Association of preoperative cerebral oxygenation with concurrent neurobehavioral scores in term neonates with congenital heart disease compared to healthy controls by Nhu N. Tran, Nhu N. Tran, Nhu N. Tran, Anna Miner, Eniola Adeleke, Rene Phan, Ken M. Brady, Mary-Lynn Brecht, Philippe Friedlich, Philippe Friedlich, Geena Zhou, Vidya Rajagopalan, Vidya Rajagopalan, Bradley S. Peterson, Bradley S. Peterson, Jodie K. Votava-Smith, Jodie K. Votava-Smith

“…The models included the main effects of group, rcSO2, and a rcSO2-by-group interaction (examined differences between groups) with covariates of postconceptional age at exam, sex, ethnicity, and preductal peripheral oxygen saturation on the percentage of abnormal neurobehavioral scores. …”
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Microbial diurnal rhythmicity in the rumen fluid impacted by feeding regimes and exogenous microbiome providing novel mechanisms regulating dynamics of the rumen microbiome by Yangyi Hao, Wei Wang, Mengmeng Li, Youyoung Choi, Mi Zhou, Yixin Wang, Zhijun Cao, Ya Jing Wang, Hongjian Yang, Linshu Jiang, Le Luo Guan, Shengli Li

“…Additionally, cross-lagged effects were observed between the relative abundance of microbial taxa and rumen fermentation parameters, which could affect feed intake, rumination time, microbial population/diversity, and microbial interactions. …”
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Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription by Wen-juan Li, Yan-chao Chen, Yi-an Lin, Yi-qin Zou, Guo-sheng Hu, Jing-jing Yang, Xin-yu Nie, Mei-yan Li, Yi-ran Wang, Yao-hui He, Yan Zhao, Yu-hua Tan, Xianming Deng, Wei-ling He, Yan Cheng, Fang-meng Fu, Wen Liu

“…Moreover, combination treatment with iPRMT1, a PRMT1 inhibitor, and menadione, an HIF1α/P300 interaction inhibitor, demonstrates synergistic effects in suppressing breast tumor growth. …”
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Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial... by Mirjam Christ-Crain, Manuel R Blum, Philipp Schuetz, Luise Adam, Elisavet Moutzouri, Martin Feller, Drahomir Aujesky, Sven Trelle, Nicolas Rodondi, Marie Méan, Rosalinde K E Poortvliet, Jürg-Hans Beer, Stefano Bassetti, Fabrice Bonnet, Sebastian Carballo, Baris Gencer, Robert Escher, Dina Zekry, Maria M Wertli, Luca Gabutti, Philipp Stefan Aebi, Moa Haller, Julia Bianca Bardoczi, Alan G Haynes, Patricia Orializ Chocano-Bedoya, Martin Egger, Douglas Bauer

“…Statin side effects and drug interactions are common in older patients and may negatively impact quality of life. …”
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Noscapine derivative 428 suppresses ferroptosis through targeting GPX4 by Youping Zhang, Haoliang Shi, Yingying Wang, Wanting Liu, Guanyi Li, Defeng Li, Wenxuan Wu, Yunzhao Wu, Ziwei Zhang, Yanjie Ji, Chujiao Zhu, Wenhui Bai, Hu Lei, Hanzhang Xu, Hua Zhong, Baohui Han, Li Yang, Ligen Liu, Wei Wang, Yaxue Zhao, Yongqiang Zhang, Yingli Wu

“…Here we show that 428, a selenide-containing noscapine derivative, effectively inhibits ferroptosis in various cell lines by enhancing the stability and activity of GPX4. …”
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The tryptophan metabolite 3-hydroxyanthranilic acid alleviates hyperoxia-induced bronchopulmonary dysplasia via inhibiting ferroptosis by Qiqi Ruan, Yingqiu Peng, Xuanyu Yi, Jingli Yang, Qing Ai, Xiaochen Liu, Yu He, Yuan Shi

“…Limited proteolysis-small molecule mapping (LiP-SMap) proteomic analysis revealed the involvement of the ferroptosis pathway in the underlying mechanism by which 3-HAA alleviated hyperoxia-induced BPD injury. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…More research is needed on how approaches shown to be effective in other settings such as mental health could be tailored for people with learning disability. …”
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Reduced response to regadenoson with increased weight: An artificial intelligence–based quantitative myocardial perfusion study by Emmanouil Androulakis, Georgios Georgiopoulos, Alessia Azzu, Elena Surkova, Adam Bakula, Panagiotis Papagkikas, Alexandros Briasoulis, Ranil De Silva, Peter Kellman, Dudley Pennell, Francisco Alpendurada

“…The aim of this study was to evaluate the effectiveness of regadenoson in patients with varying body weights using novel quantitative cardiovascular magnetic resonance (CMR) perfusion parameters in addition to standard clinical markers. …”
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Investigative needle core biopsies support multimodal deep-data generation in glioblastoma by Kenny K. H. Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev, Sonali Jindal, Michael S. Regan, Zaki Abou-Mrad, Michael C. Prabhu, Marc J. Williams, Alicia D. D’Souza, Seth W. Malinowski, Kelsey Hopland, Yuval Elhanati, Sylwia A. Stopka, Alexei Stortchevoi, Charles Couturier, Zhong He, Jingjing Sun, Yulong Chen, Alexsandra B. Espejo, Kin Hoe Chow, Smitha Yerrum, Pei-Lun Kao, Brittany Parker Kerrigan, Lisa Norberg, Douglas Nielsen, The GBM TeamLab, Vinay K. Puduvalli, Jason Huse, Rameen Beroukhim, Betty Y. S. Kim, Sangeeta Goswami, Adrienne Boire, Sarah Frisken, Michael J. Cima, Matthias Holdhoff, Calixto-Hope G. Lucas, Chetan Bettegowda, Stuart S. Levine, Tejus A. Bale, Cameron Brennan, David A. Reardon, Frederick F. Lang, E. Antonio Chiocca, Keith L. Ligon, Forest M. White, Padmanee Sharma, Viviane Tabar, Nathalie Y. R. Agar

“…Abstract Glioblastoma (GBM) is an aggressive primary brain cancer with few effective therapies. Stereotactic needle biopsies are routinely used for diagnosis; however, the feasibility and utility of investigative biopsies to monitor treatment response remains ill-defined. …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

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The influence of H. pylori infection in HER2-positive gastric cancer cell lines: insights from Wnt/β-catenin pathway by Valli De Re, Mariateresa Casarotto, Giulia Brisotto, Stefania Zanussi, Mariangela De Zorzi, Ombretta Repetto, Elena Muraro, Paola Spessotto, Paolo Baldo, Vito Racanelli, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Marino Venerito, Matteo Fassan, Matteo Fassan, Agostino Steffan, Stefano Realdon, Renato Cannizzaro, Renato Cannizzaro

“…The infection was confirmed by confocal microscopy and downstream effects of gene expression were evaluated, focusing on Wnt-β-catenin signaling genes linked to metastasis and survival in HER2+ GC. …”
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Role of tumor necrosis factor-α in coronavirus disease 2019-associated kidney injury by PANDIT Roshan, LU Junyao, HE Liheng, BAO Yujie, JI Ping, CHEN Yingying, XU Jie, WANG Ying

“…Objective·To identify relevant biomarkers for patients with coronavirus disease 2019-associated kidney injury (COVID-19-associated KI) and explore the mechanisms underlying the involvement of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) proteins in infection-related KI by affecting the interactions between renal cells and macrophages.Methods·A retrospective analysis was conducted on the clinical characteristics of COVID-19 patients with KI treated in Shanghai Ninth, People′s, hospital from December 2022 to February 2023. …”
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The association between hearing loss and depression in the China health and retirement longitudinal study by Yanju Zhang, Xiaofang He, Yibo Liu, Chunhong Tian, Hui Yang, Lin Zhang

“…Hearing loss may lead to more obstacles for middle-aged individuals in terms of work and social interactions, thereby increasing the risk of depression. …”
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Dreams and Nightmares in Early Pregnancy: A Comparative Study with a Control Group by Scarpelli S, Spinoni M, Gorgoni M, Lasaponara S, Ciolli P, Rech F, Di Muzio M, Med C, Di Pasquale Benedetti I, Grano C, De Gennaro L

“…Ordinal logistic regression revealed that being in the control group, greater attention to dreams, the presence of depressive symptoms, and a higher frequency of lucid dreaming were significant predictors of more frequent nightmares. Moderation analysis showed no significant interaction between pregnancy status and dream attitude.Conclusion: Contrary to expectations, first-trimester pregnant women had fewer nightmares than non-pregnant women. …”
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Legitimising lithium mining: Global energy transition and green developmentalism in Jujuy, Argentina by Felix Malte Dorn, Kristina Dietz

“…The theoretical underpinning of the analysis is based on a dialectical understanding of narratives, whereby narratives are seen as contingent products of social and global-local (multiscalar) interactions. …”
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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…Immunoblotting was performed to assess the expression of PANoptosis proteins, whereas YP1 (YO‐PRO‐1; Oxazole yellow) and PI (propidium iodide) fluorescence staining and immunofluorescence were used to evaluate the effects of transcription factors and SE on PANoptosis in PASMCs. …”
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Microbial Community Imbalance Drives Nitrous Oxide Emissions from Strongly Acidic Soil—Insights from a Laboratory Experiment with Microbial Inhibitors by Waqar Ahmed, Hongyang Gong, Xiaoxiao Xiang, Runze Chen, Yumeng Xu, Wenxuan Shi, Binzhe Li, Junhui Yin, Qing Chen

“…These findings highlight the consequences of microbial disruption on N₂O emission and the complex microbial interactions in acidic soils. High concentrations of microbial inhibitors effectively reduce N₂O emissions by suppressing key microbial groups in nitrification and denitrification. …”
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Acmeological technology of forecasting individual professional-oriented trajectories of students’ personality development by E. F. Zeer, L. N. Stepanova

“…The results of testing confirm its effectiveness and the possibility of use in secondary and higher educational institutions. …”
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Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation by Litteral CA, Martel MM, Mattingly DT, Moore JX

“…Future studies should explore the biological and environmental mechanisms behind these patterns to develop more effective prevention strategies.Keywords: substance use disorder, addiction, predisposition, genetic, environment, inheritance…”
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Assessment of grassland carrying capacity drivers and evaluation of pasture-livestock balance: A case study of Xinjiang, China by Guangyu Wang, Yaoming Li, Lianlian Fan, Xuexi Ma, Yuanye Liang, Tingting Hui, Wenbo Zhang, Wei Li, Jiefei Mao

“…Except for alpine steppe and alpine desert, the spatial distribution of grassland CC was primarily influenced by two-factor interactions, surpassing the impacts of single-factor effects. (3) The overgrazing rate has generally declined, peaking in 2014 and showing the mildest condition in 2017. …”
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