Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Notably, JSS1_004 exhibits pleiotropic effects on host physiology, including repressing the dndBCDE-FGH operon confirmed by transcriptome. …”
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Development and comparison of empirical models for all-sky downward longwave radiation estimation at the ocean surface using long-term observations by J. Peng, J. Peng, J. Peng, J. Peng, B. Jiang, B. Jiang, H. Liang, H. Liang, S. Li, S. Li, J. Han, J. Han, T. C. Ingalls, T. C. Ingalls, J. Cheng, J. Cheng, Y. Yao, Y. Yao, K. Jia, K. Jia, X. Zhang, X. Zhang

“…The validation results showed that the accuracy of the newly constructed model is superior to that of other models, yielding overall root mean square error (RMSE) values of 13.44 and 8.34 W m<span class="inline-formula">⁻²</span> under clear-sky conditions and 15.64 and 10.27 W m<span class="inline-formula">⁻²</span> under all-sky conditions at hourly and daily scales, respectively. Our analysis indicates that the effects of the total column cloud liquid and ice water on the ocean-surface <span class="inline-formula"><i>R</i>_l</span> also need to be considered in addition to cloud cover. …”
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Numerical Investigation of Large Wood Evolution Characteristics Transported by Flash Floods by SONG Siyuan, FEI Gaogao, WANG Xiekang

“…Each piece of large wood is constructed from multiple rigidly connected discrete particles, providing better collision calculation effects and flexibility. The two-way coupling algorithm can reflect the influence of large wood on water flow, thereby allowing the analysis of backwater rise problems caused by logjams. …”
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Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice by Qing‐Bo Lu, He‐Ting Sun, Kuo Zhou, Jia‐Bao Su, Xin‐Yu Meng, Guo Chen, Ao‐Yuan Zhang, An‐Jing Xu, Chen‐Yang Zhao, Yuan Zhang, Yao Wang, Hong‐Bo Qiu, Zhuo‐Lin Lv, Zheng‐Yang Bao, Jian Zhu, Feng Xiao, Xue‐Xue Zhu, Hai‐Jian Sun

“…Furthermore, RNA sequencing and functional analysis showed that Decr1 interacted with and upregulated pyruvate dehydrogenase kinase 4 (PDK4) in injured cardiomyocytes, and overexpression of PDK4 eliminated the benefits of Decr1 downregulation in DCM (−20% for EF, p = 0.0071; −28% for FS, p = 0.0022). …”
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Indo-Pacific Role in Iran’s East Look Strategy by Mohammad Reza Mohammadi

“…As bearers of one of Asia’s richest cultural and civilizational heritages, Iranians have long associated their identity with historical ties to the East, resulting in centuries of cultural interaction and trade with other Eastern nations. …”
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Concurrent Adaptive Control for a Robotic Leg Prosthesis via a Neuromuscular-Force-Based Impedance Method and Human-in-the-Loop Optimization by Ming Pi

“…The cost function was combined with the interaction force and tracking errors of the joints. …”
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Climate Change and Outdoor Workers: A Narrative Review by Mehdi Asghari, Mohammad Javad Ghanadzadeh, Razieh Soltani Gerdfaramarzi

“…To evaluate the vulnerability of workers' health to climate change, three key factors are  taken into account: sensitivity (the level of physical and inherent vulnerability to climate  change effects), exposure (the extent and intensity of climate change-relate interactions ), and adaptive capacity (the ability of the system to cope with and recover from the effects of climate change). …”
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p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer by Junjing Zhang, Tongguan Tian, Xinxing Li, Kai Xu, Yao Lu, Xia Li, Xinyu Zhao, Ziyi Cui, Zhenxiang Wang, Yuefan Zhou, Yixin Xu, Hongchen Li, Yan Zhang, Yu Du, Lei Lv, Yanping Xu

“…Immunohistochemistry (IHC) analysis was used to inveatigate the pathological correlation in human gastric cancer. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…The “simple” act of one party paying for health care creates interactions between the payer, the provider, and the patient. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…The “simple” act of one party paying for health care creates interactions between the payer, the provider, and the patient. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…By connecting the drastic environmental effects at the basin level with human behavioral responses at the settlement level, the research visually demonstrates how hydropower projects trigger residential space reconstruction through land resource constraints. …”
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RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer by Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei

“…Mechanistically, we found that RNF31 interacts with and ubiquitinates ALYREF, which facilitates ALYREF nuclear transportation via importin 13 (IPO13) under paclitaxel treatment. …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…The first treats them as medical devices warranting standard risk-benefit analysis, assessing safety, efficacy, and clinical outcomes.[2] The second framework situates BCIs within the emerging field of neuroethics, emphasizing concerns about privacy, cognitive liberty, data security, and the potential for manipulation.[3] Although previous work has already emphasized the ethical importance of BCIs in restoring communicative capacities, this paper develops the claim further by foregrounding what may be termed the ethical function of BCIs.[4] Their significance lies not just in enhancing particular interactions or reducing barriers, but in re-establishing the very possibility of communication, through which individuals assert their will, can participate in community, and be recognized as interlocutors. …”
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Interpretable machine learning approach for electron antineutrino selection in a large liquid scintillator detector by A. Gavrikov, V. Cerrone, A. Serafini, R. Brugnera, A. Garfagnini, M. Grassi, B. Jelmini, L. Lastrucci, S. Aiello, G. Andronico, V. Antonelli, A. Barresi, D. Basilico, M. Beretta, A. Bergnoli, M. Borghesi, A. Brigatti, R. Bruno, A. Budano, B. Caccianiga, A. Cammi, R. Caruso, D. Chiesa, C. Clementi, S. Dusini, A. Fabbri, G. Felici, F. Ferraro, M.G. Giammarchi, N. Giudice, R.M. Guizzetti, N. Guardone, C. Landini, I. Lippi, S. Loffredo, L. Loi, P. Lombardi, C. Lombardo, F. Mantovani, S.M. Mari, A. Martini, L. Miramonti, M. Montuschi, M. Nastasi, D. Orestano, F. Ortica, A. Paoloni, E. Percalli, F. Petrucci, E. Previtali, G. Ranucci, A.C. Re, M. Redchuck, B. Ricci, A. Romani, P. Saggese, G. Sava, C. Sirignano, M. Sisti, L. Stanco, E. Stanescu Farilla, V. Strati, M.D.C. Torri, A. Triossi, C. Tuvè, C. Venettacci, G. Verde, L. Votano

“…However, given the low cross-section of antineutrino interactions, the development of a powerful event selection algorithm becomes imperative to achieve effective discrimination between signal and backgrounds. …”
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High electron transfer efficiency accordion-shaped HNiZn heterostructure nanozyme for low-temperature photo-catalytic enhanced therapy of bacterial infection wounds by Hanjie Wang, Xinqi Guo, Ying Tan, Junxu Yang, Yuting Ye, Miao Mo, Yanling Liang, Guanhua Li, Zhangrui Huang, Li Zheng, Xiaofei Ding, Jingping Zhong, Jinmin Zhao

“…Through combined photocatalytic and photothermal effects, it effectively kills Escherichia coli (E. coli), clinically isolated methicillin-resistant Staphylococcus aureus (MRSA), and their biofilms. …”
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Cross-sectional evaluation of host biomarkers for guiding antibiotic use in bacterial and non-bacterial acute febrile illness in low- and middle-income tropical settings by Camille Escadafal, Patrícia Brasil, Louis Banda, Sabine Dittrich, Sunil Pokharel, B Leticia Fernandez-Carballo, Barbara Di Camillo, Martina Vettoretti, Steffen Geis, Victoria Harris, Aurélien Macé, Stefano Ongarello, Sue J Lee, Selidji Todagbe Agnandji, Braulia C Caetano, Marilda M Siqueira, Jose Moreira, Jullita Kenala Malava, Paulin N Essone, Ayodele Alabi, Meike Jakobi, Nicole Schneiderhan-Marra, Michele Atzeni, Andre M Siqueira, Anita L Kabwende, Juste Christin Bie Ondo, Marguerite Massinga-Loembe, Aline da Rocha Matos, Ana Maria Bispo de Filippis, Érica Aparecida dos Santos Ribeiro da Silva, Maria Cristina S Lourenço, Julia Häring, Anna Günther, Christine Hoogland

“…Objectives To evaluate the effectiveness of 18 different host biomarkers in differentiating bacterial from non-bacterial acute febrile illness (AFI) in resource-limited settings, specifically in Brazil, Malawi and Gabon.Design Multinational, cross-sectional study.Setting The study was carried out across multiple primary healthcare facilities, including urban and rural settings, with a total of three participating centres. …”
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Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis by Joan Clària, Ferran Aguilar, Juan-José Lozano, Laura Jiménez-Gracia, Juan C. Nieto, Berta Romero-Grimaldo, Xavi Marcos-Fa, Emma Giarracco, Emmanuel Weiss, Jonel Trebicka, Inmaculada Hernàndez, Javier Fernandez, Mireia Casulleras, Cristina López-Vicario, Sinan Muldur, Alex Hopke, Alexandru Vlagea, Ana M. Aransay, Domenica Marchese, Mauro Bernardi, Rajiv Jalan, Paolo Angeli, Giuliana Magri, Andrea Cerutti, Daniel Irimia, Holger Heyn, Vicente Arroyo, Richard Moreau

“…Bulk and single-cell RNA sequencing (scRNA-seq) and flow cytometry were performed in peripheral blood mononuclear cells (PBMCs) from 20 patients with AD cirrhosis and 34 HV exposed to albumin. Albumin’s effects on degranulation, phagocytosis, chemotaxis, and swarming of neutrophils from six patients with AD cirrhosis and nine HV were assessed by measuring myeloperoxidase enzymatic activity, the engulfment of fluorescent-labeled Escherichia coli and zymosan, and interactions of neutrophils with Candida albicans at single-cell resolution in microfluidic chambers, respectively. …”
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Emerging priorities in terrestrial herbivory research in the Arctic by Isabel C. Barrio, Katariina E.M. Vuorinen, Laura Barbero-Palacios, Mathilde Defourneaux, Matteo Petit Bon, Eleanor A. Greer, Helen B. Anderson, Tim Horstkotte, Nicolas Lecomte, Torben Windirsch, Kristy Ferraro, Bruce C. Forbes, Jennifer S. Forbey, Mariana García Criado, Liyenne Hagenberg, David S. Hik, Ilona Kater, Petr Macek, Jon Moen, Maja K. Sundqvist, Jerzy Szejgis, Miguel Villoslada, Erica Zaja, Fanny Berthelot, Katrín Björnsdóttir, Johannes Cunow, Michael den Herder, Anu Eskelinen, Katherine Hayes, Robert D. Hollister, Kolbrún í Haraldsstovu, Ingibjörg Svala Jónsdóttir, Jeppe A. Kristensen, Thomas K. Lameris, Lauri Oksanen, Tarja Oksanen, Johan Olofsson, Taejin Park, Åshild Ø. Pedersen, Juan Ignacio Ramirez, Virve T. Ravolainen, Austin Roy, Ingvild Ryde, Niels Martin Schmidt, Benedikt Schrofner-Brunner, Anna Skarin, James D.M. Speed, Mariska te Beest, Mikaela Simmonds, Rita T. Torres, Wolfgang Traylor, Risto Virtanen, Helen C. Wheeler, Juha M. Alatalo, Jan C. Axmacher, Jordi Bartolomé Filella, Elisabeth J. Cooper, Sonya R. Geange, Olivier Gilg, Paul Grogan, Carlos Hernández-Castellano, Toke T. Høye, Jeffrey T. Kerby, Kari Klanderud, Amanda M. Koltz, Johannes Lang, Mathilde Le Moullec, Maarten J.J.E. Loonen, Marc Macias-Fauria, Eric Post, Emmanuel Serrano, Matthias Siewert, Aleksandr Sokolov, Natalia Sokolova, Otso Suominen, Mariana Tamayo, Alexandra Terekhina, Alexander Volkovitskiy, Stefaniya Kamenova

“…From 288 responses received from 85 participants in two online surveys and an in-person workshop, we identified 8 scientific and 8 management priorities centred on (a) understanding and integrating fundamental ecological processes across multiple scales from individual herbivore–plant interactions up to regional and decadal scale vegetation and animal population effects; (b) evaluating climate change feedbacks; and (c) developing new research methods. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…The transformation would unravel the effort to take effective action against scandal and turn bioethical discourse into governance practices,[11] such as bioethics and research ethics committees. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Future work A definitive randomised controlled trial including an economic evaluation is needed to determine the effectiveness and cost-effectiveness of Predictive Parenting. …”
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