ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression by Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu

“…Here, we identified a previously unrecognized nuclear localization of CD147 in VSMCs, and pathological stimuli upregulated the nuclear CD147 expression through reactive oxygen species-dependent mechanisms. Multi-omics analysis integrating RNA sequencing, CUT&Tag, and protein interactome profiling revealed that nuclear CD147 directly interacts with the STAT1/STAT2 complex to activate the IRF7-IFNα/β axis under oxidative stress (H2O2 exposure), thereby driving VSMC senescence and inflammatory reprogramming. …”
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The role of the LncRNA XIST/miR-15a-5p/MN1 signaling axis in gender disparities in bladder cancer prognosis by Fangzhen Cai, Siwei Xu, Yinan Li, Yinan Li, Qingliu He, Qingfu Su, Heyi Chen, Weihui Liu, Jiabi Chen, Qingshui Wang, Yehuda G. Assaraf, Yao Lin, Wei Zhuang

“…Functional experiments including cell proliferation, migration, and invasion assays were conducted in bladder cancer cell lines. Molecular interactions were investigated through gene knockdown, overexpression, and luciferase reporter assays. …”
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Prenatal exposure to organophosphorus flame retardants and birth outcomes: A cross-sectional study in an e-waste area in China by Chuyan Zhang, Zheng Ruan, Yifan Dou, Xian Liang Sun, Huadong Xu, Zhaoqiang Jiang, Xia Rao, Xinran Wang, Shoji F. Nakayama, Teruhiko Kido, Jianlin Lou

“…Trimethyl phosphate (TMP) was significantly associated with increased birth weight and decreased birth length in newborns overall, with these effects being more pronounced in male infants following gender-stratified analysis. …”
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Alteration of m⁶A Methylation in Breast Cancer Cells by <i>Kalanchoe pinnata</i> Aqueous Extract by Carlos Rogelio Alvizo-Rodríguez, Fernando Calzada, Uriel López-Vázquez, Emmanuel Tomay Tiburcio, Juan A. Hernandez-Rivera, Alan Carrasco-Carballo, Marta Elena Hernández-Caballero

“…The FTO demethylase was overexpressed in both cell lines. In silico analysis suggested an interaction between FTO and compounds such as gallic acid and myricetin. …”
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Charged polystyrene microplastics inhibit uptake and transformation of 14C-triclosan in hydroponics-cabbage system by Enguang Nie, Yandao Chen, Shengwei Xu, Zhiyang Yu, Qingfu Ye, Qing X. Li, Zhen Yang, Haiyan Wang

“…Objective: This study aimed to investigate effects of charged polystyrene microplastics (PS-MPs) on the fate of triclosan in cabbage plants under a hydroponic system. …”
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Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative s... by Sheena E Ramsay, Richard G Watt, Falko F Sniehotta, Eileen Kaner, Martha Paisi, Neha Jain, Martin Burrows, Emma A Adams, Gillian McLellan, Emma C Joyes, Laura J McGowan, David Landes, Lorenzo Iafrate

“…The data were analysed iteratively using thematic analysis.Results Twenty-eight people experiencing SMD (age range: 27–65 years; 21% females) and 78 service providers, commissioners and policymakers (age range: 28–72 years; 63% females) were interviewed or included in focus groups. …”
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In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies by Emily Alefeld, André Haase, Dario Van Meenen, Bettina Budeus, Oliver Dräger, Natalia Miroschnikov, Saskia Ting, Deniz Kanber, Eva Biewald, Nikolaos Bechrakis, Nicole Dünker, Maike Anna Busch

“…In summary, we established an in vitro model system to investigate the interaction of RB tumor cells with their TME. Our findings contribute to a better understanding of the relationship between RB tumor malignancy and its TME and will facilitate the development of effective treatment options for eye preserving therapies.…”
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Study protocol for a multi-centre randomised controlled trial of the Thai early intervention for autism: Assistive Technology for Caregivers (TEI4A-ATC) across nine hospitals in he... by Duangkamol Tangviriyapaiboon, Samai Sirithongthaworn, Vallop Thaineua, Siripon Kanshana, Athithan Sriminipun, Suchitporn Lersilp, Kewalin Panyo, Kansinee Changsom, Mallika Panyaphab, Pimwarat Srikummoon, Salinee Thumronglaohapun, Natthanidnan Sricharoen, Patrinee Traisathit

“…The aim of the present study is to investigate the effectiveness of a computer-based intervention programme for caregivers of children with ASD called the Thai Early Intervention for Autism—Assistive Technology for Caregivers (TEI4A-ATC), designed and implemented by a multidisciplinary team.Method and analysis 160 children and their caregivers are being recruited. …”
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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…By testing multiple treatments within a single trial, platform trials can help identify the most effective treatments (and any interactions between treatments) for patients more quickly and with less burden for patients and their families. …”
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Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…Mean annual precipitation, mean annual temperature, available N, N fertilization rate and maize varieties were main factors affecting QRs, while the effects and interactions of climate, soil properties and management factors were the main causes producing differences in QRs. …”
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Implementing a group singing intervention for postpartum depression within the Italian health service by Ilaria Lega, Ilaria Luzi, Simona Mastroeni, Claudia Ferraro, Silvia Andreozzi, Serena Donati, Pietro Grussu, Valentina Cavazzana, Patrizia Proietti, Patrizia Magliocchetti, Chiara Monaldi, Cristina Biglia, Rossana Oreggia, Catterina Seia, Calum Smith, Calum Smith, Katey Warran, Katey Warran, Nils Fietje, The Italy and GLOBUS Music and Motherhood Groups

“…BackgroundIn the United Kingdom a singing intervention for Postpartum Depression (PPD) titled “Music and Motherhood” was found to be effective. The World Health Organization Regional Office for Europe coordinated a study to assess the feasibility of implementing and adapting the intervention in other countries. …”
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Cow Placenta Peptides Ameliorate D-Galactose-Induced Intestinal Barrier Damage by Regulating TLR/NF-κB Pathway by Yuquan Zhao, Zhi Zeng, Weijian Zheng, Zeru Zhang, Hanwen Zhang, Yuxin Luo, Kunshan Zhao, Yuyan Ding, Wei Lu, Fuxing Hao, Yixin Huang, Liuhong Shen

“…Transcriptome sequencing identified 1396 DEGs associated with CPP’s effects, highlighting <i>TLR4</i>, <i>IL-1β</i>, and <i>Mmp9</i> as core regulatory genes through protein–protein interaction network analysis. …”
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THE ETHICAL STARTUP? by Alexis Walker

“…Auer, “All your data (effectively) belong to us: data practices among direct-to-consumer genetic testing firms,” Genetics in Medicine 19 (2017): 513-520…”
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Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis by Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen, Ying Zheng, Bo Zheng, Fei Sun

“…Abstract Background Testicular aging has profound effects on spermatogenesis, sperm function, and the spermatogenic microenvironment, contributing to reduced male fertility. …”
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Design of a Wearable Exoskeleton Piano Practice Aid Based on Multi-Domain Mapping and Top-Down Process Model by Qiujian Xu, Meihui Li, Guoqiang Chen, Xiubo Ren, Dan Yang, Junrui Li, Xinran Yuan, Siqi Liu, Miaomiao Yang, Mufan Chen, Bo Wang, Peng Zhang, Huiguo Ma

“…While soft robotic exoskeletons have proven effective in rehabilitation therapy and daily activity assistance, challenges remain in performing highly dexterous tasks due to structural complexity and insufficient motion accuracy. …”
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Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice by I. Gálvez, M.C. Navarro, S. Torres-Piles, L. Martín-Cordero, M.D. Hinchado, E. Ortega

“…Exercise strongly modulates the immune system, inducing a plethora of dynamic responses involving the innate immune cell function and inflammatory processes that contribute to both potential health benefits and harmful side effects. Indeed, the relationship between physical exercise, stress, immunity, and metabolism serves as a paramount model of neuroimmunoendocrine interaction. …”
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Synthesis of Cu4O3 nanoparticles using pumpkin seed extract: Optimization, antimicrobial, and cytotoxicity studies by Khan Azhar U., Khan Azmat Ali, Malik Nazia, Her Jun, Gupta Mona, Panda Subhranshu, Imtiyaz Khalid, Alam Rizvi Mohammed Moshahid, Mushtaque Mohammed, Bansod Sudhakar M., Mohammad Masita, Kim Min, Pyo Kyungsoo, Alam Mahboob

“…Unlike conventional chemical methods, this eco-friendly route enables rapid, cost-effective NP production with minimal environmental impact. …”
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Insights into intestinal barrier disruption during long-term gut Chlamydia colonization in mice: a single-cell transcriptomic approach by Ziqing Wan, Yicun Jiang, Sheng Xie, Jiao Wan, Youyou Huang, Luying Wang, Qi Zhang, Zengzi Zhou, Xin Sun, Chuqiang Shu, Chuqiang Shu, Tianyuan Zhang, Tianyuan Zhang, Qi Tian, Qi Tian

“…However, the mechanisms enabling its persistence in the gut remain poorly understood, hindering the development of effective treatments for chronic infections.MethodsWe employed single-cell RNA sequencing (scRNA-seq) to analyze gene expression profiles and cellular heterogeneity in mouse colonic tissues during Chlamydia long-term colonization to characterize transcriptional changes and intercellular interactions critical for bacterial persistence.ResultsOur analysis revealed significant alterations in gene expression across intestinal cell populations, with distinct molecular pathways implicated in Chlamydia persistence. …”
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Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways by Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang

“…By employing 16S rRNA and metabolomic analysis, we identified that 3-indolepropionic acid (IPA) was the most affected differential microbial metabolite that regulated EGC gliosis. …”
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YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression by Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong

“…Protein interactions were explored by BioGRID database analysis, molecular docking, and co-immunoprecipitation assay. …”
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