Machine learning-driven multi-targeted drug discovery in colon cancer using biomarker signatures by Tingting Liu, Lifan Zhong, Xizhe Sun, Zhijiang He, Witiao Lv, Liyun Deng, Yanfei Chen

“…The model predicts toxicity risks, metabolism pathways, and drug efficacy profiles, ensuring safer and more effective treatments. The artificial intelligence model personalizes therapy by leveraging patient-specific molecular profiles, optimizing drug selection and dosage while minimizing side effects. …”
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Examining The Impact of Various Factors on Working From Home by Muhammad Fajar Nugroho

“…By utilizing the structural equation modeling method with the partial least squares (PLS) technique, this study aims to analyze the relationships between these variables and their effects on WFH implementation. …”
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A real-time framework for opinion spam detection in Arabic social networks by Cherry A. Ezzat, Abdullah M. Alkadri, Abeer Elkorany

“…This paper proposes a framework for Real-Time Arabic Opinion Spam Detection (RTAOSD) that was developed to effectively detect opinion spam within Arabic social networks. …”
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Identification of Potential Hub Proteins as Theragnostic Targets in Hepatocellular Carcinoma through Comprehensive Quantitative Tissue Proteomics Analysis by Quratul Abedin, Kulsoom Bibi, Alex von Kriegsheim, Zehra Hashim, Amber Ilyas

“…Early stage diagnosis is still challenging due to its asymptomatic behavior so there is an urgent need for effective biomarkers. This study aimed to identify effective diagnostic biomarker or therapeutic target for HCC. …”
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Hybrid Multi-Attention Network for Audio–Visual Emotion Recognition Through Multimodal Feature Fusion by Sathishkumar Moorthy, Yeon-Kug Moon

“…Despite making this assumption, it is not uncommon to see non-complementary relationships arise in real-world data, reducing the effectiveness of feature integration that assumes consistent complementarity. …”
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Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective by Yuzhou Huang, Yuzhou Huang, Baichun Hu, Haihan Liu, Jian Wang, Na Duan

“…Studying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo. CDC-like kinase isoforms (CLKs) are serine/threonine protein kinases that are involved in the phosphorylation of mRNA spliceosomes leading to the regulation of gene expression. …”
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Synthesis of Novel Benzothiazole–Profen Hybrid Amides as Potential NSAID Candidates by Iliyan Ivanov, Stanimir Manolov, Dimitar Bojilov, Yordan Stremski, Gabriel Marc, Stela Statkova-Abeghe, Smaranda Oniga, Ovidiu Oniga, Paraskev Nedialkov

“…To understand their binding affinity, molecular docking studies were perfsormed to analyze interactions with human serum albumin (HSA). …”
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Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics by Jiaqian Si, Jie Wang, Hao Dai, Tuochen Lv, Songyun Zhao, Wanying Chen, Liqun Li, Siqi Ding, Yucang He

“…Adipose-derived stem cells (ADSCs) and their exosomes (ADSCs-exosomes) are emerging as a breakthrough therapeutic strategy to reverse IRI, owing to their multi-target synergistic effects. This review systematically analyzes the two major repair modes of ADSCs and ADSCs-exosomes: the “common protection” mechanism, which includes anti-inflammatory, anti-oxidative, and anti-apoptotic effects through paracrine regulation of miRNAs targeting the NF-κB/NRF2/β-catenin signaling axis; and precision repair, which is achieved through organ-specific targets, including hepatic mitochondrial dynamics and pyroptosis inhibition, cardiac macrophage polarization and neutrophil clearance, renal anti-fibrosis and erythropoietin (EPO) activation, as well as brain iron death regulation and microglial remodeling. …”
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Public procurement planning as an immunity to the budget process by V. V. Kikavets, Yu. K. Tsaregradskaya

“…The crisis obliges the government of any country to promptly analyze and rebuild the regulatory framework for effective financial, economic, social and political management. …”
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DUAL EDUCATION AS A MEAN OF ENSURING PROPER QUALITY OF PROFESSIONAL TRAINING OF MATHEMATICS TEACHERS IN MODERN UKRAINE by Микола Працьовитий, Оксана Требенко, Олександр Школьний, Яніна Гончаренко

“…To achieve the goal of the work, we use the theoretical method of analyzing methodological literature on the researched problem. …”
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A Computational Analysis Based on Automatic Digitization of Movement Tracks Reveals the Altered Diurnal Behavior of the Western Flower Thrips, <i>Frankliniella occidentalis</i>, Su... by Chunlei Xia, Gahyeon Jin, Falguni Khan, Hye-Won Kim, Yong-Hyeok Jang, Nam Jung, Yonggyun Kim, Tae-Soo Chon

“…The RNAi treatment caused adverse effects on early-life development and adult fecundity. …”
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Applying affect coding and dynamical systems mathematical modeling to understanding the role of emotional expression on the therapeutic relationship across an entire course of subs... by Gina Cipriano, Paul R. Peluso, Emma Bright, Blanka Hutarkova

“…The findings aim to improve therapeutic outcomes by providing a deeper understanding of these emotional interactions, ultimately contributing to more effective substance abuse interventions.MethodThis study utilized the APA-produced DVD series Psychotherapy Over Time, featuring Dr. …”
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Study of mineralogical, chemical and geotechnical properties of the historic materials for restoration of the Kutubiyya Mosque by Abdelmalek Ammari, Samir Ait Oumghar, Mounsif Ibnoussina, Jamal Mounaji, Mohsine Ziani

“…Given that the renovation of facade and interior plasters is among the most common tasks in restoration projects, it is crucial to analyze the composition of stones and plasters to ensure the compatibility of materials and their effective interaction with the substrate. …”
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Influence of Free Surface on the Hydrodynamic and Acoustic Characteristics of a Highly Skewed Propeller by Duo Yu, Youbin Yu, Suoxian Yang

“…The open-water performance and noise calculations of the propeller are verified through experiments, and the effects of different immersion depths and advance coefficients on the propeller are explored. …”
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Informative architectures and citizen participation: a comparative study between the digital platforms Decidim and Rousseauv by Eli Borges Junior, Bruno Madureira Ferreira

“…This was accomplished by analyzing two aspects of the platform: 1) the conception and development of codes; 2) the functions that the platform offers and its interaction with users. …”
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Modeling and Characterization of the Uplink and Downlink Exposure in Wireless Networks by Anis Krayni, Abdelhamid Hadjem, Günter Vermeeren, Alain Sibille, Christophe Roblin, Wout Joseph, Luc Martens, Joe Wiart

“…The exposure assessment as well as the human-wave interactions has been simulated using the finite difference in time domain method (FDTD). …”
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Research on Plant Disease and Pest Diagnosis Model Based on Generalized Stochastic Petri Net by Wenxue Ran, Qilian Tang

“…The simulation results show that different combinations of infection rates have a significant impact on the probability of meeting treatment standards, with the combination of moderate and severe infection rates having the greatest impact on the probability of meeting treatment standards, while the impact of mild infection rates is relatively small. By comprehensively analyzing the interaction between mild, moderate, and severe infection rates, the critical zone surface under different disease and pest warning thresholds was obtained. …”
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COMMUNICATIVE ADAPTATION OF UKRAINIANS, WHO FLED THE WAR, TO THE LIFE IN THE UK by Svitlana Babushko, Maiia Halytska

“…The findings provide practical recommendations for improving ESL (English as a Second Language) programs for Ukrainian refugees in the UK, ensuring more effective integration into British society.…”

Green Synthesis of Polyesters Using Surfactant Catalysts in Microemulsions: The Role of Micelle Shape and Aggregation on Polymer Formation by Vadilson Malaquias dos Santos, Fabricio Uliana, Rayanne Penha Wandenkolken Lima, Eloi Alves da Silva Filho

“… In this study, we explored traditional methods commonly found in the literature to analyze how surfactants and polymers interact during the synthesis of polyesters in emulsion systems. …”
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eHealth Literacy and Cyberchondria Severity Among Undergraduate Students: Mixed Methods Study by Wan -Chen Hsu

“…Future research should examine how college students move from self-awareness to actionable change and the development of critical health literacy, which are essential for effective digital health engagement.…”
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