Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…RNA-seq analysis revealed that MPM-1 exerts its broad-spectrum anticancer effects through interactions with multiple signaling pathways, including mTOR, Wnt, Hippo, PI3K/Akt, and MAPK pathways. …”
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The Ecosystem Services Assessment of Wetlands based on the Classification of Hydrological-ecological Structures and Functions (Case study: Shadegan Wetland) by leila Rahimi, Bahram Malekmohammadi, Ahmad reza Yavari

“…The management strategies are developed based on EBM-DPSER model and trade-off analysis of wetland ecosystem services.The most important management strategies include the following: - Preparation of the wetland land use map and zoning of the wetland to appropriate and allowed areas for human activities; - Investigating existing livelihood patterns and providing alternative and eco-friendly livelihoods in the region; - Investigating existing livelihood patterns and providing alternative and eco-friendly livelihoods in the region; - Establishing a legal mechanism for allocating the right of water wetland from the upstream rivers and restoring the wetland share of the agricultural, industrial and energy sectors; - Identifying the main sources of dust and developing biomechanical and bioengineering plans using the existing capacities in the province, especially attracting local people's participation. 4-Conclusion The proposed framework has gone beyond the traditional approaches to assessing and managing wetlands, which have not yet been effective and are not based on the understanding of the structure and functions of wetlands. …”
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NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner by Yuanbo Hu, Chenbin Chen, Kezhi Lin, Xinya Tong, Tingting Huang, Tianle Qiu, Xietao Chen, Jun Xu, Wangkai Xie, Xiangwei Sun, Shiyu Feng, Mingdong Lu, Zhiguang Zhao, Xiaodong Chen, Xiangyang Xue, Xian Shen

“…We also found that both wild‐type and the m5C enzymatic‐dead mutant NSUN2 closely interacted with CUL4B. Silencing of CUL4B effectively inhibited the m5C‐independent function of NSUN2. …”
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Lysinibacillus sphaericus exposure impedes Anopheles dirus’s oviposition via downregulating vitellogenin by Shasha Yu, Zhilong Liu, Jing Wang, Hong Zheng, Shiqian Han, Feifei Zheng, Dan Zheng, Caizhi Zhao, Xin Li, Tingting Liu, Xuesen Yang, Ying Wang

“…Abstract Background Vector control using Lysinibacillus sphaericus is an effective strategy for preventing the transmission of mosquito-borne diseases. …”
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<i>Brucella ceti</i> in Common Dolphins (<i>Delphinus delphis</i>) in Portugal—Characterization of First Isolates by Sandra Cavaco, Miguel L. Grilo, Ricardo Dias, Mónica Nunes, Pedro Pascoal, Marcelo Pereira, Catarina Fogaça, Ana Beatriz Costa, Sofia Pardal, Ana Cristina Ferreira

“…Virulence genes, including those for host interaction (<i>bsp</i>E, <i>btp</i>B) and intracellular survival (<i>vir</i>B7, <i>vce</i>A), were consistent across isolates, highlighting the pathogenic potential. …”
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RCPNEOPERU trial: a cluster randomized pilot trial to assess traditional neonatal resuscitation compared to partially virtual training in remote areas by Carlos A. Delgado, Enrique Gómez Pomar, Pablo Velásquez, Víctor Sánchez, Roberto Shimabuku, Luis Huicho

“…Objective: To assess the effects of a neonatal resuscitation training program using traditional training and partial distance learning. …”
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Opinion: The role of AerChemMIP in advancing climate and air quality research by P. T. Griffiths, P. T. Griffiths, L. J. Wilcox, R. J. Allen, V. Naik, F. M. O'Connor, F. M. O'Connor, M. Prather, A. Archibald, F. Brown, M. Deushi, W. Collins, S. Fiedler, N. Oshima, L. T. Murray, B. H. Samset, C. Smith, C. Smith, S. Turnock, S. Turnock, D. Watson-Parris, D. Watson-Parris, P. J. Young, P. J. Young

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Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…Equity harms were extracted from study reports that included moderator analysis or interaction effects. Harms were initially categorised according to the PROGRESS-Plus for equity harms. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…We detect PDK1 expression in EOC tissues and cells using qRT-PCR and western blot analysis, and the effects of PDK1 on EOC cell malignant behaviors are explored. …”
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Investigating biographical post-bariatric surgery uncertainties in the light of changes in bodily practices: a mixed-method, multicentric and longitudinal research protocol by Dominique Delaunay, Adrien Sterkers, Emmanuel Disse, Matthieu Hournau, Jean-Michel Oppert, Claire Perrin, Sylvain Ferez, Cyriac Bouchet-Mayer, Lise Charissou-Pujol, Philippe Terral, Camille Couvry, Damien Issanchou, Marie-Pierre Julien, Patrick Ritz, Mathieu Baron, Yan Beldame, Anne Coquereau, Ute Duranteau, Lucie Favre, Laurène Fituque, Franshelis Garcia, Renaud Gontier, Sophie Granier, Anne Marcellini, Marius Matichescu, Yves Morales, David Nocca, Laurent Paccaud, Éric Perera, Mélanie Perez, Simona Petracovschi, Théo Rougnant, Aurélie Savart, Marta Silvestri, Marie-Alix Thébault, Kirsten Verkooijen

“…We also know that the major bodily transformations that occur in the six to twelve months following surgery produce a high degree of biographical uncertainty and affect social interactions. From a sociological perspective, the authors propose to study the processes of disruption and re-establishment of lifestyle habits in the first 24 months following bariatric surgery.Methods and analysis The ChiBarAPS study relies on a mixed-method longitudinal survey, comprising three components: qualitative, quantitative, literature and data review. …”
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Relationship between composite dietary antioxidants index and growth indicators in children aged 3–12 years: results from two observational studies by Rui Wen, Huanting Pei, Jingyi Ren, Siqi Zhu, Simeng Qiao, Pui Yee Tan, Yunyun Gong, Min Yang, Junsheng Huo, Gangqiang Ding, Yuxia Ma

“…It is recommended to consume a combination of multiple antioxidants, as their interactions may offer potential benefits. However, further research is needed to explore the underlying mechanisms of the synergistic effects of antioxidants on children's growth and development.…”
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Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…Despite advances in understanding oxidative stress in COPD pathogenesis, effective strategies to mitigate oxidative damage and normalize lung function remain a challenge. …”
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Optimizing the Postcataract Patient Journey Using AI-Driven Teleconsultation: Prospective Case Study by Joukje C Wanten, Noël J C Bauer, Mohita Chowdhury, Aisling Higham, Nick de Pennington, Frank J H M van den Biggelaar, Rudy M M A Nuijts

“…ConclusionsDora-NL1 is a safe and effective tool for automated postoperative screening following cataract surgery. …”
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Differences in transcriptome characteristics and drug repositioning of Alzheimer's disease according to sex by Jingqi Shi, Minghua Zhang, Yazhuo Hu, Jing Liu, Ke Li, Xuan Sun, Siyu Chen, Jianwei Liu, Ling Ye, Jiao Fan, Jianjun Jia

“…The results of cell communication analysis, such as collagen signaling pathway, suggest that sex disparities impact intercellular interactions within prefrontal cortex tissues among individuals with AD. …”
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Role of <i>Thymus ciliatus</i> (Thyme) to Ameliorate the Acute Neurotoxicity Induced by Bisphenol A: <i>In Vivo</i> Supported with Virtual Study by Dallal Kourat, Djallal Eddine H. Adli, Mostapha Brahmi, Faisal K. Alkholifi, Faten F. Bin Dayel, Wafaa Arabi, Marie-Laure Fauconnier, Bakhta Bouzouira, Khaled Kahloula, Miloud Slimani, Sherouk Hussein Sweilam

“…However, TEO treatment attenuated these adverse effects by restoring neurobehavioral function. Molecular docking analysis revealed an affinity between the major essential oils identified in <i>T. ciliatus</i>, BPA, and the 5HT2C receptor and the MAO, AChE, and BChE enzymes, suggesting a potential mechanism underlying BPA’s effects on behavior and memory. …”
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Shaping the Milky Way: The Interplay of Mergers and Cosmic Filaments by Arpit Arora, Nicolás Garavito-Camargo, Robyn E. Sanderson, Martin D. Weinberg, Michael S. Petersen, Silvio Varela-Lavin, Facundo A. Gómez, Kathryn V. Johnston, Chervin F. P. Laporte, Nora Shipp, Jason A. S. Hunt, Gurtina Besla, Elise Darragh-Ford, Nondh Panithanpaisal, Kathryne J. Daniel, The EXP collaboration

“…Using multichannel singular spectrum analysis, we successfully disentangle the effects of satellite mergers and filamentary accretion on quadrupole. …”
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Multifunctional MOF microneedle patch with adsorbed exosomes for enhanced diabetic wound healing by Jieyu Xiang, Ziming Li, songlu Tseng, Tianhao Li, Liquan Wang, Zhujun Li, Lin Kang, Fengzhou Du, Jiuzuo Huang, Nanze Yu, Xiao Long

“…In vitro and in vivo studies confirmed the effectiveness of the MN-MOF-Exo patch in diabetic wound healing, while RNA sequencing analysis revealed that the patch accelerated wound healing by upregulating key genes, activating the ERK1/2 and PI3K–Akt signaling pathways, and facilitating angiogenesis, cell migration, and extracellular matrix remodeling. …”
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Uric acid-induced cardiomyocytic polyamines’ insufficience: a potential mechanism mediates cardiomyocytic injury by Cuiting Lin, Cuiting Lin, Cuiting Lin, Cuiting Lin, Qiang Zheng, Qiang Zheng, Qiang Zheng, Haiyan Yu, Haiyan Yu, Ting Wu, Lin Chen, Lin Chen, Weihao Lin, Weihao Lin, Jianxin Pang, Yang Yang, Yang Yang, Yang Yang

“…Notably, exogenous supplementation with spermidine or spermine effectively mitigated the uric acid-induced decline in cardiomyocyte viability and mitochondrial membrane potential.DiscussionUric acid disrupts polyamine homeostasis, leading to mitochondrial dysfunction and cardiomyocyte damage. …”
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Highly efficient and stable NiFe oxide-based electrocatalysts for oxygen evolution in alkaline and saline solutions by Soumia El Boumlasy, Mariarosaria Pascale, Oreste De Luca, Tommaso Caruso, Salvatore Mirabella, Antonio Terrasi, Antonino Salvatore Aricò, Francesco Ruffino

“…Developing cost-effective and stable oxygen evolution reaction (OER) catalysts is crucial for advancing hydrogen production via water electrolysis. …”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…RNA sequencing analysis demonstrated that L. reuteri-CMVs repaired intestinal barrier by activating the HIF-1 signaling pathway and upregulating HMOX1 expression. …”
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