Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models by Zhixiong Cai, Zhenli Li, Wenting Zhong, Fangzhou Lin, Xiuqing Dong, Honghao Ye, Yutong Guo, Geng Chen, Xiaoling Yu, Haijun Yu, Ruijing Tang, Xiaolong Liu

“…Single‐cell transcriptome analysis shows that the combined treatment significantly reduces the proportion of fibroblasts, improves the infiltration of IFN‐γ+CD4+ and GZMK+CD8+ T cells, as well as reduces the interaction of antigen presentation‐associated ligands and receptors between antigen‐presenting Cancer‐Associated Fibroblasts (apCAFs) and naive CD4+ T cells. …”
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A Spatial Decision Support System for climate-adapted agriculture designed with and for stakeholders in West Africa by Katrin Ziegler, Daniel Abel, Lorenz König, Torsten Weber, Insa Otte, Mike Teucher, Christopher Conrad, Michael Thiel, Imoleayo Ezekiel Gbode, Vincent Olanrewaju Ajayi, Amadou Coulibaly, Seydou B. Traoré, Benewinde Jean-Bosco Zoungrana, Heiko Paeth

“…ZOOM, online surveys and email, successfully were utilized to interact with stakeholders instead of on-site activities. …”
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Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis by Magdalena Röckel, Luca Musella, Corinna Preusse, Josefine Radke, Lisa Zimmer, Kai-Martin Thoms, Florentia Dimitriou, Matthias Endres, Wolfgang Böhmerle, Waltraud Fröhlich, Sami Tayb-Boulahfa, Sarah Leonard-Louis, Yves Allenbach, Carola Berking, Werner Stenzel, Samuel Knauss, Julio Vera, Lucie Heinzerling

“…We further characterized the DEGs using network interaction and expression correlation analyses. This allowed us to describe potential differences between regulatory hubs and cells involved in irMyositis susceptible to ICI effects. …”
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Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…These findings support the concept that PrPC mediates the detrimental activities of TauOs through a direct interaction, suggesting that targeting this interaction might be a promising therapeutic strategy for AD and other tauopathies.…”
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Feasibility and cross-cultural validation of an adapted social skills group training programme (KONTAKTTM CHILD) for Chinese autistic children: a waitlist RCT protocol by Sven Bölte, Peipei Yin, Uchong Lao, Huilin Zhu, Fengjing Liang, Wuxia Bai, Xiaoqian Huang, Sonya Girdler, Xiaobing Zou

“…Additionally, preliminary efficacy and cost-effectiveness will be assessed to inform a future definitive trial.Methods and analysis This study will employ a randomised, single-blinded, waitlist-controlled feasibility design with 36 Chinese autistic children aged 8–12 years with IQ over 70 referred to the Child Development and Behavior Center in Guangzhou, China. …”
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Evaluating the potential of graphene oxide to promote skeletal muscle complex regeneration by Yulu Chen, Zeyu Zhu, Yian Shen, Xuling Liu, Yushi He, Chengqi Lyu, Jiayu Lu

“…Exosomes derived from GO-treated myoblasts upregulated genes such as PDGFRB, COL12A1, and TBX2 while downregulating inflammation-related genes such as C3, thereby demonstrating the crosstalk between muscle and bone cells.ConclusionThe conductive properties and surface roughness of GO significantly enhanced interactions between muscle and bone tissues, consequently facilitating effective musculoskeletal repair. …”
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…Results Among 20 different Pyrazole derivatives, Pyrazole 3b is the most effective compound against A. niger ATCC 11414 and A. flavus ATCC 9643 with IZDs and AIs of 32.0 mm (1.10) and 30.0 mm (1.0), respectively. …”
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Aloe ferox leaf gel extracts attenuate redox imbalance in oxidative renal injury and stimulates glucose uptake, whilst inhibiting key enzymes linked to diabetes and obesity by Huda Ismail, Almahi I. Mohamed, Md. Shahidul Islam

“…Furthermore, LC-MS analysis led to the identification of many compounds, when chlorogenic acid demonstrated a stronger molecular interaction with the active site amino acids of α-amylase and catalase compared to other compounds. …”
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An “initial-engineering-end use” quasi-market pricing mechanism under cascading risk for cross-regional water rights trading by Xuxia Li, Huimin Wang, Gang Liu, Liu Yang, Zhou Fang, Yi Xiao, Xiaoying Lai, Li Gao, Ying Teng

“…To support these stages, data from field studies is used to calibrate three unique pricing models: the stochastic differential game, incomplete contract theory, and the Nash-bargaining model. We analyze the interactions among equilibrium water prices across these stages to explore the cascade effects. …”
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Association between statins use and mortality in critically ill patients with sepsis included myocardial injury: a retrospective cohort study by Shuxing Wei, Yiming Dong, Yanqian Su, Ying Chen, Xiya Wang, Hongmeng Dong, Danlei Weng, Yue Hu, Shubin Guo, Xue Mei, Wenqing Ji

“…Given the pharmacological effects of statins in both sepsis and cardiovascular disease, this study aimed to investigate the association between statins use and the prognosis of SIMI. …”
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Development and application of a curcumin-cinnamon essential oil nanoemulsion agent against mycobacteria by Zhihui Lei, Zhihui Lei, Zhihui Lei, Yixuan Ren, Jinyao Wang, Haisu Shi, Hu Lin, Hong Chen, Lijun Bi, Lijun Bi, Yutang Wang, Hongtai Zhang, Hongtai Zhang, Hongtai Zhang

“…The nanoemulsion demonstrated high encapsulation efficiency (90.2%) and stability, with a stability coefficient of 0.984. Structural analysis revealed a dense network structure of the nanoemulsion and amorphous forms of Cur and CEO, enhanced by hydrogen bonding and electrostatic interactions, which improved solubility and bioavailability. …”
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Hepatocyte‐Targeted Lipid Nanoparticle Delivery of HERC2 Plasmid Controls Drug‐Induced Hepatotoxicity by Limiting β‐Catenin‐Regulated CYP2E1 Expression by Yunzhi Liu, Qishan Xu, Yan Liu, Sihang Cao, Jialiang Luo, Zhuojun Zheng, Jia Zhou, Xiao Lu, Liyun Zhang, Yanan Tan, Qingyun Chen, Daming Zuo

“…Abstract Understanding the molecular mechanisms that bridge hepatic inflammation and liver injury is crucial for developing effective therapeutic strategies for drug‐induced liver injury (DILI) management. …”
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Plant growth promoting fungus Cladosporium ‘BF-F’ promotes cadmium accumulation in Sesuvium portulacastrum by regulating plant metal ion transport by Wenbin Zhang, Yanyu Cao, Mengnan Ma, Ziling Li, Xiuli Jiang, Dan Wang, Dingding Cao, Christopher Rensing, Hong Liu, Xiangying Wei

“…Various approaches have been used to remove Cd from contaminated soils, with bioremediation through plants and soil microbes being the most effective. This study investigated interactions of a new plant growth promoting fungus (PGPF), Cladosporium ‘BF-F’ with Sesuvium portulacastrum plants for bioremediation of Cd in a laboratory setting. …”
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A novel method enhanced mechanical properties of a selective laser melted Mar-M247 superalloy by progressive remelting by Liyu Li, Tao Dong, Fengchun Jiang, Yi Ru, Chunhuan Guo, Mingxia Diao, Haolun Song

“…Quantitative temperature-field analysis signifies a substantial decrease in the cooling rate during manufacturing via progressive remelting, which explains crack inhibition. …”
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Enhancement of Apostichopus japonicus peptide flavor through bacterial and enzyme co-fermentation (BECF) and the identification of novel antioxidant peptides in the fermented produ... by Zhiqiang Shu, Gongming Wang, Yuexin Jing, Chunna Jiao, Leilei Sun, Hui Huang, Yue Li, Jian Zhang

“…Molecular docking studies showed significant hydrogen-bonding interactions. In conclusion, BECF is an effective strategy for enhancing the flavor of A. japonicus peptide.…”
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Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis by Yu Cao, Qirong Xie, Qiang Zheng, Jingping Zhang, Mengyu Yao, Zhongyong Du, Lujun Zhang, Tianyang Hu, Yunli Zhao, Jianlin Du, Yongyong Li, Yuxing Feng, ND Melgiri, Xiaodong Zhao, Rongzhong Huang, Yang Sun

“…Abstract Aryl Hydrocarbon Receptor‐Interacting Protein (AIP) reduces macrophage cholesterol‐ester accumulation and may prevent atherogenic foamy macrophage formation. …”
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FimC binds to the promoter region of agn43 to modulate autoaggregation by Zhihao Wang, Xiangpeng Niu, Ningyuan Zhong, Lanfang Kong, Saqib Nawaz, Haiyang Zhang, Wei Jiang, Yuanyuan Liu, Jian Tu, Xiangan Han

“…Further investigation revealed that fimC directly interacted with the promoter region of agn43 and inhibited its transcription. …”
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Towards automated and real-time multi-object detection of anguilliform fishes from sonar data using YOLOv8 deep learning algorithm by Tao Huang, Xiaoqin Zang, Grigoriy Kondyukov, Zhangshuan Hou, Guanze Peng, Joachim Pander, Josef Knott, Juergen Geist, Meklit Berihun Melesse, Paul Jacobson, Zhiqun Daniel Deng

“…Accurate and efficient detection of migrating eels can improve our understanding of fish behaviors and fish-hydraulic structure interactions from both ecological and economic perspectives. …”
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Soil pH and Nutrient Stoichiometry as Key Drivers of Phosphorus Availability in Crop Rotation Systems by Yi Yuan, Yi Zhu, Yichen Zhao, Meng Wang, Zhaoming Qu, Dongqing Lv, Yanli Liu, Yan Song, Tingting Wang, Chengliang Li, Haojie Feng

“…This five-year field experiment investigated the effects of four rotation systems (WM: wheat–maize; WP: wheat–peanut; WS: wheat–soybean; MV: maize–hairy vetch) on soil P fractions, phosphatase activities, P-cycling gene abundance, and their interactions with soil properties. …”
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SCAPAS-LungCancer—improving supportive care for patients surgically treated for non-small cell lung cancer: protocol for a prospective, longitudinal, observational and exploratory... by Wei Dai, Britt Borregaard, Zaigham Saghir, Pernille E Bidstrup, Morten Quist, Thomas Decker Christensen, Rene Horsleben Petersen, Rikke Langballe, Lin Huang, Malene Missel, Pernille Orloff Donsel, Michael Stenger, Pernille Brasch Andersen, Camilla Corvinius, Johnny Moons, Florian Fehlmann, Lisbeth Søbæk Hansen, Mai Nanna Schoenau

“…A longitudinal qualitative study, including individual interviews and ethnographic fieldwork, will be conducted to explore patients’ experiences and interactions with clinicians on symptoms and late effects. …”
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