Regulatory mechanism for host-cell contact-dependent T3SS gene expression in Vibrio parahaemolyticus by Sarunporn Tandhavanant, Hiroyuki Terashima, Hirotaka Hiyoshi, Dhira Saraswati Anggramukti, Nopadol Precha, Tetsuya Iida, Shigeaki Matsuda, Narisara Chantratita, Toshio Kodama

“…Thus, V. parahaemolyticus can effectively upregulate the expression of virulence factors when interacting with the host cells. …”
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Zoonotic diseases awareness and food safety practices among livestock farmers in Nepal by Deepak Subedi, Alok Dhakal, Sumit Jyoti, Sanjay Paudel, Sanjay Paudel, Ganesh Ranabhat, Ananda Tiwari, Ahmad I. Al-Mustapha, Ahmad I. Al-Mustapha, Ahmad I. Al-Mustapha

“…Interactions between humans and livestock could increase the risk of zoonotic disease transmission. …”
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Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection mo... by Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani

“…Several iNTS vaccine candidates are in early-stage assessment which—if found effective—would provide a valuable public health tool to reduce iNTS disease burden. …”
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Aspartate aminotransferase-to-platelet ratio index as a novel predictor of early mortality in heat stroke patients: a multi-centre retrospective study by Min Wang, Yun Li, Yuan Cao, Meng-Meng Yang, Fu-Jing Liu, Jie Jiao, Sheng-Yuan Wang, Bin Song, Lu Wang, Yi-Qi Wu, Hong-Jun Kang

“…Background The aspartate aminotransferase-to-platelet ratio index (APRI) is an effective non-invasive marker for chronic liver dysfunction. …”
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Molecular and Biological Characterization of Novel Mitovirus Infecting Phytopathogenic Fungus Ustilaginoidea virens by He Zhenrui, Zhao Wenhua, Cheng Baoping, Yang Mei, Yang Yingqing, Zhu Yiming, Zhou Erxun

“…UvMV1 is classified as a new member of the genus Unuamitovirus in the family Mitoviridae based on phylogenetic analysis. It is effectively transmitted vertically through conidia of strain Uv488 and horizontally through hyphal fusion between vegetatively compatible individuals with an 80% transmission efficiency. …”
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A methodological review of patient healthcare-seeking journeys from symptom onset to receipt of care by Madhukar Pai, Charity Oga-Omenka, Angelina Sassi, Mohammad Yasir Essar, Lavanya Huria, Namrata Rana, Rishav Das, Nathaly Aguilera Vasquez, Darryl Ku, Hanna Diploma, Kiran Saqib, Guy Stallworthy

“…Background For many diseases, early diagnosis and treatment are more cost-effective, reduce community spread of infectious diseases and result in better patient outcomes. …”
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Understanding the Impact of Salvage Radiation on the Long‐Term Natural History of Biochemically Recurrent Prostate Cancer After Radical Prostatectomy by Spyridon P. Basourakos, Stephen A. Boorjian, Phillip J. Schulte, Grant Henning, Jamie T. O'Byrne, Matthew K. Tollefson, Igor Frank, Abhinav Khanna, Ryan M. Phillips, Bradley J. Stish, R. Jeffrey Karnes, Vidit Sharma

“…However, careful patient selection and shared decision making should be encouraged in order to limit overtreatment and side effects.…”
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Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1 by Yuanyin Xi, Ruoding Wang, Man Qu, Qinwen Pan, Minghao Wang, Xiang Ai, Zihan Sun, Chao Zhang, Peng Tang, Jun Jiang, Ying Hu

“…Methods The bioinformatic analysis was used to assess the clinical significance of RBBP7 in BCa. …”
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β-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapy by Miao Yu, Hui Fang, Gang Zhou, Qin Wang, David H Munn, Balveen Kaur, Rafal Pacholczyk, Bangxing Hong, Eugene Douglass, Konstantina Kyritsi

“…Within the ANS, the sympathetic nervous system (SNS) is typically associated with protumor effects. However, whether the SNS influences the antitumor efficacy of intratumoral injections of oncolytic herpes simplex virus (oHSV) in solid tumors remains unknown.Methods In this study, we examined SNS innervation and its interaction with immune cell infiltration in both human and murine triple-negative breast cancer models during intratumoral oHSV injections and SNS blockade on oHSV’s antitumor activity.Results Intratumor oHSV injection promotes SNS innervation accompanied by CD45+cell infiltration in both the human MDA-MB-468 orthotopic model and the murine 4T1 mammary tumor model. …”
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Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinoma by Min Yu, Fei Xu, Xiaohua Wu, Jiajia Li, Xiaojun Chen, Lihua Chen, Jiaxin Chen, Mengdong Ni, Siyu Xia, Jiana Li, Chaohua Liu

“…While immunotherapy has demonstrated effectiveness in some OCCC cases, the mechanisms for heterogeneous immunoreactivity and potential combinatory strategies remain unclear.Methods Tumor samples from 13 patients with OCCC underwent single-cell mRNA-seq and TCR-seq to generate 1 40 683 cells transcriptome, while additionally 31 formalin-fixed paraffin-embedded samples were used for immunohistochemistry. …”
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Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…The western blotmethod and cell-based ELISA revealed successful purification of scFv and its attachment to EGFR on HCT 116 cells.The FTIR analysis determined the interactions between the scFv and OXPT-CS NPs. …”
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Ultrasonic Assisted Environmentally Friendly Extraction of Natural Dyes From Beta vulgaris for the Coloration of Silk Fabric Using Different Mordants by Rony Mia, Tafsir Uddin, A. Z. M. Mofasser, Nadim Ibn Sayed, Al Mojnun Shamim, Sanjida Islam, Khandaker Akil Mahadi Ohi, Moonis Ali Khan, Burhan Uddin Banna

“…In addition, a comparative analysis of the effects of five different mordants such as orange‐peel extracts, lemon peel extracts, tannic acid, ferrous sulfate, and alum on the color strength and fastness of beetroot‐dyed silk fabrics was presented in this research. …”
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Rehydrated corn grain silage with wet brewery residue and different inoculants by E. L. L. Lelis, V. B. Tavares, R. M. A. Teixeira, B. G. C. Homem, C. H. Nogueira, J. M. Silva

“… The objective was to evaluate the effects of including different proportions of Wet Brewery Residue (WBR) using inoculants on rehydrated ground corn silage quality. …”
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Interlacing biology and engineering: An introduction to textiles and their application in tissue engineering by S. Scholpp, L.A. Hoffmann, E. Schätzlein, T. Gries, C. Emonts, A. Blaeser

“…Electrospinning, though highly effective in mimicking the ECM, is structurally limited. …”
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Simulated patients’ role-portrayal in the clinical skills part of the Swiss federal licensing exam is of high quality and improves further over time as measured with the FAIR OSCE... by Schnabel, Kai P., Bauer, Daniel, Schmitz, Felix M., Hitzblech, Tanja, Brem, Beate G.

“…While the findings contribute to understanding SP effectiveness in standardized, high-stakes clinical exams, the study did not scrutinize other potential sources of variance. …”
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Caregiving Artificial Intelligence Chatbot for Older Adults and Their Preferences, Well-Being, and Social Connectivity: Mixed-Method Study by Brooke H Wolfe, Yoo Jung Oh, Hyesun Choung, Xiaoran Cui, Joshua Weinzapfel, R Amanda Cooper, Hae-Na Lee, Rebecca Lehto

“…Participants then participated in a research team–facilitated interaction with an AI chatbot, Amazon Alexa. Interview transcripts were analyzed using thematic analysis, and surveys were evaluated using descriptive statistics. …”
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Exploring Clinicians’ and Patients’ Acceptance and Utilization of a Digital Solution to Support Individualized Care in Diabetes Specialist Outpatient Care (DigiDiaS): Qualitative S... by Maria Aadland Mollestad, Annesofie Lunde Jensen, Heidi Holmen, Tone Singstad, Eirik Årsand, Jacob Andreas Winther, Astrid Torbjørnsen

“…Future research should aim to gain an in-depth understanding of clinicians’ and patients’ acceptance, as well as the effectiveness of change management strategies when implementing digital outpatient solutions in diabetes specialist outpatient care.…”
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Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studie... by Debabrata Modak, Subhajit Ghosh, Sourav Sarkar, Sudipta K. Roy, Ayan Chakraborty, Arpita Ray, Chirag N. Patel, John J. Georrge, Subarna Thakur, Soumen Bhattacharjee

“…The current study aims to identify the effective components in Drynaria quercifolia methanol rhizome extract (DME) and their probable pharmacological mechanisms in alleviating Rheumatoid Arthritis (RA) using network-pharmacology, molecular docking, molecular-dynamics simulations, and gene expression-based validation. …”
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Fungal Footprints: Soil Fungal Communities in Black Walnut and Red Oak Forests by Shaneka S. Lawson, Juan P. Frene, Niall D. Lue Sue

“…Our study underscores that grasping these specific interactions is essential for effective forest management, especially when considering how to use fungal communities to boost plant growth. …”
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MOTIVATIONAL COMPONENT AS A SUCCESS TO ORGANIZE AN INDEPENDENT WORK OF STUDENTS AT THE DEPATMENT OF THERAPEUTIC DENTISTRY by Yu. V. Sidash

“…Such assessments should include an analysis of learning activities rather than criticism of the student's personality. …”
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