A Participatory Governance Model for Comprehensive Conservation of Historical Buildings and Urban Fabric: A Grounded Theory Approach by Somayyeh Ghadimzadeh, Elnaz Abizadeh, Mahdiyeh Rahnemay Toori

“…Discussion of Results & Conclusion The findings revealed a multifaceted governance framework that effectively addressed the complex challenges of cultural heritage conservation. …”
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Exploring the Impact of Drought Stress on the Yield and Yield Components of Cumin (Cuminum cyminum L.) Ecotypes by Vahid Bazr Afshan, Farzad Paknejad, Hamid Reza Fanay, davood Habibi, Morteza Siavoshi

“…One effective strategy is to identify drought-resistant cumin cultivars. …”
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Epidemiology of Medical Errors and Incidents in Emergency Medicine by Yu. E. Voskanyan

“…Particular attention was paid to the fact that organizational vulnerabilities reduce the effectiveness of protective mechanisms during the interaction of the human factor with a complex environment.Conclusion The study showed that the provision of emergency medical care is associated with moderately high risks of incidents, including severe and critical consequences for patients. …”
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The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study by Simin Sajadi, Mohammad Amin Khadembashiri, Gholamreza Raissi, Mohamad Mehdi Khadembashiri, Korosh Mansouri, Homayoun Hadizadeh-Kharazi, Mohammad Taghi Joghataei, Seyed Pezhman Madani, Bijan Forogh, Sina Parsipour

“…Radiological outcomes showed a significant increase in cartilage thickness at specific locations (e.g., middle-lateral patella (P = 0.017), Tibial compartment lateral (P < 0.000)) in the ADMSC group after 6 months, demonstrating the regenerative potential of ADMSC in certain MRA sites. Multivariable analysis underlines the complexity of the interactions among treatment, time, and baseline level of variables. …”
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Veillonella parvula outer membrane vesicles increase ICAM-1+ neutrophils exhibiting elevated NET formation via ROS–PAD4 signaling by Lina Xu, Yiting Jiang, Xuri Zhao, Jiabao Zhuang, Huiwen Chen, Teng Li, Zhiyan He, Wei Zhou, Zhongchen Song

“…No significant differences were observed in neutrophil phagocytosis. RNA sequencing analysis revealed a significant increase in the expression of Icam-1 mRNA. …”
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Leucine-rich pentatricopeptide repeat-containing protein (LRPPRC)-stabilized lncRNA small nucleolar RNA host gene 15 (Snhg15) modulates hematopoietic injury induced by γ-ray irradi... by Shuqin Zhang, Yajia Cheng, Yujia Gao, Feifei Xu, Yuna Wang, Junling Zhang, Yue Shang, Deguan Li, Saijun Fan

“…Abstract With advancements in radiotherapy technologies, the detrimental effects of ionizing radiation on biological systems, particularly the hematopoietic system, have caused significant concern. …”
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mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage by Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero

“…Objective Here, we studied the role of mTOR in OPA-1 cleavage and its consequent effects on mitochondrial dynamics and energetics in cardiomyocytes. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. …”
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Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations by Yiyue Jiang, Zheng Zhang, Kangkang Ren, Shujuan Zhou, Yang Qiao, Weilu Huang, Nanyang Zhang, Hanyan Xu, Xinping Xu, Bing Wen, Wei Zhang, Lu Yin

“…Furthermore, transcriptomic analysis revealed a progressively shifting gene expression profile with the change in DPMSC size. …”
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DS-Modified Paeoniflorin pH-Responsive Lipid&amp;ndash;Polymer Hybrid Nanoparticles for Targeted Macrophage Polarization in a Rat Model of Rheumatoid Arthritis by Zhang J, Yang J, Yu Z, Bai H, Wang Y, Wang R

“…These findings suggest that this new delivery system could be a more effective and targeted way to treat RA, reducing the inflammation and pain caused by the disease while avoiding some of the side effects of current treatments. …”
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A compreensão da enfermagem acerca do cuidado compartilhado à criança com condição crônica hospitalizada [Nursing’s understanding of shared care for hospitalized children with a ch... by Letícia Guimarães Fassarella, Isabela Fornerolli de Macedo, Michelle Darezzo Rodrigues Nunes, Letícia Silva da Rocha, Mara Lucia Amantéa, Renata de Oliveira Maciel

“…They highlight both positive aspects to be improved so that shared care is effective and ways to achieve that. Conclusion: this study found positive aspects and challenges in the relationship between families and health personnel with a view to effective shared care. …”
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Industrial multi-machine data aggregation, AI-ready data preparation, and machine learning for virtual metrology in semiconductor wafer and slider production by Feiyang Ou, Julius Suherman, Chao Zhang, Henrik Wang, Sthitie Bom, James F. Davis, Panagiotis D. Christofides

“…This operational data are embedded in invaluable machine, process, product, and material behaviors as interaction complexities, linearities/non-linearities, and dimensional effects. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Connectivity Map analysis identified MS.275 as the top therapeutic enhancer, with experimental validation in DSS-induced colitis confirming synergistic anti-inflammatory effects with TNF-α inhibitors, improving disease activity indices and restoring signature gene expression patterns.ConclusionThis mechanistically grounded four-gene signature enables precise IBD patient stratification across distinct immunological subtypes and predicts biologic responses, providing validated molecular tools for precision immunotherapy and personalized treatment optimization.…”
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Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts by Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas

“…Peripheral blood cells of fourteen males initiating ART during acute infection and demonstrating effective viral suppression but varying magnitudes of total HIV-1 DNA were characterized by single-cell RNA sequencing. …”
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Chemical composition, antimicrobial, and antioxidant properties of essential oils from Artemisia herba-alba asso. and Artemisia huguetii caball. from Morocco: in vitro and in silic... by Mohamed El Ouardi, Mohamed El Ouardi, Aziz Drioiche, Aziz Drioiche, Fadoua El Makhoukhi, Fadoua El Makhoukhi, Jamal Mabrouki, Mohammed Hakmi, Omkulthom Al kamaly, Bshra A. Alsfouk, Brahim Eddamsyry, Hamid Khamar, Touriya Zair, Mohammed Alaoui El Belghiti

“…Molecular docking studies revealed strong interactions between these compounds and key target proteins, such as NADPH-dependent catalase and dihydrofolate reductase. …”
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Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats by Hancheng Li, Hancheng Li, Hancheng Li, Yongen Peng, Yangkai Wu, Yangkai Wu, Yiling Chen, Yiling Chen, Jieyu Li, Jieyu Li, Yunbing He, Yunbing He, Hongwu Wang, Hongwu Wang, Chaohua Luo, Zhixian Mo

“…Molecular docking identified stable interactions between MA and 12 targets, including HSP90B1, TNF, and MAP2K1, with miR-181a-5p binding to the 3′-UTR regions of these targets. …”
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Non-adherence to medication and its associations among type 2 diabetes patients following up with health coaches in primary healthcare centers, Makkah city, KSA by Ahmad Salah Alkathiri, Renad Turki Alghamdi, Abeer Ahmad Alamri, Haneen Hassan Alhazmi, Sarah Badr Alsharif, Sahab Muqbil Alharbi, Muath Aldomini, Baraa Sami Quronfulah, Mohamed O. Nour, Mohamed Osman Elamin, Abdullah Khalid Alafif, Saud Hasan Surbaya, Osama M. Hayat Noor

“…The findings demonstrate a complex interplay of psychosocial and clinical factors—particularly poor family support, difficulty coping with diabetes, and adverse medication side effects—that significantly impact adherence. These factors interact synergistically, amplifying the risk of non-adherence. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQTL) to proxy effects of expressions of 16,597 genes in 14 peripheral blood immune cells and tested them against four COVID-19 outcomes from COVID-19 Genetic Housing Initiative GWAS meta-analysis Round 7. …”
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Magnetic Field of a Ring-like Molecular Cloud by Dana Alina, Adel Umirbayeva, Yasuo Doi, Soichiro Jo, Yue Hu, Alex Lazarian, Janik Karoly, Tie Liu, Koji S. Kawabata, Alua Mukhash, Danial Zhumagayir, Tomori Hori, Tetsuharu Maruta, Ryo Imazawa, Tatsuya Nakaoka, Mahito Sasada

“…Variations in CO-derived orientations further suggest that local dynamical effects, such as gravitational interactions and turbulence, influence the cloud’s structure. …”
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Enhancing the Magnetic Behaviors of Dy₂ Complexes by Modulating the Crystal Field Environment with Different <i>μ</i>-O Bridging Ligands by Xirong Wang, Min Zhou, Wen Wang, Fangting Zhu, Shijia Qin, Xiulan Li, Feifei Bai, Qinglun Wang, Licun Li, Yue Ma, Bin Zhao

“…The 2,2′-bipyridine-N-oxide ligand (bmpo) constructed two centrosymmetric complexes [Ln₂(hfac)₆(bmpo)₂] (Ln = Dy(<b>1</b>), Tb(<b>2</b>)), with nine-coordinated Ln^III ions showing <i>C</i>_s low symmetry, while the ligand di(2-pyridyl)methanediol (py₂C(OH)₂) formed another two compounds [Ln₂(hfac)₄(py₂C(OH)O)₂] (Ln = Dy(<b>3</b>), Tb(<b>4</b>)), with two kinds of eight-coordinated Ln^III ions exhibiting improved symmetries of <i>D</i>_4d and <i>D</i>_2d. Magnetic analysis reveals that Dy₂ complex <b>1</b> shows intramolecular antiferromagnetic coupling (<i>J</i> = −1.07 cm⁻¹) and no relaxation process above 2.0 K even in a 1000 Oe dc field, owing to the low symmetry of Dy^III ions, while the similar Dy₂ complex <b>3</b> with improved Dy^III symmetry shows ferromagnetic coupling (<i>J</i> = 1.17 cm⁻¹), which induces a 1000 Oe dc field-induced two-step magnetization relaxation processes with effective energy barrier <i>U</i>_eff = 47.4 K and 25.2 K for the slow relaxation and fast relaxation processes, respectively. …”
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