Dietary energy and protein gradients drive metabolic adaptation in growing-finishing yaks on the Qinghai-Tibet plateau by Shoupei Zhao, Jia Zhou, Shengtao Guan, Xiaolin Wang, Xiao Wen, Kaiqiang Zhao, Huaming Yang, Lianghao Lu, Bao Zhang, Yuanyuan Chen, Quanhui Peng, Lizhi Wang, Zhisheng Wang, Bai Xue

“…These findings provide a theoretical foundation for the effective feeding and nutritional management of yaks.…”
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Clinical Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction and With Reduced Ejection Fraction According to the Prognostic Nutritional Ind... by Simone Solano, Mingming Yang, Paolo Tolomeo, Toru Kondo, Li Shen, Pardeep S. Jhund, Inder S. Anand, Akshay S. Desai, Carolyn S. P. Lam, Aldo P. Maggioni, Felipe A. Martinez, Jean L. Rouleau, Muthiah Vaduganathan, Dirk J. van Veldhuisen, Faiez Zannad, Michael R. Zile, Milton Packer, Scott D. Solomon, John J. V. McMurray

“…Cox regression was used to analyze clinical outcomes, and multivariable fractional polynomial interaction analysis to examine the effects of sacubitril‐valsartan, according to PNI. …”
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A multi-centred pilot randomised controlled trial of learning through play plus culturally adapted cognitive behaviour therapy for treating postnatal depression in Nigerian women by Dung Ezekiel Jidong, Dung Ezekiel Jidong, Tarela Juliet Ike, Maigari Yusuf Taru, Juliet Yop Pwajok, Charles Nnaemeka Nwoga, John Ezekiel Jidong, Christopher Francis, Shadrack Bitrus Mwankon, Karick Haruna, Zubairu Dagona, Nusrat Husain, Nusrat Husain

“…Themes identified from the qualitative dataset showed positive behaviour management, enhanced mother-child interaction and relationship, modification of negative thought processes, positive experience and relationship formation.ConclusionThe LTP+CaCBT intervention is shown to be acceptable and culturally appropriate whilst indicating potential clinical effectiveness in reducing postnatal depression and anxiety in Nigerian mothers. …”
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Systemic immune inflammation index and systemic inflammation response index predict frailty progression in older patients undergoing elective orthopedic surgery by Guanghan Gao, Zitian Zheng, Fei Wang, Yaonan Zhang, Lei Shi, Lin Wang, Hongyu Wang, Qingyun Xue

“…Finally, we presented stratified analyses and interaction tests of covariates.ResultsA total of 546 patients were included, with 109 (19.5%) experiencing postoperative frailty progression. …”
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The impact of breaking up prolonged sitting with physical activity during simulated dayshifts and nightshifts on sleep architecture: a randomised controlled trial by Charlotte C. Gupta, Imesha Vitanege, Sally A. Ferguson, Corneel Vandelanotte, Mitch J. Duncan, Dayna F. Easton, Georgia Tuckwell, Courtney Ah Shay, Philip Tucker, Michele Lastella, Maria Zerella, Grace E. Vincent

“…Sleep was monitored using polysomnography. In the analysis of day shifts, mixed model ANOVAs demonstrated a significant physical activity *sleep opportunity interaction for total sleep time (p < 0.001), sleep onset latency (p < 0.001), time spent in N2 (p < 0.001) and N3 (p = 0.03). …”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…Results Among the studied PEVs, those generated by CRP and FFV exhibited the most pronounced effects on altering cancer hallmark functions. Specifically, CRP and FFV PEVs increased proliferation in both MV3 and A2058 spheroids. …”
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Ectomycorrhizal response to bark beetle attack: a comparison of dead and surviving trees by Roman Modlinger, Vítězslava Pešková, Jan Zelený, Markéta Macháčová, Martin Leiner, Daniel Tyšer, Oto Nakládal, Václav Zumr, Peter Surový

“…Such knowledge is essential for developing effective strategies to manage and mitigate the ecological impacts of bark beetle outbreaks in forested environments.…”
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Metabolic Plasticity and Transcriptomic Reprogramming Orchestrate Hypoxia Adaptation in Yak by Ci Huang, Yilie Liao, Wei Peng, Hai Xiang, Hui Wang, Jieqiong Ma, Zhixin Chai, Zhijuan Wu, Binglin Yue, Xin Cai, Jincheng Zhong, Jikun Wang

“…Here, we investigated the effects of oxygen concentration on yak cardiac fibroblast proliferation and the underlying molecular regulatory pathways using RNA sequencing (RNA-seq) and metabolic analyses. …”
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Identification of novel anti-ZIKV drugs from viral-infection temporal gene expression profiles by Nailou Zhang, Zhongyuan Tan, Jinbo Wei, Sai Zhang, Yan Liu, Yuanjiu Miao, Qingwen Ding, Wenfu Yi, Min Gan, Chunjie Li, Bin Liu, Hanzhong Wang, Zhenhua Zheng

“…Here, we found that ZIKV effectively evaded activation of immune response-related genes and completely reprogrammed cellular transcriptional architectures. …”
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Research progress and prospect of cooling technology for drilling fluid in deep and ultra-deep wells by Chao ZHANG, Jinsheng SUN, Xianbin HUANG, Kaihe LÜ, Jintang WANG, Jian LI, Yuan GENG, Juan HE, Jiajun Dai

“…Concurrently, high temperatures exacerbate the wear and failure of drilling tools, adversely affecting the efficiency, safety, and cost-effectiveness of drilling operations. In addition, this study explores the heat transfer mechanisms between drilling fluids and geological formations, shedding light on the dynamic interactions that influence thermal behaviors within the wellbore environment. …”
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Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation by Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-ichi Hirata, Koji Fukuzawa

“…These data suggested that EGF signaling pathway could be a therapeutic target for AF and serum AREG levels provide an effective biomarker for predicting persistent AF.…”
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Nasopharyngeal Local Transcriptional Profile upon SARS-CoV-2 Omicron BA.2.2 Breakthrough Infection by Yi Zhang, Yang Zhou, Yumeng Zhang, Jiazhen Chen, Jing Wu, Peng Cui, Shiyong Wang, Yuanyuan Xu, Zhongliang Shen, Tao Xu, Yang Li, Jingwen Ai, Ning Jiang, Chao Qiu, Wenhong Zhang, Haijuan Wang

“…To better understand the anti-viral effects of vaccination on host-virus interactions during the outbreak of BA.2.2 Omicron, we conducted RNA-seq transcriptome analysis on nasopharyngeal swabs from COVID-19 patients in Shanghai. …”
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Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition by Zhenying Diao, Youcheng Liang, Yong Liu, Dou Zhang, Long Qiu, Jianbo Sun, Qiaoyou Lu, Yanlei Liu, Daxiang Cui, Ting Yin

“…Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. …”
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Benchmark Investigation of SARS-CoV-2 Mutants’ Immune Escape with 2B04 Murine Antibody: A Step Towards Unraveling a Larger Picture by Karina Kapusta, Allyson McGowan, Santanu Banerjee, Jing Wang, Wojciech Kolodziejczyk, Jerzy Leszczynski

“…Even though COVID-19 is no longer the primary focus of the global scientific community, its high mutation rate (nearly 30 substitutions per year) poses a threat of a potential comeback. Effective vaccines have been developed and administered to the population, ending the pandemic. …”
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Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2 by Chunxiao Chang, Meng Wang, Jia Li, Sihao Qi, Xiaojuan Yu, Jun Xu, Shengbin Shi

“…Understanding its molecular mechanisms is crucial for effective treatment. The NOTCH1 signaling pathway, though not fully understood, is implicated in liver injury and may be a potential therapeutic target. …”
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In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protoc... by Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

“…A detailed characterization of these immune responses will provide critical insights into host-pathogen interactions and may serve as a foundation for the development of effective T-cell–based vaccines or immunotherapies targeting HRV. …”
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Attenuation of Stress Responses to Human Handling Through Habituation in Goats by Tharun Tej Erukulla, Phaneendra Batchu, Priyanka Gurrapu, Arshad Shaik, Thomas H. Terrill, Govind Kannan

“…This experiment was conducted to determine the effects of habituation to handling on behavioral, physiological, and metabolomic responses in goats when subjected to routine handling. …”
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Smartphone Usage Patterns and Sleep Behavior in Demographic Groups: Retrospective Observational Study by Ting Wang, Anja Seiger, Alexander Markowetz, Ionut Andone, Konrad Błaszkiewicz, Thomas Penzel

“…MethodsWe conducted a retrospective analysis of data collected from the Murmuras app from January 1, 2022, to December 31, 2022. …”
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Improvement of the Regulatory Framework of Information Security for Terminal Access Devices of the State Information System by V. A. Sizov, D. M. Malinichev, V. V. Mochalov

“…The aim of the study is to increase the effectiveness of information security management for state information systems (SIS) with terminal access devices by improving regulatory legal acts that should be logically interconnected and not contradict each other, as well as use a single professional thesaurus that allows understanding and describe information security processes.Currently, state information systems with terminal access devices are used to ensure the realization of the legitimate interests of citizens in information interaction with public authorities [1].One of the types of such systems are public systems [2]. …”
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An ecological, environmental, and economic indicators-based approach towards enhancing sustainability in water and nutrient use for passion fruit cultivation in Colombia by Sonia Mercedes Polo-Murcia, Nesrine Chaali, Camilo Ignacio Jaramillo-Barrios, Sofiane Ouazaa, Victor Javier Polo, John Edisson Calderon Carvajal

“…Principal component analysis (PCA) was used to determine optimal irrigation and fertilization practices. …”
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