Exploring the therapeutic potential of marjoram (Origanum majorana L.) in polycystic ovary syndrome: insights from serum metabolomics, network pharmacology and experimental validat... by Aliaa M. Elfiky, Reham S. Ibrahim, Amira R. Khattab, Mai O. Kadry, Naglaa M. Ammar, Eman Shawky

“…Marjoram’s therapeutic effects were evaluated by analyzing oxidative stress biomarkers, hormone levels, and ovarian histopathology. …”
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Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore by Bolun Zhao, Fazhan Ban, Yuehua Li, Qiong Shi, Sen Guo, Xiuli Yi, Huina Wang, Tianwen Gao, Chunying Li, Guannan Zhu

“…Furthermore, we demonstrated that the oxidative damage mediated by TXNIP involved its interaction with thioredoxin 2 (TRX2). In conclusion, targeting mitochondrial function with disulfiram effectively inhibits BRAFi-resistant melanoma cells, independent of MAPK signaling blockage. …”
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Impact of Plateau Grassland Degradation on Ecological Suitability: Revealing Degradation Mechanisms and Dividing Potential Suitable Areas with Multi Criteria Models by Yi Chai, Lin Xu, Yong Xu, Kun Yang, Rao Zhu, Rui Zhang, Xiaxing Li

“…Our findings reveal that while grasslands exhibit superior carbon sink potential relative to forests, their productivity and ecological functionality are undergoing considerable declines due to the compounded effects of multiple interacting factors. Consequently, the spatial distribution of ecologically suitable zones has contracted significantly, with the remaining high-suitability regions concentrating in the “twin-star” zones of Baingoin and Zanda grasslands, areas recognized as focal points for future ecosystem preservation. …”
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Ischemic Postconditioning Regulates New Cell Death Mechanisms in Stroke: Disulfidptosis by Shanpeng Liu, Qike Wu, Can Xu, Liping Wang, Jialing Wang, Cuiying Liu, Heng Zhao

“…Background and Objective: Stroke poses a critical health issue without effective neuroprotection. We explore ischemic postconditioning’s (IPostC) potential to mitigate stroke-induced brain injury, focusing on its interaction with disulfidptosis, a novel cell death pathway marked by protein disulfide accumulation. …”
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MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma. by Yin-Hung Chu, Ming-Ju Hsieh, Hui-Ling Chiou, Yi-Sheng Liou, Chen-Chieh Yang, Shun-Fa Yang, Wu-Hsien Kuo

“…In addition, when combined with environmental risk factors, such as smoking and alcohol consumption, interaction effects were observed between gene polymorphisms and environmental factors (odds ratio [OR] = 4.69, 95% CI = 2.52-8.70; AOR = 3.38, 95% CI = 1.68-6.80).…”
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Potential Resistance Mechanisms Exhibited by Cystic Fibrosis Patients Against SARS-CoV-2 by Yasmin K. Elsharabassi, Nuha T. Swaidan, Mohamed M. Emara

“…The potential resistance mechanisms include blood and extracellular ATP levels, a deleted/dysfunctional CFTR gene, ACE and ACE2 regulation and expression, ACE and ACE2 polymorphism effects, host proteins and SARS-CoV-2 interactions, and SMN1 and ACE/ACE2 interactions. …”
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Shifting perspectives: exploring land tenure transformation through six community-based solar energy projects in the global south (Ethiopia, Uganda, Kenya, Namibia, Indonesia, and... by Bouchra El Houda Lamhamedi, Walter Timo de Vries

“…Conclusions The results highlight the need for a comprehensive understanding of the interactions between land tenure and renewable energy initiatives to foster effective rural development. …”
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Identification and management of key influencing factors in China’s pig supply chain from the perspective of resilience and sustainability synergy by Wendi Wang, Shanshan Wang, Dongshi Sun, Yadan Zhao

“…Moreover, this paper analyzes the relationships and constraints between influencing factors. …”
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FORMING A POSITIVE IMAGE OF A SCIENTIFIC INSTITUTION IN THE SOCIAL ENVIRONMENT by R. M. Kachalov, Y. A. Sleptsova, A. R. Klimanova

“…The ways are identified to attract attention of the target audience, as well as the principles of interaction with other research organizations and potential consumers of research results. …”
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Using social-network analysis to map institutional actors’ links with vulnerable municipalities under climate change in Honduras’ dry corridor. Pathways towards improved cooperatio... by Carlos Eduardo Gonzalez-Rodriguez, Irma Ayes-Rivera, Jean-Francois Le Coq, Rafael Renteria-Ramos, Johana Marcela Castillo-Rivera

“…Nearly half of the Honduran population depends on socio-economic activities linked to agriculture, making climate-change adaptation crucial for the agricultural sector to ensure food and nutrition security. This research analyzes how institutional structures function and interact as a network to investigate the spatial coherence and relevance of public- and private-sector interventions related to agriculture, climate change, and food security in 153 municipalities of Honduras’ dry corridor. …”
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Detection of Immunochemical Reactions Using Piezoquartz Immunosensor. Regeneration of the Electrode Bio-layer (Review) by S. S. Gogina, E. A. Smirnova, Ya. M. Stanishevskii, A. M. Stoinova

“…Particular attention is directed toward the challenge of regenerating the biosensor surface as a key aspect ensuring their effective operation and the potential for multiple uses. …”
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Optimization Study on Stakeholder Capability Configuration in Green Construction by Zhizhe Zheng, Yikun Su, Junhao Liu, Zhichao Zhou, Xing Wang

“…By analyzing the optimal capability configuration and coordination levels of regulators and executors according to the practices and constraints of green construction, this study conducted a static analysis to compare the effects of marginal value on regulators’ capability input and coordination coefficients. …”
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Introduction of LPIN1 as a potential diagnostic and prognostic biomarker for gastric cancer via integrative bioinformatics analysis of a competing endogenous RNA network and experi... by Milad Daneshmand-Parsa, Parvaneh Nikpour

“…Objective(s): Identification of effective biomarkers is crucial for the heterogeneous disease of gastric cancer (GC). …”
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India’s Vaccine Diplomacy and Global Health Governance: A Soft Power Approach in the Context of Public Policy and Religious Values by Joyprokash Mondal

“…Thus, this study contributes to understanding how religion and public policy can collaborate effectively in addressing global health challenges.…”
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Identification of glycoside hydrolase CAZymes in rhizospheric soil microbiome of the wild plant species Moringa oleifera by Mohammed Y Refai

“…In turn, plant-exuded glucose acts as a chemoattractant for beneficial bacteria, particularly Bacillus subtilis , fostering plant-microbe interactions essential for soil health and plant growth. …”
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Associations between asthma and Life’s Essential 8: a cross-sectional study by Jiao Xu, Jianlei Tang

“…Subgroup analysis showed no significant interaction effects (p > 0.05), except in the sex and drinking status subgroups (p for interaction = 0.02).ConclusionAsthma is associated with components of LE8, which warrants further attention and may contribute to reducing asthma prevalence.…”
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Social Contact Structures and Time Use Patterns in the Manicaland Province of Zimbabwe. by Alessia Melegaro, Emanuele Del Fava, Piero Poletti, Stefano Merler, Constance Nyamukapa, John Williams, Simon Gregson, Piero Manfredi

“…<h4>Conclusions</h4>With the current work, we have gathered data and information on the ways through which individuals in SSA interact, and on the factors that mostly facilitate this interaction. …”
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PEER TUTORING IN LEARNING A FOREIGN LANGUAGE AS A NON-MAJOR by E. A. Makarova

“…Peer tutoring is a form of collaborative learning based on the models of student interactions organized in pairs or groups with shared roles «peer tutor- tutee».The aim of the study is to analyze effective models of peer tutoring used abroad, to develop alternate models and apply them while teaching reading and translation at foreign language lessons in non-linguistic university.Methodology and research methods. …”
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C-terminal Substitution for Enhanced Catalytic Activity of Phenolic Acid Decarboxylase from Bacillus subtilis J6 and Its Molecular Dynamics Simulation by CHEN Yinzhu, LI Qin, HU Kaidi, LI Jianlong, ZHAO Ning, GOU Liangxun, LIU Shuliang

“…Homology modeling, molecular docking, and molecular dynamics simulation were employed to analyze the interactions between the enzyme and its substrates. …”
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Modelling inter-relationships of barriers to smart construction implementation by Beiyu You, Zhengyi Chen, Yulu Xue, Yanbo Zhang, Keyu Chen

“…Its progression is subject to a myriad of adoption barriers, and the complex dynamics of their interactions remain insufficiently understood. Therefore, this study aims to (1) explore the barriers to the adoption of smart construction; (2) analyze the impact level of each barrier; and the interaction mechanism between the barriers (3) propose effective strategies to promote the development of smart construction. …”
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