RAFT Copolymerization of Pt(II) Pincer Complexes With Water‐Soluble Polymer as an Efficient Way to Obtain Micellar‐Type Nanoparticles With Aggregation‐Induced NIR Emission by Roman A. Shilov, Vadim A. Baigildin, Kristina S. Kisel, Ekaterina E. Galenko, Alexander S. Gubarev, Mariya E. Mikhailova, Olga S. Vezo, Nikolai V. Tsvetkov, Andrey A. Shtyrov, Mikhail N. Ryazantsev, Julia R. Shakirova, Sergey P. Tunik

“…The obtained data indicate that the photophysical properties of the latter are dictated by the type of aggregation process rather than solvatochromic effects. It is shown that at low concentration in organic solvents, the platinum chromophores aggregation is either absent (dimethylformamide) or occurs predominantly at intramolecular level (MeCN), whereas in aqueous media, p(VP‐b‐LPtPV) readily aggregates into micellar‐type nanoparticles with a hydrophilic p(VP) corona and a hydrophobic Pt‐containing core, in which strong intra‐ and intermolecular Pt···Pt and/or π···π interactions result in a significant red shift of absorption and emission down to 600 and 816 nm, respectively. …”
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Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis by Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang

“…ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. …”
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Chromene flavanones from Dalea boliviana as xanthine oxidase inhibitors: in vitro biological evaluation and molecular docking studies by Einy Nallybe Bedoya Aguirre, Einy Nallybe Bedoya Aguirre, María Daniela Santi, Melisa Fabiana Negro, Melisa Fabiana Negro, Javier Echeverría, Margot Paulino Zunini, Mariana Andrea Peralta, Mariana Andrea Peralta, María Gabriela Ortega, María Gabriela Ortega

“…Further molecular dynamics simulations could provide deeper insights into their stability and interaction dynamics, aiding in the rational design of more effective XO inhibitors.ConclusionOur findings lead us to propose these chromene flavanones as lead compounds for the design and development of novel XO inhibitors for treating diseases in which exacerbated activity of this enzyme is involved.…”
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Therapeutic Potential of Cinnamon Oil: Chemical Composition, Pharmacological Actions, and Applications by Jiageng Guo, Xinya Jiang, Yu Tian, Shidu Yan, Jiaojiao Liu, Jinling Xie, Fan Zhang, Chun Yao, Erwei Hao

“…Despite the extensive research supporting its medicinal value, more clinical trials are needed to determine the optimal dosage, administration routes, and possible side effects of cinnamon oil. Additionally, exploring the interactions between cinnamon oil and other drugs, as well as its safety in different populations, is crucial. …”
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PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma by Yangqianwen Zhang, Shuowu Liu, Mixue Bai, Zihan Zhao, Shan Wang, Meiyu Bao, Jinxia Bao, Siyun Shen, Shuang Lu, Ying Xiong, Gaoxiang Gu, Hongyang Wang, Lei Chen

“…Additionally, overexpression and silence of PPP1R12B experiments showed that PPP1R12B overexpression restricted cell proliferation and colony formation in vitro, and inhibited xenografted tumor growth in vivo, while its knockdown had opposite effects. Mechanistically, PPP1R12B could interact with p21-activated kinase 2 (PAK2) to suppress β-catenin expression and phosphorylation at Ser675, thereby impeding its nuclear translocation and subsequent transcriptional activation of Cyclin D1. …”
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Nanoscale Organic Contaminant Detection at the Surface Using Nonlinear Bond Model by Hendradi Hardhienata, Muhammad Ahyad, Fasya Nabilah, Husin Alatas, Faridah Handayasari, Agus Kartono, Tony Sumaryada, Muhammad D. Birowosuto

“…The rapid detection of these contaminants with high sensitivity and selectivity is crucial and can be effectively achieved using nonlinear optical methods. …”
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Associations of device-measured physical activity across adolescence with metabolic traits: Prospective cohort study. by Joshua A Bell, Mark Hamer, Rebecca C Richmond, Nicholas J Timpson, David Carslake, George Davey Smith

“…This suggests that the metabolic effects of physical activity, if causal, depend on most recent engagement.…”
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Information Mode–Dependent Success Rates of Obtaining German Medical Informatics Initiative–Compliant Broad Consent in the Emergency Department: Single-Center Prospective Observati... by Felix Patricius Hans, Jan Kleinekort, Melanie Boerries, Alexandra Nieters, Gerhard Kindle, Micha Rautenberg, Laura Bühler, Gerda Weiser, Michael Clemens Röttger, Carolin Neufischer, Matthias Kühn, Julius Wehrle, Anna Slagman, Antje Fischer-Rosinsky, Larissa Eienbröker, Frank Hanses, Gisbert Wilhelm Teepe, Hans-Jörg Busch, Leo Benning

“…Logistic regression analysis indicated that longer interaction time significantly improved consent rates (P=.03), while female sex was associated with higher dropout rates (P=.02). …”
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Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1 by Xueting Ren, Jinpeng Wu, Jing Li, Zhen Zhai, Xiang Li, Feng Guan, Meng Wang, Xiaobin Ma, Zengqi Tan, Huafeng Kang, Shuai Lin

“…Experimental approaches were employed to increase bisecting GlcNAc levels in BC cells, followed by assessments of PD-L1 expression, CD8+ T cell-mediated cytotoxicity, extracellular vesicle (EV)-associated PD-L1, and PD-L1/PD-1 interaction. Additionally, forskolin, a bisecting GlcNAc agonist, was combined with anti-PD-L1 antibody to evaluate its antitumor effects in vivo. …”
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Addition of metformin to anti-PD-1/PD-L1 drugs activates anti-tumor immune response in peripheral immune cells of NSCLC patients by Luisa Amato, Caterina De Rosa, Gaetano Di Guida, Filippo Sepe, Annalisa Ariano, Sara Capaldo, Faiz Ul Haq, Alessandra Di Liello, Concetta Tuccillo, Stefano Lucà, Renato Franco, Viviana De Rosa, Francesca Iommelli, Alberto Servetto, Fortunato Ciardiello, Carminia Maria Della Corte, Floriana Morgillo

“…The resistance mechanisms to immunotherapy are complex, involving interactions between tumor cells and immune cells that are not fully understood. …”
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Not evolved to save the planet, yet capable to promote pro-environmental action leveraging human nature by Marco Antonio Correa Varella, Marco Antonio Correa Varella, Marco Antonio Correa Varella, Felipe Carvalho Novaes, Felipe Carvalho Novaes, Ramon Felipe Bicudo da Silva, Renato de Mei Romero, Paulo Henrique Santos Gonçalves, Paulo Henrique Santos Gonçalves, Joelson Moreno Brito de Moura, Joelson Moreno Brito de Moura, Risoneide Henriques da Silva, Risoneide Henriques da Silva, Matheus Adriano Ferreira Coelho, Matheus Adriano Ferreira Coelho, João Vitor Rodrigues Costa, Mauro Dias Silva Júnior, Mauro Dias Silva Júnior, Markus J. Rantala, Katariina Elsa Maria Vuorinen

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Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4’s oncogenic role by Siqi Ma, Yuwei Sun, Shaowei Zheng, Yilong Fu, Liangyu Wang, Dun Liu, Henan Jiao, Xuqiang Zhu, Xueyuan Li, Dongming Yan, Di Chen, Zi Ye

“…This subtype promoted therapeutic resistance through unique metabolic reprogramming, MDK-LRP1-mediated microenvironmental interactions, and immunosuppressive properties. YEATS4 knockdown effectively suppressed malignant tumor behaviors, highlighting its therapeutic potential. …”
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Insight into rifampicin resistance behind discordant mutations in RpoB of Mycobacterium tuberculosis: A molecular dynamics simulations study by Muhammad Tahir Khan, Elise Dumont, Jialou Zhu, Kashif Iqbal Sahibzada, Madeeha Shahzad Lodhi, Mehmood Qadir, Dongqing Wei

“…In this study, we aimed to find the effects of discordant mutations on RNA polymerase (RNAP) β-subunit (RpoB) thermodynamic properties leading RIF resistance. …”
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Inflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition by Agnieszka Świdnicka-Siergiejko, Jarosław Daniluk, Katarzyna Miniewska, Urszula Daniluk, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Milena Dąbrowska, Małgorzata Rusak, Michał Ciborowski, Andrzej Dąbrowski

“…PDAC mouse model can be used for further research on microbiota–PDAC interactions and towards more personalized and effective cancer therapies.…”
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Virulence of fowl adenovirus (FAdV) serotype 4 strains impacts cell proliferation and immune response of primary chicken-embryo intestinal epithelial cells by Katharina Kau-Strebinger, Ursula Reichart, Taniya Mitra, Beatrice Grafl, Michael Hess, Dieter Liebhart

“…The initial cellular interactions and intestinal immune responses are not well understood. …”
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Regulation of Interface Compatibility and Performance in Soft Magnetic Composites with Inorganic Insulation Layers by FePO₄ Intermediate Transition Layer by Sanao Huang, Junjie Ma, Yang Liu, Hao He, Peisheng Lyu, Huaqin Huang, Bing Dai

“…The research details the processes forming the FePO₄ intermediate transition layer and the SiO₂ insulation layer on the iron powder surface, along with their interaction mechanisms. An analysis comparing the scenarios with and without the FePO₄ intermediate transition layer shows its beneficial impact on the magnetic properties and mechanical strength of the soft magnetic composites. …”
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Study on stress corrosion behavior and failure mechanism of galvanized bolts in complex coal mine environments by Zhe He, Nong Zhang, Zhengzheng Xie, Chao Ma, Changliang Han, Fan Zhang, Huiqing Wang, Saad S. Alarifi

“…Studies have shown that hot-dip galvanizing is an effective solution, but the first widespread application of galvanized bolts in Xin’Shang’Hai No. 1 coal mine, China, experienced extensive failures. …”
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Enolase and 16.5‐kDa Tegument‐Associated Protein in Fasciola hepatica Extracellular Vesicles: Clues to Their Role in Pathogenesis by Aránzazu González‐Arce, Christian M. Sánchez‐López, Liz F. Sánchez‐Palencia, Antonio Marcilla, Dolores Bernal

“…This work explores the effects of two proteins found in FhEVs, enolase (Fhenolase), enriched in the vesicular lumen, as well as the 16.5‐kDa tegument‐associated protein (Fh16.5TP), highly abundant in the EV membrane, on hepatic and liver‐associated immune cells. …”
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GC-MS Profiling of Ethanol-Extracted Polyherbal Compounds from Medicinal Plant (<i>Citrullus colocynthis</i>, <i>Curcuma longa</i>, and <i>Myristica fragrans</i>): In Silico and An... by Mohd Adnan Kausar, Sadaf Anwar, Halima Mustafa Elagib, Kehkashan Parveen, Malik Asif Hussain, Mohammad Zeeshan Najm, Abhinav Nair, Subhabrata Kar

“…The present study investigates the therapeutic effects of an ethanolic polyherbal extract from <i>Citrullus colocynthis</i> (Bitter Apple), <i>Curcuma longa</i> (Turmeric), and <i>Myristica fragrans</i> (Nutmeg) using advanced in silico and analytical methods. …”
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Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy by Yan Li, Lei Wang, Bojun Xu, Liangbin Zhao, Li Li, Keyang Xu, Anqi Tang, Shasha Zhou, Lu Song, Xiao Zhang, Huakui Zhan

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to determine the molecular mechanisms and therapeutic effects of Cordyceps on the treatment of DN. Results. …”
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