Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…Antimicrobial assays against Staphylococcus aureus, Escherichia coli, Candida albicans, and Geotrichum candidum revealed that stigma extracts exhibited superior antibacterial activity (MIC = 25 mg/mL for S. aureus and E. coli), while tepal and leaf extracts showed promising antifungal effects (MIC = 12.5 mg/mL for G. candidum). The mixture design approach uncovered synergistic interactions, with an equimolar combination of stigma, tepal, and leaf extracts (33:33:33) demonstrating the strongest antibacterial activity (MIC = 25 mg/mL) and a ternary mixture (34% stigma, 30% leaf, 36% tepal) achieving the lowest antifungal MIC (6.25 mg/mL). …”
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Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis by Shuaiwei Wang, Hao Fu, Hao Fu, Xiaoqing Li, Xiaoqing Li, Hongrui Xu, Yu Bai, Wenjun Jiang, Xiaozhe Cheng, Na Chen, Na Chen, Yijie Zhang, Yijie Zhang, Wei Li

“…The role and underlying mechanisms of plasma pIgR were investigated in mouse models of sepsis and primary alveolar type 2 epithelial cells (AT2).ResultsQuantitative proteomic and ELISA analysis revealed a significant association between plasma pIgR and the prognosis of patients of pneumonia-induced sepsis. …”
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Year patterns of climate impact models' performance: Long-term simulation of rainfed spring wheat production using five crop models under various climate patterns by Funian Zhao, Qiang Zhang, Heling Wang, Kai Zhang

“…Crop models serve as powerful tools for investigating the interaction of crop traits, environmental fluctuations, and management practices. …”
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Research Progress and Prospect of Multi-robot Collaborative SLAM in Complex Agricultural Scenarios by MA Nan, CAO Shanshan, BAI Tao, KONG Fantao, SUN Wei

“…Secondly, the combination of deep learning and reinforcement learning techniques is expected to empower robots to better interpret environmental patterns, adapt to dynamic changes, and make more effective real-time decisions. Thirdly, large language models will enhance human-robot interaction by enabling natural language commands, improving collaborative operations. …”
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Exploring a fuzzy relationships among criteria for the development of community-based tourism in Malaysia: a multi-stakeholder perspective by Azizah Ismail, Norwani Mohd Nazari, Nur Ainna Aznida Abdullah

“…Practical implications – The practical implications of the study include providing guidance for tourism policymakers and key stakeholders in developing effective policy interventions for CBT in Malaysia. …”
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Review of Research on Foundation Scour of River-Crossing Bridges by WANG Lu, LIU Hong-wei, WEI Kai, Bruce Melville, NIE Rui-hua

“…The former’s prediction accuracy is severely affected by scale effects, while the latter has limited applicability. …”
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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Here, we identified a potential inhibitor of USP14, Degrasyn (DGS), and investigated its regulatory effects on ESCA radioresistance and progression. We found that DGS had marked antiproliferative effects in radiosensitive ESCA cell lines. …”
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Biochar Increases Rice Yield in Soda Saline-Alkali Paddy Fields by Improving Saline-Alkali Stress and Phosphorus Use Efficiency by Xuebin Li, Weikang Che, Junlong Piao, Yang Song, Xudong Wang, Yue Zhang, Shihao Miao, Hongyue Wang, Liming Xie, Jiayi Sun, Feng Jin

“…The application of biochar can alleviate the adverse effects of saline-alkali stress on crops. However, there is limited research on the interaction between biochar and phosphorus fertilizer concerning ionic accumulation, phosphorus utilization efficiency, and rice yield in soda saline-alkali soils. …”
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Impact of solid fuel use on asthma prognosis and consistent peak expiratory flow changes: Evidence from China by Yuexi Chen, Shuojia Xie, Xirong Chen, Xiaowen Zhong, Linhang Yang, Weitong Lin, Junfeng Huang, Ruchong Chen

“…Mixed-effects model pointed to a statistically potential interaction between gender and the influence of solid fuels on long-term reduction in PEF in patients with milder asthma forms. …”
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<i>Achnatherum inebrians</i> Bacterial Communities Associated with <i>Epichloë gansuensis</i> Endophyte Infection Under Low-Concentration Urea Treatment: Links to Plant Growth and... by Yuanyuan Jin, Zhenjiang Chen, Kamran Malik, Chunjie Li

“…These findings provide valuable insights into the knowledge of the effects of the symbiotic relationship between host plants and <i>Epichloë</i> endophyte on interspecific interactions of plant microbiome, beneficial for harnessing endophytic symbiosis, promoting plant growth.…”
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Few-layer graphene-hybrid sulfonate hydrogels for high-efficient adsorption of heavy metal (Pb2+, Ni2+, Cd2+) in water treatment by Josué M. Galindo, Carlos M. Andreu, Sonia Merino, M. Antonia Herrero, Ester Vázquez, Ana M. Sánchez-Migallón, Gregorio Castañeda

“…The incorporation of FLG interacts with the polymeric network without compromising its thermal stability, as confirmed by Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). …”
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Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway by Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao

“…Methods This study utilized database analysis and immunohistochemistry to evaluate the expression of Drp1 in ESCC tissues. …”
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Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways by Hnin Ei Ei Khine, Utid Suriya, Thanyada Rungrotmongkol, Supakarn Chamni, Yanxi Lu, Alan Bénard, Bin Lan, Debabrata Mukhopadhyay, David Chang, Andrew Biankin, Regine Schneider-Stock, Robert Grützmann, Rungroch Sungthong, Christian Pilarsky, Chatchai Chaotham

“…Furthermore, western blot analysis was performed to examine the impact the molecular mechanisms underlying JA’s anticancer activity. …”
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Integrated spatial multi‐omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression by Feng Zhao, Rui An, Yilei Ma, Shaobo Yu, Yuzhen Gao, Yanzhong Wang, Haitao Yu, Xinyou Xie, Jun Zhang

“…However, previous studies on intratumoral microbiota primarily rely on bulk tissue analysis, which may obscure their spatial distribution and localized effects. …”
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Experimental study on metallic impurity behavior with boronization wall conditioning in EAST tokamak by Yunxin Cheng, Ling Zhang, Ailan Hu, Shigeru Morita, Wenmin Zhang, Chengxi Zhou, Darío Mitnik, Fengling Zhang, Jiuyang Ma, Zhengwei Li, Yiming Cao, Haiqing Liu

“…It is then proved to be an effective wall conditioning approach for significantly controlling high-Z impurity content. …”
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Factors associated with head circumference and indices of cognitive development in early childhood by Matthew R Grigsby, William Checkley, Tahmeed Ahmed, Zulfiqar Ahmed Bhutta, Laura Nicolaou, Pascal Bessong, Margaret Kosek, Aldo A M Lima, Sanjaya Shrestha, Ram Chandyo, Estomih R Mduma, Laura Murray-Kolb, Brooks Morgan

“…To disentangle the associations between risk factors and HC from linear growth and to distinguish the direct and indirect effects of these risk factors on cognitive function, we conducted mediation analysis using longitudinal models to account for all data measured during follow-up.Results Average HC-for-age Z-score (HCAZ) was −0.54 (95% CI −0.47 to −0.62) near birth and −1.01 (95% CI −0.94 to −1.08) at 24 months. …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Interaction effects between diabetes status and follow-up time were also examined. …”
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Editorial – Revista Ambiente Contábil – Volume 17 – Número 2 – Ano 2025 (Jul./Dez. 2025) by Prof. Dr. Maurício Corrêa da Silva

“…Three dimensions of organizational justice were considered for analysis purposes: distributive, procedural and interactional justice. …”
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Temporal GeneTerrain: advancing precision medicine through dynamic gene expression visualization by Ehsan Saghapour, Ehsan Saghapour, Rahul Sharma, Delower Hossain, Delower Hossain, Kevin Song, Kevin Song, Zhandos Sembay, Zhandos Sembay, Jake Y. Chen, Jake Y. Chen

“…Conventional visualization techniques, such as heatmaps and static clustering, often fail to effectively capture these temporal dynamics, particularly when analyzing large-scale multidimensional datasets. …”
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The efficacy and safety of sodium‐glucose cotransporter 2 inhibitors in patients aged over 80 years with heart failure by Kenji Nakano, Kenji Kanenawa, Akihiro Isotani, Takashi Morinaga, Kaori Yamamoto, Norihisa Miyawaki, Euihong Ko, Miho Nakamura, Yuichi Tanaka, Kenichi Ishizu, Toru Morofuji, Masaomi Hayashi, Masato Fukunaga, Makoto Hyodo, Shinichi Shirai, Kenji Ando

“…SGLT2 inhibitors independently reduced the risk of all‐cause death [adjusted hazard ratio (HR): 0.58, 95% confidence interval (CI): 0.39–0.87, P < 0.01] and HFH (adjusted HR: 0.69, 95% CI: 0.52–0.91, P < 0.01), whereas the risk of safety composite events was not increased (adjusted HR: 0.80, 95% CI: 0.49–1.29, P = 0.36). Subgroup analysis showed no significant interactions between age, diabetes, body mass index, left ventricular ejection fraction, clinical frailty scale, geriatric nutritional risk index and SGLT2 inhibitors consistently reduced composite outcomes across all strata. …”
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