Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…These findings provide mechanistic insights into the therapeutic effects of QHCS and lay a theoretical foundation for its broader application in veterinary parasitology.…”
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M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…This interaction facilitated IGF2BP2-mediated stabilization of NUP160 mRNA, a nuclear pore complex component. …”
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Ecosystem, spatial and trophic dimensions of niche partitioning among freshwater fish predators by Milan Říha, Lukáš Vejřík, Rubén Rabaneda-Bueno, Ivan Jarić, Marie Prchalová, Ivana Vejříková, Marek Šmejkal, Petr Blabolil, Martin Čech, Vladislav Draštík, Michaela Holubová, Tomáš Jůza, Karl Ø. Gjelland, Zuzana Sajdlová, Luboš Kočvara, Michal Tušer, Jiří Peterka

“…The aim of this study is to investigate the effects of environmental variation on spatial and trophic niche overlap between two freshwater apex predators, the northern pike (Esox lucius) and the European catfish (Silurus glanis), in three different water bodies. …”
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MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF by Beatrice Vahle, Antje Schauer, Antje Augstein, Maria‐Elisa Prieto Jarabo, Janet Friedrich, Peggy Barthel, Anita Männel, Norman Mangner, Siegfried Labeit, T. Scott Bowen, Axel Linke, Volker Adams

“…MuRF1 is a muscle‐specific ubiquitin E3‐ligase that interacts with titin. Blocking this interaction via small molecules (MyoMed205) can improve muscle function and mitochondrial activity in HFpEF. …”
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Scapular dyskinesis-based exercise therapy versus multimodal physical therapy for subacromial impingement syndrome in young overhead athletes with scapular dyskinesis: a randomized... by Meilin Wen, Xuanming Hu, Guiying Bao

“…Significant Time × Group interactions were also observed for all variables (p < 0.05, η² = 0.15–0.76), prompting further simple effects analysis. …”
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Endothelial TRIM35‐Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts by Yiming Leng, Wei Wang, Jun Lu, Jingyuan Chen, Xuliang Chen, Yalan Li, Jie Wang, Yuanyuan Liu, Qian Tan, Wenjing Yang, Youxiang Jiang, Peiyuan Huang, Jingjing Cai, Hong Yuan, Liang Weng, Qingbo Xu, Yao Lu

“…However, the pathogenesis of vascular graft calcification, particularly the role of endothelial‐smooth muscle cell interaction, is still unclear. To test how ECs interact with SMCs in artery grafts, single‐cell analysis of wild‐type mice is first performed using an arterial isograft mouse model and found robust cytokine‐mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression. …”
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LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria by A. Benitez-Amaro, E. Garcia, M.T. LaChica Lhoëst, A. Polishchuk, I. Zegri-Reiriz, D. Vilades, J.M. Guerra, L. Fernández-del-Rio, S. Mirabet, V. Samouillan, O. Shirihai, M. Liesa, C. Enrich, V. Llorente-Cortés

“…This study examines (i) whether HFHC induces cholesterol accumulation in mitochondria, and impacts cardiac bioenergetics, and (ii) the effectiveness of anti-P3 Abs in mitigating HFHC-induced mitochondrial alterations. …”
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Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma by Hongqing Cai, Shen Tian, Angsi Liu, Guanchao Xie, Hongsheng Zhang, Xiaogang Wu, Jinghai Wan, Sai Li

“…The involvement of CTF1 in m6A modifications contributed to glioma progression. Enrichment analysis revealed immune response pathways linked with CTF1 in glioma, including natural killer cell cytotoxicity, NOD-like receptor signaling, Toll-like receptor signaling, antigen processing, chemokine signaling, and cytokine receptor interactions. …”
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Implications of the <i>STAT5B</i> and <i>C1QBP</i> Genes of Grain Aphid <i>Sitobion avenae</i> in the Transmission of Barley Yellow Dwarf Virus by Chiping Liu, Manwen Zhang, Chen Luo, Zuqing Hu

“…Furthermore, the effects of <i>STAT5B</i> and <i>C1QBP</i> on the acquisition, retention, and transmission of BYDV-GAV in <i>S. avenae</i> were verified using the RNA interference (RNAi) method. …”
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Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction by Guan Qun Zhu, Seung Hwan Jeon, Woong Jin Bae, Sae Woong Choi, Hyun Cheol Jeong, Kang Sup Kim, Su Jin Kim, Hyuk Jin Cho, U. Syn Ha, Sung Hoo Hong, Ji Youl Lee, Eun Bi Kwon, Sae Woong Kim

“…Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. …”
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Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice by Haoxin Li, Hao Yuan, Zi-Peng Yang, Yining Song, Jun-Jie Wang, Qingyuan Wen, Yu-Xiang Zheng, Xiu-Xiang Zhang, Miao Yu, Zi-Guo Yuan

“…However, the mechanisms of interaction between T. gondii and the reproductive system is unclear. …”
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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

“…However, the mechanisms driving these interactions, especially in humans, remain poorly understood. …”
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Fusobacterium mortiferum and its metabolite 5-aminovaleric acid promote the development of colorectal cancer in obese individuals through Wnt/β-catenin pathway by DKK2 by Jiaxin Deng, Jiawei Zhang, Mingli Su, Juan Li, Yuping Su, Qinghua Zhong, Jiancong Hu, Yongcheng Chen, Sen Liao, Dezheng Lin, Xuefeng Guo

“…This study uncovers the potential carcinogenic effects of Fusobacterium mortiferum and 5-AVA in the development of obesity and CRC. …”
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LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation by Jiayu Zhang, Jing Li, Yonghan Luo, Timothy J. Mahony, Jingru Gao, Yanchun Wang, Xiaotao Yang, Fan Yang, Xia Ou, Jihong Zhang, Heng Yang, Wei Chen

“…Our findings demonstrate that CVB5-induced LINC2781 enhances STAT1 activation by blocking the suppressive effects of G3BP2 on immune responses, providing a potential foundation for developing antiviral therapies targeting the lncRNA.IMPORTANCEWe investigate the role of lncRNA in virus-host interactions and identify a novel cytoplasmic lncRNA, LINC2781, whose expression is upregulated following CVB5 infection. …”
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Superior reversible hydrogen storage in eutectic LiBH4–KBH4 system via Ni–based catalysts synergized with graphene by Shanqing Qu, Yaxiong Yang, Mingxia Gao, Zhenglong Li, Wenping Sun, Chu Liang, Xin Zhang, Xiaoyu Zhang, Lingchao Zhang, Ruizi Wang, Hongge Pan

“…The capacity retention achieves 81.2 % after 50 cycles. DFT theoretical analysis shows that there is strong charge transfer interaction between Ni3B and LiBH4/KBH4, which destabilizes the [BH4]– structure and promotes the dehydrogenation. …”
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Assembly mechanisms, not species pool, shape β-diversity of soil methanotrophic communities in steppes of China by Yongping Kou, Zhe Feng, Huan Li, Yanjiao Liu, Yanjiao Liu, Lin Xu, Lin Xu, Xiangzhen Li

“…Furthermore, the relative significance of these assembly processes (e.g., dispersal limitation, drift, environmental filtering, and biotic interactions) varies according to spatial scales and steppe types. …”
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Facile Synthesis of Nanolayered Manganese Oxide for the Efficient and Selective Removal of Strontium(II) from Nuclear Wastewater by Fan Wang, Qi Zheng, Wenya Tai, Qiang Wu, Xinglei Li, Yehuizi Wu, Ningchao Zheng, Shunyan Ning, Deqian Zeng, Hiroshi Watabe, Yan Wu, Hai Li, Yuezhou Wei, Xiangbiao Yin

“…The adsorption mechanism of electrostatic interaction and ion exchange is revealed by combining experimental results and spectroscopic analysis, such as Transmission Electron Microscope and X‐ray diffraction. …”
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Antibiogram use on dairy cattle for bovine respiratory disease: Factors associated with bacterial pathogen identification and prediction of bacterial recovery using machine learnin... by Hugo F. Monteiro, Alejandro Hoyos-Jaramillo, Adriana Garzon, Heather M. Fritz, Craig C. Miramontes, Isabelle M. Matos, Terry W. Lehenbauer, Sharif Aly, Fabio S. Lima, Richard V. Pereira

“…ABSTRACT: Effective isolation of bacterial pathogens for bovine respiratory disease (BRD) is a critical step for accurate diagnosis of the agent associated with this disease on the dairy. …”
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Transformative Transparency for Local Natural Resource Revenue Management by Primi Suharmadhi Putri

“…Second, the thesis proposes a Transparency Cube as an analytical framework to facilitate research on the effectiveness of transparency initiatives that work through state-citizen interaction. …”
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Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach by Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Mohammed Cherkaoui, Maged Gomaa Hemida

“…Furthermore, hydrogen bond monitor analysis over the 50 ns simulation confirmed persistent and specific interactions between the ligand and proteins, suggesting that GS441524 may effectively inhibit the NA, and PB2/CBD might potentially disrupt PB2-mediated RNA synthesis. (4) Conclusions: Our findings are consistent with previous evidence supporting the antiviral activity of certain nucleoside analog inhibitors, including GS441524, against various coronaviruses. …”
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