Appropriate nitrogen application rate with decreased basal/topdressing ratio improves yield, quality, water productivity, and N-use efficiency of forage maize in a rainfed region by Zhongli Li, Wei Gao, Congze Jiang, Yongli Lu, Muhammad Kamran, Xianlong Yang

“…A two-year field experiment was conducted from 2021 to 2022 in a typical rainfed region of northwestern China to investigate the effects of four N application rates (0, 90, 180, 270 kg hm−2) and two basal/topdressing ratios (2:8 and 4:6) and their interactions on the growth, dry matter (DM) yield, forage quality, water productivity (WP), and N-use efficiency of forage maize (Zea mays L.). …”
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Endoplasmic reticulum stress-induced CRELD2 promotes APMAP-mediated activation of TGF-β/SMAD and NF-κB pathways in esophageal squamous cell carcinoma by Fangyu Su, Fangyu Su, Xia Yang, Zhaoyang Yan, Junhong Wu, Xiaoxu Li, Tongxin Xu, Huanchen Xu, Xinhao Wang, Zhaokun Hu, Juntao Lu, Wei Guo

“…CRELD2 facilitated physical interaction with APMAP and promoted its cell membrane localization under ER stress. …”
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Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study by Gary Abel, Helen Atherton, Jon Sussex, Nurunnahar Akter, Abodunrin Q Aminu, Wiktoria Bak, Carol Bryce, Christopher E Clark, Emma Cockcroft, Hamish Evans, Evangelos Gkousis, Georgia Jenkins, Caroline Jenkinson, Nada Khan, Jeffrey Lambert, Brandi Leach, Christine Marriott, Jennifer Newbould, Sarah Parkinson, Jo Parsons, Emma Pitchforth, Laura Sheard, Stephanie Stockwell, Chloe Thomas, Bethan Treadgold, Rachel Winder, John L Campbell

“…Results The synthesis of findings from the literature review, surveys and qualitative work resulted in the identification of 11 thematic groups (distinct from, but incorporating, the results of the qualitative thematic analysis): 3 scene-setting themes relating to the context in which DF takes place, and 8 themes related to types of DF, their implementation and effectiveness. …”
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Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti by Maria A. A. Bertonceli, Vitor D. C. Cristo, Ivo J. Vieira, Francisco J. A. Lemos, Arnoldo R. Façanha, Raimundo Braz-Filho, Gustavo V. T. Batista, Luis G. M. Basso, Sérgio H. Seabra, Thalya S. R. Nogueira, Felipe F. Moreira, Arícia L. E. M. Assis, Antônia E. A. Oliveira, Kátia V. S. Fernandes

“…The nanocomposite was synthesized using a controlled ionic gelation method incorporating the TPP-β-CD inclusion complex, which resulted in nanoparticles with smaller size, improved polydispersity index, and enhanced stability, evidenced by a higher zeta potential. FTIR analysis confirmed rotenoid incorporation into the nanocomposite and suggested hydrogen bonding or potential covalent interaction with chitosan functional groups. …”
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In Vitro and In Silico Assessments of Curcuminoids and Turmerones from <i>Curcuma longa</i> as Novel Inhibitors of <i>Leishmania infantum</i> Arginase by Flora F. S. Spíndola, Anderson S. Pinheiro, Maria Athana Mpalantinos, Jefferson R. A. Silva, Walter S. M. F. Neto, Raissa A. Conceição, Eduarda M. Barreto, Barbara A. Abrahim-Vieira, Carlos R. Rodrigues, Alessandra M. T. Souza, Dirlei Nico, Ana Claudia F. Amaral, Andreza R. Garcia, Igor A. Rodrigues

“…This study investigates the inhibitory effects of <i>C. longa</i> extracts and curcumin on <i>Leishmania infantum</i> arginase, a key enzyme in polyamine and trypanothione biosynthesis, and evaluates their antiparasitic activity. …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…Focused on a mined, urban environment, a range of approaches have been applied to both characterise the environmental change before geothermal activities to generate “time zero” datasets, and to develop novel monitoring tools for cost-effective and environmentally-sound geothermal operations. …”
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SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx by Cameron Martino, Benjamin P. Kellman, Daniel R. Sandoval, Thomas Mandel Clausen, Robert Cooper, Alhosna Benjdia, Feryel Soualmia, Alex E. Clark, Aaron F. Garretson, Clarisse A. Marotz, Se Jin Song, Stephen Wandro, Livia S. Zaramela, Rodolfo A. Salido, Qiyun Zhu, Erick Armingol, Yoshiki Vázquez-Baeza, Daniel McDonald, James T. Sorrentino, Bryn Taylor, Pedro Belda-Ferre, Promi Das, Farhana Ali, Chenguang Liang, Yujie Zhang, Luca Schifanella, Alice Covizzi, Alessia Lai, Agostino Riva, Christopher Basting, Courtney Ann Broedlow, Aki S. Havulinna, Pekka Jousilahti, Mehrbod Estaki, Tomasz Kosciolek, Rayus Kuplicki, Teresa A. Victor, Martin P. Paulus, Kristen E. Savage, Jennifer L. Benbow, Emma S. Spielfogel, Cheryl A. M. Anderson, Maria Elena Martinez, James V. Lacey, Shi Huang, Niina Haiminen, Laxmi Parida, Ho-Cheol Kim, Jack A. Gilbert, Daniel A. Sweeney, Sarah M. Allard, Austin D. Swafford, Susan Cheng, Michael Inouye, Teemu Niiranen, Mohit Jain, Veikko Salomaa, Karsten Zengler, Nichole R. Klatt, Jeff Hasty, Olivier Berteau, Aaron F. Carlin, Jeffrey D. Esko, Nathan E. Lewis, Rob Knight

“…Moreover, we engineered the common probiotic Escherichia coli Nissle 1917 (EcN) to effectively block SARS-CoV-2 binding and infection of human cell cultures. …”
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A novel methodology for the extraction, purification and characterization of immunoglobulin G (IgG) nanoparticles from bovine colostrum: implications for food and therapeutic indus... by Fawze Alnadari, Yusof A.Y.A. Mohammed, Mustapha Muhammad Nasiru, Amirah S. Alahmari, Mohammed A. Alqahtani, Osama Abdulaziz, Isaiah Henry Ibeogu, Rongchang Wang, Chao Chen, Salem Baldi, Ibrahim Khalifa, Mohamed Abdin, Ahmed M. Saad, Mohamed T. El-Saadony

“…Rocket immunoelectrophoretic demonstrated that IgG NPs retained consistent antigen-antibody interactions across varying concentrations, highlighting their potential for diagnostic and therapeutic applications. …”
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The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways by Chao-Yu Hsu, Jyun-Yi Li, Jyun-Yi Li, Wei-Ru Huang, Wei-Ru Huang, Tsai-Ling Liao, Tsai-Ling Liao, Hsiao-Wei Wen, Chi-Young Wang, Chi-Young Wang, Lon-Fye Lye, Brent L. Nielsen, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu, Hung-Jen Liu

“…Analysis of TKs5, Nck1, and Rab40b mRNA levels by quantitative real-time RT-PCR. …”
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Construction of symbiosis corridors for heritage resources and optimization of conservation strategies in the basin: A case study of the Yellow River basin in Shandong, China by Ying Yu, Bin Yu, Xinwen Zhang, Lin Ma, Caijun Zhao, Yanyan Jia, Shujun Hou, Xin Han, Kun Li, Xinchuang Chen, Chuanrong Li, Bing Liu

“…However, significant gaps still remain in the effective integration of HRs into natural environmental networks, particularly in achieving regional synergies and holistic ecological and cultural conservation in alignment with the UN Sustainable Development Goals (SDGs). …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

“…Consequently, identifying molecular targets that specifically inhibit the proliferation and metastasis of HCC cells is critical for improving treatment outcomes. Database analysis using Targetscan identified complementary binding sites for the human-specific miRNA hsa-miR-6894-3p (hereafter referred to as miR-6894-3p) on SHROOM2, and Starbase data suggested a potential regulatory interaction between lnc-MAP3K13-3:1 and miR-6894-3p in liver cancer. …”
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Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination by Yanqin Bian, Fang Li, Xinyu A, Zheng Xiang, Nanshan Ma, Jianye Wang, Boran Cao, Pengfei Xin, Xuan Cheng, Chang Liu, Bei Xiang, Jun Shen, Qigui Lu, Lianbo Xiao

“…To evaluate therapeutic efficacy, a collagen-induced arthritis (CIA) rat model with lncRNA ITSN1-2 overexpression was established. JBQG's effects were assessed through histopathological examination and serum inflammation factors analysis following 23 g/kg/day treatment for 4 weeks. …”
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Early findings from the integration of hypertension care into differentiated service delivery models for HIV in Uganda: a mixed‐method study by John Baptist Kiggundu, Fred C. Semitala, Chelsea Faith Lipoto, Lilian Giibwa, Robert Twine, Savio Mwaka, Florence Ayebare, Christine Kiwala, Evelyn N. Magambo, Gerald Mutungi, Isaac Ssinabulya, Donna Spiegelman, James Kayima, Martin Muddu, Jeremy I. Schwartz, Anne R. Katahoire, Chris T. Longenecker

“…However, two clinics showed significant time interaction effects (Wald test χ2 (7) = 69.94, p < 0.001), with a decrease in the intensive models over time. …”
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Ultrastructural organization and reproduction of virions in Vero (E6) cells in influenza A/H1N1 pmd09 virus monoinfection and coinfection with SARS-CoV-2 (Delta and Omicron strains... by Ksenia F. Emtsova, Ekaterina V. Spiridonova, Vladimir V. Omigov, Anastasia A. Moiseeva, Elena I. Danilenko, Oleg S. Taranov

“…The Vero (E6) cell line model was used for in vitro study of the viral infection effects and an analysis of the dynamics of changes in the number of intracellular viral particles. …”
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LAPTM4B enhances the stemness of CD133+ liver cancer stem-like cells via WNT/β-catenin signaling by Jiahong Wang, Jianping Liao, Ye Cheng, Meirong Chen, Aimin Huang

“…Therefore, we investigated the effects of LAPTM4B on the stemness regulation of cluster of differentiation 133 (CD133)+ liver cancer stem-like cells (CSLCs). …”
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Impact of Blood Metabolic Profile and Ingestive Behaviours Registered with Noseband Sensor on Methane Emission During Transition Period in Dairy Cows by Justina Krištolaitytė, Karina Džermeikaitė, Arūnas Rutkauskas, Greta Šertvytytė, Gabija Lembovičiūtė, Samanta Arlauskaitė, Akvilė Girdauskaitė, Violeta Juškienė, Remigijus Juška, Walter Baumgartner, Ramūnas Antanaitis

“…Cows were retrospectively classified into low, medium, and high rumination groups according to their average daily rumination duration to investigate the effects of behavioural influences. During the prepartum period, the methane concentration was moderately positively correlated with drinking time (r = 0.41, <i>p</i> < 0.01) and weakly negatively correlated with chews per minute (r = −0.358, <i>p</i> < 0.05). …”
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Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway by Fan Lin, Wenjing Yu, Wenjing Yu, Ping Li, Ping Li, Shuyao Tang, Yitong Ouyang, Liya Huang, Di Wu, Shaowu Cheng, Shaowu Cheng, Zhenyan Song, Zhenyan Song

“…Network pharmacology analysis was used to predict PSP targets, and molecular docking validated key protein interactions. …”
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Knowledge, attitude, and perception of Pakistani populations toward monkeypox: a cross-section study by Humayun Yousaf, Abdul Qadeer, Muhammad Sohail, Maqbool Khan, Muhammad Farooq, Zakir Khan, Dalia Fouad, Yu-Chia Liu, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…About 83.95% (2909) answered that during interaction with the Mpox patient, they’d dress in the appropriate personal protective clothing, like masks, gloves, and gowns. …”
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DNA gyrase inhibition by Ni(II)-Schiff base complexes via in silico molecular docking studies: Spectroscopic, DFT calculations and in vitro pharmacological assessment by Ikechukwu P. Ejidike, Amani Direm, Cemal Parlak, Solomon A. Olaleru, Charles O. Adetunji, Fanyana M. Mtunzi, Athar Ata, Michael O. Eze, Hadley S. Clayton, Peter A. Ajibade, Joshua W. Hollett

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Atmospheric processing and aerosol aging responsible for observed increase in absorptivity of long-range-transported smoke over the southeast Atlantic by A. A. Fakoya, J. Redemann, P. E. Saide, P. E. Saide, L. Gao, L. T. Mitchell, C. Howes, A. Dobracki, A. Dobracki, I. Chang, G. A. Ferrada, G. A. Ferrada, K. Pistone, K. Pistone, S. E. Leblanc, S. E. Leblanc, M. Segal-Rozenhaimer, M. Segal-Rozenhaimer, A. J. Sedlacek III, T. Eck, T. Eck, B. Holben, P. Gupta, E. Lind, P. Zuidema, G. Carmichael, G. Carmichael, C. J. Flynn

“…These particles have strong radiative effects in the southeast Atlantic (SEA), which depend in part on the radiative contrast between the aerosol layer in the free troposphere (FT) and the underlying cloud layer. …”
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