visual Question Answering with Cross-Attention Fusion by Junkai Zhang, Bin Li, Shoujun Zhou

“…The framework also incorporates a cross-attention fusion module where images serve as queries and text as key-value pairs. This approach effectively avoids the irrelevant signals introduced by global interactions while achieving lower computational complexity compared to global self-attention fusion modules. …”
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Peperomia Pellucida (L.) Kunth: A Decade of Ethnopharmacological, Phytochemical, and Pharmacological Insights (2014–2025) by Teodhora, Hendriani R, Sumiwi SA, Levita J

“…It was reported in vitro studies that the extracts and essential oils of this plant exerted their pharmacological effects through multiple pathways, such as inhibiting COX, NF-κB, and NOS, and scavenging free radicals, which are driven by terpenoids, phenolics, and flavonoids. …”
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THEORETICAL AND METHODOLOGICAL PECULIARITIES OF THE DEVELOPMENT PROCESS OF DYNAMIC COMPETITIVE STRATEGIES FOR BAKERY ENTERPRISES by Д. В. Завертаний

“…Thus, the strategic process of baking plants cannot be considered without defining the strategy concept, as well as without analyzing the types of strategic processes. The key to the effectiveness of the strategic process is the interaction of internal and external environments, which in turn include operational and intelligence processes.…”
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Distribution and Influences on Butterfly Diversity in Urban Park Green Spaces: A Case Study of Harbin, China by Kai Wang, Yuxin Qi, Yuandong Hu, Dan Han

“…This study focuses on the effects of spatial heterogeneity in the surrounding matrix and its interaction with park resources on butterfly diversity in urban parks. …”
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Association of quality antenatal care and completion of eight or more antenatal care visits with skilled delivery care utilization among pregnant women in Bangladesh: A nationwide... by Md Obaidur Rahman, Md Abdur Rauf, Yunefit Ulfa, Md Nure Alam Siddiqi, Md Rafiqul Islam, Kimiko Inaoka, Reiko Miyahara, Daisuke Yoneoka, Erika Ota

“…<h4>Introduction</h4>Provision of quality antenatal care (QANC) services and delivery care by skilled health professionals can effectively reduce and manage complications throughout pregnancy and childbirth, leading to better maternal and neonatal health outcomes. …”
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Social isolation among indigenous college students in Peru: the role of language, culture, and acculturation by Margit Julia Guerra Ayala, Carlos Antonio Valdivia Laura, Hania Nancy Bernedo Perez, Apolinar Florez Lucana, Rildo Raul Tapia Condori, Emma Lourdes Durand-Gómez

“…Results indicated that Spanish L2 proficiency strongly predicted social isolation, explaining 82.3% of the variance independently and 85.6% when combined with psychological acculturation. Interaction effects between gender, cultural background, and academic performance were not significant. …”
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Greenness, blueness, and whiteness evaluation of a quantitative nuclear magnetic resonance procedure for concurrent assay of aspirin and omeprazole in their single and fixed-dose c... by Amal A. El-Masry, Abdallah M. Zeid, Nora A. Abdallah

“…This work enables clinicians to simultaneously monitor aspirin and omeprazole levels in both single and fixed-dose combination tablets, ensuring precise dosing and effective treatment management. For patients, it supports safer therapy by reducing the risks associated with improper dosing or drug interactions in combination therapies. …”
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When do employees feel isolated when working from home? Longitudinal trajectories, antecedents and outcomes of workplace isolation during the COVID-19 pandemic by Ilona Efimov, Annika Krick, Volker Harth, Jörg Felfe, Stefanie Mache

“…Based on job demands-resources and conservation-of-resources theories, this study aims to analyze workplace isolation of employees WFH in relation to their WFH intensity.MethodsThis study examined the change in workplace isolation and WFH intensity over 5 measurement points of 512 employees using multilevel growth curve analysis (GCA), identified groups of participants with distinct trajectories of workplace isolation and WFH intensity using latent profile analysis (LPA), and investigated antecedents and consequences of profile membership.ResultsGCA indicated an overall negative linear and quadratic relationship between time and workplace isolation, as well as interaction effects between time and WFH intensity on workplace isolation. …”
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