Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2 by Lin Zhang, Fang Fang, Danrui Liu, Geman Xia, Tong Feng, Jingzhu Lv, Jinying Qi, Tengteng Li, Hui Liu, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian

“…To address this, we used cultured THP-1(A) macrophages to characterize the effects of secreted ESAT-6 on cellular host defenses and apoptosis. …”
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Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay by Anusha Klett, Anusha Klett, Dennis Raith, Dennis Raith, Paula Silvestrini, Paula Silvestrini, Paula Silvestrini, Matías Stingl, Jonas Bermeitinger, Avani Sapre, Avani Sapre, Avani Sapre, Martin Condor, Roman Melachrinos, Mira Kusterer, Alexandra Brand, Guido Pisani, Guido Pisani, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Marie Follo, Marie Follo, Jesús Duque-Afonso, Roland Mertelsmann, Roland Mertelsmann

“…Furthermore, it allows detailed, long-term studies of cell-cell interactions and treatment responses using live-cell imaging and AI-assisted cell tracking. …”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…The vitamin K‐dependent Gla modification of PRRG1 was crucial for its membrane localization and pro‐tumorigenic effects, and was inhibited by low‐dose warfarin, a clinical vitamin K antagonist. …”
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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

“…The mechanisms underlying their interaction with immune cells remain unclear. Methods We conducted a multi-omics analysis—encompassing DNA methylation, total RNA sequencing, and microRNAs (miRNAs; N = 800) profiling on primary CICs and differentiated tumor cell lines, including autologous pairs. …”
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Assessment of <italic>L</italic>-Band Passive Microwave Soil Moisture Retrievals Against In Situ Measurements in the North American Boreal Biome by Azza Gorrab, Oliver Sonnentag, Arnaud Mialon, Chelene C. Hanes, Juliette Ortet, Aaron A. Berg, Muhammad Umair, Alexandre Roy

“…By analyzing the correlations between <italic>r</italic> and in situ SM data, we demonstrated that the soil effective temperature partly affects performances in terms of R_TB. …”
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Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D by Jiani Lu, Yan Tang, Hongtao Li, Saisai Tian, Xixiang Chen, Xueyue Song, Pengcheng Qin, Jianrong Xu, Haiyan Zhu, Liqiang Ni, Huarong Du, Weidong Zhang, Weihua Li, Lili Chen

“…Blocking viral entry is a crucial step in preventing infection, with the interaction between the S receptor binding domain (S-RBD) and ACE2 being a key antiviral target. …”
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Cyborg Adolescents and Digital Data: Examining Education and Revenue Generation in the Digital Lives of Youth through More-than-Human Ethnography by Davood Zahrani, Ali Hashemianfar, Ahmad Mehrshad

“…Anderson (2010) argues that the interactions among actors occur in a cyclical process of action. …”
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A pioneering longterm experiment on mesophotic macrofouling communities in the North Atlantic by João Canning-Clode, Francesca Gizzi, Andreia Braga-Henriques, Patrício Ramalhosa, Pedro Abreu, Soledad Álvarez, Manuel Biscoito, Pål Buhl-Mortensen, João Delgado, Diane Esson, Mafalda Freitas, Magno Freitas, Filipe Henriques, Joachim Jakobsen, Kirsten Jakobsen, Francis Kerckhof, Carsten Lüter, Carlos J. Moura, Marko Radeta, Rosana M. Rocha, Romana Santos, Pedro Sepúlveda, Rodrigo Silva, Teresa Silva, Javier Souto, Raül Triay-Portella, Peter Wirtz, Joana R. Xavier, Rolando Bastida-Zavala, Nikoleta Bellou, Sonia K. M. Gueroun, João G. Monteiro

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Science of science by S. Fortunato, C. T. Bergstrom, K. Börner, J. A. Evans, D. Helbing, S. Milojević, A. M. Petersen, F. Radicchi, R. Sinatra, B. Uzzi, A. Vespignani, L. Waltman, D. Wang, A.-L. Barabási

“…The value proposition of SciSci is that with a deeper understanding of the factors that drive successful science, we can more effectively address environmental, societal, and technological problems.ADVANCES. …”
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Upregulation of circGDI2 inhibits tumorigenesis by stabilizing the expression of RNA m6A demethylase FTO in oral squamous cell carcinoma by Yuwei Gu, Ling Sheng, Xiaoxiao Wei, Yuling Chen, Yuntao Lin, Zhangfu Li, Xiaolian Li, Huijun Yang, Yufan Wang, Hongyu Yang, Yuehong Shen

“…This interaction was found to prevent the degradation of the FTO protein. …”
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Determinantes para a excelência na Orientação: as representações de treinadores e atletas de elite (Determinants for excellence in Orienteering: the representation of elite coache... by Tadeu Ferreira de Sousa Celestino, José Carlos Gomes de Carvalho Leitão, Antonino Manuel de Almeida Pereira

“…Supported by these results, we may conclude that excellence in orientation presents a multidimensional matrix and its effective implementation is determined by the successful interaction between the dimensions of performance and the socio-contextual and cultural dimensions that involve the orienteering modality. …”
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Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells by Ye Yang, Ye Yang, Jieyun Zhou, Qiaoying Lv, Qicheng Ni, Qicheng Ni, Baichun Hu, Yulong Wang, Shuning Qu, Guoting Li, Wenjie Yang, Ruihua Zhong, Xiaojun Chen, Yan Zhu

“…Treatment with CANA, alone or in combination with MPA, effectively reduced the expression of these proteins. …”
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PEDAGOGICAL VALUE OF THE COMMUNICATION AS A PROFESSIONAL ETHICAL PHENOMENON IN THE EDUCATION OF DENTISTS STUDENTS by R.M. Khopta

“…Students should learn effective and humane communication during their lessons in the process of solving different situations that contributes to the formation of communicative knowledge and skills. …”
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Distribution of Size-Fractionated Phytoplankton and Their Relationships with Environmental Variables in Bivalves Mariculture Areas of Haizhou Bay by Xue GONG, Jihong ZHANG, Xinmeng WANG, Wenguang WU, Rongzhao MENG, Liushuyi TAN, Haojie MA

“…Consequently, nutrient salts mainly regulated the Chl-a concentration of phytoplankton in Area 1, whereas the effects of nutrient salts and cultured bivalve influenced the Chl-a concentration of phytoplankton in Area 2. …”
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Bringing it all together: science priorities for improved understanding of Earth system change and to support international climate policy by C. G. Jones, F. Adloff, B. B. B. Booth, P. M. Cox, V. Eyring, V. Eyring, P. Friedlingstein, P. Friedlingstein, K. Frieler, H. T. Hewitt, H. A. Jeffery, S. Joussaume, T. Koenigk, T. Koenigk, B. N. Lawrence, E. O'Rourke, M. J. Roberts, B. M. Sanderson, R. Séférian, S. Somot, P. L. Vidale, D. van Vuuren, D. van Vuuren, M. Acosta, M. Bentsen, M. Bentsen, R. Bernardello, R. Betts, R. Betts, E. Blockley, J. Boé, T. Bracegirdle, P. Braconnot, V. Brovkin, C. Buontempo, F. Doblas-Reyes, F. Doblas-Reyes, M. Donat, I. Epicoco, I. Epicoco, P. Falloon, P. Falloon, S. Fiore, T. Frölicher, T. Frölicher, N. S. Fučkar, N. S. Fučkar, M. J. Gidden, H. F. Goessling, R. G. Graversen, S. Gualdi, J. M. Gutiérrez, T. Ilyina, T. Ilyina, T. Ilyina, D. Jacob, C. D. Jones, C. D. Jones, M. Juckes, M. Juckes, E. Kendon, E. Kendon, E. Kjellström, R. Knutti, J. Lowe, J. Lowe, M. Mizielinski, P. Nassisi, M. Obersteiner, P. Regnier, R. Roehrig, D. Salas y Mélia, C.-F. Schleussner, M. Schulz, E. Scoccimarro, L. Terray, H. Thiemann, R. A. Wood, S. Yang, S. Zaehle

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NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer by Guang Yang, Chengsheng Ding, Xiao Yang, Jiang Jiang, Shiyuan He, Yanfei Shao, Enkui Zhang, Xiaodong Fan, Xueliang Zhou, Ling Huang, Cindy Xinyu Zhang, Jing Sun, Yu Wang, Lu Zang, Minhua Zheng, Junjun Ma

“…Introduction: Cetuximab (CTX) is an effective targeted drug for the treatment of metastatic colorectal cancer, but it is effective only in patients with wild-type KRAS genes. …”
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Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma by Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Annamaria Salvati, Giovanni Nassa, Jessica Lamberti, Domenico Memoli, Patrizia Sabatelli, Marina Comelli, Arianna Bellazzo, Albina Fejza, Lucrezia Camicia, Lorena Baboci, Michele Dal Bo, Alessia Covre, Tuula A. Nyman, Alessandro Weisz, Agostino Steffan, Michele Maio, Luca Sigalotti, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta

“…Abstract Background About 50% of cutaneous melanoma (CM) harbors the activating BRAFV600 mutation which exerts most of the oncogenic effects through the MAPK signaling pathway. In the last years, a number of MAPK modulators have been identified, including Spry1. …”
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Nitrogen fertilizer and faba bean density as sources of nitrogen supply in sustainable production of forage corn by Samaneh Ghorbi, Ali Ebadi, Saeid Khomari, Masoud Hashemi

“…The highest fertility rate was observed at the densities of 80 and 40 plants m-2.CornOur results showed that the interaction between faba bean density and N fertilizer had effects on plant height, chlorophyll index, protein harvest index, physiological nitrogen efficiency, nitrogen uptake efficiency, and dry forage yield. …”
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Design, Construction, and Evaluation of a Spatial Depth Measurement System for Subsoiler in Sugarcane Fields by N. Loveimi, A. Azizi, A. Kaab, A. Neisi

“…Specifically, within these ranges, the deep range exhibited an average depth error of 2.33 cm, and the surface range had an average error of 3.65 cm. Statistical analysis revealed that only indices related to minimum and maximum errors for interactions between factors were significant. …”
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Realizing Environmentally Scalable Pre-Lithiation via Protective Coating of LiSi Alloys to Promote High-Energy-Density Lithium-Ion Batteries by Yinan Liu, Wei Jiang, Congcong Zhang, Pingshan Jia, Zhiyuan Zhang, Yun Zheng, Kunye Yan, Jun Wang, Yunxian Qian, Junpo Guo, Rong Chen, Yike Huang, Yingying Shen, Lifen Long, Bang Zheng, Huaiyu Shao

“…DFT calculations and in situ XRD measurements reveal that the paraffin-dominated coating membrane, featuring weak dipole–dipole interactions with water molecules, effectively reduces the moisture-induced oxidation kinetics of Li₁₃Si₄@P-CNTs in air. …”
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